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P49864

- GRAK_RAT

UniProt

P49864 - GRAK_RAT

Protein

Granzyme K

Gene

Gzmk

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei66 – 661Charge relay systemBy similarity
    Active sitei110 – 1101Charge relay systemBy similarity
    Active sitei208 – 2081Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro
    2. serine-type peptidase activity Source: RGD

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.146.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Granzyme K (EC:3.4.21.-)
    Alternative name(s):
    NK-tryptase-2
    Short name:
    NK-Tryp-2
    Gene namesi
    Name:Gzmk
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi68401. Gzmk.

    Subcellular locationi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Propeptidei24 – 252Activation peptide1 PublicationPRO_0000027419
    Chaini26 – 258233Granzyme KPRO_0000027420Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi51 ↔ 67PROSITE-ProRule annotation
    Disulfide bondi143 ↔ 214PROSITE-ProRule annotation
    Disulfide bondi175 ↔ 193PROSITE-ProRule annotation
    Disulfide bondi204 ↔ 228PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Proteomic databases

    PaxDbiP49864.
    PRIDEiP49864.

    Expressioni

    Tissue specificityi

    Speen, lungs and liver non-parenchymal cells.

    Gene expression databases

    GenevestigatoriP49864.

    Interactioni

    Protein-protein interaction databases

    IntActiP49864. 1 interaction.
    STRINGi10116.ENSRNOP00000014319.

    Structurei

    3D structure databases

    ProteinModelPortaliP49864.
    SMRiP49864. Positions 25-254.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 253228Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP49864.
    KOiK08663.
    PhylomeDBiP49864.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49864-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFSSSALVF LVAGIYMSSE SFHTEIIGGR EVQPHSRPFM ASIQYRGKHI    50
    CGGVLIHPQW VLTAAHCYSR GHSPTVVLGA HSLSKNEPMK QTFEIKEFIP 100
    FSGFKSGTND IMLIKLRTAA ELNKHVQLLH LRSKNYIRDG TKCQVTGWGS 150
    TKPDVLTTSD TLQEVTVTII SRKRCNSQSY YNHKPVITKD MICAGDRRGE 200
    KDSCKGDSGG PLICKGVFHA LVSGGYKCGI SNKPGVYTLL TKKYQTWIKS 250
    KLAPSSAH 258
    Length:258
    Mass (Da):28,465
    Last modified:October 1, 1996 - v1
    Checksum:i988AD71DB08AFBB4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19694 mRNA. Translation: AAA42057.1.
    PIRiI56220.
    RefSeqiNP_058815.1. NM_017119.2.
    UniGeneiRn.11190.

    Genome annotation databases

    GeneIDi29165.
    KEGGirno:29165.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19694 mRNA. Translation: AAA42057.1 .
    PIRi I56220.
    RefSeqi NP_058815.1. NM_017119.2.
    UniGenei Rn.11190.

    3D structure databases

    ProteinModelPortali P49864.
    SMRi P49864. Positions 25-254.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P49864. 1 interaction.
    STRINGi 10116.ENSRNOP00000014319.

    Chemistry

    ChEMBLi CHEMBL4557.

    Protein family/group databases

    MEROPSi S01.146.

    Proteomic databases

    PaxDbi P49864.
    PRIDEi P49864.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29165.
    KEGGi rno:29165.

    Organism-specific databases

    CTDi 3003.
    RGDi 68401. Gzmk.

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P49864.
    KOi K08663.
    PhylomeDBi P49864.

    Miscellaneous databases

    NextBioi 608211.
    PROi P49864.

    Gene expression databases

    Genevestigatori P49864.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Purification and cloning of a novel serine protease, RNK-Tryp-2, from the granules of a rat NK cell leukemia."
      Sayers T.J., Wiltrout T.A., Smyth M.J., Ottaway K.S., Pilaro A.M., Sowder R., Henderson L.E., Sprenger H., Lloyd A.R.
      J. Immunol. 152:2289-2297(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 26-58.
      Strain: Fischer 344.
      Tissue: Lymphocyte.

    Entry informationi

    Entry nameiGRAK_RAT
    AccessioniPrimary (citable) accession number: P49864
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3