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P49874

- SFTPA_PIG

UniProt

P49874 - SFTPA_PIG

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Protein

Pulmonary surfactant-associated protein A

Gene
SFTPA1, SFTP1, SFTPA
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

In presence of calcium ions, PSAP binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi216 – 2161Calcium By similarity
Metal bindingi218 – 2181Calcium; via carbonyl oxygen By similarity
Metal bindingi235 – 2351Calcium By similarity
Metal bindingi236 – 2361Calcium By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. respiratory gaseous exchange Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Gaseous exchange

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_217421. Signal regulatory protein (SIRP) family interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein A
Short name:
PSAP
Short name:
PSP-A
Short name:
SP-A
Gene namesi
Name:SFTPA1
Synonyms:SFTP1, SFTPA
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular space Source: UniProtKB-SubCell
  3. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted, Surface film

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 249229Pulmonary surfactant-associated protein APRO_0000017460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 – 26Interchain By similarity
Modified residuei30 – 3014-hydroxyproline By similarity
Modified residuei33 – 3314-hydroxyproline By similarity
Modified residuei36 – 3614-hydroxyproline By similarity
Modified residuei42 – 4214-hydroxyproline By similarity
Modified residuei54 – 5414-hydroxyproline By similarity
Modified residuei57 – 5714-hydroxyproline By similarity
Modified residuei63 – 6314-hydroxyproline By similarity
Modified residuei70 – 7014-hydroxyproline By similarity
Disulfide bondi155 ↔ 247 By similarity
Glycosylationi208 – 2081N-linked (GlcNAc...) By similarity
Disulfide bondi225 ↔ 239 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiP49874.

Interactioni

Subunit structurei

Oligomeric complex of 6 set of homotrimers.

Structurei

3D structure databases

ProteinModelPortaliP49874.
SMRiP49874. Positions 104-249.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 10073Collagen-likeAdd
BLAST
Domaini133 – 249117C-type lectinAdd
BLAST

Sequence similaritiesi

Belongs to the SFTPA family.

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG315755.
HOGENOMiHOG000085660.
HOVERGENiHBG108270.
KOiK10067.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49874-1 [UniParc]FASTAAdd to Basket

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MLRWPLALTF LLLAVSGLEC DVKEVCLASP GIPGTPGSHG LPGRDGRDGI    50
KGDPGPPGPM GPPGGMAGPP GQDGMIGAPG LPGERGEKGE PGERGPPGLP 100
AHLDEELQSA LHEIRHQILQ SMGVLSFQEF MLAVGEKVFS TNGQSVAFWM 150
SLESCVPEQV GRIAAPRSPE ENEAIASIVK KHNTYAYLGL VEGPTAGDFF 200
YLDGTPVNYT NWYPGEPRGR GKEKCVEMYT DGQWNDRNCQ QYRLAICEF 249
Length:249
Mass (Da):26,702
Last modified:October 1, 1996 - v1
Checksum:i3C4E05AD07F2A7CD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41350 mRNA. Translation: AAA88403.1.
RefSeqiNP_999430.1. NM_214265.1.
UniGeneiSsc.16255.

Genome annotation databases

GeneIDi397503.
KEGGissc:397503.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41350 mRNA. Translation: AAA88403.1 .
RefSeqi NP_999430.1. NM_214265.1.
UniGenei Ssc.16255.

3D structure databases

ProteinModelPortali P49874.
SMRi P49874. Positions 104-249.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P49874.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397503.
KEGGi ssc:397503.

Organism-specific databases

CTDi 653509.

Phylogenomic databases

eggNOGi NOG315755.
HOGENOMi HOG000085660.
HOVERGENi HBG108270.
KOi K10067.

Enzyme and pathway databases

Reactomei REACT_217421. Signal regulatory protein (SIRP) family interactions.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view ]
Pfami PF01391. Collagen. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A cDNA clone for the porcine pulmonary surfactant - associated protein (PSP-A)."
    Adamou J.E., Elshourbagy N.A.
    Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiSFTPA_PIG
AccessioniPrimary (citable) accession number: P49874
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi