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P49848

- TAF6_HUMAN

UniProt

P49848 - TAF6_HUMAN

Protein

Transcription initiation factor TFIID subunit 6

Gene

TAF6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. DNA-templated transcription, initiation Source: UniProtKB
    2. gene expression Source: Reactome
    3. negative regulation of cell cycle Source: UniProtKB
    4. negative regulation of cell proliferation Source: UniProtKB
    5. regulation of sequence-specific DNA binding transcription factor activity Source: InterPro
    6. regulation of transcription, DNA-templated Source: GOC
    7. transcription elongation from RNA polymerase II promoter Source: Reactome
    8. transcription from RNA polymerase II promoter Source: UniProtKB
    9. transcription initiation from RNA polymerase II promoter Source: UniProtKB
    10. viral process Source: Reactome

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
    REACT_1851. RNA Polymerase II Transcription Initiation.
    REACT_2089. RNA Polymerase II Promoter Escape.
    REACT_22107. RNA Polymerase II Pre-transcription Events.
    REACT_6233. Transcription of the HIV genome.
    REACT_6253. RNA Polymerase II HIV Promoter Escape.
    REACT_6332. HIV Transcription Initiation.
    REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription initiation factor TFIID subunit 6
    Alternative name(s):
    RNA polymerase II TBP-associated factor subunit E
    Transcription initiation factor TFIID 70 kDa subunit
    Short name:
    TAF(II)70
    Short name:
    TAFII-70
    Short name:
    TAFII70
    Transcription initiation factor TFIID 80 kDa subunit
    Short name:
    TAF(II)80
    Short name:
    TAFII-80
    Short name:
    TAFII80
    Gene namesi
    Name:TAF6
    Synonyms:TAF2E, TAFII70
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:11540. TAF6.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. MLL1 complex Source: UniProtKB
    3. nucleoplasm Source: Reactome
    4. nucleus Source: HPA
    5. transcription factor TFIID complex Source: MGI
    6. transcription factor TFTC complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36315.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 677677Transcription initiation factor TFIID subunit 6PRO_0000118873Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei248 – 2481PhosphothreonineBy similarity
    Modified residuei253 – 2531PhosphotyrosineBy similarity
    Modified residuei264 – 2641PhosphoserineBy similarity
    Modified residuei653 – 6531Phosphoserine2 Publications
    Modified residuei660 – 6601Phosphothreonine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP49848.
    PaxDbiP49848.
    PRIDEiP49848.

    PTM databases

    PhosphoSiteiP49848.

    Expressioni

    Gene expression databases

    ArrayExpressiP49848.
    BgeeiP49848.
    CleanExiHS_TAF6.
    GenevestigatoriP49848.

    Organism-specific databases

    HPAiHPA006566.

    Interactioni

    Subunit structurei

    TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Interacts directly with TBP, TAF1/TAFII250, TAF9/TAFII31 AND TAF12/TAFII20. The TAF6/TAFII70-TAF9/TAFII31 heterodimer forms an octamer complex with the TAF4B/TFII105-TAF12/TFIID20 heterodimer. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Also interacts with the GTFs, TFIIEalpha/GTF2E1 and TFIIFalpha/GTF2F1. Component of the TFTC-HAT complex.5 Publications

    Protein-protein interaction databases

    BioGridi112741. 52 interactions.
    DIPiDIP-773N.
    IntActiP49848. 8 interactions.
    MINTiMINT-1211769.
    STRINGi9606.ENSP00000344537.

    Structurei

    3D structure databases

    ProteinModelPortaliP49848.
    SMRiP49848. Positions 9-76, 214-392.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TAF6 family.Curated

    Phylogenomic databases

    eggNOGiCOG5095.
    HOGENOMiHOG000253001.
    HOVERGENiHBG012489.
    InParanoidiP49848.
    KOiK03131.
    OrthoDBiEOG7TQV0B.
    PhylomeDBiP49848.
    TreeFamiTF313632.

    Family and domain databases

    Gene3Di1.10.20.10. 1 hit.
    1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR011442. DUF1546.
    IPR009072. Histone-fold.
    IPR004823. TAF_TATA-bd.
    [Graphical view]
    PfamiPF07571. DUF1546. 1 hit.
    PF02969. TAF. 1 hit.
    [Graphical view]
    SMARTiSM00803. TAF. 1 hit.
    [Graphical view]
    SUPFAMiSSF47113. SSF47113. 1 hit.
    SSF48371. SSF48371. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P49848-1) [UniParc]FASTAAdd to Basket

    Also known as: Alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEEKKLKLS NTVLPSESMK VVAESMGIAQ IQEETCQLLT DEVSYRIKEI    50
    AQDALKFMHM GKRQKLTTSD IDYALKLKNV EPLYGFHAQE FIPFRFASGG 100
    GRELYFYEEK EVDLSDIINT PLPRVPLDVC LKAHWLSIEG CQPAIPENPP 150
    PAPKEQQKAE ATEPLKSAKP GQEEDGPLKG KGQGATTADG KGKEKKAPPL 200
    LEGAPLRLKP RSIHELSVEQ QLYYKEITEA CVGSCEAKRA EALQSIATDP 250
    GLYQMLPRFS TFISEGVRVN VVQNNLALLI YLMRMVKALM DNPTLYLEKY 300
    VHELIPAVMT CIVSRQLCLR PDVDNHWALR DFAARLVAQI CKHFSTTTNN 350
    IQSRITKTFT KSWVDEKTPW TTRYGSIAGL AELGHDVIKT LILPRLQQEG 400
    ERIRSVLDGP VLSNIDRIGA DHVQSLLLKH CAPVLAKLRP PPDNQDAYRA 450
    EFGSLGPLLC SQVVKARAQA ALQAQQVNRT TLTITQPRPT LTLSQAPQPG 500
    PRTPGLLKVP GSIALPVQTL VSARAAAPPQ PSPPPTKFIV MSSSSSAPST 550
    QQVLSLSTSA PGSGSTTTSP VTTTVPSVQP IVKLVSTATT APPSTAPSGP 600
    GSVQKYIVVS LPPTGEGKGG PTSHPSPVPP PASSPSPLSG SALCGGKQEA 650
    GDSPPPAPGT PKANGSQPNS GSPQPAP 677
    Length:677
    Mass (Da):72,668
    Last modified:October 1, 1996 - v1
    Checksum:i06C6BFA563580823
    GO
    Isoform 2 (identifier: P49848-2) [UniParc]FASTAAdd to Basket

    Also known as: Gamma

    The sequence of this isoform differs from the canonical sequence as follows:
         477-486: Missing.

    Show »
    Length:667
    Mass (Da):71,540
    Checksum:i85488E83976800FC
    GO
    Isoform 3 (identifier: P49848-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MTKRRLQTITACLQLREGSPSLHRGLHPSREEKRDSRM

    Note: No experimental confirmation available.

    Show »
    Length:714
    Mass (Da):76,995
    Checksum:i1A1E41AB1BC47388
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti196 – 1961K → E in CAH10485. (PubMed:17974005)Curated
    Sequence conflicti417 – 4171R → W in CAH10485. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti36 – 361C → S.1 Publication
    Corresponds to variant rs4134897 [ dbSNP | Ensembl ].
    VAR_014349

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MTKRRLQTITACLQLREGSP SLHRGLHPSREEKRDSRM in isoform 3. 1 PublicationVSP_043709
    Alternative sequencei477 – 48610Missing in isoform 2. 1 PublicationVSP_037476

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L25444 mRNA. Translation: AAA63643.1.
    U31659 mRNA. Translation: AAA84390.1.
    AK300005 mRNA. Translation: BAG61823.1.
    CR627390 mRNA. Translation: CAH10485.1.
    AY149894 Genomic DNA. Translation: AAN10295.1.
    CH236956 Genomic DNA. Translation: EAL23851.1.
    CH236956 Genomic DNA. Translation: EAL23852.1.
    CH471091 Genomic DNA. Translation: EAW76589.1.
    CH471091 Genomic DNA. Translation: EAW76591.1.
    CH471091 Genomic DNA. Translation: EAW76592.1.
    BC018115 mRNA. Translation: AAH18115.1.
    CCDSiCCDS55135.1. [P49848-3]
    CCDS5686.1. [P49848-1]
    RefSeqiNP_001177344.1. NM_001190415.1. [P49848-3]
    NP_005632.1. NM_005641.3. [P49848-1]
    NP_647476.1. NM_139315.2. [P49848-1]
    XP_006716163.1. XM_006716100.1. [P49848-1]
    UniGeneiHs.489309.

    Genome annotation databases

    EnsembliENST00000344095; ENSP00000344537; ENSG00000106290. [P49848-1]
    ENST00000437822; ENSP00000399982; ENSG00000106290. [P49848-3]
    ENST00000452041; ENSP00000416396; ENSG00000106290. [P49848-1]
    ENST00000453269; ENSP00000389575; ENSG00000106290. [P49848-1]
    GeneIDi6878.
    KEGGihsa:6878.
    UCSCiuc003uti.3. human. [P49848-1]
    uc011kji.2. human. [P49848-3]

    Polymorphism databases

    DMDMi1729810.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L25444 mRNA. Translation: AAA63643.1 .
    U31659 mRNA. Translation: AAA84390.1 .
    AK300005 mRNA. Translation: BAG61823.1 .
    CR627390 mRNA. Translation: CAH10485.1 .
    AY149894 Genomic DNA. Translation: AAN10295.1 .
    CH236956 Genomic DNA. Translation: EAL23851.1 .
    CH236956 Genomic DNA. Translation: EAL23852.1 .
    CH471091 Genomic DNA. Translation: EAW76589.1 .
    CH471091 Genomic DNA. Translation: EAW76591.1 .
    CH471091 Genomic DNA. Translation: EAW76592.1 .
    BC018115 mRNA. Translation: AAH18115.1 .
    CCDSi CCDS55135.1. [P49848-3 ]
    CCDS5686.1. [P49848-1 ]
    RefSeqi NP_001177344.1. NM_001190415.1. [P49848-3 ]
    NP_005632.1. NM_005641.3. [P49848-1 ]
    NP_647476.1. NM_139315.2. [P49848-1 ]
    XP_006716163.1. XM_006716100.1. [P49848-1 ]
    UniGenei Hs.489309.

    3D structure databases

    ProteinModelPortali P49848.
    SMRi P49848. Positions 9-76, 214-392.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112741. 52 interactions.
    DIPi DIP-773N.
    IntActi P49848. 8 interactions.
    MINTi MINT-1211769.
    STRINGi 9606.ENSP00000344537.

    PTM databases

    PhosphoSitei P49848.

    Polymorphism databases

    DMDMi 1729810.

    Proteomic databases

    MaxQBi P49848.
    PaxDbi P49848.
    PRIDEi P49848.

    Protocols and materials databases

    DNASUi 6878.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344095 ; ENSP00000344537 ; ENSG00000106290 . [P49848-1 ]
    ENST00000437822 ; ENSP00000399982 ; ENSG00000106290 . [P49848-3 ]
    ENST00000452041 ; ENSP00000416396 ; ENSG00000106290 . [P49848-1 ]
    ENST00000453269 ; ENSP00000389575 ; ENSG00000106290 . [P49848-1 ]
    GeneIDi 6878.
    KEGGi hsa:6878.
    UCSCi uc003uti.3. human. [P49848-1 ]
    uc011kji.2. human. [P49848-3 ]

    Organism-specific databases

    CTDi 6878.
    GeneCardsi GC07M099704.
    HGNCi HGNC:11540. TAF6.
    HPAi HPA006566.
    MIMi 602955. gene.
    neXtProti NX_P49848.
    PharmGKBi PA36315.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5095.
    HOGENOMi HOG000253001.
    HOVERGENi HBG012489.
    InParanoidi P49848.
    KOi K03131.
    OrthoDBi EOG7TQV0B.
    PhylomeDBi P49848.
    TreeFami TF313632.

    Enzyme and pathway databases

    Reactomei REACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
    REACT_1851. RNA Polymerase II Transcription Initiation.
    REACT_2089. RNA Polymerase II Promoter Escape.
    REACT_22107. RNA Polymerase II Pre-transcription Events.
    REACT_6233. Transcription of the HIV genome.
    REACT_6253. RNA Polymerase II HIV Promoter Escape.
    REACT_6332. HIV Transcription Initiation.
    REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.

    Miscellaneous databases

    GeneWikii TAF6.
    GenomeRNAii 6878.
    NextBioi 26859.
    PROi P49848.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49848.
    Bgeei P49848.
    CleanExi HS_TAF6.
    Genevestigatori P49848.

    Family and domain databases

    Gene3Di 1.10.20.10. 1 hit.
    1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR011442. DUF1546.
    IPR009072. Histone-fold.
    IPR004823. TAF_TATA-bd.
    [Graphical view ]
    Pfami PF07571. DUF1546. 1 hit.
    PF02969. TAF. 1 hit.
    [Graphical view ]
    SMARTi SM00803. TAF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47113. SSF47113. 1 hit.
    SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of Drosophila TAFII60 and human TAFII70 reveal conserved interactions with other subunits of TFIID."
      Weinzierl R.O., Ruppert S., Dynlacht B.D., Tanese N., Tjian R.
      EMBO J. 12:5303-5309(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), PROTEIN SEQUENCE OF 78-95 AND 501-521, INTERACTION WITH TBP AND TAF1.
      Tissue: Cervix carcinoma.
    2. "Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors."
      Hisatake K., Ohta T., Takada R., Guermah M., Horikoshi M., Nakatani Y., Roeder R.G.
      Proc. Natl. Acad. Sci. U.S.A. 92:8195-8199(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 78-103; 113-127; 368-383 AND 441-455, INTERACTION WITH TBP; TAF1; TAF9; TAF12; GTF2F1 AND GTF2E1.
      Tissue: Placenta.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain cortex.
    5. NIEHS SNPs program
      Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-36.
    6. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Pancreas.
    9. "Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis."
      Cavusoglu N., Brand M., Tora L., van Dorsselaer A.
      Proteomics 3:217-223(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE TFTC-HAT COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    10. "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF."
      Dou Y., Milne T.A., Tackett A.J., Smith E.R., Fukuda A., Wysocka J., Allis C.D., Chait B.T., Hess J.L., Roeder R.G.
      Cell 121:873-885(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE MLL1/MLL COMPLEX.
    11. Cited for: INTERACTION WITH TAF9 IN A COMPLEX WITH TAF6; TAF9; TAF12 AND TAF4B, DNA-BINDING.
    12. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-653 AND THR-660, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-653 AND THR-660, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTAF6_HUMAN
    AccessioniPrimary (citable) accession number: P49848
    Secondary accession number(s): A4D2B2
    , A4D2B3, B4DT11, D6W5U2, Q6AI29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 146 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3