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Protein

Transcription initiation factor TFIID subunit 6

Gene

Taf6

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.1 Publication

GO - Biological processi

  • neurogenesis Source: FlyBase
  • positive regulation of transcription of Notch receptor target Source: FlyBase
  • regulation of sequence-specific DNA binding transcription factor activity Source: InterPro
  • RNA polymerase II transcriptional preinitiation complex assembly Source: GOC
  • transcription from RNA polymerase II promoter Source: FlyBase
  • transcription initiation from RNA polymerase II promoter Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DME-674695. RNA Polymerase II Pre-transcription Events.
R-DME-6807505. RNA polymerase II transcribes snRNA genes.
R-DME-73776. RNA Polymerase II Promoter Escape.
R-DME-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-DME-75953. RNA Polymerase II Transcription Initiation.
R-DME-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 6
Alternative name(s):
TAFII-60
TAFII-62
Transcription initiation factor TFIID 62 kDa subunit
Short name:
p62
Gene namesi
Name:Taf6
Synonyms:Taf60
ORF Names:CG32211
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0010417. Taf6.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase
  • transcription factor TFIID complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188771 – 606Transcription initiation factor TFIID subunit 6Add BLAST606

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei546Phosphoserine1 Publication1
Modified residuei547Phosphoserine1 Publication1
Modified residuei550Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP49847.
PRIDEiP49847.

PTM databases

iPTMnetiP49847.

Expressioni

Gene expression databases

BgeeiFBgn0010417.
ExpressionAtlasiP49847. baseline.
GenevisibleiP49847. DM.

Interactioni

Subunit structurei

Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (TAFs). E(y)1 and Taf6 exist as a heterotetramer. Interacts with Taf1.2 Publications

Protein-protein interaction databases

BioGridi65404. 21 interactors.
DIPiDIP-778N.
IntActiP49847. 2 interactors.
MINTiMINT-755268.
STRINGi7227.FBpp0074709.

Structurei

Secondary structure

1606
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi23 – 32Combined sources10
Helixi40 – 67Combined sources28
Beta strandi71 – 73Combined sources3
Helixi75 – 82Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TAFX-ray2.00B15-84[»]
ProteinModelPortaliP49847.
SMRiP49847.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49847.

Family & Domainsi

Sequence similaritiesi

Belongs to the TAF6 family.Curated

Phylogenomic databases

eggNOGiKOG2549. Eukaryota.
COG5095. LUCA.
GeneTreeiENSGT00640000091486.
InParanoidiP49847.
KOiK03131.
OMAiEPQYGFV.
OrthoDBiEOG091G05S9.
PhylomeDBiP49847.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR009072. Histone-fold.
IPR011442. TAF6_C.
IPR004823. TAF_TATA-bd.
[Graphical view]
PfamiPF02969. TAF. 1 hit.
PF07571. TAF6_C. 1 hit.
[Graphical view]
SMARTiSM00803. TAF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
SSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

P49847-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKPSKPSS PSSSMLYGSS ISAESMKVIA ESIGVGSLSD DAAKELAEDV
60 70 80 90 100
SIKLKRIVQD AAKFMNHAKR QKLSVRDIDM SLKVRNVEPQ YGFVAKDFIP
110 120 130 140 150
FRFASGGGRE LHFTEDKEID LGEITSTNSV KIPLDLTLRS HWFVVEGVQP
160 170 180 190 200
TVPENPPPLS KDSQLLDSVN PVIKMDQGLN KDAAGKPTTG KIHKLKNVET
210 220 230 240 250
IHVKQLATHE LSVEQQLYYK EITEACVGSD EPRRGEALQS LGSDPGLHEM
260 270 280 290 300
LPRMCTFIAE GVKVNVVQNN LALLIYLMRM VRALLDNPSL FLEKYLHELI
310 320 330 340 350
PSVMTCIVSK QLCMRPELDN HWALRDFASR LMAQICKNFN TLTNNLQTRV
360 370 380 390 400
TRIFSKALQN DKTHLSSLYG SIAGLSELGG EVIKVFIIPR LKFISERIEP
410 420 430 440 450
HLLGTSISNT DKTAAGHIRA MLQKCCPPIL RQMRSAPDTA EDYKNDFGFL
460 470 480 490 500
GPSLCQAVVK VRNAPASSIV TLSSNTINTA PITSAAQTAT TIGRVSMPTT
510 520 530 540 550
QRQGSPGVSS LPQIRAIQAN QPAQKFVIVT QNSPQQGQAK VVRRGSSPHS
560 570 580 590 600
VVLSAASNAA SASNSNSSSS GSLLAAAQRS SDNVCVIAGS EAPAVDGITV

QSFRAS
Length:606
Mass (Da):65,654
Last modified:January 27, 2003 - v2
Checksum:i9D93C3496A23C0A3
GO

Sequence cautioni

The sequence AAA16536 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC46480 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3G → K AA sequence (PubMed:7545910).Curated1
Sequence conflicti101F → L in AAA16536 (PubMed:8262073).Curated1
Sequence conflicti582D → E in AAC46480 (PubMed:7545910).Curated1
Sequence conflicti582D → E in AAA16536 (PubMed:8262073).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49139.2.
AY051702 mRNA. Translation: AAK93126.1.
U06459 mRNA. Translation: AAC46480.1. Different initiation.
L25443 mRNA. Translation: AAA16536.1. Different initiation.
RefSeqiNP_524161.2. NM_079437.4.
UniGeneiDm.2802.

Genome annotation databases

EnsemblMetazoaiFBtr0074941; FBpp0074709; FBgn0010417.
GeneIDi40134.
KEGGidme:Dmel_CG32211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49139.2.
AY051702 mRNA. Translation: AAK93126.1.
U06459 mRNA. Translation: AAC46480.1. Different initiation.
L25443 mRNA. Translation: AAA16536.1. Different initiation.
RefSeqiNP_524161.2. NM_079437.4.
UniGeneiDm.2802.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TAFX-ray2.00B15-84[»]
ProteinModelPortaliP49847.
SMRiP49847.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi65404. 21 interactors.
DIPiDIP-778N.
IntActiP49847. 2 interactors.
MINTiMINT-755268.
STRINGi7227.FBpp0074709.

PTM databases

iPTMnetiP49847.

Proteomic databases

PaxDbiP49847.
PRIDEiP49847.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074941; FBpp0074709; FBgn0010417.
GeneIDi40134.
KEGGidme:Dmel_CG32211.

Organism-specific databases

CTDi6878.
FlyBaseiFBgn0010417. Taf6.

Phylogenomic databases

eggNOGiKOG2549. Eukaryota.
COG5095. LUCA.
GeneTreeiENSGT00640000091486.
InParanoidiP49847.
KOiK03131.
OMAiEPQYGFV.
OrthoDBiEOG091G05S9.
PhylomeDBiP49847.

Enzyme and pathway databases

ReactomeiR-DME-674695. RNA Polymerase II Pre-transcription Events.
R-DME-6807505. RNA polymerase II transcribes snRNA genes.
R-DME-73776. RNA Polymerase II Promoter Escape.
R-DME-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-DME-75953. RNA Polymerase II Transcription Initiation.
R-DME-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Miscellaneous databases

EvolutionaryTraceiP49847.
GenomeRNAii40134.
PROiP49847.

Gene expression databases

BgeeiFBgn0010417.
ExpressionAtlasiP49847. baseline.
GenevisibleiP49847. DM.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR009072. Histone-fold.
IPR011442. TAF6_C.
IPR004823. TAF_TATA-bd.
[Graphical view]
PfamiPF02969. TAF. 1 hit.
PF07571. TAF6_C. 1 hit.
[Graphical view]
SMARTiSM00803. TAF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
SSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTAF6_DROME
AccessioniPrimary (citable) accession number: P49847
Secondary accession number(s): Q961B6, Q9VW16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 27, 2003
Last modified: November 30, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.