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Protein

Selenoprotein P

Gene

SELENOP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis.

GO - Molecular functioni

  • selenium binding Source: ProtInc

GO - Biological processi

Keywordsi

LigandSelenium

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein P1 Publication
Short name:
SeP
Gene namesi
Name:SELENOP1 PublicationImported
Synonyms:SELPImported, SEPP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000250722.5
HGNCiHGNC:10751 SELENOP
MIMi601484 gene
neXtProtiNX_P49908

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6414
OpenTargetsiENSG00000250722
PharmGKBiPA35672

Polymorphism and mutation databases

BioMutaiSEPP1
DMDMi172046864

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000002231320 – 381Selenoprotein PAdd BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi83N-linked (GlcNAc...) (complex) asparagine3 Publications1
Glycosylationi119N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi128N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi174N-linked (GlcNAc...) asparagineBy similarity1
Modified residuei266PhosphoserineCombined sources1
Glycosylationi338N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylation sites are present in the extracellular medium.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP49908
PeptideAtlasiP49908
PRIDEiP49908

PTM databases

iPTMnetiP49908
PhosphoSitePlusiP49908

Expressioni

Tissue specificityi

Made in the liver and heart and secreted into the plasma. It is also found in the kidney.

Gene expression databases

BgeeiENSG00000250722
CleanExiHS_SELP
HS_SEPP1
ExpressionAtlasiP49908 baseline and differential
GenevisibleiP49908 HS

Organism-specific databases

HPAiHPA036287

Interactioni

Protein-protein interaction databases

BioGridi112313, 4 interactors
IntActiP49908, 15 interactors
STRINGi9606.ENSP00000420939

Structurei

3D structure databases

ProteinModelPortaliP49908
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi244 – 249Poly-His6

Domaini

The C-terminus is not required for endocytic uptake in the proximal tubule epithelium.By similarity

Sequence similaritiesi

Belongs to the selenoprotein P family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXIQ Eukaryota
ENOG4111JK7 LUCA
GeneTreeiENSGT00510000049326
HOVERGENiHBG108473
InParanoidiP49908
OMAiLPSLCSX
OrthoDBiEOG091G18QW
PhylomeDBiP49908
TreeFamiTF333425

Family and domain databases

InterProiView protein in InterPro
IPR007671 Selenoprotein-P_N
IPR007672 SelP_C
IPR037941 SeP
PANTHERiPTHR10105 PTHR10105, 1 hit
PfamiView protein in Pfam
PF04593 SelP_C, 1 hit
PF04592 SelP_N, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49908-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRSLGLALA LCLLPSGGTE SQDQSSLCKQ PPAWSIRDQD PMLNSNGSVT
60 70 80 90 100
VVALLQASUY LCILQASKLE DLRVKLKKEG YSNISYIVVN HQGISSRLKY
110 120 130 140 150
THLKNKVSEH IPVYQQEENQ TDVWTLLNGS KDDFLIYDRC GRLVYHLGLP
160 170 180 190 200
FSFLTFPYVE EAIKIAYCEK KCGNCSLTTL KDEDFCKRVS LATVDKTVET
210 220 230 240 250
PSPHYHHEHH HNHGHQHLGS SELSENQQPG APNAPTHPAP PGLHHHHKHK
260 270 280 290 300
GQHRQGHPEN RDMPASEDLQ DLQKKLCRKR CINQLLCKLP TDSELAPRSU
310 320 330 340 350
CCHCRHLIFE KTGSAITUQC KENLPSLCSU QGLRAEENIT ESCQURLPPA
360 370 380
AUQISQQLIP TEASASURUK NQAKKUEUPS N
Length:381
Mass (Da):43,174
Last modified:February 26, 2008 - v3
Checksum:i00872B8030840B02
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64 – 65LQ → IE in CAA77836 (PubMed:8421687).Curated2
Sequence conflicti187K → E in AAH15875 (PubMed:15489334).Curated1
Sequence conflicti347L → F in AAH46152 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023256112P → S1 PublicationCorresponds to variant dbSNP:rs28919895Ensembl.1
Natural variantiVAR_023257234A → T2 PublicationsCorresponds to variant dbSNP:rs3877899Ensembl.1
Natural variantiVAR_023258278R → Q1 PublicationCorresponds to variant dbSNP:rs28919923Ensembl.1
Natural variantiVAR_023259314S → P1 PublicationCorresponds to variant dbSNP:rs28919925Ensembl.1
Natural variantiVAR_023260368R → C1 PublicationCorresponds to variant dbSNP:rs28919926Ensembl.1

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei59Selenocysteine1
Non-standard residuei300Selenocysteine1
Non-standard residuei318Selenocysteine1
Non-standard residuei330Selenocysteine1
Non-standard residuei345Selenocysteine1
Non-standard residuei352Selenocysteine1
Non-standard residuei367Selenocysteine1
Non-standard residuei369Selenocysteine1
Non-standard residuei376Selenocysteine1
Non-standard residuei378Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11793 mRNA Translation: CAA77836.2
DQ022288 Genomic DNA Translation: AAY26400.1
AC008945 Genomic DNA No translation available.
BC005244 mRNA No translation available.
BC015875 mRNA Translation: AAH15875.1
BC040075 mRNA Translation: AAH40075.1
BC046152 mRNA Translation: AAH46152.1
BC058919 mRNA Translation: AAH58919.1
CCDSiCCDS43311.1
PIRiA47327
RefSeqiNP_001078955.1, NM_001085486.2
NP_001087195.1, NM_001093726.2
NP_005401.3, NM_005410.3
UniGeneiHs.275775
Hs.745017

Genome annotation databases

EnsembliENST00000506577; ENSP00000425915; ENSG00000250722
ENST00000511224; ENSP00000427671; ENSG00000250722
ENST00000514985; ENSP00000420939; ENSG00000250722
GeneIDi6414
KEGGihsa:6414
UCSCiuc011cpt.3 human

Keywords - Coding sequence diversityi

Polymorphism, Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiSEPP1_HUMAN
AccessioniPrimary (citable) accession number: P49908
Secondary accession number(s): Q6PD59
, Q6PI43, Q6PI87, Q6PJF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 26, 2008
Last modified: February 28, 2018
This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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