Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 165

Gene

ZNF165

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri290 – 314C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri344 – 366C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 165
Alternative name(s):
Cancer/testis antigen 53
Short name:
CT53
LD65
Zinc finger and SCAN domain-containing protein 7
Gene namesi
Name:ZNF165
Synonyms:ZPF165, ZSCAN7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000197279.3
HGNCiHGNC:12953 ZNF165
MIMi600834 gene
neXtProtiNX_P49910

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7718
OpenTargetsiENSG00000197279
PharmGKBiPA37535

Polymorphism and mutation databases

BioMutaiZNF165
DMDMi1731420

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474361 – 485Zinc finger protein 165Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki23Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki162Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki195Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP49910
PaxDbiP49910
PeptideAtlasiP49910
PRIDEiP49910

PTM databases

iPTMnetiP49910
PhosphoSitePlusiP49910

Expressioni

Tissue specificityi

Expressed specifically in testis.

Gene expression databases

BgeeiENSG00000197279
CleanExiHS_ZNF165
ExpressionAtlasiP49910 baseline and differential
GenevisibleiP49910 HS

Organism-specific databases

HPAiHPA007247

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113511, 22 interactors
IntActiP49910, 36 interactors
MINTiP49910
STRINGi9606.ENSP00000366542

Structurei

3D structure databases

ProteinModelPortaliP49910
SMRiP49910
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 127SCAN boxPROSITE-ProRule annotationAdd BLAST66

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri290 – 314C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri344 – 366C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiP49910
KOiK09230
OMAiNEFTHQK
OrthoDBiEOG091G09O3
PhylomeDBiP49910
TreeFamiTF338304

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequencei

Sequence statusi: Complete.

P49910-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATEPKKAAA QNSPEDEGLL IVKIEEEEFI HGQDTCLQRS ELLKQELCRQ
60 70 80 90 100
LFRQFCYQDS PGPREALSRL RELCCQWLKP EIHTKEQILE LLVLEQFLTI
110 120 130 140 150
LPGDLQAWVH EHYPESGEEA VTILEDLERG TDEAVLQVQA HEHGQEIFQK
160 170 180 190 200
KVSPPGPALN VKLQPVETKA HFDSSEPQLL WDCDNESENS RSMPKLEIFE
210 220 230 240 250
KIESQRIISG RISGYISEAS GESQDICKSA GRVKRQWEKE SGESQRLSSA
260 270 280 290 300
QDEGFGKILT HKNTVRGEII SHDGCERRLN LNSNEFTHQK SCKHGTCDQS
310 320 330 340 350
FKWNSDFINH QIIYAGEKNH QYGKSFKSPK LAKHAAVFSG DKTHQCNECG
360 370 380 390 400
KAFRHSSKLA RHQRIHTGER CYECNECGKS FAESSDLTRH RRIHTGERPF
410 420 430 440 450
GCKECGRAFN LNSHLIRHQR IHTREKPYEC SECGKTFRVS SHLIRHFRIH
460 470 480
TGEKPYECSE CGRAFSQSSN LSQHQRIHMR ENLLM
Length:485
Mass (Da):55,771
Last modified:October 1, 1996 - v1
Checksum:i1265D859D1713AE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84801 mRNA Translation: CAA59268.1
U78722 mRNA Translation: AAC51658.1
U88086, U88084, U88085 Genomic DNA Translation: AAD04755.1
AL121944 Genomic DNA No translation available.
BC026092 mRNA Translation: AAH26092.1
CCDSiCCDS4643.1
PIRiS52411
RefSeqiNP_003438.1, NM_003447.3
XP_016866747.1, XM_017011258.1
XP_016866748.1, XM_017011259.1
XP_016866749.1, XM_017011260.1
UniGeneiHs.55481

Genome annotation databases

EnsembliENST00000377325; ENSP00000366542; ENSG00000197279
GeneIDi7718
KEGGihsa:7718

Similar proteinsi

Entry informationi

Entry nameiZN165_HUMAN
AccessioniPrimary (citable) accession number: P49910
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health