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P49864

- GRAK_RAT

UniProt

P49864 - GRAK_RAT

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Protein

Granzyme K

Gene

Gzmk

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei66 – 661Charge relay systemBy similarity
Active sitei110 – 1101Charge relay systemBy similarity
Active sitei208 – 2081Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
  2. serine-type peptidase activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.146.

Names & Taxonomyi

Protein namesi
Recommended name:
Granzyme K (EC:3.4.21.-)
Alternative name(s):
NK-tryptase-2
Short name:
NK-Tryp-2
Gene namesi
Name:Gzmk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi68401. Gzmk.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 252Activation peptide1 PublicationPRO_0000027419
Chaini26 – 258233Granzyme KPRO_0000027420Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 67PROSITE-ProRule annotation
Disulfide bondi143 ↔ 214PROSITE-ProRule annotation
Disulfide bondi175 ↔ 193PROSITE-ProRule annotation
Disulfide bondi204 ↔ 228PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP49864.
PRIDEiP49864.

Expressioni

Tissue specificityi

Speen, lungs and liver non-parenchymal cells.

Gene expression databases

GenevestigatoriP49864.

Interactioni

Protein-protein interaction databases

IntActiP49864. 1 interaction.
STRINGi10116.ENSRNOP00000014319.

Structurei

3D structure databases

ProteinModelPortaliP49864.
SMRiP49864. Positions 25-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 253228Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP49864.
KOiK08663.
PhylomeDBiP49864.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49864-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFSSSALVF LVAGIYMSSE SFHTEIIGGR EVQPHSRPFM ASIQYRGKHI
60 70 80 90 100
CGGVLIHPQW VLTAAHCYSR GHSPTVVLGA HSLSKNEPMK QTFEIKEFIP
110 120 130 140 150
FSGFKSGTND IMLIKLRTAA ELNKHVQLLH LRSKNYIRDG TKCQVTGWGS
160 170 180 190 200
TKPDVLTTSD TLQEVTVTII SRKRCNSQSY YNHKPVITKD MICAGDRRGE
210 220 230 240 250
KDSCKGDSGG PLICKGVFHA LVSGGYKCGI SNKPGVYTLL TKKYQTWIKS

KLAPSSAH
Length:258
Mass (Da):28,465
Last modified:October 1, 1996 - v1
Checksum:i988AD71DB08AFBB4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19694 mRNA. Translation: AAA42057.1.
PIRiI56220.
RefSeqiNP_058815.1. NM_017119.2.
UniGeneiRn.11190.

Genome annotation databases

GeneIDi29165.
KEGGirno:29165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19694 mRNA. Translation: AAA42057.1 .
PIRi I56220.
RefSeqi NP_058815.1. NM_017119.2.
UniGenei Rn.11190.

3D structure databases

ProteinModelPortali P49864.
SMRi P49864. Positions 25-254.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P49864. 1 interaction.
STRINGi 10116.ENSRNOP00000014319.

Chemistry

ChEMBLi CHEMBL4557.

Protein family/group databases

MEROPSi S01.146.

Proteomic databases

PaxDbi P49864.
PRIDEi P49864.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 29165.
KEGGi rno:29165.

Organism-specific databases

CTDi 3003.
RGDi 68401. Gzmk.

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P49864.
KOi K08663.
PhylomeDBi P49864.

Miscellaneous databases

NextBioi 608211.
PROi P49864.

Gene expression databases

Genevestigatori P49864.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Purification and cloning of a novel serine protease, RNK-Tryp-2, from the granules of a rat NK cell leukemia."
    Sayers T.J., Wiltrout T.A., Smyth M.J., Ottaway K.S., Pilaro A.M., Sowder R., Henderson L.E., Sprenger H., Lloyd A.R.
    J. Immunol. 152:2289-2297(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 26-58.
    Strain: Fischer 344.
    Tissue: Lymphocyte.

Entry informationi

Entry nameiGRAK_RAT
AccessioniPrimary (citable) accession number: P49864
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 1, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3