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P49822

- ALBU_CANFA

UniProt

P49822 - ALBU_CANFA

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Protein

Serum albumin

Gene
ALB
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Copper By similarity
Metal bindingi91 – 911Zinc By similarity
Metal bindingi123 – 1231Zinc By similarity
Metal bindingi271 – 2711Zinc By similarity
Metal bindingi273 – 2731Zinc By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. drug binding Source: UniProtKB
  3. fatty acid binding Source: UniProtKB
  4. metal ion binding Source: UniProtKB-KW
  5. pyridoxal phosphate binding Source: UniProtKB
  6. toxic substance binding Source: UniProtKB

GO - Biological processi

  1. cellular response to starvation Source: UniProtKB
  2. hemolysis by symbiont of host erythrocytes Source: UniProtKB
  3. maintenance of mitochondrion location Source: UniProtKB
  4. negative regulation of apoptotic process Source: UniProtKB
  5. transport Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Copper, Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Alternative name(s):
Allergen: Can f 3
Gene namesi
Name:ALB
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: InterPro
  2. protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.2 Publications

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei176. Can f 3.
3171. Can f 3.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Propeptidei19 – 224PRO_0000001059
Chaini25 – 608584Serum albuminPRO_0000001060Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi77 ↔ 86 By similarity
Modified residuei82 – 821Phosphoserine By similarity
Disulfide bondi99 ↔ 115 By similarity
Disulfide bondi114 ↔ 125 By similarity
Disulfide bondi148 ↔ 193 By similarity
Disulfide bondi192 ↔ 201 By similarity
Disulfide bondi224 ↔ 270 By similarity
Modified residuei229 – 2291N6-succinyllysine By similarity
Disulfide bondi269 ↔ 277 By similarity
Disulfide bondi289 ↔ 303 By similarity
Disulfide bondi302 ↔ 313 By similarity
Disulfide bondi340 ↔ 385 By similarity
Disulfide bondi384 ↔ 393 By similarity
Disulfide bondi416 ↔ 462 By similarity
Modified residuei443 – 4431Phosphoserine By similarity
Modified residuei444 – 4441Phosphothreonine By similarity
Modified residuei446 – 4461Phosphothreonine By similarity
Modified residuei460 – 4601N6-succinyllysine By similarity
Disulfide bondi461 ↔ 472 By similarity
Disulfide bondi485 ↔ 501 By similarity
Disulfide bondi500 ↔ 511 By similarity
Disulfide bondi538 ↔ 583 By similarity
Disulfide bondi582 ↔ 591 By similarity
Modified residuei588 – 5881N6-succinyllysine By similarity

Post-translational modificationi

Phosphorylation sites are present in the extracellular medium By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP49822.
PRIDEiP49822.

2D gel databases

UCD-2DPAGEP49822.

Expressioni

Tissue specificityi

Plasma.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000032573.

Structurei

3D structure databases

ProteinModelPortaliP49822.
SMRiP49822. Positions 29-585.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 210192Albumin 1Add
BLAST
Domaini211 – 403193Albumin 2Add
BLAST
Domaini404 – 601198Albumin 3Add
BLAST

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.
Contains 3 albumin domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG45992.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
KOiK16141.

Family and domain databases

InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49822-1 [UniParc]FASTAAdd to Basket

« Hide

MKWVTFISLF FLFSSAYSRG LVRREAYKSE IAHRYNDLGE EHFRGLVLVA    50
FSQYLQQCPF EDHVKLAKEV TEFAKACAAE ESGANCDKSL HTLFGDKLCT 100
VASLRDKYGD MADCCEKQEP DRNECFLAHK DDNPGFPPLV APEPDALCAA 150
FQDNEQLFLG KYLYEIARRH PYFYAPELLY YAQQYKGVFA ECCQAADKAA 200
CLGPKIEALR EKVLLSSAKE RFKCASLQKF GDRAFKAWSV ARLSQRFPKA 250
DFAEISKVVT DLTKVHKECC HGDLLECADD RADLAKYMCE NQDSISTKLK 300
ECCDKPVLEK SQCLAEVERD ELPGDLPSLA ADFVEDKEVC KNYQEAKDVF 350
LGTFLYEYAR RHPEYSVSLL LRLAKEYEAT LEKCCATDDP PTCYAKVLDE 400
FKPLVDEPQN LVKTNCELFE KLGEYGFQNA LLVRYTKKAP QVSTPTLVEV 450
SRKLGKVGTK CCKKPESERM SCAEDFLSVV LNRLCVLHEK TPVSERVTKC 500
CSESLVNRRP CFSGLEVDET YVPKEFNAET FTFHADLCTL PEAEKQVKKQ 550
TALVELLKHK PKATDEQLKT VMGDFGAFVE KCCAAENKEG CFSEEGPKLV 600
AAAQAALV 608
Length:608
Mass (Da):68,605
Last modified:December 21, 2004 - v3
Checksum:i3DB012FF7C979CF3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 2626MKWVT…VRREA → MDT in CAA76841. 1 PublicationAdd
BLAST
Sequence conflicti146 – 1461A → R in CAA76841. 1 Publication
Sequence conflicti206 – 2061I → T in CAA76841. 1 Publication
Sequence conflicti349 – 3491V → A in CAA76841. 1 Publication
Sequence conflicti359 – 3591A → S in CAA76841. 1 Publication
Sequence conflicti359 – 3591A → S in AAB30434. 1 Publication
Sequence conflicti448 – 4481V → VV in AAB30434. 1 Publication
Sequence conflicti474 – 4741E → D in CAA76841. 1 Publication
Sequence conflicti474 – 4741E → D in AAB30434. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ133489 mRNA. Translation: CAB64867.1.
Y17737 mRNA. Translation: CAA76841.1.
AB090854 mRNA. Translation: BAC10663.1.
S72946 mRNA. Translation: AAB30434.1.
PIRiS29749.
RefSeqiNP_001003026.1. NM_001003026.1.
UniGeneiCfa.5991.

Genome annotation databases

GeneIDi403550.
KEGGicfa:403550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ133489 mRNA. Translation: CAB64867.1 .
Y17737 mRNA. Translation: CAA76841.1 .
AB090854 mRNA. Translation: BAC10663.1 .
S72946 mRNA. Translation: AAB30434.1 .
PIRi S29749.
RefSeqi NP_001003026.1. NM_001003026.1.
UniGenei Cfa.5991.

3D structure databases

ProteinModelPortali P49822.
SMRi P49822. Positions 29-585.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000032573.

Protein family/group databases

Allergomei 176. Can f 3.
3171. Can f 3.0101.

2D gel databases

UCD-2DPAGE P49822.

Proteomic databases

PaxDbi P49822.
PRIDEi P49822.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 403550.
KEGGi cfa:403550.

Organism-specific databases

CTDi 213.

Phylogenomic databases

eggNOGi NOG45992.
HOGENOMi HOG000293137.
HOVERGENi HBG004207.
KOi K16141.

Miscellaneous databases

NextBioi 20817059.

Family and domain databases

InterProi IPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view ]
Pfami PF00273. Serum_albumin. 3 hits.
[Graphical view ]
PIRSFi PIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSi PR00802. SERUMALBUMIN.
SMARTi SM00103. ALBUMIN. 3 hits.
[Graphical view ]
SUPFAMi SSF48552. SSF48552. 3 hits.
PROSITEi PS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Hilger C.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Beagle.
    Tissue: Liver.
  2. "Escherichia coli expression and purification of recombinant dog albumin, a cross-reactive animal allergen."
    Pandjaitan B., Swoboda I., Brandejsky-Pichler F., Rumpold H., Valenta R., Spitzauer S.
    J. Allergy Clin. Immunol. 105:279-285(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.
    Tissue: Liver.
  3. "Isolation of a cDNA encoding canine serum albumin."
    Miyake M., Okazaki M., Iwabuchi S.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Beagle.
    Tissue: Liver.
  4. "Isolation, amino acid sequence and copper(II)-binding properties of peptide (1-24) of dog serum albumin."
    Dixon J.W., Sarkar B.
    J. Biol. Chem. 249:5872-5877(1974) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-48.
  5. "HSC-2DPAGE and the two-dimensional gel electrophoresis database of dog heart proteins."
    Dunn M.J., Corbett J.M., Wheeler C.H.
    Electrophoresis 18:2795-2802(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-38.
    Tissue: Heart.
  6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 215-478, ALLERGEN.
    Tissue: Salivary gland.

Entry informationi

Entry nameiALBU_CANFA
AccessioniPrimary (citable) accession number: P49822
Secondary accession number(s): O77705, Q9TSZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 21, 2004
Last modified: March 19, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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