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Protein

Granzyme K

Gene

GZMK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei67Charge relay system1
Active sitei116Charge relay system1
Active sitei214Charge relay system1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: InterPro
  • serine-type peptidase activity Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113088-MONOMER.
BRENDAi3.4.21.B4. 2681.

Protein family/group databases

MEROPSiS01.146.

Names & Taxonomyi

Protein namesi
Recommended name:
Granzyme K (EC:3.4.21.-)
Alternative name(s):
Fragmentin-3
Granzyme-3
NK-tryptase-2
Short name:
NK-Tryp-2
Gene namesi
Name:GZMK
Synonyms:TRYP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:4711. GZMK.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3003.
OpenTargetsiENSG00000113088.
PharmGKBiPA29089.

Chemistry databases

ChEMBLiCHEMBL4930.

Polymorphism and mutation databases

BioMutaiGZMK.
DMDMi1708035.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000002741525 – 26Activation peptide2 Publications2
ChainiPRO_000002741627 – 264Granzyme KAdd BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 68
Disulfide bondi149 ↔ 220
Disulfide bondi181 ↔ 199
Disulfide bondi210 ↔ 234

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP49863.
PeptideAtlasiP49863.
PRIDEiP49863.

PTM databases

iPTMnetiP49863.
PhosphoSitePlusiP49863.

Expressioni

Tissue specificityi

Expressed in lung, spleen, thymus and peripheral blood leukocytes.

Gene expression databases

BgeeiENSG00000113088.
CleanExiHS_GZMK.
GenevisibleiP49863. HS.

Organism-specific databases

HPAiHPA063181.

Interactioni

Protein-protein interaction databases

BioGridi109258. 12 interactors.
IntActiP49863. 2 interactors.
STRINGi9606.ENSP00000231009.

Chemistry databases

BindingDBiP49863.

Structurei

Secondary structure

1264
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi41 – 46Combined sources6
Beta strandi49 – 58Combined sources10
Beta strandi61 – 64Combined sources4
Helixi66 – 68Combined sources3
Beta strandi78 – 83Combined sources6
Beta strandi85 – 89Combined sources5
Beta strandi95 – 104Combined sources10
Beta strandi111 – 115Combined sources5
Beta strandi118 – 124Combined sources7
Beta strandi130 – 132Combined sources3
Beta strandi148 – 153Combined sources6
Beta strandi169 – 175Combined sources7
Helixi178 – 181Combined sources4
Turni184 – 191Combined sources8
Beta strandi197 – 201Combined sources5
Beta strandi217 – 220Combined sources4
Beta strandi223 – 228Combined sources6
Beta strandi241 – 245Combined sources5
Helixi248 – 257Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MZAX-ray2.23A25-264[»]
1MZDX-ray2.90A25-264[»]
ProteinModelPortaliP49863.
SMRiP49863.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49863.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 259Peptidase S1PROSITE-ProRule annotationAdd BLAST233

Sequence similaritiesi

Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP49863.
KOiK08663.
OMAiSYYNHKP.
OrthoDBiEOG091G0AH5.
PhylomeDBiP49863.
TreeFamiTF333630.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49863-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKFSSFSLF FLIVGAYMTH VCFNMEIIGG KEVSPHSRPF MASIQYGGHH
60 70 80 90 100
VCGGVLIDPQ WVLTAAHCQY RFTKGQSPTV VLGAHSLSKN EASKQTLEIK
110 120 130 140 150
KFIPFSRVTS DPQSNDIMLV KLQTAAKLNK HVKMLHIRSK TSLRSGTKCK
160 170 180 190 200
VTGWGATDPD SLRPSDTLRE VTVTVLSRKL CNSQSYYNGD PFITKDMVCA
210 220 230 240 250
GDAKGQKDSC KGDSGGPLIC KGVFHAIVSG GHECGVATKP GIYTLLTKKY
260
QTWIKSNLVP PHTN
Length:264
Mass (Da):28,882
Last modified:October 1, 1996 - v1
Checksum:i2A93FDBAF9286CC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34S → Q AA sequence (PubMed:1460416).Curated1
Sequence conflicti43S → A AA sequence (PubMed:1460416).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35237 mRNA. Translation: AAA79063.1.
U26174 mRNA. Translation: AAA74578.1.
AK312074 mRNA. Translation: BAG35010.1.
CH471123 Genomic DNA. Translation: EAW54899.1.
BC035802 mRNA. Translation: AAH35802.1.
CCDSiCCDS3964.1.
PIRiS65663.
RefSeqiNP_002095.1. NM_002104.2.
UniGeneiHs.277937.

Genome annotation databases

EnsembliENST00000231009; ENSP00000231009; ENSG00000113088.
GeneIDi3003.
KEGGihsa:3003.
UCSCiuc003jpl.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35237 mRNA. Translation: AAA79063.1.
U26174 mRNA. Translation: AAA74578.1.
AK312074 mRNA. Translation: BAG35010.1.
CH471123 Genomic DNA. Translation: EAW54899.1.
BC035802 mRNA. Translation: AAH35802.1.
CCDSiCCDS3964.1.
PIRiS65663.
RefSeqiNP_002095.1. NM_002104.2.
UniGeneiHs.277937.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MZAX-ray2.23A25-264[»]
1MZDX-ray2.90A25-264[»]
ProteinModelPortaliP49863.
SMRiP49863.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109258. 12 interactors.
IntActiP49863. 2 interactors.
STRINGi9606.ENSP00000231009.

Chemistry databases

BindingDBiP49863.
ChEMBLiCHEMBL4930.

Protein family/group databases

MEROPSiS01.146.

PTM databases

iPTMnetiP49863.
PhosphoSitePlusiP49863.

Polymorphism and mutation databases

BioMutaiGZMK.
DMDMi1708035.

Proteomic databases

PaxDbiP49863.
PeptideAtlasiP49863.
PRIDEiP49863.

Protocols and materials databases

DNASUi3003.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231009; ENSP00000231009; ENSG00000113088.
GeneIDi3003.
KEGGihsa:3003.
UCSCiuc003jpl.2. human.

Organism-specific databases

CTDi3003.
DisGeNETi3003.
GeneCardsiGZMK.
HGNCiHGNC:4711. GZMK.
HPAiHPA063181.
MIMi600784. gene.
neXtProtiNX_P49863.
OpenTargetsiENSG00000113088.
PharmGKBiPA29089.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP49863.
KOiK08663.
OMAiSYYNHKP.
OrthoDBiEOG091G0AH5.
PhylomeDBiP49863.
TreeFamiTF333630.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113088-MONOMER.
BRENDAi3.4.21.B4. 2681.

Miscellaneous databases

EvolutionaryTraceiP49863.
GeneWikiiGZMK.
GenomeRNAii3003.
PROiP49863.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113088.
CleanExiHS_GZMK.
GenevisibleiP49863. HS.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRAK_HUMAN
AccessioniPrimary (citable) accession number: P49863
Secondary accession number(s): B2R563
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.