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P49910 (ZN165_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 165
Alternative name(s):
Cancer/testis antigen 53
Short name=CT53
LD65
Zinc finger and SCAN domain-containing protein 7
Gene names
Name:ZNF165
Synonyms:ZPF165, ZSCAN7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Tissue specificity

Expressed specifically in testis.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 6 C2H2-type zinc fingers.

Contains 1 SCAN box domain.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 485485Zinc finger protein 165
PRO_0000047436

Regions

Domain62 – 12766SCAN box
Zinc finger290 – 31425C2H2-type 1; degenerate
Zinc finger344 – 36623C2H2-type 2
Zinc finger372 – 39423C2H2-type 3
Zinc finger400 – 42223C2H2-type 4
Zinc finger428 – 45023C2H2-type 5
Zinc finger456 – 47823C2H2-type 6

Sequences

Sequence LengthMass (Da)Tools
P49910 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 1265D859D1713AE8

FASTA48555,771
        10         20         30         40         50         60 
MATEPKKAAA QNSPEDEGLL IVKIEEEEFI HGQDTCLQRS ELLKQELCRQ LFRQFCYQDS 

        70         80         90        100        110        120 
PGPREALSRL RELCCQWLKP EIHTKEQILE LLVLEQFLTI LPGDLQAWVH EHYPESGEEA 

       130        140        150        160        170        180 
VTILEDLERG TDEAVLQVQA HEHGQEIFQK KVSPPGPALN VKLQPVETKA HFDSSEPQLL 

       190        200        210        220        230        240 
WDCDNESENS RSMPKLEIFE KIESQRIISG RISGYISEAS GESQDICKSA GRVKRQWEKE 

       250        260        270        280        290        300 
SGESQRLSSA QDEGFGKILT HKNTVRGEII SHDGCERRLN LNSNEFTHQK SCKHGTCDQS 

       310        320        330        340        350        360 
FKWNSDFINH QIIYAGEKNH QYGKSFKSPK LAKHAAVFSG DKTHQCNECG KAFRHSSKLA 

       370        380        390        400        410        420 
RHQRIHTGER CYECNECGKS FAESSDLTRH RRIHTGERPF GCKECGRAFN LNSHLIRHQR 

       430        440        450        460        470        480 
IHTREKPYEC SECGKTFRVS SHLIRHFRIH TGEKPYECSE CGRAFSQSSN LSQHQRIHMR 


ENLLM 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a novel zinc finger gene (ZNF165) mapping to 6p21 that is expressed specifically in testis."
Tirosvoutis K.N., Divane A., Jones M., Affara N.A.
Genomics 28:485-490(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain."
Lee P.L., Gelbart T., West C., Adams M., Blackstone R., Beutler E.
Genomics 43:191-201(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X84801 mRNA. Translation: CAA59268.1.
U78722 mRNA. Translation: AAC51658.1.
U88086, U88084, U88085 Genomic DNA. Translation: AAD04755.1.
AL121944 Genomic DNA. Translation: CAB92080.1.
BC026092 mRNA. Translation: AAH26092.1.
CCDSCCDS4643.1.
PIRS52411.
RefSeqNP_003438.1. NM_003447.3.
XP_005249428.1. XM_005249371.1.
XP_005249429.1. XM_005249372.1.
XP_005249430.1. XM_005249373.1.
UniGeneHs.55481.

3D structure databases

ProteinModelPortalP49910.
SMRP49910. Positions 46-132, 297-484.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113511. 15 interactions.
IntActP49910. 13 interactions.
MINTMINT-8417731.
STRING9606.ENSP00000252206.

PTM databases

PhosphoSiteP49910.

Polymorphism databases

DMDM1731420.

Proteomic databases

PaxDbP49910.
PRIDEP49910.

Protocols and materials databases

DNASU7718.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000377325; ENSP00000366542; ENSG00000197279.
GeneID7718.
KEGGhsa:7718.
UCSCuc003nkh.3. human.

Organism-specific databases

CTD7718.
GeneCardsGC06P028046.
HGNCHGNC:12953. ZNF165.
HPAHPA007247.
MIM600834. gene.
neXtProtNX_P49910.
PharmGKBPA37535.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234619.
HOVERGENHBG018163.
InParanoidP49910.
KOK09230.
OMAIHKRENL.
OrthoDBEOG7F24SH.
PhylomeDBP49910.
TreeFamTF338304.

Gene expression databases

ArrayExpressP49910.
BgeeP49910.
CleanExHS_ZNF165.
GenevestigatorP49910.

Family and domain databases

Gene3D3.30.160.60. 5 hits.
InterProIPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF02023. SCAN. 1 hit.
[Graphical view]
SMARTSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMSSF47353. SSF47353. 1 hit.
PROSITEPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiZinc_finger_protein_165.
GenomeRNAi7718.
NextBio29912.
PROP49910.
SOURCESearch...

Entry information

Entry nameZN165_HUMAN
AccessionPrimary (citable) accession number: P49910
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM