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P49862

- KLK7_HUMAN

UniProt

P49862 - KLK7_HUMAN

Protein

Kallikrein-7

Gene

KLK7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.1 Publication

    Catalytic activityi

    Cleavage of proteins with aromatic side chains in the P1 position.

    Enzyme regulationi

    Inhibited by Zn2+ and Cu2+ at low micromolar concentrations. Inhibited by SERPINA12.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei70 – 701Charge relay system1 Publication
    Sitei109 – 1091Major binding site for inhibitory zinc or copper
    Active sitei112 – 1121Charge relay system1 Publication
    Active sitei205 – 2051Charge relay system1 Publication

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro
    2. serine-type peptidase activity Source: ProtInc

    GO - Biological processi

    1. epidermis development Source: ProtInc
    2. extracellular matrix disassembly Source: Reactome
    3. extracellular matrix organization Source: Reactome

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BRENDAi3.4.21.117. 1154.
    ReactomeiREACT_118572. Degradation of the extracellular matrix.

    Protein family/group databases

    MEROPSiS01.300.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kallikrein-7 (EC:3.4.21.117)
    Short name:
    hK7
    Alternative name(s):
    Serine protease 6
    Stratum corneum chymotryptic enzyme
    Short name:
    hSCCE
    Gene namesi
    Name:KLK7
    Synonyms:PRSS6, SCCE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6368. KLK7.

    Subcellular locationi

    Secreted 1 Publication
    Note: In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.

    GO - Cellular componenti

    1. epidermal lamellar body Source: UniProtKB
    2. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi54 – 541H → F: No effect on zinc inhibition. 1 Publication
    Mutagenesisi109 – 1091H → A: No zinc inhibition. 1 Publication

    Organism-specific databases

    PharmGKBiPA30157.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 22221 PublicationAdd
    BLAST
    Propeptidei23 – 297Activation peptidePRO_0000027942
    Chaini30 – 253224Kallikrein-7PRO_0000027943Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi36 ↔ 165
    Disulfide bondi55 ↔ 71
    Disulfide bondi137 ↔ 239
    Disulfide bondi144 ↔ 211
    Disulfide bondi176 ↔ 190
    Disulfide bondi201 ↔ 226
    Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiP49862.
    PRIDEiP49862.

    PTM databases

    PhosphoSiteiP49862.

    Miscellaneous databases

    PMAP-CutDBP49862.

    Expressioni

    Tissue specificityi

    Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level).2 Publications

    Inductioni

    By estrogens and glucocorticoids in a breast carcinoma cell line.1 Publication

    Gene expression databases

    ArrayExpressiP49862.
    BgeeiP49862.
    CleanExiHS_KLK7.
    GenevestigatoriP49862.

    Organism-specific databases

    HPAiCAB026342.
    HPA018994.

    Interactioni

    Protein-protein interaction databases

    BioGridi111631. 3 interactions.
    STRINGi9606.ENSP00000304791.

    Structurei

    Secondary structure

    1
    253
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi44 – 496
    Beta strandi52 – 6110
    Beta strandi64 – 674
    Helixi69 – 713
    Beta strandi76 – 816
    Beta strandi90 – 956
    Beta strandi97 – 1004
    Turni106 – 1083
    Beta strandi114 – 1174
    Beta strandi143 – 1508
    Beta strandi152 – 1565
    Beta strandi164 – 1718
    Helixi173 – 1808
    Helixi181 – 1833
    Beta strandi188 – 1925
    Beta strandi208 – 2114
    Beta strandi214 – 2218
    Beta strandi224 – 2263
    Beta strandi233 – 2375
    Helixi238 – 2403
    Helixi242 – 25110

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2QXGX-ray2.60A/B30-253[»]
    2QXHX-ray2.00A30-253[»]
    2QXIX-ray1.00A30-253[»]
    2QXJX-ray2.10A30-253[»]
    3BSQX-ray2.80A/B/C30-250[»]
    ProteinModelPortaliP49862.
    SMRiP49862. Positions 30-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP49862.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 250221Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP49862.
    KOiK08668.
    OMAiVLVNERW.
    PhylomeDBiP49862.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P49862-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARSLLLPLQ ILLLSLALET AGEEAQGDKI IDGAPCARGS HPWQVALLSG    50
    NQLHCGGVLV NERWVLTAAH CKMNEYTVHL GSDTLGDRRA QRIKASKSFR 100
    HPGYSTQTHV NDLMLVKLNS QARLSSMVKK VRLPSRCEPP GTTCTVSGWG 150
    TTTSPDVTFP SDLMCVDVKL ISPQDCTKVY KDLLENSMLC AGIPDSKKNA 200
    CNGDSGGPLV CRGTLQGLVS WGTFPCGQPN DPGVYTQVCK FTKWINDTMK 250
    KHR 253
    Length:253
    Mass (Da):27,525
    Last modified:October 1, 1996 - v1
    Checksum:i2D68B6B15A76A668
    GO
    Isoform 2 (identifier: P49862-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         1-72: Missing.

    Show »
    Length:181
    Mass (Da):19,887
    Checksum:i86A28A03B80C2D78
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti226 – 2261C → W in AAH32005. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7272Missing in isoform 2. 1 PublicationVSP_013581Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L33404 mRNA. Translation: AAC37551.1.
    AF166330 Genomic DNA. Translation: AAD49718.1.
    AF243527 Genomic DNA. Translation: AAG33360.1.
    AF332583 Genomic DNA. Translation: AAK69624.1.
    AF411214 mRNA. Translation: AAN03662.1.
    AF411215 mRNA. Translation: AAN03663.1.
    AY601109 mRNA. Translation: AAU04540.1.
    AK289660 mRNA. Translation: BAF82349.1.
    CH471135 Genomic DNA. Translation: EAW71959.1.
    BC032005 mRNA. Translation: AAH32005.1.
    CCDSiCCDS12812.1. [P49862-1]
    CCDS59414.1. [P49862-2]
    PIRiA53968.
    RefSeqiNP_001193982.1. NM_001207053.1. [P49862-2]
    NP_001230055.1. NM_001243126.1.
    NP_005037.1. NM_005046.3. [P49862-1]
    NP_644806.1. NM_139277.2. [P49862-1]
    UniGeneiHs.151254.

    Genome annotation databases

    EnsembliENST00000391807; ENSP00000375683; ENSG00000169035. [P49862-1]
    ENST00000595820; ENSP00000470538; ENSG00000169035. [P49862-1]
    ENST00000597707; ENSP00000469950; ENSG00000169035. [P49862-2]
    GeneIDi5650.
    KEGGihsa:5650.
    UCSCiuc002puo.3. human. [P49862-1]

    Polymorphism databases

    DMDMi1710878.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L33404 mRNA. Translation: AAC37551.1 .
    AF166330 Genomic DNA. Translation: AAD49718.1 .
    AF243527 Genomic DNA. Translation: AAG33360.1 .
    AF332583 Genomic DNA. Translation: AAK69624.1 .
    AF411214 mRNA. Translation: AAN03662.1 .
    AF411215 mRNA. Translation: AAN03663.1 .
    AY601109 mRNA. Translation: AAU04540.1 .
    AK289660 mRNA. Translation: BAF82349.1 .
    CH471135 Genomic DNA. Translation: EAW71959.1 .
    BC032005 mRNA. Translation: AAH32005.1 .
    CCDSi CCDS12812.1. [P49862-1 ]
    CCDS59414.1. [P49862-2 ]
    PIRi A53968.
    RefSeqi NP_001193982.1. NM_001207053.1. [P49862-2 ]
    NP_001230055.1. NM_001243126.1.
    NP_005037.1. NM_005046.3. [P49862-1 ]
    NP_644806.1. NM_139277.2. [P49862-1 ]
    UniGenei Hs.151254.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2QXG X-ray 2.60 A/B 30-253 [» ]
    2QXH X-ray 2.00 A 30-253 [» ]
    2QXI X-ray 1.00 A 30-253 [» ]
    2QXJ X-ray 2.10 A 30-253 [» ]
    3BSQ X-ray 2.80 A/B/C 30-250 [» ]
    ProteinModelPortali P49862.
    SMRi P49862. Positions 30-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111631. 3 interactions.
    STRINGi 9606.ENSP00000304791.

    Chemistry

    BindingDBi P49862.
    ChEMBLi CHEMBL2443.

    Protein family/group databases

    MEROPSi S01.300.

    PTM databases

    PhosphoSitei P49862.

    Polymorphism databases

    DMDMi 1710878.

    Proteomic databases

    PaxDbi P49862.
    PRIDEi P49862.

    Protocols and materials databases

    DNASUi 5650.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000391807 ; ENSP00000375683 ; ENSG00000169035 . [P49862-1 ]
    ENST00000595820 ; ENSP00000470538 ; ENSG00000169035 . [P49862-1 ]
    ENST00000597707 ; ENSP00000469950 ; ENSG00000169035 . [P49862-2 ]
    GeneIDi 5650.
    KEGGi hsa:5650.
    UCSCi uc002puo.3. human. [P49862-1 ]

    Organism-specific databases

    CTDi 5650.
    GeneCardsi GC19M051479.
    HGNCi HGNC:6368. KLK7.
    HPAi CAB026342.
    HPA018994.
    MIMi 604438. gene.
    neXtProti NX_P49862.
    PharmGKBi PA30157.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P49862.
    KOi K08668.
    OMAi VLVNERW.
    PhylomeDBi P49862.
    TreeFami TF331065.

    Enzyme and pathway databases

    BRENDAi 3.4.21.117. 1154.
    Reactomei REACT_118572. Degradation of the extracellular matrix.

    Miscellaneous databases

    EvolutionaryTracei P49862.
    GeneWikii KLK7.
    GenomeRNAii 5650.
    NextBioi 21952.
    PMAP-CutDB P49862.
    PROi P49862.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49862.
    Bgeei P49862.
    CleanExi HS_KLK7.
    Genevestigatori P49862.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase."
      Hansson L., Stroemqvist M., Baeckman A., Wallbrandt P., Carlstein A., Egelrud T.
      J. Biol. Chem. 269:19420-19426(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 23-53.
      Tissue: Skin.
    2. "The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family -- genomic characterization, mapping, tissue expression and hormonal regulation."
      Yousef G.M., Scorilas A., Magklara A., Soosaipillai A., Diamandis E.P.
      Gene 254:119-128(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, INDUCTION.
      Tissue: Keratinocyte.
    3. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
      Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.
      Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis."
      Hansson L., Backman A., Ny A., Edlund M., Ekholm E., Ekstrand Hammarstrom B., Tornell J., Wallbrandt P., Wennbo H., Egelrud T.
      J. Invest. Dermatol. 118:444-449(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers."
      Dong Y., Kaushal A., Brattsand M., Nicklin J., Clements J.A.
      Clin. Cancer Res. 9:1710-1720(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Ovarian carcinoma.
    6. "Prostate epithelial cells KLK7 protein."
      Mo Z., Yang X.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Prostate.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    10. "Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme."
      Skytt A., Stroemqvist M., Egelrud T.
      Biochem. Biophys. Res. Commun. 211:586-589(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    11. Cited for: FUNCTION, CLEAVAGE SPECIFICITY FOR INSULIN, ENZYME REGULATION.
    12. "Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7."
      Debela M., Hess P., Magdolen V., Schechter N.M., Steiner T., Huber R., Bode W., Goettig P.
      Proc. Natl. Acad. Sci. U.S.A. 104:16086-16091(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.0 ANGSTROMS) OF 30-253 IN COMPLEX WITH ZINC OR COPPER, ACTIVE SITE, DISULFIDE BONDS, MUTAGENESIS OF HIS-54 AND HIS-109.
    13. "Crystal structure of human epidermal kallikrein 7 (hK7) synthesized directly in its native state in E. coli: insights into the atomic basis of its inhibition by LEKTI domain 6 (LD6)."
      Fernandez I.S., Standker L., Magert H.J., Forssmann W.G., Gimenez-Gallego G., Romero A.
      J. Mol. Biol. 377:1488-1497(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 30-250, DISULFIDE BONDS.

    Entry informationi

    Entry nameiKLK7_HUMAN
    AccessioniPrimary (citable) accession number: P49862
    Secondary accession number(s): A8K0U5, Q8N5N9, Q8NFV7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3