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P49848

- TAF6_HUMAN

UniProt

P49848 - TAF6_HUMAN

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Protein

Transcription initiation factor TFIID subunit 6

Gene

TAF6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. DNA-templated transcription, initiation Source: UniProtKB
  2. gene expression Source: Reactome
  3. negative regulation of cell cycle Source: UniProtKB
  4. negative regulation of cell proliferation Source: UniProtKB
  5. regulation of sequence-specific DNA binding transcription factor activity Source: InterPro
  6. regulation of transcription, DNA-templated Source: GOC
  7. transcription elongation from RNA polymerase II promoter Source: Reactome
  8. transcription from RNA polymerase II promoter Source: UniProtKB
  9. transcription initiation from RNA polymerase II promoter Source: UniProtKB
  10. viral process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_1851. RNA Polymerase II Transcription Initiation.
REACT_2089. RNA Polymerase II Promoter Escape.
REACT_22107. RNA Polymerase II Pre-transcription Events.
REACT_6233. Transcription of the HIV genome.
REACT_6253. RNA Polymerase II HIV Promoter Escape.
REACT_6332. HIV Transcription Initiation.
REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 6
Alternative name(s):
RNA polymerase II TBP-associated factor subunit E
Transcription initiation factor TFIID 70 kDa subunit
Short name:
TAF(II)70
Short name:
TAFII-70
Short name:
TAFII70
Transcription initiation factor TFIID 80 kDa subunit
Short name:
TAF(II)80
Short name:
TAFII-80
Short name:
TAFII80
Gene namesi
Name:TAF6
Synonyms:TAF2E, TAFII70
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:11540. TAF6.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. MLL1 complex Source: UniProtKB
  3. nucleoplasm Source: Reactome
  4. nucleus Source: HPA
  5. transcription factor TFIID complex Source: MGI
  6. transcription factor TFTC complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36315.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 677677Transcription initiation factor TFIID subunit 6PRO_0000118873Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei248 – 2481PhosphothreonineBy similarity
Modified residuei253 – 2531PhosphotyrosineBy similarity
Modified residuei264 – 2641PhosphoserineBy similarity
Modified residuei653 – 6531Phosphoserine2 Publications
Modified residuei660 – 6601Phosphothreonine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP49848.
PaxDbiP49848.
PRIDEiP49848.

PTM databases

PhosphoSiteiP49848.

Expressioni

Gene expression databases

BgeeiP49848.
CleanExiHS_TAF6.
ExpressionAtlasiP49848. baseline and differential.
GenevestigatoriP49848.

Organism-specific databases

HPAiHPA006566.

Interactioni

Subunit structurei

TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Interacts directly with TBP, TAF1/TAFII250, TAF9/TAFII31 AND TAF12/TAFII20. The TAF6/TAFII70-TAF9/TAFII31 heterodimer forms an octamer complex with the TAF4B/TFII105-TAF12/TFIID20 heterodimer. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Also interacts with the GTFs, TFIIEalpha/GTF2E1 and TFIIFalpha/GTF2F1. Component of the TFTC-HAT complex.5 Publications

Protein-protein interaction databases

BioGridi112741. 52 interactions.
DIPiDIP-773N.
IntActiP49848. 8 interactions.
MINTiMINT-1211769.
STRINGi9606.ENSP00000344537.

Structurei

3D structure databases

ProteinModelPortaliP49848.
SMRiP49848. Positions 9-76, 214-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TAF6 family.Curated

Phylogenomic databases

eggNOGiCOG5095.
GeneTreeiENSGT00640000091486.
HOGENOMiHOG000253001.
HOVERGENiHBG012489.
InParanoidiP49848.
KOiK03131.
OrthoDBiEOG7TQV0B.
PhylomeDBiP49848.
TreeFamiTF313632.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011442. DUF1546.
IPR009072. Histone-fold.
IPR004823. TAF_TATA-bd.
[Graphical view]
PfamiPF07571. DUF1546. 1 hit.
PF02969. TAF. 1 hit.
[Graphical view]
SMARTiSM00803. TAF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
SSF48371. SSF48371. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P49848-1) [UniParc]FASTAAdd to Basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEEKKLKLS NTVLPSESMK VVAESMGIAQ IQEETCQLLT DEVSYRIKEI
60 70 80 90 100
AQDALKFMHM GKRQKLTTSD IDYALKLKNV EPLYGFHAQE FIPFRFASGG
110 120 130 140 150
GRELYFYEEK EVDLSDIINT PLPRVPLDVC LKAHWLSIEG CQPAIPENPP
160 170 180 190 200
PAPKEQQKAE ATEPLKSAKP GQEEDGPLKG KGQGATTADG KGKEKKAPPL
210 220 230 240 250
LEGAPLRLKP RSIHELSVEQ QLYYKEITEA CVGSCEAKRA EALQSIATDP
260 270 280 290 300
GLYQMLPRFS TFISEGVRVN VVQNNLALLI YLMRMVKALM DNPTLYLEKY
310 320 330 340 350
VHELIPAVMT CIVSRQLCLR PDVDNHWALR DFAARLVAQI CKHFSTTTNN
360 370 380 390 400
IQSRITKTFT KSWVDEKTPW TTRYGSIAGL AELGHDVIKT LILPRLQQEG
410 420 430 440 450
ERIRSVLDGP VLSNIDRIGA DHVQSLLLKH CAPVLAKLRP PPDNQDAYRA
460 470 480 490 500
EFGSLGPLLC SQVVKARAQA ALQAQQVNRT TLTITQPRPT LTLSQAPQPG
510 520 530 540 550
PRTPGLLKVP GSIALPVQTL VSARAAAPPQ PSPPPTKFIV MSSSSSAPST
560 570 580 590 600
QQVLSLSTSA PGSGSTTTSP VTTTVPSVQP IVKLVSTATT APPSTAPSGP
610 620 630 640 650
GSVQKYIVVS LPPTGEGKGG PTSHPSPVPP PASSPSPLSG SALCGGKQEA
660 670
GDSPPPAPGT PKANGSQPNS GSPQPAP
Length:677
Mass (Da):72,668
Last modified:October 1, 1996 - v1
Checksum:i06C6BFA563580823
GO
Isoform 2 (identifier: P49848-2) [UniParc]FASTAAdd to Basket

Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     477-486: Missing.

Show »
Length:667
Mass (Da):71,540
Checksum:i85488E83976800FC
GO
Isoform 3 (identifier: P49848-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTKRRLQTITACLQLREGSPSLHRGLHPSREEKRDSRM

Note: No experimental confirmation available.

Show »
Length:714
Mass (Da):76,995
Checksum:i1A1E41AB1BC47388
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti196 – 1961K → E in CAH10485. (PubMed:17974005)Curated
Sequence conflicti417 – 4171R → W in CAH10485. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361C → S.1 Publication
Corresponds to variant rs4134897 [ dbSNP | Ensembl ].
VAR_014349

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MTKRRLQTITACLQLREGSP SLHRGLHPSREEKRDSRM in isoform 3. 1 PublicationVSP_043709
Alternative sequencei477 – 48610Missing in isoform 2. 1 PublicationVSP_037476

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L25444 mRNA. Translation: AAA63643.1.
U31659 mRNA. Translation: AAA84390.1.
AK300005 mRNA. Translation: BAG61823.1.
CR627390 mRNA. Translation: CAH10485.1.
AY149894 Genomic DNA. Translation: AAN10295.1.
CH236956 Genomic DNA. Translation: EAL23851.1.
CH236956 Genomic DNA. Translation: EAL23852.1.
CH471091 Genomic DNA. Translation: EAW76589.1.
CH471091 Genomic DNA. Translation: EAW76591.1.
CH471091 Genomic DNA. Translation: EAW76592.1.
BC018115 mRNA. Translation: AAH18115.1.
CCDSiCCDS55135.1. [P49848-3]
CCDS5686.1. [P49848-1]
RefSeqiNP_001177344.1. NM_001190415.1. [P49848-3]
NP_005632.1. NM_005641.3. [P49848-1]
NP_647476.1. NM_139315.2. [P49848-1]
XP_006716163.1. XM_006716100.1. [P49848-1]
UniGeneiHs.489309.

Genome annotation databases

EnsembliENST00000344095; ENSP00000344537; ENSG00000106290. [P49848-1]
ENST00000437822; ENSP00000399982; ENSG00000106290. [P49848-3]
ENST00000452041; ENSP00000416396; ENSG00000106290. [P49848-1]
ENST00000453269; ENSP00000389575; ENSG00000106290. [P49848-1]
GeneIDi6878.
KEGGihsa:6878.
UCSCiuc003uti.3. human. [P49848-1]
uc011kji.2. human. [P49848-3]

Polymorphism databases

DMDMi1729810.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L25444 mRNA. Translation: AAA63643.1 .
U31659 mRNA. Translation: AAA84390.1 .
AK300005 mRNA. Translation: BAG61823.1 .
CR627390 mRNA. Translation: CAH10485.1 .
AY149894 Genomic DNA. Translation: AAN10295.1 .
CH236956 Genomic DNA. Translation: EAL23851.1 .
CH236956 Genomic DNA. Translation: EAL23852.1 .
CH471091 Genomic DNA. Translation: EAW76589.1 .
CH471091 Genomic DNA. Translation: EAW76591.1 .
CH471091 Genomic DNA. Translation: EAW76592.1 .
BC018115 mRNA. Translation: AAH18115.1 .
CCDSi CCDS55135.1. [P49848-3 ]
CCDS5686.1. [P49848-1 ]
RefSeqi NP_001177344.1. NM_001190415.1. [P49848-3 ]
NP_005632.1. NM_005641.3. [P49848-1 ]
NP_647476.1. NM_139315.2. [P49848-1 ]
XP_006716163.1. XM_006716100.1. [P49848-1 ]
UniGenei Hs.489309.

3D structure databases

ProteinModelPortali P49848.
SMRi P49848. Positions 9-76, 214-392.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112741. 52 interactions.
DIPi DIP-773N.
IntActi P49848. 8 interactions.
MINTi MINT-1211769.
STRINGi 9606.ENSP00000344537.

PTM databases

PhosphoSitei P49848.

Polymorphism databases

DMDMi 1729810.

Proteomic databases

MaxQBi P49848.
PaxDbi P49848.
PRIDEi P49848.

Protocols and materials databases

DNASUi 6878.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344095 ; ENSP00000344537 ; ENSG00000106290 . [P49848-1 ]
ENST00000437822 ; ENSP00000399982 ; ENSG00000106290 . [P49848-3 ]
ENST00000452041 ; ENSP00000416396 ; ENSG00000106290 . [P49848-1 ]
ENST00000453269 ; ENSP00000389575 ; ENSG00000106290 . [P49848-1 ]
GeneIDi 6878.
KEGGi hsa:6878.
UCSCi uc003uti.3. human. [P49848-1 ]
uc011kji.2. human. [P49848-3 ]

Organism-specific databases

CTDi 6878.
GeneCardsi GC07M099704.
HGNCi HGNC:11540. TAF6.
HPAi HPA006566.
MIMi 602955. gene.
neXtProti NX_P49848.
PharmGKBi PA36315.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5095.
GeneTreei ENSGT00640000091486.
HOGENOMi HOG000253001.
HOVERGENi HBG012489.
InParanoidi P49848.
KOi K03131.
OrthoDBi EOG7TQV0B.
PhylomeDBi P49848.
TreeFami TF313632.

Enzyme and pathway databases

Reactomei REACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_1851. RNA Polymerase II Transcription Initiation.
REACT_2089. RNA Polymerase II Promoter Escape.
REACT_22107. RNA Polymerase II Pre-transcription Events.
REACT_6233. Transcription of the HIV genome.
REACT_6253. RNA Polymerase II HIV Promoter Escape.
REACT_6332. HIV Transcription Initiation.
REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Miscellaneous databases

GeneWikii TAF6.
GenomeRNAii 6878.
NextBioi 26859.
PROi P49848.
SOURCEi Search...

Gene expression databases

Bgeei P49848.
CleanExi HS_TAF6.
ExpressionAtlasi P49848. baseline and differential.
Genevestigatori P49848.

Family and domain databases

Gene3Di 1.10.20.10. 1 hit.
1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011442. DUF1546.
IPR009072. Histone-fold.
IPR004823. TAF_TATA-bd.
[Graphical view ]
Pfami PF07571. DUF1546. 1 hit.
PF02969. TAF. 1 hit.
[Graphical view ]
SMARTi SM00803. TAF. 1 hit.
[Graphical view ]
SUPFAMi SSF47113. SSF47113. 1 hit.
SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of Drosophila TAFII60 and human TAFII70 reveal conserved interactions with other subunits of TFIID."
    Weinzierl R.O., Ruppert S., Dynlacht B.D., Tanese N., Tjian R.
    EMBO J. 12:5303-5309(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), PROTEIN SEQUENCE OF 78-95 AND 501-521, INTERACTION WITH TBP AND TAF1.
    Tissue: Cervix carcinoma.
  2. "Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors."
    Hisatake K., Ohta T., Takada R., Guermah M., Horikoshi M., Nakatani Y., Roeder R.G.
    Proc. Natl. Acad. Sci. U.S.A. 92:8195-8199(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 78-103; 113-127; 368-383 AND 441-455, INTERACTION WITH TBP; TAF1; TAF9; TAF12; GTF2F1 AND GTF2E1.
    Tissue: Placenta.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain cortex.
  5. NIEHS SNPs program
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-36.
  6. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreas.
  9. "Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis."
    Cavusoglu N., Brand M., Tora L., van Dorsselaer A.
    Proteomics 3:217-223(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE TFTC-HAT COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  10. "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF."
    Dou Y., Milne T.A., Tackett A.J., Smith E.R., Fukuda A., Wysocka J., Allis C.D., Chait B.T., Hess J.L., Roeder R.G.
    Cell 121:873-885(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE MLL1/MLL COMPLEX.
  11. Cited for: INTERACTION WITH TAF9 IN A COMPLEX WITH TAF6; TAF9; TAF12 AND TAF4B, DNA-BINDING.
  12. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-653 AND THR-660, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-653 AND THR-660, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTAF6_HUMAN
AccessioniPrimary (citable) accession number: P49848
Secondary accession number(s): A4D2B2
, A4D2B3, B4DT11, D6W5U2, Q6AI29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3