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Protein

Probable nuclear hormone receptor HR38

Gene

Hr38

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to NGFI-B response elements. Plays an important role in late stages of epidermal metamorphosis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi741 – 816Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri744 – 764NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri780 – 804NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • core promoter binding Source: CAFA
  • nuclear receptor activity Source: FlyBase
  • protein heterodimerization activity Source: CAFA
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: FlyBase
  • sequence-specific DNA binding Source: CAFA
  • signaling receptor binding Source: CAFA
  • steroid hormone receptor activity Source: InterPro
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cuticle development Source: FlyBase
  • positive regulation of transcription by RNA polymerase II Source: FlyBase
  • regulation of adult chitin-containing cuticle pigmentation Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-198693 AKT phosphorylates targets in the nucleus
R-DME-383280 Nuclear Receptor transcription pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nuclear hormone receptor HR38
Short name:
dHR38
Alternative name(s):
Nuclear receptor subfamily 4 group A member 4
Gene namesi
Name:Hr38
Synonyms:NR4A4
ORF Names:CG1864
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0014859 Hr38

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537251 – 1073Probable nuclear hormone receptor HR38Add BLAST1073

Proteomic databases

PaxDbiP49869
PRIDEiP49869

Expressioni

Tissue specificityi

Ubiquitously expressed in preblastoderm embryos, specifically in central nervous system and intestinal tract. Highly expressed in third instar larval imaginal disks and brain complexes, but not in ovaries.1 Publication

Developmental stagei

Low levels in 0-8 hours embryos and adults. Higher in late embryogenesis and during larval and pupal stages. Short isoform is enriched in pupae and adults, long isoform in larvae.

Gene expression databases

BgeeiFBgn0014859
ExpressionAtlasiP49869 differential
GenevisibleiP49869 DM

Interactioni

Subunit structurei

Forms a heterodimer with USP.

GO - Molecular functioni

  • protein heterodimerization activity Source: CAFA
  • signaling receptor binding Source: CAFA

Protein-protein interaction databases

BioGridi61295, 4 interactors
DIPiDIP-929N
IntActiP49869, 2 interactors
STRINGi7227.FBpp0080927

Structurei

Secondary structure

11073
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi844 – 854Combined sources11
Helixi859 – 861Combined sources3
Turni865 – 867Combined sources3
Helixi874 – 896Combined sources23
Helixi902 – 904Combined sources3
Helixi907 – 929Combined sources23
Beta strandi935 – 938Combined sources4
Beta strandi942 – 946Combined sources5
Helixi947 – 954Combined sources8
Helixi957 – 971Combined sources15
Helixi975 – 986Combined sources12
Helixi996 – 1016Combined sources21
Helixi1018 – 1021Combined sources4
Helixi1026 – 1031Combined sources6
Helixi1033 – 1054Combined sources22
Helixi1061 – 1065Combined sources5
Turni1066 – 1068Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PDUX-ray2.30A/B842-1073[»]
DisProtiDP00594
ProteinModelPortaliP49869
SMRiP49869
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49869

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini840 – 1070NR LBDPROSITE-ProRule annotationAdd BLAST231

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi188 – 192Poly-Ala5
Compositional biasi206 – 218Poly-AlaAdd BLAST13
Compositional biasi221 – 228Poly-Ala8
Compositional biasi268 – 272Poly-Thr5
Compositional biasi294 – 312Poly-GlnAdd BLAST19
Compositional biasi441 – 462Poly-GlnAdd BLAST22
Compositional biasi505 – 508Poly-Ser4
Compositional biasi619 – 626Poly-Gln8
Compositional biasi661 – 665Poly-Ala5

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri744 – 764NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri780 – 804NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4217 Eukaryota
ENOG410YWNC LUCA
GeneTreeiENSGT00760000118887
HOGENOMiHOG000046504
InParanoidiP49869
KOiK08558
OrthoDBiEOG091G0GUM

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P49869-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMRDRLASLI VVKQEGGSNT SISHHQATAI KCEASLYTES SLFQEINNNS
60 70 80 90 100
CYRQNLNAPT HQQSHTSHLQ HAQQHQTHQQ HPLLPPPLPT LPLIYPCRNL
110 120 130 140 150
FPDGCDINHL ACCSSSNSNS NCNSDSNSTS SSPGNSHFFA NGNTCAAALT
160 170 180 190 200
PAPPATEPRK IKPLGAGKLK VGKTDSNSDS NSNCDSRAAA AASTSATSAT
210 220 230 240 250
SATTLAATAA ATAAAAEAGG AASAAAAAKI SQVRLTNQAT TSMLLLQPNS
260 270 280 290 300
SFSSLSPFDN FSTQTASTTT TTSASAAGHH QHHNHLLHQQ HHNQQQQQQQ
310 320 330 340 350
QQQQQQQQQQ QQEHLQQQHQ QQLVSPQQHL LKSETLLSHE EDQLISNLTD
360 370 380 390 400
SSVVSHSELF SDLFFPSDSN NSLLSPTTSG YPDNPAEDLT SSIENLTKLT
410 420 430 440 450
CLRDKRLSSI PEQQLSSEQE QQLCLLSLRS SSDPAIALHA QQQQQQQQQQ
460 470 480 490 500
QQQQQQHQQQ QQHLQLQLIS PIGGPLSCGS SLPSFQETYS LKYNSSSGSS
510 520 530 540 550
PQQASSSSTA APTPTDQVLT LKMDEDCFPP LSGGWSASPP APSQLQQLHT
560 570 580 590 600
LQSQAQMSHP NSSNNSSNNA GNSHNNSGGY NYHGHFNAIN ASANLSPSSS
610 620 630 640 650
ASSLYEYNGV SAADNFYGQQ QQQQQQSYQQ HNYNSHNGER YSLPTFPTIS
660 670 680 690 700
ELAAATAAVE AAAAATVGGP PPVRRASLPV QRTVSPAGST AQSPKLAKIT
710 720 730 740 750
LNQRHSHAHA HALQLNSAPN SAASSPASAD LQAGRLLQAP SQLCAVCGDT
760 770 780 790 800
AACQHYGVRT CEGCKGFFKR TVQKGSKYVC LADKNCPVDK RRRNRCQFCR
810 820 830 840 850
FQKCLVVGMV KEVVRTDSLK GRRGRLPSKP KSPQESPPSP PISLITALVR
860 870 880 890 900
SHVDTTPDPS CLDYSHYEEQ SMSEADKVQQ FYQLLTSSVD VIKQFAEKIP
910 920 930 940 950
GYFDLLPEDQ ELLFQSASLE LFVLRLAYRA RIDDTKLIFC NGTVLHRTQC
960 970 980 990 1000
LRSFGEWLND IMEFSRSLHN LEIDISAFAC LCALTLITER HGLREPKKVE
1010 1020 1030 1040 1050
QLQMKIIGSL RDHVTYNAEA QKKQHYFSRL LGKLPELRSL SVQGLQRIFY
1060 1070
LKLEDLVPAP ALIENMFVTT LPF
Length:1,073
Mass (Da):116,992
Last modified:December 1, 2000 - v3
Checksum:i126A30DAFA1C096A
GO
Isoform Short (identifier: P49869-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-522: Missing.

Show »
Length:551
Mass (Da):60,797
Checksum:i739ACB447F8F45DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti667V → VSSPSV in AAF53914 (PubMed:10731132).Curated1
Sequence conflicti685S → L (PubMed:7644522).Curated1
Sequence conflicti685S → L (PubMed:9649534).Curated1
Sequence conflicti689 – 692STAQ → LHGER in CAA75690 (PubMed:9704500).Curated4
Sequence conflicti697A → D in CAA75690 (PubMed:9704500).Curated1
Sequence conflicti702N → S in CAA75690 (PubMed:9704500).Curated1
Sequence conflicti1041S → R in CAA75690 (PubMed:9704500).Curated1
Sequence conflicti1064E → D in CAA75690 (PubMed:9704500).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0037141 – 522Missing in isoform Short. 1 PublicationAdd BLAST522

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89246 mRNA Translation: CAA61534.1
Y15606 Genomic DNA Translation: CAA75690.1
AJ002073 mRNA Translation: CAA05172.1
AE014134 Genomic DNA Translation: AAF53914.1
U36762 mRNA Translation: AAC46926.1
RefSeqiNP_477119.1, NM_057771.4
UniGeneiDm.2701

Genome annotation databases

EnsemblMetazoaiFBtr0081397; FBpp0080927; FBgn0014859
GeneIDi35332
KEGGidme:Dmel_CG1864

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHR38_DROME
AccessioniPrimary (citable) accession number: P49869
Secondary accession number(s): O18383, Q9VIK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 168 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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