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Protein

Serine/threonine-protein kinase 19

Gene

STK19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to be a protein kinase. In vitro it can phosphorylate casein-alpha on serine and threonine residues and histones on serine residues.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mn2+Note: Divalent metal cations. Has a preference for Mn2+.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: ProtInc

GO - Biological processi

  • protein phosphorylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Manganese, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS09371-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 19 (EC:2.7.11.1)
Alternative name(s):
Protein G11
Protein RP1
Gene namesi
Name:STK19
Synonyms:G11, RP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:11398. STK19.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi300K → P: Partial loss of activity. 1
Mutagenesisi315K → P: Partial loss of activity. 1
Mutagenesisi317K → P: Complete loss of activity. 1

Organism-specific databases

DisGeNETi8859.
OpenTargetsiENSG00000204344.
ENSG00000226033.
ENSG00000226257.
ENSG00000234947.
ENSG00000236250.
PharmGKBiPA36206.

Polymorphism and mutation databases

BioMutaiSTK19.
DMDMi19860281.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722751 – 368Serine/threonine-protein kinase 19Add BLAST368

Proteomic databases

EPDiP49842.
MaxQBiP49842.
PaxDbiP49842.
PeptideAtlasiP49842.
PRIDEiP49842.

PTM databases

iPTMnetiP49842.
PhosphoSitePlusiP49842.

Expressioni

Tissue specificityi

Monocytes, hepatocytes, epithelial cells, T- and B-lymphocytes.

Gene expression databases

BgeeiENSG00000204344.
CleanExiHS_RP1.
HS_STK19.
ExpressionAtlasiP49842. baseline and differential.
GenevisibleiP49842. HS.

Organism-specific databases

HPAiHPA031510.
HPA031511.
HPA068559.

Interactioni

Subunit structurei

The N-terminus interacts with BAG1.1 Publication

Protein-protein interaction databases

BioGridi114383. 8 interactors.
IntActiP49842. 6 interactors.
MINTiMINT-1032657.
STRINGi9606.ENSP00000364482.

Structurei

3D structure databases

ProteinModelPortaliP49842.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STK19 family.Curated

Phylogenomic databases

eggNOGiENOG410IEVV. Eukaryota.
ENOG410YGZ8. LUCA.
GeneTreeiENSGT00390000018295.
HOVERGENiHBG056144.
InParanoidiP49842.
KOiK08880.
OMAiRECPRRE.
OrthoDBiEOG091G0OOT.
PhylomeDBiP49842.
TreeFamiTF105332.

Family and domain databases

InterProiIPR018865. Ser/Thr_kinase_19.
[Graphical view]
PfamiPF10494. Stk19. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P49842-1) [UniParc]FASTAAdd to basket
Also known as: G11-Z

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQKWFSAFDD AIIQRQWRAN PSRGGGGVSF TKEVDTNVAT GAPPRRQRVP
60 70 80 90 100
GRACPWREPI RGRRGARPGG GDAGGTPGET VRHCSAPEDP IFRFSSLHSY
110 120 130 140 150
PFPGTIKSRD MSWKRHHLIP ETFGVKRRRK RGPVESDPLR GEPGSARAAV
160 170 180 190 200
SELMQLFPRG LFEDALPPIV LRSQVYSLVP DRTVADRQLK ELQEQGEIRI
210 220 230 240 250
VQLGFDLDAH GIIFTEDYRT RVCDCVLKAC DGRPYAGAVQ KFLASVLPAC
260 270 280 290 300
GDLSFQQDQM TQTFGFRDSE ITHLVNAGVL TVRDAGSWWL AVPGAGRFIK
310 320 330 340 350
YFVKGRQAVL SMVRKAKYRE LLLSELLGRR APVVVRLGLT YHVHDLIGAQ
360
LVDCISTTSG TLLRLPET
Length:368
Mass (Da):40,916
Last modified:October 18, 2001 - v2
Checksum:iA05AC847081DE8F8
GO
Isoform 2 (identifier: P49842-2) [UniParc]FASTAAdd to basket
Also known as: G11-Z-short

The sequence of this isoform differs from the canonical sequence as follows:
     222-225: Missing.

Show »
Length:364
Mass (Da):40,495
Checksum:iB904F6999B7C533E
GO
Isoform 3 (identifier: P49842-3) [UniParc]FASTAAdd to basket
Also known as: G11-Y

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Show »
Length:258
Mass (Da):28,885
Checksum:iBE79A520BA211E22
GO
Isoform 4 (identifier: P49842-4) [UniParc]FASTAAdd to basket
Also known as: G11-Y-short

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.
     222-225: Missing.

Show »
Length:254
Mass (Da):28,465
Checksum:i1B3800438D9DD5A9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195 – 197QGE → GQR in AAA99716 (PubMed:8575831).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05138739A → D.Corresponds to variant rs34843142dbSNPEnsembl.1
Natural variantiVAR_04236189D → N in a metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant rs267600971dbSNPEnsembl.1
Natural variantiVAR_042362311S → G.2 PublicationsCorresponds to variant rs616634dbSNPEnsembl.1
Natural variantiVAR_042363331A → V.1 PublicationCorresponds to variant rs7743647dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0044321 – 110Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST110
Alternative sequenceiVSP_004433222 – 225Missing in isoform 2 and isoform 4. 2 Publications4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77474
, X77489, X77490, X77491 Genomic DNA. Translation: CAA54622.1.
X77474
, X77489, X77490, X77491 Genomic DNA. Translation: CAA54623.1.
X77386 mRNA. Translation: CAA54565.1.
L26261 Genomic DNA. Translation: AAA20120.1.
L26260 mRNA. Translation: AAA20122.1.
AF019413 Genomic DNA. Translation: AAB67976.1.
AL049547 Genomic DNA. Translation: CAB89303.1.
AL049547 Genomic DNA. Translation: CAB89304.1.
AL662849 Genomic DNA. Translation: CAI17468.2.
AL662849 Genomic DNA. Translation: CAI17470.2.
AL844853 Genomic DNA. Translation: CAI41868.1.
CR753822, BX679671 Genomic DNA. Translation: CAM26056.1.
CR753822, BX679671 Genomic DNA. Translation: CAM26057.1.
BX679671, CR753822 Genomic DNA. Translation: CAM26064.1.
BX679671, CR753822 Genomic DNA. Translation: CAM26065.1.
CR759782 Genomic DNA. Translation: CAQ07123.1.
CR759782 Genomic DNA. Translation: CAQ07124.1.
AL645922 Genomic DNA. Translation: CAQ09282.1.
AL645922 Genomic DNA. Translation: CAQ09283.1.
CR753845 Genomic DNA. Translation: CAQ10913.1.
CR753845 Genomic DNA. Translation: CAQ10914.1.
CH471081 Genomic DNA. Translation: EAX03566.1.
CH471081 Genomic DNA. Translation: EAX03567.1.
U24578 Genomic DNA. Translation: AAA99716.1.
CCDSiCCDS34417.1. [P49842-2]
CCDS4733.1. [P49842-1]
PIRiB53439. A53439.
RefSeqiNP_004188.1. NM_004197.1. [P49842-2]
NP_115830.1. NM_032454.1. [P49842-1]
UniGeneiHs.654371.

Genome annotation databases

EnsembliENST00000375331; ENSP00000364480; ENSG00000204344. [P49842-2]
ENST00000375333; ENSP00000364482; ENSG00000204344. [P49842-1]
ENST00000383327; ENSP00000372817; ENSG00000206342.
ENST00000424104; ENSP00000393272; ENSG00000236250. [P49842-2]
ENST00000425138; ENSP00000395028; ENSG00000234947. [P49842-2]
ENST00000426802; ENSP00000389352; ENSG00000226257. [P49842-2]
ENST00000431383; ENSP00000403479; ENSG00000226033. [P49842-1]
ENST00000433397; ENSP00000395864; ENSG00000234947. [P49842-1]
ENST00000438256; ENSP00000391798; ENSG00000236250. [P49842-1]
ENST00000444147; ENSP00000399915; ENSG00000226033. [P49842-2]
ENST00000452688; ENSP00000413766; ENSG00000226257. [P49842-1]
GeneIDi8859.
KEGGihsa:8859.
UCSCiuc003nyv.4. human. [P49842-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77474
, X77489, X77490, X77491 Genomic DNA. Translation: CAA54622.1.
X77474
, X77489, X77490, X77491 Genomic DNA. Translation: CAA54623.1.
X77386 mRNA. Translation: CAA54565.1.
L26261 Genomic DNA. Translation: AAA20120.1.
L26260 mRNA. Translation: AAA20122.1.
AF019413 Genomic DNA. Translation: AAB67976.1.
AL049547 Genomic DNA. Translation: CAB89303.1.
AL049547 Genomic DNA. Translation: CAB89304.1.
AL662849 Genomic DNA. Translation: CAI17468.2.
AL662849 Genomic DNA. Translation: CAI17470.2.
AL844853 Genomic DNA. Translation: CAI41868.1.
CR753822, BX679671 Genomic DNA. Translation: CAM26056.1.
CR753822, BX679671 Genomic DNA. Translation: CAM26057.1.
BX679671, CR753822 Genomic DNA. Translation: CAM26064.1.
BX679671, CR753822 Genomic DNA. Translation: CAM26065.1.
CR759782 Genomic DNA. Translation: CAQ07123.1.
CR759782 Genomic DNA. Translation: CAQ07124.1.
AL645922 Genomic DNA. Translation: CAQ09282.1.
AL645922 Genomic DNA. Translation: CAQ09283.1.
CR753845 Genomic DNA. Translation: CAQ10913.1.
CR753845 Genomic DNA. Translation: CAQ10914.1.
CH471081 Genomic DNA. Translation: EAX03566.1.
CH471081 Genomic DNA. Translation: EAX03567.1.
U24578 Genomic DNA. Translation: AAA99716.1.
CCDSiCCDS34417.1. [P49842-2]
CCDS4733.1. [P49842-1]
PIRiB53439. A53439.
RefSeqiNP_004188.1. NM_004197.1. [P49842-2]
NP_115830.1. NM_032454.1. [P49842-1]
UniGeneiHs.654371.

3D structure databases

ProteinModelPortaliP49842.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114383. 8 interactors.
IntActiP49842. 6 interactors.
MINTiMINT-1032657.
STRINGi9606.ENSP00000364482.

PTM databases

iPTMnetiP49842.
PhosphoSitePlusiP49842.

Polymorphism and mutation databases

BioMutaiSTK19.
DMDMi19860281.

Proteomic databases

EPDiP49842.
MaxQBiP49842.
PaxDbiP49842.
PeptideAtlasiP49842.
PRIDEiP49842.

Protocols and materials databases

DNASUi8859.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375331; ENSP00000364480; ENSG00000204344. [P49842-2]
ENST00000375333; ENSP00000364482; ENSG00000204344. [P49842-1]
ENST00000383327; ENSP00000372817; ENSG00000206342.
ENST00000424104; ENSP00000393272; ENSG00000236250. [P49842-2]
ENST00000425138; ENSP00000395028; ENSG00000234947. [P49842-2]
ENST00000426802; ENSP00000389352; ENSG00000226257. [P49842-2]
ENST00000431383; ENSP00000403479; ENSG00000226033. [P49842-1]
ENST00000433397; ENSP00000395864; ENSG00000234947. [P49842-1]
ENST00000438256; ENSP00000391798; ENSG00000236250. [P49842-1]
ENST00000444147; ENSP00000399915; ENSG00000226033. [P49842-2]
ENST00000452688; ENSP00000413766; ENSG00000226257. [P49842-1]
GeneIDi8859.
KEGGihsa:8859.
UCSCiuc003nyv.4. human. [P49842-1]

Organism-specific databases

CTDi8859.
DisGeNETi8859.
GeneCardsiSTK19.
H-InvDBHIX0058171.
HGNCiHGNC:11398. STK19.
HPAiHPA031510.
HPA031511.
HPA068559.
MIMi604977. gene.
neXtProtiNX_P49842.
OpenTargetsiENSG00000204344.
ENSG00000226033.
ENSG00000226257.
ENSG00000234947.
ENSG00000236250.
PharmGKBiPA36206.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEVV. Eukaryota.
ENOG410YGZ8. LUCA.
GeneTreeiENSGT00390000018295.
HOVERGENiHBG056144.
InParanoidiP49842.
KOiK08880.
OMAiRECPRRE.
OrthoDBiEOG091G0OOT.
PhylomeDBiP49842.
TreeFamiTF105332.

Enzyme and pathway databases

BioCyciZFISH:HS09371-MONOMER.

Miscellaneous databases

ChiTaRSiSTK19. human.
GeneWikiiSTK19.
GenomeRNAii8859.
PROiP49842.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204344.
CleanExiHS_RP1.
HS_STK19.
ExpressionAtlasiP49842. baseline and differential.
GenevisibleiP49842. HS.

Family and domain databases

InterProiIPR018865. Ser/Thr_kinase_19.
[Graphical view]
PfamiPF10494. Stk19. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTK19_HUMAN
AccessioniPrimary (citable) accession number: P49842
Secondary accession number(s): A6NF95
, A6NFW8, B0QZR5, Q13159, Q31617, Q5JP77, Q5ST72, Q5ST75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 18, 2001
Last modified: November 2, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.