Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P49910

- ZN165_HUMAN

UniProt

P49910 - ZN165_HUMAN

Protein

Zinc finger protein 165

Gene

ZNF165

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri290 – 31425C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri344 – 36623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri372 – 39423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri400 – 42223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri428 – 45023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri456 – 47823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 165
    Alternative name(s):
    Cancer/testis antigen 53
    Short name:
    CT53
    LD65
    Zinc finger and SCAN domain-containing protein 7
    Gene namesi
    Name:ZNF165
    Synonyms:ZPF165, ZSCAN7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:12953. ZNF165.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37535.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 485485Zinc finger protein 165PRO_0000047436Add
    BLAST

    Proteomic databases

    PaxDbiP49910.
    PRIDEiP49910.

    PTM databases

    PhosphoSiteiP49910.

    Expressioni

    Tissue specificityi

    Expressed specifically in testis.

    Gene expression databases

    ArrayExpressiP49910.
    BgeeiP49910.
    CleanExiHS_ZNF165.
    GenevestigatoriP49910.

    Organism-specific databases

    HPAiHPA007247.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CCDC130P139942EBI-741694,EBI-716093
    DVL2O146412EBI-741694,EBI-740850
    EWSR1Q018442EBI-741694,EBI-739737

    Protein-protein interaction databases

    BioGridi113511. 15 interactions.
    IntActiP49910. 13 interactions.
    MINTiMINT-8417731.
    STRINGi9606.ENSP00000252206.

    Structurei

    3D structure databases

    ProteinModelPortaliP49910.
    SMRiP49910. Positions 46-132, 297-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini62 – 12766SCAN boxPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SCAN box domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri290 – 31425C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri344 – 36623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri372 – 39423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri400 – 42223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri428 – 45023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri456 – 47823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234619.
    HOVERGENiHBG018163.
    InParanoidiP49910.
    KOiK09230.
    OMAiIHKRENL.
    OrthoDBiEOG7F24SH.
    PhylomeDBiP49910.
    TreeFamiTF338304.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    InterProiIPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF02023. SCAN. 1 hit.
    [Graphical view]
    SMARTiSM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 6 hits.
    [Graphical view]
    SUPFAMiSSF47353. SSF47353. 1 hit.
    PROSITEiPS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P49910-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATEPKKAAA QNSPEDEGLL IVKIEEEEFI HGQDTCLQRS ELLKQELCRQ    50
    LFRQFCYQDS PGPREALSRL RELCCQWLKP EIHTKEQILE LLVLEQFLTI 100
    LPGDLQAWVH EHYPESGEEA VTILEDLERG TDEAVLQVQA HEHGQEIFQK 150
    KVSPPGPALN VKLQPVETKA HFDSSEPQLL WDCDNESENS RSMPKLEIFE 200
    KIESQRIISG RISGYISEAS GESQDICKSA GRVKRQWEKE SGESQRLSSA 250
    QDEGFGKILT HKNTVRGEII SHDGCERRLN LNSNEFTHQK SCKHGTCDQS 300
    FKWNSDFINH QIIYAGEKNH QYGKSFKSPK LAKHAAVFSG DKTHQCNECG 350
    KAFRHSSKLA RHQRIHTGER CYECNECGKS FAESSDLTRH RRIHTGERPF 400
    GCKECGRAFN LNSHLIRHQR IHTREKPYEC SECGKTFRVS SHLIRHFRIH 450
    TGEKPYECSE CGRAFSQSSN LSQHQRIHMR ENLLM 485
    Length:485
    Mass (Da):55,771
    Last modified:October 1, 1996 - v1
    Checksum:i1265D859D1713AE8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84801 mRNA. Translation: CAA59268.1.
    U78722 mRNA. Translation: AAC51658.1.
    U88086, U88084, U88085 Genomic DNA. Translation: AAD04755.1.
    AL121944 Genomic DNA. Translation: CAB92080.1.
    BC026092 mRNA. Translation: AAH26092.1.
    CCDSiCCDS4643.1.
    PIRiS52411.
    RefSeqiNP_003438.1. NM_003447.3.
    XP_005249428.1. XM_005249371.1.
    XP_005249429.1. XM_005249372.1.
    XP_005249430.1. XM_005249373.1.
    UniGeneiHs.55481.

    Genome annotation databases

    EnsembliENST00000377325; ENSP00000366542; ENSG00000197279.
    GeneIDi7718.
    KEGGihsa:7718.
    UCSCiuc003nkh.3. human.

    Polymorphism databases

    DMDMi1731420.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84801 mRNA. Translation: CAA59268.1 .
    U78722 mRNA. Translation: AAC51658.1 .
    U88086 , U88084 , U88085 Genomic DNA. Translation: AAD04755.1 .
    AL121944 Genomic DNA. Translation: CAB92080.1 .
    BC026092 mRNA. Translation: AAH26092.1 .
    CCDSi CCDS4643.1.
    PIRi S52411.
    RefSeqi NP_003438.1. NM_003447.3.
    XP_005249428.1. XM_005249371.1.
    XP_005249429.1. XM_005249372.1.
    XP_005249430.1. XM_005249373.1.
    UniGenei Hs.55481.

    3D structure databases

    ProteinModelPortali P49910.
    SMRi P49910. Positions 46-132, 297-484.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113511. 15 interactions.
    IntActi P49910. 13 interactions.
    MINTi MINT-8417731.
    STRINGi 9606.ENSP00000252206.

    PTM databases

    PhosphoSitei P49910.

    Polymorphism databases

    DMDMi 1731420.

    Proteomic databases

    PaxDbi P49910.
    PRIDEi P49910.

    Protocols and materials databases

    DNASUi 7718.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377325 ; ENSP00000366542 ; ENSG00000197279 .
    GeneIDi 7718.
    KEGGi hsa:7718.
    UCSCi uc003nkh.3. human.

    Organism-specific databases

    CTDi 7718.
    GeneCardsi GC06P028046.
    HGNCi HGNC:12953. ZNF165.
    HPAi HPA007247.
    MIMi 600834. gene.
    neXtProti NX_P49910.
    PharmGKBi PA37535.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234619.
    HOVERGENi HBG018163.
    InParanoidi P49910.
    KOi K09230.
    OMAi IHKRENL.
    OrthoDBi EOG7F24SH.
    PhylomeDBi P49910.
    TreeFami TF338304.

    Miscellaneous databases

    GeneWikii Zinc_finger_protein_165.
    GenomeRNAii 7718.
    NextBioi 29912.
    PROi P49910.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49910.
    Bgeei P49910.
    CleanExi HS_ZNF165.
    Genevestigatori P49910.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    InterProi IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF02023. SCAN. 1 hit.
    [Graphical view ]
    SMARTi SM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 6 hits.
    [Graphical view ]
    SUPFAMi SSF47353. SSF47353. 1 hit.
    PROSITEi PS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a novel zinc finger gene (ZNF165) mapping to 6p21 that is expressed specifically in testis."
      Tirosvoutis K.N., Divane A., Jones M., Affara N.A.
      Genomics 28:485-490(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain."
      Lee P.L., Gelbart T., West C., Adams M., Blackstone R., Beutler E.
      Genomics 43:191-201(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiZN165_HUMAN
    AccessioniPrimary (citable) accession number: P49910
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3