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Protein

Caveolin-1

Gene

Cav1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.1 Publication

GO - Molecular functioni

  1. enzyme binding Source: MGI
  2. nitric-oxide synthase binding Source: BHF-UCL
  3. peptidase activator activity Source: MGI
  4. protein kinase binding Source: BHF-UCL
  5. receptor binding Source: MGI
  6. structural molecule activity Source: MGI

GO - Biological processi

  1. angiogenesis Source: MGI
  2. angiotensin-activated signaling pathway involved in heart process Source: BHF-UCL
  3. apoptotic signaling pathway Source: MGI
  4. calcium ion homeostasis Source: MGI
  5. calcium ion transport Source: MGI
  6. caveola assembly Source: BHF-UCL
  7. caveolin-mediated endocytosis Source: MGI
  8. cellular calcium ion homeostasis Source: MGI
  9. cellular response to hyperoxia Source: MGI
  10. cellular response to peptide hormone stimulus Source: BHF-UCL
  11. cellular response to starvation Source: Ensembl
  12. cellular response to transforming growth factor beta stimulus Source: MGI
  13. cholesterol homeostasis Source: MGI
  14. cytosolic calcium ion homeostasis Source: MGI
  15. endocytosis Source: MGI
  16. inactivation of MAPK activity Source: MGI
  17. lactation Source: MGI
  18. lipid storage Source: MGI
  19. mammary gland development Source: MGI
  20. mammary gland involution Source: MGI
  21. MAPK cascade Source: MGI
  22. membrane depolarization Source: MGI
  23. negative regulation of anoikis Source: UniProtKB
  24. negative regulation of BMP signaling pathway Source: MGI
  25. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  26. negative regulation of cell proliferation Source: MGI
  27. negative regulation of cytokine-mediated signaling pathway Source: MGI
  28. negative regulation of endothelial cell proliferation Source: MGI
  29. negative regulation of epithelial cell differentiation Source: MGI
  30. negative regulation of JAK-STAT cascade Source: MGI
  31. negative regulation of MAPK cascade Source: MGI
  32. negative regulation of MAP kinase activity Source: MGI
  33. negative regulation of nitric oxide biosynthetic process Source: MGI
  34. negative regulation of nitric-oxide synthase activity Source: MGI
  35. negative regulation of peptidyl-serine phosphorylation Source: MGI
  36. negative regulation of peptidyl-tyrosine autophosphorylation Source: BHF-UCL
  37. negative regulation of pinocytosis Source: MGI
  38. negative regulation of protein binding Source: MGI
  39. negative regulation of protein tyrosine kinase activity Source: BHF-UCL
  40. negative regulation of protein ubiquitination Source: UniProtKB
  41. negative regulation of signal transduction Source: MGI
  42. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  43. negative regulation of tyrosine phosphorylation of Stat5 protein Source: MGI
  44. nitric oxide homeostasis Source: MGI
  45. positive regulation of calcium ion transport into cytosol Source: BHF-UCL
  46. positive regulation of canonical Wnt signaling pathway Source: MGI
  47. positive regulation of extrinsic apoptotic signaling pathway Source: MGI
  48. positive regulation of gap junction assembly Source: BHF-UCL
  49. positive regulation of gene expression Source: BHF-UCL
  50. positive regulation of intrinsic apoptotic signaling pathway Source: MGI
  51. positive regulation of metalloenzyme activity Source: MGI
  52. positive regulation of peptidase activity Source: GOC
  53. positive regulation of peptidyl-serine phosphorylation Source: MGI
  54. positive regulation of vasoconstriction Source: MGI
  55. posttranscriptional regulation of gene expression Source: BHF-UCL
  56. protein homooligomerization Source: MGI
  57. protein localization Source: MGI
  58. protein oligomerization Source: MGI
  59. receptor internalization involved in canonical Wnt signaling pathway Source: MGI
  60. regulation of blood coagulation Source: MGI
  61. regulation of cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
  62. regulation of fatty acid metabolic process Source: MGI
  63. regulation of heart rate by cardiac conduction Source: BHF-UCL
  64. regulation of peptidase activity Source: MGI
  65. regulation of smooth muscle contraction Source: MGI
  66. regulation of the force of heart contraction Source: MGI
  67. regulation of the force of heart contraction by chemical signal Source: MGI
  68. regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL
  69. response to calcium ion Source: BHF-UCL
  70. response to estrogen Source: MGI
  71. response to hypoxia Source: MGI
  72. response to ischemia Source: MGI
  73. response to progesterone Source: MGI
  74. skeletal muscle tissue development Source: MGI
  75. T cell costimulation Source: UniProtKB
  76. triglyceride metabolic process Source: MGI
  77. vasculogenesis Source: MGI
  78. vasoconstriction Source: MGI
  79. vesicle organization Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_211508. Basigin interactions.
REACT_215995. NOSTRIN mediated eNOS trafficking.
REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_221264. eNOS activation.
REACT_245618. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.
REACT_261840. VEGFR2 mediated vascular permeability.

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolin-1
Gene namesi
Name:Cav1
Synonyms:Cav
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:102709. Cav1.

Subcellular locationi

Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity. Membranecaveola 1 Publication; Peripheral membrane protein 1 Publication. Membrane raft By similarity
Note: Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 104103CytoplasmicSequence AnalysisAdd
BLAST
Intramembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Topological domaini126 – 17853CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. acrosomal membrane Source: MGI
  2. apical plasma membrane Source: MGI
  3. basolateral plasma membrane Source: MGI
  4. caveola Source: UniProtKB
  5. cell cortex Source: MGI
  6. cilium Source: MGI
  7. cytoplasmic vesicle Source: MGI
  8. endoplasmic reticulum Source: HGNC
  9. endosome Source: UniProtKB
  10. focal adhesion Source: MGI
  11. Golgi apparatus Source: MGI
  12. Golgi membrane Source: HGNC
  13. integral component of membrane Source: MGI
  14. integral component of plasma membrane Source: MGI
  15. intracellular Source: MGI
  16. membrane Source: MGI
  17. membrane raft Source: MGI
  18. perinuclear region of cytoplasm Source: MGI
  19. plasma membrane Source: MGI
  20. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 178177Caveolin-1PRO_0000004766Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei5 – 51N6-acetyllysine1 Publication
Modified residuei6 – 61PhosphotyrosineBy similarity
Modified residuei14 – 141Phosphotyrosine; by ABL1 and INSR2 Publications
Modified residuei25 – 251PhosphotyrosineBy similarity
Modified residuei42 – 421PhosphotyrosineBy similarity
Lipidationi133 – 1331S-palmitoyl cysteineBy similarity
Lipidationi143 – 1431S-palmitoyl cysteineBy similarity
Lipidationi156 – 1561S-palmitoyl cysteineBy similarity

Post-translational modificationi

The N-terminus of both isoforms are blocked.
Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.2 Publications

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP49817.
PaxDbiP49817.
PRIDEiP49817.

PTM databases

PhosphoSiteiP49817.

Expressioni

Gene expression databases

BgeeiP49817.
CleanExiMM_CAV1.
ExpressionAtlasiP49817. baseline and differential.
GenevestigatoriP49817.

Interactioni

Subunit structurei

Homooligomer (By similarity). Interacts (via the N-terminus) with DPP4; the interaction is direct (By similarity). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9 (By similarity). Interacts with PACSIN2.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MCL1Q078203EBI-1161338,EBI-1003422From a different organism.
SCP2P223073EBI-1161338,EBI-1050999From a different organism.

Protein-protein interaction databases

BioGridi198514. 9 interactions.
DIPiDIP-35140N.
IntActiP49817. 11 interactions.
MINTiMINT-1542313.

Family & Domainsi

Sequence similaritiesi

Belongs to the caveolin family.Curated

Phylogenomic databases

eggNOGiNOG86001.
GeneTreeiENSGT00390000014924.
HOGENOMiHOG000036550.
HOVERGENiHBG003422.
InParanoidiP49817.
KOiK06278.
OMAiVHTFCDP.
OrthoDBiEOG7V1FSD.
PhylomeDBiP49817.
TreeFamiTF315736.

Family and domain databases

InterProiIPR001612. Caveolin.
IPR015504. Caveolin_1.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERiPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF5. PTHR10844:SF5. 1 hit.
PfamiPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEiPS01210. CAVEOLIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform 1 (identifier: P49817-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADEVTEKQ VYDAHTKEID
60 70 80 90 100
LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY
110 120 130 140 150
RLLSTIFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI
160 170
YVHTFCDPLF EAIGKIFSNI RISTQKEI
Length:178
Mass (Da):20,539
Last modified:October 1, 1996 - v1
Checksum:iCF88FE9B1D3D67AE
GO
Isoform 2 (identifier: P49817-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:147
Mass (Da):17,090
Checksum:iF1D1A06351AF6C3C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti170 – 1701I → F in BAC29118. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3131Missing in isoform 2. 2 PublicationsVSP_018693Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07645 mRNA. Translation: AAA85784.1.
AB029929 mRNA. Translation: BAA89461.1.
AB029930 mRNA. Translation: BAA89462.1.
AB029931 Genomic DNA. Translation: BAA89463.1.
AY439333 mRNA. Translation: AAR99702.1.
AK003489 mRNA. Translation: BAB22817.1.
AK028738 mRNA. Translation: BAC26091.1.
AK035592 mRNA. Translation: BAC29118.1.
AK090074 mRNA. Translation: BAC41079.1.
BC038280 mRNA. Translation: AAH38280.1.
BC052859 mRNA. Translation: AAH52859.1.
CCDSiCCDS19924.1. [P49817-1]
PIRiI48976.
RefSeqiNP_001229993.1. NM_001243064.1. [P49817-2]
NP_031642.1. NM_007616.4. [P49817-1]
XP_006505037.1. XM_006504974.1. [P49817-1]
XP_006505038.1. XM_006504975.1. [P49817-2]
XP_006505039.1. XM_006504976.1. [P49817-2]
UniGeneiMm.28278.

Genome annotation databases

EnsembliENSMUST00000007799; ENSMUSP00000007799; ENSMUSG00000007655. [P49817-1]
ENSMUST00000115453; ENSMUSP00000111113; ENSMUSG00000007655. [P49817-2]
ENSMUST00000115454; ENSMUSP00000111114; ENSMUSG00000007655. [P49817-2]
ENSMUST00000115456; ENSMUSP00000111116; ENSMUSG00000007655. [P49817-1]
GeneIDi12389.
KEGGimmu:12389.
UCSCiuc009azo.2. mouse. [P49817-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07645 mRNA. Translation: AAA85784.1.
AB029929 mRNA. Translation: BAA89461.1.
AB029930 mRNA. Translation: BAA89462.1.
AB029931 Genomic DNA. Translation: BAA89463.1.
AY439333 mRNA. Translation: AAR99702.1.
AK003489 mRNA. Translation: BAB22817.1.
AK028738 mRNA. Translation: BAC26091.1.
AK035592 mRNA. Translation: BAC29118.1.
AK090074 mRNA. Translation: BAC41079.1.
BC038280 mRNA. Translation: AAH38280.1.
BC052859 mRNA. Translation: AAH52859.1.
CCDSiCCDS19924.1. [P49817-1]
PIRiI48976.
RefSeqiNP_001229993.1. NM_001243064.1. [P49817-2]
NP_031642.1. NM_007616.4. [P49817-1]
XP_006505037.1. XM_006504974.1. [P49817-1]
XP_006505038.1. XM_006504975.1. [P49817-2]
XP_006505039.1. XM_006504976.1. [P49817-2]
UniGeneiMm.28278.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198514. 9 interactions.
DIPiDIP-35140N.
IntActiP49817. 11 interactions.
MINTiMINT-1542313.

PTM databases

PhosphoSiteiP49817.

Proteomic databases

MaxQBiP49817.
PaxDbiP49817.
PRIDEiP49817.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000007799; ENSMUSP00000007799; ENSMUSG00000007655. [P49817-1]
ENSMUST00000115453; ENSMUSP00000111113; ENSMUSG00000007655. [P49817-2]
ENSMUST00000115454; ENSMUSP00000111114; ENSMUSG00000007655. [P49817-2]
ENSMUST00000115456; ENSMUSP00000111116; ENSMUSG00000007655. [P49817-1]
GeneIDi12389.
KEGGimmu:12389.
UCSCiuc009azo.2. mouse. [P49817-1]

Organism-specific databases

CTDi857.
MGIiMGI:102709. Cav1.

Phylogenomic databases

eggNOGiNOG86001.
GeneTreeiENSGT00390000014924.
HOGENOMiHOG000036550.
HOVERGENiHBG003422.
InParanoidiP49817.
KOiK06278.
OMAiVHTFCDP.
OrthoDBiEOG7V1FSD.
PhylomeDBiP49817.
TreeFamiTF315736.

Enzyme and pathway databases

ReactomeiREACT_211508. Basigin interactions.
REACT_215995. NOSTRIN mediated eNOS trafficking.
REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_221264. eNOS activation.
REACT_245618. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.
REACT_261840. VEGFR2 mediated vascular permeability.

Miscellaneous databases

NextBioi281122.
PROiP49817.
SOURCEiSearch...

Gene expression databases

BgeeiP49817.
CleanExiMM_CAV1.
ExpressionAtlasiP49817. baseline and differential.
GenevestigatoriP49817.

Family and domain databases

InterProiIPR001612. Caveolin.
IPR015504. Caveolin_1.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERiPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF5. PTHR10844:SF5. 1 hit.
PfamiPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEiPS01210. CAVEOLIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C."
    Tang Z., Scherer P.E., Lisanti M.P.
    Gene 147:299-300(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: BALB/c.
  2. "Caveolin-1 isoforms are encoded in distinct mRNAs: identification of mouse caveolin-1 mRNA variants caused by alternative transcription initiation and splicing."
    Kogo H., Fujimoto T.
    FEBS Lett. 465:119-123(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
  3. "Met gene is a candidate for the mouse pulmonary adenoma resistance 4 (Par4) locus."
    Zaffaroni D., Dragani T.A.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: SWR/J.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Embryo, Skin and Urinary bladder.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C3H/He.
    Tissue: Mesenchymal cell.
  6. "Caveolin isoforms differ in their N-terminal protein sequence and subcellular distribution. Identification and epitope mapping of an isoform-specific monoclonal antibody probe."
    Scherer P.E., Tang Z., Chun M., Sargiacomo M., Lodish H.F., Lisanti M.P.
    J. Biol. Chem. 270:16395-16401(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 5-26; 47-77 AND 165-176.
  7. "Caveolin-1 expression inhibits Wnt/beta-catenin/Lef-1 signaling by recruiting beta-catenin to caveolae membrane domains."
    Galbiati F., Volonte D., Brown A.M., Weinstein D.E., Ben-Ze'ev A., Pestell R.G., Lisanti M.P.
    J. Biol. Chem. 275:23368-23377(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1."
    Kimura A., Mora S., Shigematsu S., Pessin J.E., Saltiel A.R.
    J. Biol. Chem. 277:30153-30158(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-14.
  9. "c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14."
    Sanguinetti A.R., Mastick C.C.
    Cell. Signal. 15:289-298(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-14.
  10. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  12. "Essential role of PACSIN2/syndapin-II in caveolae membrane sculpting."
    Senju Y., Itoh Y., Takano K., Hamada S., Suetsugu S.
    J. Cell Sci. 124:2032-2040(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PACSIN2, SUBCELLULAR LOCATION.
  13. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2 AND LYS-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiCAV1_MOUSE
AccessioniPrimary (citable) accession number: P49817
Secondary accession number(s): Q8C1X7
, Q8CBP4, Q9QYH3, Q9QYH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 4, 2015
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.