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P49910

- ZN165_HUMAN

UniProt

P49910 - ZN165_HUMAN

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Protein

Zinc finger protein 165

Gene

ZNF165

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri290 – 31425C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri428 – 45023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri456 – 47823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 165
Alternative name(s):
Cancer/testis antigen 53
Short name:
CT53
LD65
Zinc finger and SCAN domain-containing protein 7
Gene namesi
Name:ZNF165
Synonyms:ZPF165, ZSCAN7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:12953. ZNF165.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37535.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485Zinc finger protein 165PRO_0000047436Add
BLAST

Proteomic databases

MaxQBiP49910.
PaxDbiP49910.
PRIDEiP49910.

PTM databases

PhosphoSiteiP49910.

Expressioni

Tissue specificityi

Expressed specifically in testis.

Gene expression databases

BgeeiP49910.
CleanExiHS_ZNF165.
ExpressionAtlasiP49910. baseline and differential.
GenevestigatoriP49910.

Organism-specific databases

HPAiHPA007247.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC130P139942EBI-741694,EBI-716093
DVL2O146412EBI-741694,EBI-740850
EWSR1Q018442EBI-741694,EBI-739737

Protein-protein interaction databases

BioGridi113511. 15 interactions.
IntActiP49910. 13 interactions.
MINTiMINT-8417731.
STRINGi9606.ENSP00000252206.

Structurei

3D structure databases

ProteinModelPortaliP49910.
SMRiP49910. Positions 46-132, 277-484.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 12766SCAN boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri290 – 31425C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri428 – 45023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri456 – 47823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiP49910.
KOiK09230.
OMAiIHKRENL.
OrthoDBiEOG7F24SH.
PhylomeDBiP49910.
TreeFamiTF338304.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49910-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATEPKKAAA QNSPEDEGLL IVKIEEEEFI HGQDTCLQRS ELLKQELCRQ
60 70 80 90 100
LFRQFCYQDS PGPREALSRL RELCCQWLKP EIHTKEQILE LLVLEQFLTI
110 120 130 140 150
LPGDLQAWVH EHYPESGEEA VTILEDLERG TDEAVLQVQA HEHGQEIFQK
160 170 180 190 200
KVSPPGPALN VKLQPVETKA HFDSSEPQLL WDCDNESENS RSMPKLEIFE
210 220 230 240 250
KIESQRIISG RISGYISEAS GESQDICKSA GRVKRQWEKE SGESQRLSSA
260 270 280 290 300
QDEGFGKILT HKNTVRGEII SHDGCERRLN LNSNEFTHQK SCKHGTCDQS
310 320 330 340 350
FKWNSDFINH QIIYAGEKNH QYGKSFKSPK LAKHAAVFSG DKTHQCNECG
360 370 380 390 400
KAFRHSSKLA RHQRIHTGER CYECNECGKS FAESSDLTRH RRIHTGERPF
410 420 430 440 450
GCKECGRAFN LNSHLIRHQR IHTREKPYEC SECGKTFRVS SHLIRHFRIH
460 470 480
TGEKPYECSE CGRAFSQSSN LSQHQRIHMR ENLLM
Length:485
Mass (Da):55,771
Last modified:October 1, 1996 - v1
Checksum:i1265D859D1713AE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84801 mRNA. Translation: CAA59268.1.
U78722 mRNA. Translation: AAC51658.1.
U88086, U88084, U88085 Genomic DNA. Translation: AAD04755.1.
AL121944 Genomic DNA. Translation: CAB92080.1.
BC026092 mRNA. Translation: AAH26092.1.
CCDSiCCDS4643.1.
PIRiS52411.
RefSeqiNP_003438.1. NM_003447.3.
XP_005249428.1. XM_005249371.1.
XP_005249429.1. XM_005249372.1.
XP_005249430.1. XM_005249373.1.
UniGeneiHs.55481.

Genome annotation databases

EnsembliENST00000377325; ENSP00000366542; ENSG00000197279.
GeneIDi7718.
KEGGihsa:7718.
UCSCiuc003nkh.3. human.

Polymorphism databases

DMDMi1731420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84801 mRNA. Translation: CAA59268.1 .
U78722 mRNA. Translation: AAC51658.1 .
U88086 , U88084 , U88085 Genomic DNA. Translation: AAD04755.1 .
AL121944 Genomic DNA. Translation: CAB92080.1 .
BC026092 mRNA. Translation: AAH26092.1 .
CCDSi CCDS4643.1.
PIRi S52411.
RefSeqi NP_003438.1. NM_003447.3.
XP_005249428.1. XM_005249371.1.
XP_005249429.1. XM_005249372.1.
XP_005249430.1. XM_005249373.1.
UniGenei Hs.55481.

3D structure databases

ProteinModelPortali P49910.
SMRi P49910. Positions 46-132, 277-484.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113511. 15 interactions.
IntActi P49910. 13 interactions.
MINTi MINT-8417731.
STRINGi 9606.ENSP00000252206.

PTM databases

PhosphoSitei P49910.

Polymorphism databases

DMDMi 1731420.

Proteomic databases

MaxQBi P49910.
PaxDbi P49910.
PRIDEi P49910.

Protocols and materials databases

DNASUi 7718.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377325 ; ENSP00000366542 ; ENSG00000197279 .
GeneIDi 7718.
KEGGi hsa:7718.
UCSCi uc003nkh.3. human.

Organism-specific databases

CTDi 7718.
GeneCardsi GC06P028046.
HGNCi HGNC:12953. ZNF165.
HPAi HPA007247.
MIMi 600834. gene.
neXtProti NX_P49910.
PharmGKBi PA37535.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234619.
HOVERGENi HBG018163.
InParanoidi P49910.
KOi K09230.
OMAi IHKRENL.
OrthoDBi EOG7F24SH.
PhylomeDBi P49910.
TreeFami TF338304.

Miscellaneous databases

GeneWikii Zinc_finger_protein_165.
GenomeRNAii 7718.
NextBioi 29912.
PROi P49910.
SOURCEi Search...

Gene expression databases

Bgeei P49910.
CleanExi HS_ZNF165.
ExpressionAtlasi P49910. baseline and differential.
Genevestigatori P49910.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
InterProi IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF02023. SCAN. 1 hit.
[Graphical view ]
SMARTi SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view ]
SUPFAMi SSF47353. SSF47353. 1 hit.
PROSITEi PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a novel zinc finger gene (ZNF165) mapping to 6p21 that is expressed specifically in testis."
    Tirosvoutis K.N., Divane A., Jones M., Affara N.A.
    Genomics 28:485-490(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain."
    Lee P.L., Gelbart T., West C., Adams M., Blackstone R., Beutler E.
    Genomics 43:191-201(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZN165_HUMAN
AccessioniPrimary (citable) accession number: P49910
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3