Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P49896 (IOD2_LITCT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type II iodothyronine deiodinase

EC=1.97.1.10
Alternative name(s):
5DII
DIOII
Type 2 DI
Type-II 5'-deiodinase
Gene names
Name:dio2
Synonyms:itdi2, txdi2
OrganismLithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Taxonomic identifier8400 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeRanaAquarana

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Is responsible for the majority of the intracellular T3 in tissues such as the pituitary, brain and brown fat by mediating local deiodination of T4, and is important in regulating thyroid hormone action in these tissues. Plays a major role in development.

Catalytic activity

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Tissue specificity

High levels seen in the metamorphosing tail.

Sequence similarities

Belongs to the iodothyronine deiodinase family.

Ontologies

Keywords
   Biological processThyroid hormones biosynthesis
   Cellular componentMembrane
   Coding sequence diversitySelenocysteine
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processhormone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

thyroid hormone metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionthyroxine 5'-deiodinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 264264Type II iodothyronine deiodinase
PRO_0000154322

Regions

Transmembrane8 – 2821Helical; Potential

Sites

Active site1241

Amino acid modifications

Non-standard residue1241Selenocysteine

Sequences

Sequence LengthMass (Da)Tools
P49896 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: DEA60ED11FC03F46

FASTA26429,342
        10         20         30         40         50         60 
MGLLSVDLLI TLQILPGFFS NCLFLALYDS VVLVKHVLLQ LNRSKSSHGQ WRRMLTPEGL 

        70         80         90        100        110        120 
RCVWNSFLLD AYKQVKLGGD APNSNVIHVT DKNSSSGKPG TPCHLLDFAS SERPLVVNFG 

       130        140        150        160        170        180 
SATUPPFISQ LPAFSKMVEE FSAVADFLLV YIDEAHPSDG WAAPGISSYE VKKHRNQEDR 

       190        200        210        220        230        240 
CAAANKLLEQ YSLPPQCQVV ADCMDNNTNA AYGVSFERVC IVQRQKIVYL GGKGPFFYNL 

       250        260 
QEVRQWLELT FGKKAESGQT GTEK 

« Hide

References

[1]"Cloning of a cDNA for the type II iodothyronine deiodinase."
Davey J.C., Becker K.B., Schneider M.J., St Germain D.L., Galton V.A.
J. Biol. Chem. 270:26786-26789(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42815 Genomic DNA. Translation: AAC42231.2.
PIRT10530.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG000099.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11781. PTHR11781. 1 hit.
PfamPF00837. T4_deiodinase. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIOD2_LITCT
AccessionPrimary (citable) accession number: P49896
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 26, 2008
Last modified: February 19, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families