Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P49874

- SFTPA_PIG

UniProt

P49874 - SFTPA_PIG

Protein

Pulmonary surfactant-associated protein A

Gene

SFTPA1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    In presence of calcium ions, PSAP binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi216 – 2161CalciumBy similarity
    Metal bindingi218 – 2181Calcium; via carbonyl oxygenBy similarity
    Metal bindingi235 – 2351CalciumBy similarity
    Metal bindingi236 – 2361CalciumBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. respiratory gaseous exchange Source: UniProtKB-KW

    Keywords - Biological processi

    Gaseous exchange

    Keywords - Ligandi

    Calcium, Lectin, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_217421. Signal regulatory protein (SIRP) family interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pulmonary surfactant-associated protein A
    Short name:
    PSAP
    Short name:
    PSP-A
    Short name:
    SP-A
    Gene namesi
    Name:SFTPA1
    Synonyms:SFTP1, SFTPA
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular space Source: UniProtKB-SubCell
    3. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted, Surface film

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 249229Pulmonary surfactant-associated protein APRO_0000017460Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi26 – 26InterchainPROSITE-ProRule annotation
    Modified residuei30 – 3014-hydroxyprolineBy similarity
    Modified residuei33 – 3314-hydroxyprolineBy similarity
    Modified residuei36 – 3614-hydroxyprolineBy similarity
    Modified residuei42 – 4214-hydroxyprolineBy similarity
    Modified residuei54 – 5414-hydroxyprolineBy similarity
    Modified residuei57 – 5714-hydroxyprolineBy similarity
    Modified residuei63 – 6314-hydroxyprolineBy similarity
    Modified residuei70 – 7014-hydroxyprolineBy similarity
    Disulfide bondi155 ↔ 247PROSITE-ProRule annotation
    Glycosylationi208 – 2081N-linked (GlcNAc...)By similarity
    Disulfide bondi225 ↔ 239PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Hydroxylation

    Proteomic databases

    PaxDbiP49874.

    Interactioni

    Subunit structurei

    Oligomeric complex of 6 set of homotrimers.

    Structurei

    3D structure databases

    ProteinModelPortaliP49874.
    SMRiP49874. Positions 104-249.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 10073Collagen-likeAdd
    BLAST
    Domaini133 – 249117C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SFTPA family.Curated
    Contains 1 C-type lectin domain.PROSITE-ProRule annotation
    Contains 1 collagen-like domain.Curated

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG315755.
    HOGENOMiHOG000085660.
    HOVERGENiHBG108270.
    KOiK10067.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR008160. Collagen.
    [Graphical view]
    PfamiPF01391. Collagen. 1 hit.
    PF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49874-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRWPLALTF LLLAVSGLEC DVKEVCLASP GIPGTPGSHG LPGRDGRDGI    50
    KGDPGPPGPM GPPGGMAGPP GQDGMIGAPG LPGERGEKGE PGERGPPGLP 100
    AHLDEELQSA LHEIRHQILQ SMGVLSFQEF MLAVGEKVFS TNGQSVAFWM 150
    SLESCVPEQV GRIAAPRSPE ENEAIASIVK KHNTYAYLGL VEGPTAGDFF 200
    YLDGTPVNYT NWYPGEPRGR GKEKCVEMYT DGQWNDRNCQ QYRLAICEF 249
    Length:249
    Mass (Da):26,702
    Last modified:October 1, 1996 - v1
    Checksum:i3C4E05AD07F2A7CD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41350 mRNA. Translation: AAA88403.1.
    RefSeqiNP_999430.1. NM_214265.1.
    UniGeneiSsc.16255.

    Genome annotation databases

    GeneIDi397503.
    KEGGissc:397503.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41350 mRNA. Translation: AAA88403.1 .
    RefSeqi NP_999430.1. NM_214265.1.
    UniGenei Ssc.16255.

    3D structure databases

    ProteinModelPortali P49874.
    SMRi P49874. Positions 104-249.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P49874.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397503.
    KEGGi ssc:397503.

    Organism-specific databases

    CTDi 653509.

    Phylogenomic databases

    eggNOGi NOG315755.
    HOGENOMi HOG000085660.
    HOVERGENi HBG108270.
    KOi K10067.

    Enzyme and pathway databases

    Reactomei REACT_217421. Signal regulatory protein (SIRP) family interactions.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR008160. Collagen.
    [Graphical view ]
    Pfami PF01391. Collagen. 1 hit.
    PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A cDNA clone for the porcine pulmonary surfactant - associated protein (PSP-A)."
      Adamou J.E., Elshourbagy N.A.
      Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiSFTPA_PIG
    AccessioniPrimary (citable) accession number: P49874
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3