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Protein

C-C motif chemokine 8

Gene

CCL8

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes. This protein can bind heparin.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 8
Alternative name(s):
Monocyte chemoattractant protein 2
Monocyte chemotactic protein 2
Short name:
MCP-2
Small-inducible cytokine A8
Gene namesi
Name:CCL8
Synonyms:MCP2, SCYA8
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000000519124 – 99C-C motif chemokine 8Add BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi34 ↔ 59By similarity
Disulfide bondi35 ↔ 75By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP49873.
PRIDEiP49873.

Interactioni

Subunit structurei

Monomer or homodimer; in equilibrium.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000018777.

Structurei

3D structure databases

ProteinModelPortaliP49873.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP49873.

Family and domain databases

InterProiIPR033225. CCL8.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF74. PTHR12015:SF74. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49873-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVSAALLCL LLTTAAFSTQ VLAQPDSVSI PITCCFGLVN GKIPFKKLES
60 70 80 90
YTRITNSQCP QEAVIFKTKA DKEVCADPQQ KWVQNSMKLL DQKSQTPKP
Length:99
Mass (Da):10,903
Last modified:October 1, 1996 - v1
Checksum:iD3DAA0F7A964CDB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48480 mRNA. Translation: CAA88371.1.
PIRiJC2417.
UniGeneiSsc.9957.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48480 mRNA. Translation: CAA88371.1.
PIRiJC2417.
UniGeneiSsc.9957.

3D structure databases

ProteinModelPortaliP49873.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000018777.

Proteomic databases

PaxDbiP49873.
PRIDEiP49873.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP49873.

Family and domain databases

InterProiIPR033225. CCL8.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF74. PTHR12015:SF74. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL8_PIG
AccessioniPrimary (citable) accession number: P49873
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 5, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.