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Protein

Pulmonary surfactant-associated protein A

Gene

SFTPA1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

In presence of calcium ions, PSAP binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi216 – 2161CalciumBy similarity
Metal bindingi218 – 2181Calcium; via carbonyl oxygenBy similarity
Metal bindingi235 – 2351CalciumBy similarity
Metal bindingi236 – 2361CalciumBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. respiratory gaseous exchange Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Gaseous exchange

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_217421. Signal regulatory protein (SIRP) family interactions.
REACT_238071. Toll Like Receptor 4 (TLR4) Cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein A
Short name:
PSAP
Short name:
PSP-A
Short name:
SP-A
Gene namesi
Name:SFTPA1
Synonyms:SFTP1, SFTPA
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular space Source: UniProtKB-SubCell
  3. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted, Surface film

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 249229Pulmonary surfactant-associated protein APRO_0000017460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 – 26InterchainPROSITE-ProRule annotation
Modified residuei30 – 3014-hydroxyprolineBy similarity
Modified residuei33 – 3314-hydroxyprolineBy similarity
Modified residuei36 – 3614-hydroxyprolineBy similarity
Modified residuei42 – 4214-hydroxyprolineBy similarity
Modified residuei54 – 5414-hydroxyprolineBy similarity
Modified residuei57 – 5714-hydroxyprolineBy similarity
Modified residuei63 – 6314-hydroxyprolineBy similarity
Modified residuei70 – 7014-hydroxyprolineBy similarity
Disulfide bondi155 ↔ 247PROSITE-ProRule annotation
Glycosylationi208 – 2081N-linked (GlcNAc...)By similarity
Disulfide bondi225 ↔ 239PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiP49874.

Interactioni

Subunit structurei

Oligomeric complex of 6 set of homotrimers.

Structurei

3D structure databases

ProteinModelPortaliP49874.
SMRiP49874. Positions 104-249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 10073Collagen-likeAdd
BLAST
Domaini133 – 249117C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SFTPA family.Curated
Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG315755.
HOGENOMiHOG000085660.
HOVERGENiHBG108270.
InParanoidiP49874.
KOiK10067.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49874-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRWPLALTF LLLAVSGLEC DVKEVCLASP GIPGTPGSHG LPGRDGRDGI
60 70 80 90 100
KGDPGPPGPM GPPGGMAGPP GQDGMIGAPG LPGERGEKGE PGERGPPGLP
110 120 130 140 150
AHLDEELQSA LHEIRHQILQ SMGVLSFQEF MLAVGEKVFS TNGQSVAFWM
160 170 180 190 200
SLESCVPEQV GRIAAPRSPE ENEAIASIVK KHNTYAYLGL VEGPTAGDFF
210 220 230 240
YLDGTPVNYT NWYPGEPRGR GKEKCVEMYT DGQWNDRNCQ QYRLAICEF
Length:249
Mass (Da):26,702
Last modified:October 1, 1996 - v1
Checksum:i3C4E05AD07F2A7CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41350 mRNA. Translation: AAA88403.1.
RefSeqiNP_999430.1. NM_214265.1.
UniGeneiSsc.16255.

Genome annotation databases

GeneIDi397503.
KEGGissc:397503.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41350 mRNA. Translation: AAA88403.1.
RefSeqiNP_999430.1. NM_214265.1.
UniGeneiSsc.16255.

3D structure databases

ProteinModelPortaliP49874.
SMRiP49874. Positions 104-249.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiP49874.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397503.
KEGGissc:397503.

Organism-specific databases

CTDi653509.

Phylogenomic databases

eggNOGiNOG315755.
HOGENOMiHOG000085660.
HOVERGENiHBG108270.
InParanoidiP49874.
KOiK10067.

Enzyme and pathway databases

ReactomeiREACT_217421. Signal regulatory protein (SIRP) family interactions.
REACT_238071. Toll Like Receptor 4 (TLR4) Cascade.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A cDNA clone for the porcine pulmonary surfactant - associated protein (PSP-A)."
    Adamou J.E., Elshourbagy N.A.
    Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiSFTPA_PIG
AccessioniPrimary (citable) accession number: P49874
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.