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P49820 - NDUV2_CANFA


NADH dehydrogenase [ubiquinone] flavoprotein 2



Canis familiaris (Dog) (Canis lupus familiaris)
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.


    Binds 1 2Fe-2S cluster.Curated

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    Keywords - Molecular functioni


    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    2Fe-2S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] flavoprotein 2 (EC:, EC:
    Alternative name(s):
    NADH-ubiquinone oxidoreductase 24 kDa subunit
    Gene namesi
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›11›11NADH dehydrogenase [ubiquinone] flavoprotein 2PRO_0000118684Add

    2D gel databases



    Subunit structurei

    Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme By similarity.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 24 kDa subunit family.Curated


    Sequence statusi: Fragment.

    P49820-1 [UniParc]FASTAAdd to Basket

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    GAGGALFVHR D                                             11
    Mass (Da):1,099
    Last modified:July 15, 1998 - v2

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei11 – 111


    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    2D gel databases

    UCD-2DPAGE P49820.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...


    1. "HSC-2DPAGE and the two-dimensional gel electrophoresis database of dog heart proteins."
      Dunn M.J., Corbett J.M., Wheeler C.H.
      Electrophoresis 18:2795-2802(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Heart.

    Entry informationi

    Entry nameiNDUV2_CANFA
    AccessioniPrimary (citable) accession number: P49820
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 58 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program


    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome


    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3