Reviewed, UniProtKB/Swiss-Prot P49908 (SEPP1_HUMAN)

Names and origin

Protein names

Recommended name:
    Selenoprotein P
      Short name=SeP

Gene names

Name:	SEPP1
Synonyms:	SELP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis.
Subcellular location	Secreted.
Tissue specificity	Made in the liver and heart and secreted into the plasma. It is also found in the kidney.
Sequence similarities	Belongs to the selenoprotein P family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism Selenocysteine
Domain	Signal
Ligand	Selenium
PTM	Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	response to oxidative stress Traceable author statement. Source: ProtInc
Molecular function	selenium binding Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19
	Chain	20 – 381	362	Selenoprotein P		PRO_0000022313
Regions
	Compositional bias	244 – 249	6	Poly-His
Amino acid modifications
	Non-standard residue	59	1	Selenocysteine
	Non-standard residue	300	1	Selenocysteine
	Non-standard residue	318	1	Selenocysteine
	Non-standard residue	330	1	Selenocysteine
	Non-standard residue	345	1	Selenocysteine
	Non-standard residue	352	1	Selenocysteine
	Non-standard residue	367	1	Selenocysteine
	Non-standard residue	369	1	Selenocysteine
	Non-standard residue	376	1	Selenocysteine
	Non-standard residue	378	1	Selenocysteine
	Glycosylation	46	1	N-linked (GlcNAc...) Potential
	Glycosylation	83	1	N-linked (GlcNAc...) Ref.8
	Glycosylation	119	1	N-linked (GlcNAc...) Ref.8
	Glycosylation	128	1	N-linked (GlcNAc...) Ref.8
	Glycosylation	174	1	N-linked (GlcNAc...) By similarity
	Glycosylation	338	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	112	1	P → S Ref.2		VAR_023256
	Natural variant	234	1	A → T: dbSNP rs3877899. Ref.2 Ref.3		VAR_023257
	Natural variant	278	1	R → Q Ref.2		VAR_023258
	Natural variant	314	1	S → P Ref.2		VAR_023259
	Natural variant	368	1	R → C Ref.2		VAR_023260
Experimental info
	Sequence conflict	64 – 65	2	LQ → IE in CAA77836. Ref.1
	Sequence conflict	187	1	K → E in AAH15875. Ref.3
	Sequence conflict	347	1	L → F in AAH46152. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P49908-1 [UniParc]. Last modified February 26, 2008. Version 3. Checksum: 00872B8030840B02	FASTA	381	43,174
	10 20 30 40 50 60 MWRSLGLALA LCLLPSGGTE SQDQSSLCKQ PPAWSIRDQD PMLNSNGSVT VVALLQASUY 70 80 90 100 110 120 LCILQASKLE DLRVKLKKEG YSNISYIVVN HQGISSRLKY THLKNKVSEH IPVYQQEENQ 130 140 150 160 170 180 TDVWTLLNGS KDDFLIYDRC GRLVYHLGLP FSFLTFPYVE EAIKIAYCEK KCGNCSLTTL 190 200 210 220 230 240 KDEDFCKRVS LATVDKTVET PSPHYHHEHH HNHGHQHLGS SELSENQQPG APNAPTHPAP 250 260 270 280 290 300 PGLHHHHKHK GQHRQGHPEN RDMPASEDLQ DLQKKLCRKR CINQLLCKLP TDSELAPRSU 310 320 330 340 350 360 CCHCRHLIFE KTGSAITUQC KENLPSLCSU QGLRAEENIT ESCQURLPPA AUQISQQLIP 370 380 TEASASURUK NQAKKUEUPS N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA." Hill K.E., Lloyd R.S., Burk R.F. Proc. Natl. Acad. Sci. U.S.A. 90:537-541(1993) [PubMed: 8421687] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart and Liver.
[2]	NIEHS SNPs program Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-112; THR-234; GLN-278; PRO-314 AND CYS-368.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-234. Tissue: Bone marrow, Brain, Liver and PNS.
[4]	"Purification of selenoprotein P from human plasma." Aakesson B., Bellew T., Burk R.F. Biochim. Biophys. Acta 1204:243-249(1994) [PubMed: 8142465] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE.
[5]	"A novel method for the purification of selenoprotein P from human plasma." Mostert V., Lombeck I., Abel J. Arch. Biochem. Biophys. 357:326-330(1998) [PubMed: 9735174] [Abstract] Cited for: CHARACTERIZATION.
[6]	"Selenoprotein P: properties, functions, and regulation." Mostert V. Arch. Biochem. Biophys. 376:433-438(2000) [PubMed: 10775431] [Abstract] Cited for: CHARACTERIZATION.
[7]	"Selenoprotein P. A selenium-rich extracellular glycoprotein." Burk R.F., Hill K.E. J. Nutr. 124:1891-1897(1994) [PubMed: 7931697] [Abstract] Cited for: REVIEW.
[8]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-83; ASN-119 AND ASN-128, MASS SPECTROMETRY. Tissue: Plasma.
[9]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-83 AND ASN-119, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z11793 mRNA. Translation: CAA77836.1. DQ022288 Genomic DNA. Translation: AAY26400.1. BC005244 mRNA. No translation available. BC015875 mRNA. Translation: AAH15875.1. BC040075 mRNA. Translation: AAH40075.1. BC046152 mRNA. Translation: AAH46152.1. BC058919 mRNA. Translation: AAH58919.1.
IPI	IPI00029061.
PIR	A47327.
RefSeq	NP_001078955.1. NP_005401.3.
UniGene	Hs.275775 Hs.714733
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P49908.
Genome annotation databases
Ensembl	ENSG00000211446. Homo sapiens. [Contig view]
GeneID	6414.
KEGG	hsa:6414.
Organism-specific databases
GeneCards	GC05M042835.
HGNC	HGNC:10751. SEPP1.
HPA	CAB008668.
MIM	601484. gene.
PharmGKB	PA35672.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P49908.
HOVERGEN	P49908.
OMA	P49908. MWRSLGL.
Gene expression databases
ArrayExpress	P49908.
CleanEx	HS_SELP. HS_SEPP1.
GermOnline	ENSG00000211446. Homo sapiens.
Family and domain databases
InterPro	IPR007672. SelP_C. IPR007671. SelP_N. [Graphical view]
Pfam	PF04593. SelP_C. 1 hit. PF04592. SelP_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	24910.
SOURCE	Search...

Entry information

Entry name

SEPP1_HUMAN

Accession

Primary (citable) accession number: P49908
Secondary accession number(s): Q6PD59 , Q6PI43, Q6PI87, Q6PJF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	February 26, 2008
Last modified:	June 16, 2009
This is version 77 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)