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Protein

Transcription initiation factor TFIID subunit 5

Gene

Taf5

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in helping to anchor Taf4 within the TFIID complex. May be involved in transducing signals from various transcriptional regulators to the RNA polymerase II transcription machinery.1 Publication

GO - Biological processi

  • neurogenesis Source: FlyBase
  • positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • positive regulation of transcription of Notch receptor target Source: FlyBase
  • RNA polymerase II transcriptional preinitiation complex assembly Source: GOC
  • transcription initiation from RNA polymerase II promoter Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DME-674695. RNA Polymerase II Pre-transcription Events.
R-DME-6807505. RNA polymerase II transcribes snRNA genes.
R-DME-73776. RNA Polymerase II Promoter Escape.
R-DME-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-DME-75953. RNA Polymerase II Transcription Initiation.
R-DME-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
SignaLinkiP49846.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 5
Alternative name(s):
TAFII-80
Transcription initiation factor TFIID 85 kDa subunit
Short name:
p85
Gene namesi
Name:Taf5
Synonyms:TAF80
ORF Names:CG7704
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0010356. Taf5.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase
  • transcription factor TFIID complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512561 – 704Transcription initiation factor TFIID subunit 5Add BLAST704

Proteomic databases

PaxDbiP49846.
PRIDEiP49846.

Expressioni

Gene expression databases

BgeeiFBgn0010356.
GenevisibleiP49846. DM.

Interactioni

Subunit structurei

Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (Tafs). Interacts with Tbp and Taf4.1 Publication

Protein-protein interaction databases

BioGridi71045. 17 interactors.
DIPiDIP-48906N.
STRINGi7227.FBpp0087335.

Structurei

3D structure databases

ProteinModelPortaliP49846.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati376 – 405WD 1Add BLAST30
Repeati448 – 478WD 2Add BLAST31
Repeati490 – 520WD 3Add BLAST31
Repeati532 – 562WD 4Add BLAST31
Repeati574 – 604WD 5Add BLAST31
Repeati616 – 646WD 6Add BLAST31

Sequence similaritiesi

Belongs to the WD repeat TAF5 family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0263. Eukaryota.
ENOG410XPM5. LUCA.
GeneTreeiENSGT00860000133707.
InParanoidiP49846.
KOiK03130.
OMAiIWNIIQE.
OrthoDBiEOG091G03SP.
PhylomeDBiP49846.

Family and domain databases

CDDicd08044. TAF5_NTD2. 1 hit.
Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR007582. TFIID_NTD2.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04494. TFIID_NTD2. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49846-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLEVSNING GNGTQLSHDK RELLCLLKLI KKYQLKSTEE LLCQEANVSS
60 70 80 90 100
VELSEISESD VQQVLGAVLG AGDANRERKH VQSPAQGHKQ SAVTEANAAE
110 120 130 140 150
ELAKFIDDDS FDAQHYEQAY KELRTFVEDS LDIYKHELSM VLYPILVQIY
160 170 180 190 200
FKILASGLRE KAKEFIEKYK CDLDGYYIEG LFNLLLLSKP EELLENDLVV
210 220 230 240 250
AMEQDKFVIR MSRDSHSLFK RHIQDRRQEV VADIVSKYLH FDTYEGMARN
260 270 280 290 300
KLQCVATAGS HLGEAKRQDN KMRVYYGLLK EVDFQTLTTP APAPEEEDDD
310 320 330 340 350
PDAPDRPKKK KPKKDPLLSK KSKSDPNAPS IDRIPLPELK DSDKLLKLKA
360 370 380 390 400
LREASKRLAL SKDQLPSAVF YTVLNSHQGV TCAEISDDST MLACGFGDSS
410 420 430 440 450
VRIWSLTPAK LRTLKDADSL RELDKESADI NVRMLDDRSG EVTRSLMGHT
460 470 480 490 500
GPVYRCAFAP EMNLLLSCSE DSTIRLWSLL TWSCVVTYRG HVYPVWDVRF
510 520 530 540 550
APHGYYFVSC SYDKTARLWA TDSNQALRVF VGHLSDVDCV QFHPNSNYVA
560 570 580 590 600
TGSSDRTVRL WDNMTGQSVR LMTGHKGSVS SLAFSACGRY LASGSVDHNI
610 620 630 640 650
IIWDLSNGSL VTTLLRHTST VTTITFSRDG TVLAAAGLDN NLTLWDFHKV
660 670 680 690 700
TEDYISNHIT VSHHQDENDE DVYLMRTFPS KNSPFVSLHF TRRNLLMCVG

LFKS
Length:704
Mass (Da):79,325
Last modified:October 1, 1996 - v1
Checksum:iF4E2F12534501EF6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti410 – 411KL → NV AA sequence (PubMed:8483503).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06460 mRNA. Translation: AAC46481.1.
AE013599 Genomic DNA. Translation: AAF58737.1.
AY051960 mRNA. Translation: AAK93384.1.
PIRiS33263.
RefSeqiNP_476957.1. NM_057609.6.
UniGeneiDm.19905.

Genome annotation databases

EnsemblMetazoaiFBtr0088240; FBpp0087335; FBgn0010356.
GeneIDi47900.
KEGGidme:Dmel_CG7704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06460 mRNA. Translation: AAC46481.1.
AE013599 Genomic DNA. Translation: AAF58737.1.
AY051960 mRNA. Translation: AAK93384.1.
PIRiS33263.
RefSeqiNP_476957.1. NM_057609.6.
UniGeneiDm.19905.

3D structure databases

ProteinModelPortaliP49846.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi71045. 17 interactors.
DIPiDIP-48906N.
STRINGi7227.FBpp0087335.

Proteomic databases

PaxDbiP49846.
PRIDEiP49846.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088240; FBpp0087335; FBgn0010356.
GeneIDi47900.
KEGGidme:Dmel_CG7704.

Organism-specific databases

CTDi6877.
FlyBaseiFBgn0010356. Taf5.

Phylogenomic databases

eggNOGiKOG0263. Eukaryota.
ENOG410XPM5. LUCA.
GeneTreeiENSGT00860000133707.
InParanoidiP49846.
KOiK03130.
OMAiIWNIIQE.
OrthoDBiEOG091G03SP.
PhylomeDBiP49846.

Enzyme and pathway databases

ReactomeiR-DME-674695. RNA Polymerase II Pre-transcription Events.
R-DME-6807505. RNA polymerase II transcribes snRNA genes.
R-DME-73776. RNA Polymerase II Promoter Escape.
R-DME-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-DME-75953. RNA Polymerase II Transcription Initiation.
R-DME-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
SignaLinkiP49846.

Miscellaneous databases

GenomeRNAii47900.
PROiP49846.

Gene expression databases

BgeeiFBgn0010356.
GenevisibleiP49846. DM.

Family and domain databases

CDDicd08044. TAF5_NTD2. 1 hit.
Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR007582. TFIID_NTD2.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04494. TFIID_NTD2. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAF5_DROME
AccessioniPrimary (citable) accession number: P49846
Secondary accession number(s): Q9V5R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.