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P49874 (SFTPA_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pulmonary surfactant-associated protein A

Short name=PSAP
Short name=PSP-A
Short name=SP-A
Gene names
Name:SFTPA1
Synonyms:SFTP1, SFTPA
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

In presence of calcium ions, PSAP binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.

Subunit structure

Oligomeric complex of 6 set of homotrimers.

Subcellular location

Secretedextracellular spaceextracellular matrix. Secretedextracellular spacesurface film.

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Sequence similarities

Belongs to the SFTPA family.

Contains 1 C-type lectin domain.

Contains 1 collagen-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 249229Pulmonary surfactant-associated protein A
PRO_0000017460

Regions

Domain28 – 10073Collagen-like
Domain133 – 249117C-type lectin

Sites

Metal binding2161Calcium By similarity
Metal binding2181Calcium; via carbonyl oxygen By similarity
Metal binding2351Calcium By similarity
Metal binding2361Calcium By similarity

Amino acid modifications

Modified residue3014-hydroxyproline By similarity
Modified residue3314-hydroxyproline By similarity
Modified residue3614-hydroxyproline By similarity
Modified residue4214-hydroxyproline By similarity
Modified residue5414-hydroxyproline By similarity
Modified residue5714-hydroxyproline By similarity
Modified residue6314-hydroxyproline By similarity
Modified residue7014-hydroxyproline By similarity
Glycosylation2081N-linked (GlcNAc...) By similarity
Disulfide bond26Interchain By similarity
Disulfide bond155 ↔ 247 By similarity
Disulfide bond225 ↔ 239 By similarity

Sequences

Sequence LengthMass (Da)Tools
P49874 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 3C4E05AD07F2A7CD

FASTA24926,702
        10         20         30         40         50         60 
MLRWPLALTF LLLAVSGLEC DVKEVCLASP GIPGTPGSHG LPGRDGRDGI KGDPGPPGPM 

        70         80         90        100        110        120 
GPPGGMAGPP GQDGMIGAPG LPGERGEKGE PGERGPPGLP AHLDEELQSA LHEIRHQILQ 

       130        140        150        160        170        180 
SMGVLSFQEF MLAVGEKVFS TNGQSVAFWM SLESCVPEQV GRIAAPRSPE ENEAIASIVK 

       190        200        210        220        230        240 
KHNTYAYLGL VEGPTAGDFF YLDGTPVNYT NWYPGEPRGR GKEKCVEMYT DGQWNDRNCQ 


QYRLAICEF 

« Hide

References

[1]"A cDNA clone for the porcine pulmonary surfactant - associated protein (PSP-A)."
Adamou J.E., Elshourbagy N.A.
Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L41350 mRNA. Translation: AAA88403.1.
RefSeqNP_999430.1. NM_214265.1.
UniGeneSsc.16255.

3D structure databases

ProteinModelPortalP49874.
SMRP49874. Positions 104-249.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP49874.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397503.
KEGGssc:397503.

Organism-specific databases

CTD653509.

Phylogenomic databases

eggNOGNOG315755.
HOGENOMHOG000085660.
HOVERGENHBG108270.
KOK10067.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view]
PfamPF01391. Collagen. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
PROSITEPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSFTPA_PIG
AccessionPrimary (citable) accession number: P49874
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families