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Protein

Transcription initiation factor TFIID subunit 6

Gene

Taf6

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.1 Publication

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription of Notch receptor target Source: FlyBase
  • regulation of DNA binding transcription factor activity Source: InterPro
  • RNA polymerase II transcriptional preinitiation complex assembly Source: GOC
  • transcription by RNA polymerase II Source: FlyBase
  • transcription initiation from RNA polymerase II promoter Source: FlyBase

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DME-674695 RNA Polymerase II Pre-transcription Events
R-DME-6807505 RNA polymerase II transcribes snRNA genes
R-DME-73776 RNA Polymerase II Promoter Escape
R-DME-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-DME-75953 RNA Polymerase II Transcription Initiation
R-DME-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 6
Alternative name(s):
TAFII-60
TAFII-62
Transcription initiation factor TFIID 62 kDa subunit
Short name:
p62
Gene namesi
Name:Taf6
Synonyms:Taf60
ORF Names:CG32211
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0010417 Taf6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188771 – 606Transcription initiation factor TFIID subunit 6Add BLAST606

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei546Phosphoserine1 Publication1
Modified residuei547Phosphoserine1 Publication1
Modified residuei550Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP49847
PRIDEiP49847

PTM databases

iPTMnetiP49847

Expressioni

Gene expression databases

BgeeiFBgn0010417
ExpressionAtlasiP49847 differential
GenevisibleiP49847 DM

Interactioni

Subunit structurei

Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (TAFs). E(y)1 and Taf6 exist as a heterotetramer. Interacts with Taf1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
e(y)1Q272723EBI-136204,EBI-174260

GO - Molecular functioni

Protein-protein interaction databases

BioGridi65404, 33 interactors
DIPiDIP-778N
IntActiP49847, 9 interactors
STRINGi7227.FBpp0074709

Structurei

Secondary structure

1606
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi23 – 32Combined sources10
Helixi40 – 67Combined sources28
Beta strandi71 – 73Combined sources3
Helixi75 – 82Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TAFX-ray2.00B15-84[»]
ProteinModelPortaliP49847
SMRiP49847
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49847

Family & Domainsi

Sequence similaritiesi

Belongs to the TAF6 family.Curated

Phylogenomic databases

eggNOGiKOG2549 Eukaryota
COG5095 LUCA
GeneTreeiENSGT00640000091486
InParanoidiP49847
KOiK03131
OMAiCPPILKQ
OrthoDBiEOG091G05S9
PhylomeDBiP49847

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR009072 Histone-fold
IPR037796 TAF6
IPR011442 TAF6_C
IPR004823 TAF_TATA-bd
PANTHERiPTHR10221 PTHR10221, 1 hit
PfamiView protein in Pfam
PF02969 TAF, 1 hit
PF07571 TAF6_C, 1 hit
SMARTiView protein in SMART
SM00803 TAF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
SSF48371 SSF48371, 1 hit

Sequencei

Sequence statusi: Complete.

P49847-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKPSKPSS PSSSMLYGSS ISAESMKVIA ESIGVGSLSD DAAKELAEDV
60 70 80 90 100
SIKLKRIVQD AAKFMNHAKR QKLSVRDIDM SLKVRNVEPQ YGFVAKDFIP
110 120 130 140 150
FRFASGGGRE LHFTEDKEID LGEITSTNSV KIPLDLTLRS HWFVVEGVQP
160 170 180 190 200
TVPENPPPLS KDSQLLDSVN PVIKMDQGLN KDAAGKPTTG KIHKLKNVET
210 220 230 240 250
IHVKQLATHE LSVEQQLYYK EITEACVGSD EPRRGEALQS LGSDPGLHEM
260 270 280 290 300
LPRMCTFIAE GVKVNVVQNN LALLIYLMRM VRALLDNPSL FLEKYLHELI
310 320 330 340 350
PSVMTCIVSK QLCMRPELDN HWALRDFASR LMAQICKNFN TLTNNLQTRV
360 370 380 390 400
TRIFSKALQN DKTHLSSLYG SIAGLSELGG EVIKVFIIPR LKFISERIEP
410 420 430 440 450
HLLGTSISNT DKTAAGHIRA MLQKCCPPIL RQMRSAPDTA EDYKNDFGFL
460 470 480 490 500
GPSLCQAVVK VRNAPASSIV TLSSNTINTA PITSAAQTAT TIGRVSMPTT
510 520 530 540 550
QRQGSPGVSS LPQIRAIQAN QPAQKFVIVT QNSPQQGQAK VVRRGSSPHS
560 570 580 590 600
VVLSAASNAA SASNSNSSSS GSLLAAAQRS SDNVCVIAGS EAPAVDGITV

QSFRAS
Length:606
Mass (Da):65,654
Last modified:January 27, 2003 - v2
Checksum:i9D93C3496A23C0A3
GO

Sequence cautioni

The sequence AAA16536 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC46480 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3G → K AA sequence (PubMed:7545910).Curated1
Sequence conflicti101F → L in AAA16536 (PubMed:8262073).Curated1
Sequence conflicti582D → E in AAC46480 (PubMed:7545910).Curated1
Sequence conflicti582D → E in AAA16536 (PubMed:8262073).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF49139.2
AY051702 mRNA Translation: AAK93126.1
U06459 mRNA Translation: AAC46480.1 Different initiation.
L25443 mRNA Translation: AAA16536.1 Different initiation.
RefSeqiNP_524161.2, NM_079437.4
UniGeneiDm.2802

Genome annotation databases

EnsemblMetazoaiFBtr0074941; FBpp0074709; FBgn0010417
GeneIDi40134
KEGGidme:Dmel_CG32211

Similar proteinsi

Entry informationi

Entry nameiTAF6_DROME
AccessioniPrimary (citable) accession number: P49847
Secondary accession number(s): Q961B6, Q9VW16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 27, 2003
Last modified: March 28, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health