Reviewed, UniProtKB/Swiss-Prot P49842 (STK19_HUMAN)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase 19
      Short name=Protein RP1
    EC=2.7.11.1
Alternative name(s):
    Protein G11

Gene names

Name:	STK19
Synonyms:	G11, RP1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Seems to be a protein kinase. In vitro it can phosphorylate casein-alpha on serine and threonine residues and histones on serine residues.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Cofactor	Divalent cations. Has a preference for manganese.
Subunit structure	The N-terminus interacts with BAG1. Ref.8
Subcellular location	Nucleus.
Tissue specificity	Monocytes, hepatocytes, epithelial cells, T- and B-lymphocytes.
Sequence similarities	Belongs to the STK19 family.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Manganese Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Ref.7 Traceable author statement. Source: ProtInc
Cellular component	nucleus Ref.7 Traceable author statement. Source: ProtInc
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct protein serine/threonine kinase activity Ref.7 Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
POLE	Q07864	1	EBI-347581,EBI-348526
POLR2G	P62487	1	EBI-347581,EBI-347928
PRAME	P78395	1	EBI-347581,EBI-348325
SF3B4	Q15427	1	EBI-347581,EBI-348469
SLC29A1	Q99808	1	EBI-347581,EBI-347907
SP3	Q02447	1	EBI-347581,EBI-348158

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P49842-1)

Also known as: G11-Z;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P49842-2)

Also known as: G11-Z-short;

The sequence of this isoform differs from the canonical sequence as follows:
     222-225: Missing.

Isoform 3 (identifier: P49842-3)

Also known as: G11-Y;

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Isoform 4 (identifier: P49842-4)

Also known as: G11-Y-short;

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.
     222-225: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 368	368	Serine/threonine-protein kinase 19		PRO_0000072275
Natural variations
	Alternative sequence	1 – 110	110	Missing in isoform 3 and isoform 4.		VSP_004432
	Alternative sequence	222 – 225	4	Missing in isoform 2 and isoform 4.		VSP_004433
	Natural variant	39	1	A → D: dbSNP rs34843142.		VAR_051387
	Natural variant	89	1	D → N in a metastatic melanoma sample; somatic mutation. Ref.9		VAR_042361
	Natural variant	311	1	S → G: dbSNP rs616634. Ref.9 Ref.4		VAR_042362
	Natural variant	331	1	A → V		VAR_042363
Experimental info
	Mutagenesis	300	1	K → P: Partial loss of activity.
	Mutagenesis	315	1	K → P: Partial loss of activity.
	Mutagenesis	317	1	K → P: Complete loss of activity.
	Sequence conflict	195 – 197	3	QGE → GQR in AAA99716. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (G11-Z) [UniParc]. Last modified October 18, 2001. Version 2. Checksum: A05AC847081DE8F8	FASTA	368	40,916
	10 20 30 40 50 60 MQKWFSAFDD AIIQRQWRAN PSRGGGGVSF TKEVDTNVAT GAPPRRQRVP GRACPWREPI 70 80 90 100 110 120 RGRRGARPGG GDAGGTPGET VRHCSAPEDP IFRFSSLHSY PFPGTIKSRD MSWKRHHLIP 130 140 150 160 170 180 ETFGVKRRRK RGPVESDPLR GEPGSARAAV SELMQLFPRG LFEDALPPIV LRSQVYSLVP 190 200 210 220 230 240 DRTVADRQLK ELQEQGEIRI VQLGFDLDAH GIIFTEDYRT RVCDCVLKAC DGRPYAGAVQ 250 260 270 280 290 300 KFLASVLPAC GDLSFQQDQM TQTFGFRDSE ITHLVNAGVL TVRDAGSWWL AVPGAGRFIK 310 320 330 340 350 360 YFVKGRQAVL SMVRKAKYRE LLLSELLGRR APVVVRLGLT YHVHDLIGAQ LVDCISTTSG TLLRLPET
	Isoform 2 (G11-Z-short). Checksum: B904F6999B7C533E	FASTA	364	40,495
	10 20 30 40 50 60 MQKWFSAFDD AIIQRQWRAN PSRGGGGVSF TKEVDTNVAT GAPPRRQRVP GRACPWREPI 70 80 90 100 110 120 RGRRGARPGG GDAGGTPGET VRHCSAPEDP IFRFSSLHSY PFPGTIKSRD MSWKRHHLIP 130 140 150 160 170 180 ETFGVKRRRK RGPVESDPLR GEPGSARAAV SELMQLFPRG LFEDALPPIV LRSQVYSLVP 190 200 210 220 230 240 DRTVADRQLK ELQEQGEIRI VQLGFDLDAH GIIFTEDYRT RVLKACDGRP YAGAVQKFLA 250 260 270 280 290 300 SVLPACGDLS FQQDQMTQTF GFRDSEITHL VNAGVLTVRD AGSWWLAVPG AGRFIKYFVK 310 320 330 340 350 360 GRQAVLSMVR KAKYRELLLS ELLGRRAPVV VRLGLTYHVH DLIGAQLVDC ISTTSGTLLR LPET
	Isoform 3 (G11-Y). Checksum: BE79A520BA211E22	FASTA	258	28,885
	10 20 30 40 50 60 MSWKRHHLIP ETFGVKRRRK RGPVESDPLR GEPGSARAAV SELMQLFPRG LFEDALPPIV 70 80 90 100 110 120 LRSQVYSLVP DRTVADRQLK ELQEQGEIRI VQLGFDLDAH GIIFTEDYRT RVCDCVLKAC 130 140 150 160 170 180 DGRPYAGAVQ KFLASVLPAC GDLSFQQDQM TQTFGFRDSE ITHLVNAGVL TVRDAGSWWL 190 200 210 220 230 240 AVPGAGRFIK YFVKGRQAVL SMVRKAKYRE LLLSELLGRR APVVVRLGLT YHVHDLIGAQ 250 LVDCISTTSG TLLRLPET
	Isoform 4 (G11-Y-short). Checksum: 1B3800438D9DD5A9	FASTA	254	28,465
	10 20 30 40 50 60 MSWKRHHLIP ETFGVKRRRK RGPVESDPLR GEPGSARAAV SELMQLFPRG LFEDALPPIV 70 80 90 100 110 120 LRSQVYSLVP DRTVADRQLK ELQEQGEIRI VQLGFDLDAH GIIFTEDYRT RVLKACDGRP 130 140 150 160 170 180 YAGAVQKFLA SVLPACGDLS FQQDQMTQTF GFRDSEITHL VNAGVLTVRD AGSWWLAVPG 190 200 210 220 230 240 AGRFIKYFVK GRQAVLSMVR KAKYRELLLS ELLGRRAPVV VRLGLTYHVH DLIGAQLVDC 250 ISTTSGTLLR LPET

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterisation of the novel gene G11 lying adjacent to the complement C4A gene in the human major histocompatibility complex." Sargent C.A., Anderson M.J., Hsieh S.-L., Kendall E., Gomez-Escobar N., Campbell R.D. Hum. Mol. Genet. 3:481-488(1994) [PubMed: 8012361] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 3 AND 4).
[2]	"Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication." Liming S., Wu L., Sanlioglu S., Chen R., Mendoza A.R., Dangel A.W., Carroll M.C., Zipf W.B., Yu C. J. Biol. Chem. 269:8466-8476(1994) [PubMed: 8132574] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2).
[3]	"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse." Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L. Genome Res. 13:2621-2636(2003) [PubMed: 14656967] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-311.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"Complete sequence of the complement C4 gene from the HLA-A1, B8, C4AQ0, C4B1, DR3 haplotype." Ulgiati D., Townend D.C., Christiansen F.T., Dawkins R.L., Abraham L.J. Immunogenetics 43:250-252(1996) [PubMed: 8575831] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 4). Tissue: Blood.
[7]	"The G11 gene located in the major histocompatibility complex encodes a novel nuclear serine/threonine protein kinase." Gomez-Escobar N., Chou C.-F., Lin W.-W., Hsieh S.-L., Campbell R.D. J. Biol. Chem. 273:30954-30960(1998) [PubMed: 9812991] [Abstract] Cited for: CHARACTERIZATION.
[8]	"Characterization of Hap/BAG-1 variants as RP1 binding proteins with antiapoptotic activity." Wadle A., Mischo A., Henrich P.P., Stenner-Lieven F., Scherer C., Imig J., Petersen G., Pfreundschuh M., Renner C. Int. J. Cancer 117:896-904(2005) [PubMed: 15986447] [Abstract] Cited for: INTERACTION WITH BAG1. Tissue: T-cell.
[9]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-89; GLY-311 AND VAL-331.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X77474 , X77489, X77490, X77491 Genomic DNA. Translation: CAA54622.1. X77474 , X77489, X77490, X77491 Genomic DNA. Translation: CAA54623.1. X77386 mRNA. Translation: CAA54565.1. L26261 Genomic DNA. Translation: AAA20120.1. L26260 mRNA. Translation: AAA20122.1. AF019413 Genomic DNA. Translation: AAB67976.1. AL844853 Genomic DNA. Translation: CAI41868.1. AL049547 Genomic DNA. Translation: CAB89303.1. AL049547 Genomic DNA. Translation: CAB89304.1. AL645922 Genomic DNA. Translation: CAQ09283.1. AL662849 Genomic DNA. Translation: CAI17470.2. BX679671, CR753822 Genomic DNA. Translation: CAM26064.1. CR753822, BX679671 Genomic DNA. Translation: CAM26056.1. CR753845 Genomic DNA. Translation: CAQ10914.1. CR759782 Genomic DNA. Translation: CAQ07124.1. CH471081 Genomic DNA. Translation: EAX03567.1. U24578 Genomic DNA. Translation: AAA99716.1.
IPI	IPI00028571. IPI00216280. IPI00216282. IPI00923535.
PIR	A53439. B53439.
RefSeq	NP_004188.1. NP_115830.1.
UniGene	Hs.654371
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P49842. 6 interactions.
STRING	P49842.
Proteomic databases
PRIDE	P49842.
Genome annotation databases
Ensembl	ENST00000375331; ENSP00000364480; ENSG00000204344; Homo sapiens. [Genome view] ENST00000375333; ENSP00000364482; ENSG00000204344; Homo sapiens. [Genome view] ENST00000375338; ENSP00000364487; ENSG00000204344; Homo sapiens. [Genome view] ENST00000383327; ENSP00000372817; ENSG00000206342; Homo sapiens. [Genome view] ENST00000395649; ENSP00000379010; ENSG00000226257; Homo sapiens. [Genome view] ENST00000411893; ENSP00000416764; ENSG00000204344; Homo sapiens. [Genome view] ENST00000413058; ENSP00000394404; ENSG00000234947; Homo sapiens. [Genome view] ENST00000413964; ENSP00000391593; ENSG00000226257; Homo sapiens. [Genome view] ENST00000415730; ENSP00000404777; ENSG00000204344; Homo sapiens. [Genome view] ENST00000419141; ENSP00000389205; ENSG00000234947; Homo sapiens. [Genome view] ENST00000424104; ENSP00000393272; ENSG00000236250; Homo sapiens. [Genome view] ENST00000424166; ENSP00000398527; ENSG00000234947; Homo sapiens. [Genome view] ENST00000425138; ENSP00000395028; ENSG00000234947; Homo sapiens. [Genome view] ENST00000425617; ENSP00000392523; ENSG00000236250; Homo sapiens. [Genome view] ENST00000425795; ENSP00000397838; ENSG00000226257; Homo sapiens. [Genome view] ENST00000426802; ENSP00000389352; ENSG00000226257; Homo sapiens. [Genome view] ENST00000429125; ENSP00000399351; ENSG00000236250; Homo sapiens. [Genome view] ENST00000430509; ENSP00000395626; ENSG00000236250; Homo sapiens. [Genome view] ENST00000431383; ENSP00000403479; ENSG00000226033; Homo sapiens. [Genome view] ENST00000433397; ENSP00000395864; ENSG00000234947; Homo sapiens. [Genome view] ENST00000435654; ENSP00000395561; ENSG00000226033; Homo sapiens. [Genome view] ENST00000438256; ENSP00000391798; ENSG00000236250; Homo sapiens. [Genome view] ENST00000439899; ENSP00000416202; ENSG00000226033; Homo sapiens. [Genome view] ENST00000440307; ENSP00000398065; ENSG00000204344; Homo sapiens. [Genome view] ENST00000444147; ENSP00000399915; ENSG00000226033; Homo sapiens. [Genome view] ENST00000445159; ENSP00000400015; ENSG00000236250; Homo sapiens. [Genome view] ENST00000452688; ENSP00000413766; ENSG00000226257; Homo sapiens. [Genome view] ENST00000452843; ENSP00000394235; ENSG00000226033; Homo sapiens. [Genome view]
GeneID	8859.
KEGG	hsa:8859.
UCSC	uc003nyt.1. human. uc003nyv.1. human.
Organism-specific databases
CTD	8859.
GeneCards	GC06P032047.
H-InvDB	HIX0032880. HIX0057991. HIX0058171.
HGNC	HGNC:11398. STK19.
MIM	604977. gene.
PharmGKB	PA36206.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P49842.
HOVERGEN	P49842.
OMA	DCISTTS.
Enzyme and pathway databases
BRENDA	2.7.11.1. 247.
Gene expression databases
Bgee	P49842.
CleanEx	HS_RP1. HS_STK19.
Genevestigator	P49842.
GermOnline	ENSG00000204344. Homo sapiens.
Family and domain databases
InterPro	IPR018865. Ser/Thr_prot_kinase_19. [Graphical view]
Pfam	PF10494. Stk19. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	33267.
SOURCE	Search...

Entry information

Entry name

STK19_HUMAN

Accession

Primary (citable) accession number: P49842
Secondary accession number(s): A6NF95 , A6NFW8, B0QZR5, Q13159, Q31617, Q5JP77, Q5ST75

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 18, 2001
Last modified:	November 3, 2009
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.