P49910 (ZN165_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 165

Alternative name(s):
Cancer/testis antigen 53
Short name=CT53
LD65
Zinc finger and SCAN domain-containing protein 7

Gene names

Name:	ZNF165
Synonyms:	ZPF165, ZSCAN7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Tissue specificity	Expressed specifically in testis.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 6 C2H2-type zinc fingers. Contains 1 SCAN box domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW viral reproduction Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Non-traceable author statement. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CCDC130	P13994	2	EBI-741694,EBI-716093
DVL2	O14641	2	EBI-741694,EBI-740850
EWSR1	Q01844	2	EBI-741694,EBI-739737

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 485	485	Zinc finger protein 165		PRO_0000047436
Regions
	Domain	62 – 127	66	SCAN box
	Zinc finger	290 – 314	25	C2H2-type 1; degenerate
	Zinc finger	344 – 366	23	C2H2-type 2
	Zinc finger	372 – 394	23	C2H2-type 3
	Zinc finger	400 – 422	23	C2H2-type 4
	Zinc finger	428 – 450	23	C2H2-type 5
	Zinc finger	456 – 478	23	C2H2-type 6

Sequences

	Sequence		Length	Mass (Da)
	P49910 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 1265D859D1713AE8	FASTA	485	55,771
	10 20 30 40 50 60 MATEPKKAAA QNSPEDEGLL IVKIEEEEFI HGQDTCLQRS ELLKQELCRQ LFRQFCYQDS 70 80 90 100 110 120 PGPREALSRL RELCCQWLKP EIHTKEQILE LLVLEQFLTI LPGDLQAWVH EHYPESGEEA 130 140 150 160 170 180 VTILEDLERG TDEAVLQVQA HEHGQEIFQK KVSPPGPALN VKLQPVETKA HFDSSEPQLL 190 200 210 220 230 240 WDCDNESENS RSMPKLEIFE KIESQRIISG RISGYISEAS GESQDICKSA GRVKRQWEKE 250 260 270 280 290 300 SGESQRLSSA QDEGFGKILT HKNTVRGEII SHDGCERRLN LNSNEFTHQK SCKHGTCDQS 310 320 330 340 350 360 FKWNSDFINH QIIYAGEKNH QYGKSFKSPK LAKHAAVFSG DKTHQCNECG KAFRHSSKLA 370 380 390 400 410 420 RHQRIHTGER CYECNECGKS FAESSDLTRH RRIHTGERPF GCKECGRAFN LNSHLIRHQR 430 440 450 460 470 480 IHTREKPYEC SECGKTFRVS SHLIRHFRIH TGEKPYECSE CGRAFSQSSN LSQHQRIHMR ENLLM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a novel zinc finger gene (ZNF165) mapping to 6p21 that is expressed specifically in testis." Tirosvoutis K.N., Divane A., Jones M., Affara N.A. Genomics 28:485-490(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain." Lee P.L., Gelbart T., West C., Adams M., Blackstone R., Beutler E. Genomics 43:191-201(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X84801 mRNA. Translation: CAA59268.1. U78722 mRNA. Translation: AAC51658.1. U88086, U88084, U88085 Genomic DNA. Translation: AAD04755.1. AL121944 Genomic DNA. Translation: CAB92080.1. BC026092 mRNA. Translation: AAH26092.1.
IPI	IPI00029075.
PIR	S52411.
RefSeq	NP_003438.1. NM_003447.3.
UniGene	Hs.55481.
3D structure databases
ProteinModelPortal	P49910.
ModBase	Search...
Protein-protein interaction databases
IntAct	P49910. 12 interactions.
STRING	9606.ENSP00000252206.
PTM databases
PhosphoSite	P49910.
Polymorphism databases
DMDM	1731420.
Proteomic databases
PaxDb	P49910.
PRIDE	P49910.
Protocols and materials databases
DNASU	7718.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377325; ENSP00000366542; ENSG00000197279.
GeneID	7718.
KEGG	hsa:7718.
UCSC	uc003nkh.3. human.
Organism-specific databases
CTD	7718.
GeneCards	GC06P028046.
HGNC	HGNC:12953. ZNF165.
HPA	HPA007247.
MIM	600834. gene.
neXtProt	NX_P49910.
PharmGKB	PA37535.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234619.
HOVERGEN	HBG018163.
InParanoid	P49910.
KO	K09230.
OMA	HQYGKSF.
OrthoDB	EOG4QRH3V.
PhylomeDB	P49910.
Gene expression databases
ArrayExpress	P49910.
Bgee	P49910.
CleanEx	HS_ZNF165.
Genevestigator	P49910.
GermOnline	ENSG00000197279. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 5 hits.
InterPro	IPR008916. Retrov_capsid_C. IPR003309. Tscrpt_reg_SCAN. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF02023. SCAN. 1 hit. [Graphical view]
SMART	SM00431. SCAN. 1 hit. SM00355. ZnF_C2H2. 6 hits. [Graphical view]
SUPFAM	SSF47353. Retrov_capsid_C. 1 hit.
PROSITE	PS50804. SCAN_BOX. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 5 hits. PS50157. ZINC_FINGER_C2H2_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7718.
NextBio	29912.
SOURCE	Search...

Entry information

Entry name

ZN165_HUMAN

Accession

Primary (citable) accession number: P49910

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 118 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.