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P49822

- ALBU_CANFA

UniProt

P49822 - ALBU_CANFA

Protein

Serum albumin

Gene

ALB

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 3 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi27 – 271CopperBy similarity
    Metal bindingi91 – 911ZincBy similarity
    Metal bindingi123 – 1231ZincBy similarity
    Metal bindingi271 – 2711ZincBy similarity
    Metal bindingi273 – 2731ZincBy similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. drug binding Source: UniProtKB
    3. fatty acid binding Source: UniProtKB
    4. metal ion binding Source: UniProtKB-KW
    5. pyridoxal phosphate binding Source: UniProtKB
    6. toxic substance binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to starvation Source: UniProtKB
    2. hemolysis by symbiont of host erythrocytes Source: UniProtKB
    3. maintenance of mitochondrion location Source: UniProtKB
    4. negative regulation of apoptotic process Source: UniProtKB
    5. transport Source: InterPro

    Keywords - Ligandi

    Copper, Lipid-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serum albumin
    Alternative name(s):
    Allergen: Can f 3
    Gene namesi
    Name:ALB
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: InterPro
    2. protein complex Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.2 Publications

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei176. Can f 3.
    3171. Can f 3.0101.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 224PRO_0000001059
    Chaini25 – 608584Serum albuminPRO_0000001060Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
    Modified residuei82 – 821PhosphoserineBy similarity
    Disulfide bondi99 ↔ 115PROSITE-ProRule annotation
    Disulfide bondi114 ↔ 125PROSITE-ProRule annotation
    Disulfide bondi148 ↔ 193PROSITE-ProRule annotation
    Disulfide bondi192 ↔ 201PROSITE-ProRule annotation
    Disulfide bondi224 ↔ 270PROSITE-ProRule annotation
    Modified residuei229 – 2291N6-succinyllysineBy similarity
    Disulfide bondi269 ↔ 277PROSITE-ProRule annotation
    Disulfide bondi289 ↔ 303PROSITE-ProRule annotation
    Disulfide bondi302 ↔ 313PROSITE-ProRule annotation
    Disulfide bondi340 ↔ 385PROSITE-ProRule annotation
    Disulfide bondi384 ↔ 393PROSITE-ProRule annotation
    Disulfide bondi416 ↔ 462PROSITE-ProRule annotation
    Modified residuei443 – 4431PhosphoserineBy similarity
    Modified residuei444 – 4441PhosphothreonineBy similarity
    Modified residuei446 – 4461PhosphothreonineBy similarity
    Modified residuei460 – 4601N6-succinyllysineBy similarity
    Disulfide bondi461 ↔ 472PROSITE-ProRule annotation
    Disulfide bondi485 ↔ 501PROSITE-ProRule annotation
    Disulfide bondi500 ↔ 511PROSITE-ProRule annotation
    Disulfide bondi538 ↔ 583PROSITE-ProRule annotation
    Disulfide bondi582 ↔ 591PROSITE-ProRule annotation
    Modified residuei588 – 5881N6-succinyllysineBy similarity

    Post-translational modificationi

    Phosphorylation sites are present in the extracellular medium.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

    Proteomic databases

    PaxDbiP49822.
    PRIDEiP49822.

    2D gel databases

    UCD-2DPAGEP49822.

    Expressioni

    Tissue specificityi

    Plasma.

    Interactioni

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000032573.

    Structurei

    3D structure databases

    ProteinModelPortaliP49822.
    SMRiP49822. Positions 29-585.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 210192Albumin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini211 – 403193Albumin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini404 – 601198Albumin 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
    Contains 3 albumin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG45992.
    HOGENOMiHOG000293137.
    HOVERGENiHBG004207.
    KOiK16141.

    Family and domain databases

    InterProiIPR000264. ALB/AFP/VDB.
    IPR020858. Serum_albumin-like.
    IPR021177. Serum_albumin/AFP.
    IPR020857. Serum_albumin_CS.
    IPR014760. Serum_albumin_N.
    [Graphical view]
    PfamiPF00273. Serum_albumin. 3 hits.
    [Graphical view]
    PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
    PRINTSiPR00802. SERUMALBUMIN.
    SMARTiSM00103. ALBUMIN. 3 hits.
    [Graphical view]
    SUPFAMiSSF48552. SSF48552. 3 hits.
    PROSITEiPS00212. ALBUMIN_1. 3 hits.
    PS51438. ALBUMIN_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49822-1 [UniParc]FASTAAdd to Basket

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    MKWVTFISLF FLFSSAYSRG LVRREAYKSE IAHRYNDLGE EHFRGLVLVA    50
    FSQYLQQCPF EDHVKLAKEV TEFAKACAAE ESGANCDKSL HTLFGDKLCT 100
    VASLRDKYGD MADCCEKQEP DRNECFLAHK DDNPGFPPLV APEPDALCAA 150
    FQDNEQLFLG KYLYEIARRH PYFYAPELLY YAQQYKGVFA ECCQAADKAA 200
    CLGPKIEALR EKVLLSSAKE RFKCASLQKF GDRAFKAWSV ARLSQRFPKA 250
    DFAEISKVVT DLTKVHKECC HGDLLECADD RADLAKYMCE NQDSISTKLK 300
    ECCDKPVLEK SQCLAEVERD ELPGDLPSLA ADFVEDKEVC KNYQEAKDVF 350
    LGTFLYEYAR RHPEYSVSLL LRLAKEYEAT LEKCCATDDP PTCYAKVLDE 400
    FKPLVDEPQN LVKTNCELFE KLGEYGFQNA LLVRYTKKAP QVSTPTLVEV 450
    SRKLGKVGTK CCKKPESERM SCAEDFLSVV LNRLCVLHEK TPVSERVTKC 500
    CSESLVNRRP CFSGLEVDET YVPKEFNAET FTFHADLCTL PEAEKQVKKQ 550
    TALVELLKHK PKATDEQLKT VMGDFGAFVE KCCAAENKEG CFSEEGPKLV 600
    AAAQAALV 608
    Length:608
    Mass (Da):68,605
    Last modified:December 21, 2004 - v3
    Checksum:i3DB012FF7C979CF3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 2626MKWVT…VRREA → MDT in CAA76841. (PubMed:10669848)CuratedAdd
    BLAST
    Sequence conflicti146 – 1461A → R in CAA76841. (PubMed:10669848)Curated
    Sequence conflicti206 – 2061I → T in CAA76841. (PubMed:10669848)Curated
    Sequence conflicti349 – 3491V → A in CAA76841. (PubMed:10669848)Curated
    Sequence conflicti359 – 3591A → S in CAA76841. (PubMed:10669848)Curated
    Sequence conflicti359 – 3591A → S in AAB30434. (PubMed:7512102)Curated
    Sequence conflicti448 – 4481V → VV in AAB30434. (PubMed:7512102)Curated
    Sequence conflicti474 – 4741E → D in CAA76841. (PubMed:10669848)Curated
    Sequence conflicti474 – 4741E → D in AAB30434. (PubMed:7512102)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ133489 mRNA. Translation: CAB64867.1.
    Y17737 mRNA. Translation: CAA76841.1.
    AB090854 mRNA. Translation: BAC10663.1.
    S72946 mRNA. Translation: AAB30434.1.
    PIRiS29749.
    RefSeqiNP_001003026.1. NM_001003026.1.
    UniGeneiCfa.5991.

    Genome annotation databases

    GeneIDi403550.
    KEGGicfa:403550.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ133489 mRNA. Translation: CAB64867.1 .
    Y17737 mRNA. Translation: CAA76841.1 .
    AB090854 mRNA. Translation: BAC10663.1 .
    S72946 mRNA. Translation: AAB30434.1 .
    PIRi S29749.
    RefSeqi NP_001003026.1. NM_001003026.1.
    UniGenei Cfa.5991.

    3D structure databases

    ProteinModelPortali P49822.
    SMRi P49822. Positions 29-585.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000032573.

    Protein family/group databases

    Allergomei 176. Can f 3.
    3171. Can f 3.0101.

    2D gel databases

    UCD-2DPAGE P49822.

    Proteomic databases

    PaxDbi P49822.
    PRIDEi P49822.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 403550.
    KEGGi cfa:403550.

    Organism-specific databases

    CTDi 213.

    Phylogenomic databases

    eggNOGi NOG45992.
    HOGENOMi HOG000293137.
    HOVERGENi HBG004207.
    KOi K16141.

    Miscellaneous databases

    NextBioi 20817059.

    Family and domain databases

    InterProi IPR000264. ALB/AFP/VDB.
    IPR020858. Serum_albumin-like.
    IPR021177. Serum_albumin/AFP.
    IPR020857. Serum_albumin_CS.
    IPR014760. Serum_albumin_N.
    [Graphical view ]
    Pfami PF00273. Serum_albumin. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF002520. Serum_albumin_subgroup. 1 hit.
    PRINTSi PR00802. SERUMALBUMIN.
    SMARTi SM00103. ALBUMIN. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48552. SSF48552. 3 hits.
    PROSITEi PS00212. ALBUMIN_1. 3 hits.
    PS51438. ALBUMIN_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Hilger C.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Beagle.
      Tissue: Liver.
    2. "Escherichia coli expression and purification of recombinant dog albumin, a cross-reactive animal allergen."
      Pandjaitan B., Swoboda I., Brandejsky-Pichler F., Rumpold H., Valenta R., Spitzauer S.
      J. Allergy Clin. Immunol. 105:279-285(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.
      Tissue: Liver.
    3. "Isolation of a cDNA encoding canine serum albumin."
      Miyake M., Okazaki M., Iwabuchi S.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Beagle.
      Tissue: Liver.
    4. "Isolation, amino acid sequence and copper(II)-binding properties of peptide (1-24) of dog serum albumin."
      Dixon J.W., Sarkar B.
      J. Biol. Chem. 249:5872-5877(1974) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-48.
    5. "HSC-2DPAGE and the two-dimensional gel electrophoresis database of dog heart proteins."
      Dunn M.J., Corbett J.M., Wheeler C.H.
      Electrophoresis 18:2795-2802(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-38.
      Tissue: Heart.
    6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 215-478, ALLERGEN.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiALBU_CANFA
    AccessioniPrimary (citable) accession number: P49822
    Secondary accession number(s): O77705, Q9TSZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 98 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3