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P49894 (IOD1_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type I iodothyronine deiodinase

EC=1.97.1.10
Alternative name(s):
5DI
DIOI
Type 1 DI
Type-I 5'-deiodinase
Gene names
Name:DIO1
Synonyms:ITDI1, TXDI1
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.

Catalytic activity

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the iodothyronine deiodinase family.

Ontologies

Keywords
   Biological processThyroid hormones biosynthesis
   Cellular componentEndoplasmic reticulum
Membrane
   Coding sequence diversitySelenocysteine
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhormone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionthyroxine 5'-deiodinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 244244Type I iodothyronine deiodinase
PRO_0000154310

Regions

Transmembrane13 – 3321Helical; Potential

Sites

Active site1211

Amino acid modifications

Non-standard residue1211Selenocysteine

Sequences

Sequence LengthMass (Da)Tools
P49894 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: E347D761A60618DC

FASTA24428,424
        10         20         30         40         50         60 
MGLPRPVLWL RRLWVLLQVA VQVAVGKVFL KLFPARVKQH IVAMNGKNPH FSYDNWAPTL 

        70         80         90        100        110        120 
YSMQYFWFVL KVQWQRLEDR TEPGGLAPNC PVVRLSGQRC NIWDFMQGNR PLVLNFGSCT 

       130        140        150        160        170        180 
UPSFLFKFDQ FKRLIEDFCS TADFLIIYIE EAHASDGWAF KNNVNIRTHQ TLQDRLQAAR 

       190        200        210        220        230        240 
LLLDRAPPCP VVVDTMRNQS SQFYAALPER LFVLQEGRIL YKGKPGPWNY HPEEVRAVLE 


KLHS 

« Hide

References

[1]"Identification of critical amino acids for 3,5,3'-triiodothyronine deiodination by human type 1 deiodinase based on comparative functional-structural analyses of the human, dog, and rat enzymes."
Toyoda N., Harney J.W., Berry M.J., Larsen P.R.
J. Biol. Chem. 269:20329-20334(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Mongrel.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U11762 mRNA. Translation: AAA53207.2.
RefSeqNP_001007127.1. NM_001007126.2.
UniGeneCfa.3500.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000028141.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID403635.
KEGGcfa:403635.

Organism-specific databases

CTD1733.

Phylogenomic databases

eggNOGNOG149534.
HOGENOMHOG000169547.
HOVERGENHBG000099.
InParanoidP49894.
KOK01562.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11781. PTHR11781. 1 hit.
PfamPF00837. T4_deiodinase. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20817140.

Entry information

Entry nameIOD1_CANFA
AccessionPrimary (citable) accession number: P49894
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 26, 2008
Last modified: March 19, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families