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Protein

Transcription initiation factor TFIID subunit 6

Gene

TAF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

GO - Molecular functioni

  • aryl hydrocarbon receptor binding Source: CAFA
  • DNA binding Source: UniProtKB
  • DNA binding transcription factor activity Source: UniProtKB
  • protein heterodimerization activity Source: InterPro

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 6
Alternative name(s):
RNA polymerase II TBP-associated factor subunit E
Transcription initiation factor TFIID 70 kDa subunit
Short name:
TAF(II)70
Short name:
TAFII-70
Short name:
TAFII70
Transcription initiation factor TFIID 80 kDa subunit
Short name:
TAF(II)80
Short name:
TAFII-80
Short name:
TAFII80
Gene namesi
Name:TAF6
Synonyms:TAF2E, TAFII70
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106290.14
HGNCiHGNC:11540 TAF6
MIMi602955 gene
neXtProtiNX_P49848

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Alazami-Yuan syndrome (ALYUS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive syndrome reminiscent of Cornelia de Lange syndrome and characterized by delayed psychomotor development with intellectual disability, hypotonia, microcephaly, short stature, poor speech, and dysmorphic features.
See also OMIM:617126
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07784046R → C in ALYUS; decreased interaction with TAF1 and TBP shown by functional expression studies in a Drosophila cell line. 1 PublicationCorresponds to variant dbSNP:rs727503778EnsemblClinVar.1
Natural variantiVAR_07784171I → T in ALYUS; decreased interaction with TAF1, TAF9 and TBP shown by functional expression studies in a Drosophila cell line. 2 PublicationsCorresponds to variant dbSNP:rs374993554EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNETi6878
MalaCardsiTAF6
MIMi617126 phenotype
OpenTargetsiENSG00000106290
PharmGKBiPA36315

Polymorphism and mutation databases

BioMutaiTAF6
DMDMi1729810

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188731 – 677Transcription initiation factor TFIID subunit 6Add BLAST677

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei120PhosphothreonineCombined sources1
Cross-linki196Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei248PhosphothreonineBy similarity1
Modified residuei253PhosphotyrosineBy similarity1
Modified residuei264PhosphoserineBy similarity1
Modified residuei524Omega-N-methylarginineCombined sources1
Modified residuei626PhosphoserineBy similarity1
Modified residuei634PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Modified residuei653PhosphoserineCombined sources1
Modified residuei660PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP49848
MaxQBiP49848
PaxDbiP49848
PeptideAtlasiP49848
PRIDEiP49848

PTM databases

iPTMnetiP49848
PhosphoSitePlusiP49848

Expressioni

Gene expression databases

BgeeiENSG00000106290
CleanExiHS_TAF6
ExpressionAtlasiP49848 baseline and differential
GenevisibleiP49848 HS

Organism-specific databases

HPAiHPA006566

Interactioni

Subunit structurei

TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Interacts directly with TBP, TAF1/TAFII250, TAF9/TAFII31 AND TAF12/TAFII20. The TAF6/TAFII70-TAF9/TAFII31 heterodimer forms an octamer complex with the TAF4B/TFII105-TAF12/TFIID20 heterodimer. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Also interacts with the GTFs, TFIIEalpha/GTF2E1 and TFIIFalpha/GTF2F1. Component of the TFTC-HAT complex.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PB1Q1K9H52EBI-1560206,EBI-6050669From Influenza A virus (strain A/Wilson-Smith/1933 H1N1).

GO - Molecular functioni

  • aryl hydrocarbon receptor binding Source: CAFA
  • protein heterodimerization activity Source: InterPro

Protein-protein interaction databases

BioGridi112741, 66 interactors
CORUMiP49848
DIPiDIP-773N
IntActiP49848, 25 interactors
MINTiP49848
STRINGi9606.ENSP00000399982

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5FURelectron microscopy8.50J/K1-677[»]
ProteinModelPortaliP49848
SMRiP49848
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TAF6 family.Curated

Phylogenomic databases

eggNOGiKOG2549 Eukaryota
COG5095 LUCA
GeneTreeiENSGT00640000091486
HOGENOMiHOG000253001
HOVERGENiHBG012489
InParanoidiP49848
KOiK03131
PhylomeDBiP49848
TreeFamiTF313632

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR009072 Histone-fold
IPR037796 TAF6
IPR011442 TAF6_C
IPR004823 TAF_TATA-bd
PANTHERiPTHR10221 PTHR10221, 1 hit
PfamiView protein in Pfam
PF02969 TAF, 1 hit
PF07571 TAF6_C, 1 hit
SMARTiView protein in SMART
SM00803 TAF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
SSF48371 SSF48371, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P49848-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEEKKLKLS NTVLPSESMK VVAESMGIAQ IQEETCQLLT DEVSYRIKEI
60 70 80 90 100
AQDALKFMHM GKRQKLTTSD IDYALKLKNV EPLYGFHAQE FIPFRFASGG
110 120 130 140 150
GRELYFYEEK EVDLSDIINT PLPRVPLDVC LKAHWLSIEG CQPAIPENPP
160 170 180 190 200
PAPKEQQKAE ATEPLKSAKP GQEEDGPLKG KGQGATTADG KGKEKKAPPL
210 220 230 240 250
LEGAPLRLKP RSIHELSVEQ QLYYKEITEA CVGSCEAKRA EALQSIATDP
260 270 280 290 300
GLYQMLPRFS TFISEGVRVN VVQNNLALLI YLMRMVKALM DNPTLYLEKY
310 320 330 340 350
VHELIPAVMT CIVSRQLCLR PDVDNHWALR DFAARLVAQI CKHFSTTTNN
360 370 380 390 400
IQSRITKTFT KSWVDEKTPW TTRYGSIAGL AELGHDVIKT LILPRLQQEG
410 420 430 440 450
ERIRSVLDGP VLSNIDRIGA DHVQSLLLKH CAPVLAKLRP PPDNQDAYRA
460 470 480 490 500
EFGSLGPLLC SQVVKARAQA ALQAQQVNRT TLTITQPRPT LTLSQAPQPG
510 520 530 540 550
PRTPGLLKVP GSIALPVQTL VSARAAAPPQ PSPPPTKFIV MSSSSSAPST
560 570 580 590 600
QQVLSLSTSA PGSGSTTTSP VTTTVPSVQP IVKLVSTATT APPSTAPSGP
610 620 630 640 650
GSVQKYIVVS LPPTGEGKGG PTSHPSPVPP PASSPSPLSG SALCGGKQEA
660 670
GDSPPPAPGT PKANGSQPNS GSPQPAP
Length:677
Mass (Da):72,668
Last modified:October 1, 1996 - v1
Checksum:i06C6BFA563580823
GO
Isoform 2 (identifier: P49848-2) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     477-486: Missing.

Show »
Length:667
Mass (Da):71,540
Checksum:i85488E83976800FC
GO
Isoform 3 (identifier: P49848-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTKRRLQTITACLQLREGSPSLHRGLHPSREEKRDSRM

Note: No experimental confirmation available.
Show »
Length:714
Mass (Da):76,995
Checksum:i1A1E41AB1BC47388
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196K → E in CAH10485 (PubMed:17974005).Curated1
Sequence conflicti417R → W in CAH10485 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01434936C → S1 PublicationCorresponds to variant dbSNP:rs4134897Ensembl.1
Natural variantiVAR_07784046R → C in ALYUS; decreased interaction with TAF1 and TBP shown by functional expression studies in a Drosophila cell line. 1 PublicationCorresponds to variant dbSNP:rs727503778EnsemblClinVar.1
Natural variantiVAR_07784171I → T in ALYUS; decreased interaction with TAF1, TAF9 and TBP shown by functional expression studies in a Drosophila cell line. 2 PublicationsCorresponds to variant dbSNP:rs374993554EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0437091M → MTKRRLQTITACLQLREGSP SLHRGLHPSREEKRDSRM in isoform 3. 1 Publication1
Alternative sequenceiVSP_037476477 – 486Missing in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25444 mRNA Translation: AAA63643.1
U31659 mRNA Translation: AAA84390.1
AK300005 mRNA Translation: BAG61823.1
CR627390 mRNA Translation: CAH10485.1
AY149894 Genomic DNA Translation: AAN10295.1
CH236956 Genomic DNA Translation: EAL23851.1
CH236956 Genomic DNA Translation: EAL23852.1
CH471091 Genomic DNA Translation: EAW76589.1
CH471091 Genomic DNA Translation: EAW76591.1
CH471091 Genomic DNA Translation: EAW76592.1
BC018115 mRNA Translation: AAH18115.1
CCDSiCCDS55135.1 [P49848-3]
CCDS5686.1 [P49848-1]
RefSeqiNP_001177344.1, NM_001190415.1 [P49848-3]
NP_005632.1, NM_005641.3 [P49848-1]
NP_647476.1, NM_139315.2 [P49848-1]
XP_006716163.1, XM_006716100.2 [P49848-1]
UniGeneiHs.489309

Genome annotation databases

EnsembliENST00000344095; ENSP00000344537; ENSG00000106290 [P49848-1]
ENST00000437822; ENSP00000399982; ENSG00000106290 [P49848-3]
ENST00000452041; ENSP00000416396; ENSG00000106290 [P49848-1]
ENST00000453269; ENSP00000389575; ENSG00000106290 [P49848-1]
GeneIDi6878
KEGGihsa:6878
UCSCiuc003uti.4 human [P49848-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTAF6_HUMAN
AccessioniPrimary (citable) accession number: P49848
Secondary accession number(s): A4D2B2
, A4D2B3, B4DT11, D6W5U2, Q6AI29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 183 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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