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Protein

Sperm mitochondrial-associated cysteine-rich protein

Gene

SMCP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fertilization

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm mitochondrial-associated cysteine-rich protein
Gene namesi
Name:SMCP
Synonyms:MCS, MCSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:6962. SMCP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30710.

Polymorphism and mutation databases

BioMutaiSMCP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 116116Sperm mitochondrial-associated cysteine-rich proteinPRO_0000096307Add
BLAST

Proteomic databases

PaxDbiP49901.
PeptideAtlasiP49901.
PRIDEiP49901.

PTM databases

PhosphoSiteiP49901.

Expressioni

Tissue specificityi

Testis. Is selectively expressed in the spermatids of seminiferous tubules.1 Publication

Developmental stagei

Expressed in postmeiotic cells.1 Publication

Gene expression databases

BgeeiENSG00000163206.
CleanExiHS_SMCP.
ExpressionAtlasiP49901. baseline and differential.
GenevisibleiP49901. HS.

Organism-specific databases

HPAiHPA035105.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CALCOCO2Q131373EBI-750494,EBI-739580
GOLGA2Q083793EBI-750494,EBI-618309
KRT31Q153233EBI-750494,EBI-948001
KRTAP10-5P603703EBI-750494,EBI-10172150
KRTAP10-7P604093EBI-750494,EBI-10172290
KRTAP10-8P604103EBI-750494,EBI-10171774
KRTAP10-9P604113EBI-750494,EBI-10172052
KRTAP4-11Q9BYQ63EBI-750494,EBI-10302392
KRTAP4-12Q9BQ665EBI-750494,EBI-739863
KRTAP4-7Q9BYR03EBI-750494,EBI-10302547
KRTAP5-6Q6L8G93EBI-750494,EBI-10250562
KRTAP5-9P263715EBI-750494,EBI-3958099
KRTAP9-2Q9BYQ43EBI-750494,EBI-1044640
KRTAP9-4Q9BYQ23EBI-750494,EBI-10185730
LCE4AQ5TA783EBI-750494,EBI-10246358
NOTCH2NLQ7Z3S93EBI-750494,EBI-945833
RGS17Q9UGC63EBI-750494,EBI-3918154
TCF4P158843EBI-750494,EBI-533224

Protein-protein interaction databases

BioGridi110350. 20 interactions.
IntActiP49901. 19 interactions.
MINTiMINT-1436940.
STRINGi9606.ENSP00000357754.

Structurei

3D structure databases

ProteinModelPortaliP49901.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 1381
Repeati14 – 2182
Repeati30 – 3783
Repeati38 – 4584
Repeati46 – 5385
Repeati54 – 6186
Repeati62 – 6877

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni6 – 68637 X 7 (OR 8) AA approximate repeatsAdd
BLAST

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KI9M. Eukaryota.
ENOG4110QG7. LUCA.
GeneTreeiENSGT00440000039991.
HOGENOMiHOG000113504.
HOVERGENiHBG057842.
InParanoidiP49901.
OMAiGNQCCPP.
OrthoDBiEOG091G12JZ.
PhylomeDBiP49901.

Sequencei

Sequence statusi: Complete.

P49901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDQTKHSKC CPAKGNQCCP PQQNQCCQSK GNQCCPPKQN QCCQPKGSQC
60 70 80 90 100
CPPKHNHCCQ PKPPCCIQAR CCGLETKPEV SPLNMESEPN SPQTQDKGCQ
110
TQQQPHSPQN ESRPSK
Length:116
Mass (Da):12,767
Last modified:January 31, 2002 - v2
Checksum:i242191C60AEE03B2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631P → A in CAA62000 (PubMed:8833144).Curated
Sequence conflicti63 – 631P → A in CAD56487 (PubMed:8833144).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89960 mRNA. Translation: CAA62000.1.
X89961 Genomic DNA. Translation: CAD56487.1.
BC014593 mRNA. Translation: AAH14593.1.
BC016744 mRNA. Translation: AAH16744.1.
CCDSiCCDS1029.1.
RefSeqiNP_109588.2. NM_030663.2.
UniGeneiHs.111850.

Genome annotation databases

EnsembliENST00000368765; ENSP00000357754; ENSG00000163206.
GeneIDi4184.
KEGGihsa:4184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89960 mRNA. Translation: CAA62000.1.
X89961 Genomic DNA. Translation: CAD56487.1.
BC014593 mRNA. Translation: AAH14593.1.
BC016744 mRNA. Translation: AAH16744.1.
CCDSiCCDS1029.1.
RefSeqiNP_109588.2. NM_030663.2.
UniGeneiHs.111850.

3D structure databases

ProteinModelPortaliP49901.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110350. 20 interactions.
IntActiP49901. 19 interactions.
MINTiMINT-1436940.
STRINGi9606.ENSP00000357754.

PTM databases

PhosphoSiteiP49901.

Polymorphism and mutation databases

BioMutaiSMCP.

Proteomic databases

PaxDbiP49901.
PeptideAtlasiP49901.
PRIDEiP49901.

Protocols and materials databases

DNASUi4184.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368765; ENSP00000357754; ENSG00000163206.
GeneIDi4184.
KEGGihsa:4184.

Organism-specific databases

CTDi4184.
GeneCardsiSMCP.
HGNCiHGNC:6962. SMCP.
HPAiHPA035105.
MIMi601148. gene.
neXtProtiNX_P49901.
PharmGKBiPA30710.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KI9M. Eukaryota.
ENOG4110QG7. LUCA.
GeneTreeiENSGT00440000039991.
HOGENOMiHOG000113504.
HOVERGENiHBG057842.
InParanoidiP49901.
OMAiGNQCCPP.
OrthoDBiEOG091G12JZ.
PhylomeDBiP49901.

Miscellaneous databases

ChiTaRSiSMCP. human.
GeneWikiiSMCP.
GenomeRNAii4184.
PROiP49901.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163206.
CleanExiHS_SMCP.
ExpressionAtlasiP49901. baseline and differential.
GenevisibleiP49901. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiMCSP_HUMAN
AccessioniPrimary (citable) accession number: P49901
Secondary accession number(s): Q96A42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 31, 2002
Last modified: September 7, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to be a selenoprotein and was known as sperm mitochondrial capsule selenoprotein.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.