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Protein

Caveolin-1

Gene

Cav1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (PubMed:10816572). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19546242).By similarity2 Publications

GO - Molecular functioni

  • ATPase binding Source: MGI
  • enzyme binding Source: MGI
  • identical protein binding Source: MGI
  • inward rectifier potassium channel inhibitor activity Source: MGI
  • ion channel binding Source: MGI
  • nitric-oxide synthase binding Source: BHF-UCL
  • peptidase activator activity Source: MGI
  • protein binding, bridging Source: BHF-UCL
  • protein complex scaffold activity Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • protein kinase binding Source: BHF-UCL
  • Rac GTPase binding Source: MGI
  • receptor binding Source: MGI
  • structural molecule activity Source: MGI

GO - Biological processi

  • angiogenesis Source: MGI
  • angiotensin-activated signaling pathway involved in heart process Source: BHF-UCL
  • apoptotic signaling pathway Source: MGI
  • calcium ion homeostasis Source: MGI
  • calcium ion transport Source: MGI
  • caveola assembly Source: MGI
  • caveolin-mediated endocytosis Source: MGI
  • cellular calcium ion homeostasis Source: MGI
  • cellular response to exogenous dsRNA Source: MGI
  • cellular response to hyperoxia Source: MGI
  • cellular response to peptide hormone stimulus Source: BHF-UCL
  • cellular response to transforming growth factor beta stimulus Source: MGI
  • cholesterol homeostasis Source: MGI
  • endocytosis Source: MGI
  • inactivation of MAPK activity Source: MGI
  • lactation Source: MGI
  • lipid storage Source: MGI
  • mammary gland development Source: MGI
  • mammary gland involution Source: MGI
  • MAPK cascade Source: MGI
  • membrane depolarization Source: MGI
  • negative regulation of anoikis Source: UniProtKB
  • negative regulation of BMP signaling pathway Source: MGI
  • negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of cytokine-mediated signaling pathway Source: MGI
  • negative regulation of endothelial cell proliferation Source: MGI
  • negative regulation of epithelial cell differentiation Source: MGI
  • negative regulation of inward rectifier potassium channel activity Source: MGI
  • negative regulation of JAK-STAT cascade Source: MGI
  • negative regulation of MAPK cascade Source: MGI
  • negative regulation of MAP kinase activity Source: MGI
  • negative regulation of necroptotic process Source: CACAO
  • negative regulation of nitric oxide biosynthetic process Source: MGI
  • negative regulation of nitric-oxide synthase activity Source: MGI
  • negative regulation of peptidyl-serine phosphorylation Source: MGI
  • negative regulation of peptidyl-tyrosine autophosphorylation Source: BHF-UCL
  • negative regulation of pinocytosis Source: MGI
  • negative regulation of potassium ion transmembrane transport Source: MGI
  • negative regulation of protein binding Source: MGI
  • negative regulation of protein tyrosine kinase activity Source: BHF-UCL
  • negative regulation of protein ubiquitination Source: UniProtKB
  • negative regulation of signal transduction Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
  • negative regulation of tyrosine phosphorylation of STAT protein Source: MGI
  • nitric oxide homeostasis Source: MGI
  • positive regulation of calcium ion transport into cytosol Source: BHF-UCL
  • positive regulation of canonical Wnt signaling pathway Source: MGI
  • positive regulation of catalytic activity Source: MGI
  • positive regulation of cell adhesion molecule production Source: MGI
  • positive regulation of extrinsic apoptotic signaling pathway Source: MGI
  • positive regulation of gap junction assembly Source: BHF-UCL
  • positive regulation of gene expression Source: BHF-UCL
  • positive regulation of intrinsic apoptotic signaling pathway Source: MGI
  • positive regulation of peptidyl-serine phosphorylation Source: MGI
  • positive regulation of protein binding Source: MGI
  • positive regulation of protein ubiquitination Source: MGI
  • positive regulation of toll-like receptor 3 signaling pathway Source: MGI
  • positive regulation of vasoconstriction Source: MGI
  • posttranscriptional regulation of gene expression Source: BHF-UCL
  • protein homooligomerization Source: MGI
  • protein localization Source: MGI
  • protein oligomerization Source: MGI
  • receptor internalization Source: UniProtKB
  • receptor internalization involved in canonical Wnt signaling pathway Source: MGI
  • receptor-mediated endocytosis of virus by host cell Source: MGI
  • regulation of blood coagulation Source: MGI
  • regulation of cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
  • regulation of cytosolic calcium ion concentration Source: MGI
  • regulation of entry of bacterium into host cell Source: MGI
  • regulation of fatty acid metabolic process Source: MGI
  • regulation of heart rate by cardiac conduction Source: BHF-UCL
  • regulation of membrane repolarization during action potential Source: MGI
  • regulation of peptidase activity Source: MGI
  • regulation of ruffle assembly Source: MGI
  • regulation of smooth muscle contraction Source: MGI
  • regulation of the force of heart contraction Source: MGI
  • regulation of the force of heart contraction by chemical signal Source: MGI
  • regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL
  • response to bacterium Source: MGI
  • response to calcium ion Source: BHF-UCL
  • response to estrogen Source: MGI
  • response to hypoxia Source: MGI
  • response to ischemia Source: MGI
  • response to progesterone Source: MGI
  • skeletal muscle tissue development Source: MGI
  • T cell costimulation Source: UniProtKB
  • triglyceride metabolic process Source: MGI
  • vasculogenesis Source: MGI
  • vasoconstriction Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-163560. Triglyceride catabolism.
R-MMU-203615. eNOS activation.
R-MMU-203641. NOSTRIN mediated eNOS trafficking.
R-MMU-210991. Basigin interactions.
R-MMU-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolin-1
Gene namesi
Name:Cav1
Synonyms:Cav
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:102709. Cav1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 104CytoplasmicSequence analysisAdd BLAST103
Intramembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 178CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000047662 – 178Caveolin-1Add BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineBy similarity1
Modified residuei5N6-acetyllysine; alternateCombined sources1
Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Modified residuei6PhosphotyrosineBy similarity1
Modified residuei9PhosphoserineCombined sources1
Modified residuei14Phosphotyrosine; by ABL1 and INSRCombined sources2 Publications1
Modified residuei25PhosphotyrosineBy similarity1
Cross-linki26Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki30Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki39Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki47Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki57Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Lipidationi133S-palmitoyl cysteineBy similarity1
Lipidationi143S-palmitoyl cysteineBy similarity1
Lipidationi156S-palmitoyl cysteineBy similarity1

Post-translational modificationi

The N-terminus of both isoforms are blocked.
Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.2 Publications
Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP49817.
PaxDbiP49817.
PeptideAtlasiP49817.
PRIDEiP49817.

PTM databases

iPTMnetiP49817.
PhosphoSitePlusiP49817.
SwissPalmiP49817.

Expressioni

Tissue specificityi

Adipose tissue, lung, heart, skeletal muscle, stomach, small bowel, kidney, spleen and testis (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000007655.
CleanExiMM_CAV1.
ExpressionAtlasiP49817. baseline and differential.
GenevisibleiP49817. MM.

Interactioni

Subunit structurei

Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1 (By similarity). Interacts with PACSIN2 (PubMed:21610094). Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with EHD2 in a cholesterol-dependent manner (By similarity). Interacts with CAVIN1 (PubMed:19546242). Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation (By similarity).By similarity2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • ATPase binding Source: MGI
  • enzyme binding Source: MGI
  • identical protein binding Source: MGI
  • ion channel binding Source: MGI
  • nitric-oxide synthase binding Source: BHF-UCL
  • protein binding, bridging Source: BHF-UCL
  • protein complex scaffold activity Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • protein kinase binding Source: BHF-UCL
  • Rac GTPase binding Source: MGI
  • receptor binding Source: MGI

Protein-protein interaction databases

BioGridi198514. 10 interactors.
DIPiDIP-35140N.
IntActiP49817. 15 interactors.
MINTiMINT-1542313.
STRINGi10090.ENSMUSP00000007799.

Structurei

3D structure databases

SMRiP49817.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 94Required for homooligomerizationBy similarityAdd BLAST93
Regioni82 – 94Interaction with CAVIN3By similarityAdd BLAST13

Sequence similaritiesi

Belongs to the caveolin family.Curated

Phylogenomic databases

eggNOGiENOG410IV7A. Eukaryota.
ENOG4111HJR. LUCA.
GeneTreeiENSGT00390000014924.
HOGENOMiHOG000036550.
HOVERGENiHBG003422.
InParanoidiP49817.
KOiK06278.
OMAiIYVHTFC.
OrthoDBiEOG091G0M1R.
PhylomeDBiP49817.
TreeFamiTF315736.

Family and domain databases

InterProiView protein in InterPro
IPR015504. CAV-1.
IPR001612. Caveolin.
IPR018361. Caveolin_CS.
PANTHERiPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF18. PTHR10844:SF18. 1 hit.
PfamiView protein in Pfam
PF01146. Caveolin. 1 hit.
PROSITEiView protein in PROSITE
PS01210. CAVEOLIN. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: P49817-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADEVTEKQ VYDAHTKEID
60 70 80 90 100
LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY
110 120 130 140 150
RLLSTIFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI
160 170
YVHTFCDPLF EAIGKIFSNI RISTQKEI
Length:178
Mass (Da):20,539
Last modified:October 1, 1996 - v1
Checksum:iCF88FE9B1D3D67AE
GO
Isoform 2 (identifier: P49817-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:147
Mass (Da):17,090
Checksum:iF1D1A06351AF6C3C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170I → F in BAC29118 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0186931 – 31Missing in isoform 2. 2 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07645 mRNA. Translation: AAA85784.1.
AB029929 mRNA. Translation: BAA89461.1.
AB029930 mRNA. Translation: BAA89462.1.
AB029931 Genomic DNA. Translation: BAA89463.1.
AY439333 mRNA. Translation: AAR99702.1.
AK003489 mRNA. Translation: BAB22817.1.
AK028738 mRNA. Translation: BAC26091.1.
AK035592 mRNA. Translation: BAC29118.1.
AK090074 mRNA. Translation: BAC41079.1.
BC038280 mRNA. Translation: AAH38280.1.
BC052859 mRNA. Translation: AAH52859.1.
CCDSiCCDS19924.1. [P49817-1]
CCDS57410.1. [P49817-2]
PIRiI48976.
RefSeqiNP_001229993.1. NM_001243064.1. [P49817-2]
NP_031642.1. NM_007616.4. [P49817-1]
XP_006505037.1. XM_006504974.1. [P49817-1]
XP_006505038.1. XM_006504975.1. [P49817-2]
XP_006505039.1. XM_006504976.1. [P49817-2]
UniGeneiMm.28278.

Genome annotation databases

EnsembliENSMUST00000007799; ENSMUSP00000007799; ENSMUSG00000007655. [P49817-1]
ENSMUST00000115453; ENSMUSP00000111113; ENSMUSG00000007655. [P49817-2]
ENSMUST00000115454; ENSMUSP00000111114; ENSMUSG00000007655. [P49817-2]
ENSMUST00000115456; ENSMUSP00000111116; ENSMUSG00000007655. [P49817-1]
GeneIDi12389.
KEGGimmu:12389.
UCSCiuc009azo.2. mouse. [P49817-1]

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiCAV1_MOUSE
AccessioniPrimary (citable) accession number: P49817
Secondary accession number(s): Q8C1X7
, Q8CBP4, Q9QYH3, Q9QYH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 186 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families