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P49817

- CAV1_MOUSE

UniProt

P49817 - CAV1_MOUSE

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Protein

Caveolin-1

Gene

Cav1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.1 Publication

GO - Molecular functioni

  1. peptidase activator activity Source: MGI
  2. structural molecule activity Source: Ensembl

GO - Biological processi

  1. angiogenesis Source: MGI
  2. apoptotic signaling pathway Source: Ensembl
  3. calcium ion homeostasis Source: MGI
  4. calcium ion transport Source: MGI
  5. caveola assembly Source: MGI
  6. caveolin-mediated endocytosis Source: Ensembl
  7. cellular calcium ion homeostasis Source: MGI
  8. cellular response to hyperoxia Source: Ensembl
  9. cellular response to starvation Source: Ensembl
  10. cholesterol homeostasis Source: MGI
  11. cytosolic calcium ion homeostasis Source: Ensembl
  12. endocytosis Source: MGI
  13. inactivation of MAPK activity Source: MGI
  14. lactation Source: MGI
  15. lipid storage Source: MGI
  16. mammary gland development Source: MGI
  17. mammary gland involution Source: MGI
  18. MAPK cascade Source: MGI
  19. membrane depolarization Source: MGI
  20. negative regulation of anoikis Source: UniProtKB
  21. negative regulation of BMP signaling pathway Source: Ensembl
  22. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  23. negative regulation of cell proliferation Source: MGI
  24. negative regulation of cytokine-mediated signaling pathway Source: MGI
  25. negative regulation of endothelial cell proliferation Source: MGI
  26. negative regulation of epithelial cell differentiation Source: MGI
  27. negative regulation of JAK-STAT cascade Source: MGI
  28. negative regulation of MAPK cascade Source: MGI
  29. negative regulation of MAP kinase activity Source: MGI
  30. negative regulation of nitric oxide biosynthetic process Source: MGI
  31. negative regulation of nitric-oxide synthase activity Source: MGI
  32. negative regulation of peptidyl-serine phosphorylation Source: Ensembl
  33. negative regulation of pinocytosis Source: Ensembl
  34. negative regulation of protein binding Source: Ensembl
  35. negative regulation of protein ubiquitination Source: UniProtKB
  36. negative regulation of signal transduction Source: MGI
  37. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  38. negative regulation of tyrosine phosphorylation of Stat5 protein Source: MGI
  39. nitric oxide homeostasis Source: MGI
  40. positive regulation of calcium ion transport into cytosol Source: BHF-UCL
  41. positive regulation of canonical Wnt signaling pathway Source: Ensembl
  42. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  43. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
  44. positive regulation of metalloenzyme activity Source: MGI
  45. positive regulation of peptidase activity Source: GOC
  46. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  47. positive regulation of vasoconstriction Source: MGI
  48. protein homooligomerization Source: MGI
  49. protein localization Source: MGI
  50. protein oligomerization Source: MGI
  51. receptor internalization involved in canonical Wnt signaling pathway Source: Ensembl
  52. regulation of blood coagulation Source: Ensembl
  53. regulation of fatty acid metabolic process Source: MGI
  54. regulation of peptidase activity Source: MGI
  55. regulation of smooth muscle contraction Source: MGI
  56. regulation of the force of heart contraction Source: MGI
  57. regulation of the force of heart contraction by chemical signal Source: MGI
  58. response to calcium ion Source: BHF-UCL
  59. response to estrogen Source: MGI
  60. response to hypoxia Source: MGI
  61. response to ischemia Source: MGI
  62. response to progesterone Source: MGI
  63. skeletal muscle tissue development Source: MGI
  64. T cell costimulation Source: UniProtKB
  65. triglyceride metabolic process Source: MGI
  66. vasculogenesis Source: MGI
  67. vasoconstriction Source: MGI
  68. vesicle organization Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_211508. Basigin interactions.
REACT_215995. NOSTRIN mediated eNOS trafficking.
REACT_221264. eNOS activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolin-1
Gene namesi
Name:Cav1
Synonyms:Cav
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:102709. Cav1.

Subcellular locationi

Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity. Membranecaveola 1 Publication; Peripheral membrane protein 1 Publication. Membrane raft By similarity
Note: Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity).By similarity

GO - Cellular componenti

  1. acrosomal membrane Source: MGI
  2. apical plasma membrane Source: Ensembl
  3. basolateral plasma membrane Source: Ensembl
  4. caveola Source: UniProtKB
  5. cell cortex Source: MGI
  6. cilium Source: MGI
  7. cytoplasmic vesicle Source: MGI
  8. endoplasmic reticulum Source: HGNC
  9. endosome Source: UniProtKB
  10. Golgi apparatus Source: MGI
  11. Golgi membrane Source: HGNC
  12. integral component of membrane Source: MGI
  13. integral component of plasma membrane Source: MGI
  14. membrane Source: MGI
  15. membrane raft Source: MGI
  16. perinuclear region of cytoplasm Source: MGI
  17. plasma membrane Source: MGI
  18. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 178177Caveolin-1PRO_0000004766Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei5 – 51N6-acetyllysine1 Publication
Modified residuei6 – 61PhosphotyrosineBy similarity
Modified residuei14 – 141Phosphotyrosine; by ABL1 and INSR2 Publications
Modified residuei25 – 251PhosphotyrosineBy similarity
Modified residuei42 – 421PhosphotyrosineBy similarity
Lipidationi133 – 1331S-palmitoyl cysteineBy similarity
Lipidationi143 – 1431S-palmitoyl cysteineBy similarity
Lipidationi156 – 1561S-palmitoyl cysteineBy similarity

Post-translational modificationi

The N-terminus of both isoforms are blocked.
Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.2 Publications

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP49817.
PaxDbiP49817.
PRIDEiP49817.

PTM databases

PhosphoSiteiP49817.

Expressioni

Gene expression databases

BgeeiP49817.
CleanExiMM_CAV1.
ExpressionAtlasiP49817. baseline and differential.
GenevestigatoriP49817.

Interactioni

Subunit structurei

Homooligomer (By similarity). Interacts (via the N-terminus) with DPP4; the interaction is direct (By similarity). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9 (By similarity). Interacts with PACSIN2.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MCL1Q078203EBI-1161338,EBI-1003422From a different organism.
SCP2P223073EBI-1161338,EBI-1050999From a different organism.

Protein-protein interaction databases

BioGridi198514. 9 interactions.
DIPiDIP-35140N.
IntActiP49817. 11 interactions.
MINTiMINT-1542313.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 104103CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini126 – 17853CytoplasmicSequence AnalysisAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei105 – 12521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the caveolin family.Curated

Phylogenomic databases

eggNOGiNOG86001.
GeneTreeiENSGT00390000014924.
HOGENOMiHOG000036550.
HOVERGENiHBG003422.
InParanoidiP49817.
KOiK06278.
OMAiRINMQKE.
OrthoDBiEOG7V1FSD.
PhylomeDBiP49817.
TreeFamiTF315736.

Family and domain databases

InterProiIPR001612. Caveolin.
IPR015504. Caveolin_1.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERiPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF5. PTHR10844:SF5. 1 hit.
PfamiPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEiPS01210. CAVEOLIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform 1 (identifier: P49817-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADEVTEKQ VYDAHTKEID
60 70 80 90 100
LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY
110 120 130 140 150
RLLSTIFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI
160 170
YVHTFCDPLF EAIGKIFSNI RISTQKEI
Length:178
Mass (Da):20,539
Last modified:October 1, 1996 - v1
Checksum:iCF88FE9B1D3D67AE
GO
Isoform 2 (identifier: P49817-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-31: Missing.

Show »
Length:148
Mass (Da):17,221
Checksum:iF19874C9347CDD0C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti170 – 1701I → F in BAC29118. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 3130Missing in isoform 2. 2 PublicationsVSP_018693Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U07645 mRNA. Translation: AAA85784.1.
AB029929 mRNA. Translation: BAA89461.1.
AB029930 mRNA. Translation: BAA89462.1.
AB029931 Genomic DNA. Translation: BAA89463.1.
AY439333 mRNA. Translation: AAR99702.1.
AK003489 mRNA. Translation: BAB22817.1.
AK028738 mRNA. Translation: BAC26091.1.
AK035592 mRNA. Translation: BAC29118.1.
AK090074 mRNA. Translation: BAC41079.1.
BC038280 mRNA. Translation: AAH38280.1.
BC052859 mRNA. Translation: AAH52859.1.
CCDSiCCDS19924.1. [P49817-1]
PIRiI48976.
RefSeqiNP_001229993.1. NM_001243064.1.
NP_031642.1. NM_007616.4. [P49817-1]
XP_006505037.1. XM_006504974.1. [P49817-1]
XP_006505038.1. XM_006504975.1.
XP_006505039.1. XM_006504976.1.
UniGeneiMm.28278.

Genome annotation databases

EnsembliENSMUST00000007799; ENSMUSP00000007799; ENSMUSG00000007655. [P49817-1]
ENSMUST00000115453; ENSMUSP00000111113; ENSMUSG00000007655.
ENSMUST00000115454; ENSMUSP00000111114; ENSMUSG00000007655.
ENSMUST00000115456; ENSMUSP00000111116; ENSMUSG00000007655. [P49817-1]
GeneIDi12389.
KEGGimmu:12389.
UCSCiuc009azo.2. mouse. [P49817-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U07645 mRNA. Translation: AAA85784.1 .
AB029929 mRNA. Translation: BAA89461.1 .
AB029930 mRNA. Translation: BAA89462.1 .
AB029931 Genomic DNA. Translation: BAA89463.1 .
AY439333 mRNA. Translation: AAR99702.1 .
AK003489 mRNA. Translation: BAB22817.1 .
AK028738 mRNA. Translation: BAC26091.1 .
AK035592 mRNA. Translation: BAC29118.1 .
AK090074 mRNA. Translation: BAC41079.1 .
BC038280 mRNA. Translation: AAH38280.1 .
BC052859 mRNA. Translation: AAH52859.1 .
CCDSi CCDS19924.1. [P49817-1 ]
PIRi I48976.
RefSeqi NP_001229993.1. NM_001243064.1.
NP_031642.1. NM_007616.4. [P49817-1 ]
XP_006505037.1. XM_006504974.1. [P49817-1 ]
XP_006505038.1. XM_006504975.1.
XP_006505039.1. XM_006504976.1.
UniGenei Mm.28278.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198514. 9 interactions.
DIPi DIP-35140N.
IntActi P49817. 11 interactions.
MINTi MINT-1542313.

PTM databases

PhosphoSitei P49817.

Proteomic databases

MaxQBi P49817.
PaxDbi P49817.
PRIDEi P49817.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000007799 ; ENSMUSP00000007799 ; ENSMUSG00000007655 . [P49817-1 ]
ENSMUST00000115453 ; ENSMUSP00000111113 ; ENSMUSG00000007655 .
ENSMUST00000115454 ; ENSMUSP00000111114 ; ENSMUSG00000007655 .
ENSMUST00000115456 ; ENSMUSP00000111116 ; ENSMUSG00000007655 . [P49817-1 ]
GeneIDi 12389.
KEGGi mmu:12389.
UCSCi uc009azo.2. mouse. [P49817-1 ]

Organism-specific databases

CTDi 857.
MGIi MGI:102709. Cav1.

Phylogenomic databases

eggNOGi NOG86001.
GeneTreei ENSGT00390000014924.
HOGENOMi HOG000036550.
HOVERGENi HBG003422.
InParanoidi P49817.
KOi K06278.
OMAi RINMQKE.
OrthoDBi EOG7V1FSD.
PhylomeDBi P49817.
TreeFami TF315736.

Enzyme and pathway databases

Reactomei REACT_211508. Basigin interactions.
REACT_215995. NOSTRIN mediated eNOS trafficking.
REACT_221264. eNOS activation.

Miscellaneous databases

NextBioi 281122.
PROi P49817.
SOURCEi Search...

Gene expression databases

Bgeei P49817.
CleanExi MM_CAV1.
ExpressionAtlasi P49817. baseline and differential.
Genevestigatori P49817.

Family and domain databases

InterProi IPR001612. Caveolin.
IPR015504. Caveolin_1.
IPR018361. Caveolin_CS.
[Graphical view ]
PANTHERi PTHR10844. PTHR10844. 1 hit.
PTHR10844:SF5. PTHR10844:SF5. 1 hit.
Pfami PF01146. Caveolin. 1 hit.
[Graphical view ]
PROSITEi PS01210. CAVEOLIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C."
    Tang Z., Scherer P.E., Lisanti M.P.
    Gene 147:299-300(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: BALB/c.
  2. "Caveolin-1 isoforms are encoded in distinct mRNAs: identification of mouse caveolin-1 mRNA variants caused by alternative transcription initiation and splicing."
    Kogo H., Fujimoto T.
    FEBS Lett. 465:119-123(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
  3. "Met gene is a candidate for the mouse pulmonary adenoma resistance 4 (Par4) locus."
    Zaffaroni D., Dragani T.A.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: SWR/J.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Embryo, Skin and Urinary bladder.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C3H/He.
    Tissue: Mesenchymal cell.
  6. "Caveolin isoforms differ in their N-terminal protein sequence and subcellular distribution. Identification and epitope mapping of an isoform-specific monoclonal antibody probe."
    Scherer P.E., Tang Z., Chun M., Sargiacomo M., Lodish H.F., Lisanti M.P.
    J. Biol. Chem. 270:16395-16401(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 5-26; 47-77 AND 165-176.
  7. "Caveolin-1 expression inhibits Wnt/beta-catenin/Lef-1 signaling by recruiting beta-catenin to caveolae membrane domains."
    Galbiati F., Volonte D., Brown A.M., Weinstein D.E., Ben-Ze'ev A., Pestell R.G., Lisanti M.P.
    J. Biol. Chem. 275:23368-23377(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1."
    Kimura A., Mora S., Shigematsu S., Pessin J.E., Saltiel A.R.
    J. Biol. Chem. 277:30153-30158(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-14.
  9. "c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14."
    Sanguinetti A.R., Mastick C.C.
    Cell. Signal. 15:289-298(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-14.
  10. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  12. "Essential role of PACSIN2/syndapin-II in caveolae membrane sculpting."
    Senju Y., Itoh Y., Takano K., Hamada S., Suetsugu S.
    J. Cell Sci. 124:2032-2040(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PACSIN2, SUBCELLULAR LOCATION.
  13. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2 AND LYS-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiCAV1_MOUSE
AccessioniPrimary (citable) accession number: P49817
Secondary accession number(s): Q8C1X7
, Q8CBP4, Q9QYH3, Q9QYH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3