##gff-version 3
P49895	UniProtKB	Chain	1	249	.	.	.	ID=PRO_0000154311;Note=Type I iodothyronine deiodinase	
P49895	UniProtKB	Transmembrane	13	33	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P49895	UniProtKB	Active site	126	126	.	.	.	.	
P49895	UniProtKB	Non-standard residue	126	126	.	.	.	Note=Selenocysteine	
P49895	UniProtKB	Alternative sequence	26	40	.	.	.	ID=VSP_012772;Note=In isoform 6. GKVLLILFPDRVKRN->APSISGSSURSVGSD;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2	
P49895	UniProtKB	Alternative sequence	41	249	.	.	.	ID=VSP_012773;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2	
P49895	UniProtKB	Alternative sequence	50	113	.	.	.	ID=VSP_012774;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2	
P49895	UniProtKB	Alternative sequence	50	89	.	.	.	ID=VSP_012779;Note=In isoform 9. MTRNPHFSHDNWIPTFFSTQYFWFVLKVRWQRLEDTTELG->PLAATRGHDUARGSGPKLPGGPPLRTEVQHLGVYARWLGF;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2	
P49895	UniProtKB	Alternative sequence	50	85	.	.	.	ID=VSP_012775;Note=In isoform 8. MTRNPHFSHDNWIPTFFSTQYFWFVLKVRWQRLEDT->PLAATRGHDUARGSGPKLPGGPPLRTEVQHLGVYAR;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2	
P49895	UniProtKB	Alternative sequence	78	109	.	.	.	ID=VSP_012777;Note=In isoform 3. RWQRLEDTTELGGLAPNCPVVRLSGQRCNIWE->IGHWCUILEVVPDLHLCSNLTSSRGLLKTLVP;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2	
P49895	UniProtKB	Alternative sequence	86	249	.	.	.	ID=VSP_012776;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2	
P49895	UniProtKB	Alternative sequence	90	249	.	.	.	ID=VSP_012780;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2	
P49895	UniProtKB	Alternative sequence	110	249	.	.	.	ID=VSP_012778;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2	
P49895	UniProtKB	Alternative sequence	113	160	.	.	.	ID=VSP_012781;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2	
P49895	UniProtKB	Alternative sequence	114	249	.	.	.	ID=VSP_012782;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2	
P49895	UniProtKB	Alternative sequence	161	161	.	.	.	ID=VSP_012783;Note=In isoform 5. D->G;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334	
P49895	UniProtKB	Alternative sequence	162	249	.	.	.	ID=VSP_012784;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2;Dbxref=PMID:15489334	
P49895	UniProtKB	Natural variant	94	94	.	.	.	ID=VAR_087106;Note=In THMA2%3B reduced catalytic activity%2C due to a 2-fold reduction in T4 substrate affinity. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32718224;Dbxref=dbSNP:rs754694815,PMID:32718224	
P49895	UniProtKB	Natural variant	201	201	.	.	.	ID=VAR_087107;Note=In THMA2%3B reduced catalytic activity%2C due to a 3-fold reduction in T4 substrate affinity. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32718224;Dbxref=dbSNP:rs201420507,PMID:32718224