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Protein

Pulmonary surfactant-associated protein A

Gene

SFTPA1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi216CalciumBy similarity1
Metal bindingi218Calcium; via carbonyl oxygenBy similarity1
Metal bindingi235CalciumBy similarity1
Metal bindingi236CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Gaseous exchange

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein A
Short name:
PSAP
Short name:
PSP-A
Short name:
SP-A
Gene namesi
Name:SFTPA1
Synonyms:SFTP1, SFTPA
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted, Surface film

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001746021 – 249Pulmonary surfactant-associated protein AAdd BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26InterchainPROSITE-ProRule annotation
Modified residuei304-hydroxyprolineBy similarity1
Modified residuei334-hydroxyprolineBy similarity1
Modified residuei364-hydroxyprolineBy similarity1
Modified residuei424-hydroxyprolineBy similarity1
Modified residuei544-hydroxyprolineBy similarity1
Modified residuei574-hydroxyprolineBy similarity1
Modified residuei634-hydroxyprolineBy similarity1
Modified residuei704-hydroxyprolineBy similarity1
Disulfide bondi155 ↔ 247PROSITE-ProRule annotation
Glycosylationi208N-linked (GlcNAc...)By similarity1
Disulfide bondi225 ↔ 239PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiP49874.
PeptideAtlasiP49874.
PRIDEiP49874.

Expressioni

Gene expression databases

BgeeiENSSSCG00000010336.
GenevisibleiP49874. SS.

Interactioni

Subunit structurei

Oligomeric complex of 6 set of homotrimers.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011022.

Structurei

3D structure databases

ProteinModelPortaliP49874.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 100Collagen-likeAdd BLAST73
Domaini133 – 249C-type lectinPROSITE-ProRule annotationAdd BLAST117

Sequence similaritiesi

Belongs to the SFTPA family.Curated
Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000085660.
HOVERGENiHBG108270.
InParanoidiP49874.
KOiK10067.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49874-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRWPLALTF LLLAVSGLEC DVKEVCLASP GIPGTPGSHG LPGRDGRDGI
60 70 80 90 100
KGDPGPPGPM GPPGGMAGPP GQDGMIGAPG LPGERGEKGE PGERGPPGLP
110 120 130 140 150
AHLDEELQSA LHEIRHQILQ SMGVLSFQEF MLAVGEKVFS TNGQSVAFWM
160 170 180 190 200
SLESCVPEQV GRIAAPRSPE ENEAIASIVK KHNTYAYLGL VEGPTAGDFF
210 220 230 240
YLDGTPVNYT NWYPGEPRGR GKEKCVEMYT DGQWNDRNCQ QYRLAICEF
Length:249
Mass (Da):26,702
Last modified:October 1, 1996 - v1
Checksum:i3C4E05AD07F2A7CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41350 mRNA. Translation: AAA88403.1.
RefSeqiNP_999430.1. NM_214265.1.
UniGeneiSsc.16255.

Genome annotation databases

GeneIDi397503.
KEGGissc:397503.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41350 mRNA. Translation: AAA88403.1.
RefSeqiNP_999430.1. NM_214265.1.
UniGeneiSsc.16255.

3D structure databases

ProteinModelPortaliP49874.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011022.

Proteomic databases

PaxDbiP49874.
PeptideAtlasiP49874.
PRIDEiP49874.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397503.
KEGGissc:397503.

Organism-specific databases

CTDi653509.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000085660.
HOVERGENiHBG108270.
InParanoidiP49874.
KOiK10067.

Gene expression databases

BgeeiENSSSCG00000010336.
GenevisibleiP49874. SS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSFTPA_PIG
AccessioniPrimary (citable) accession number: P49874
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.