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P49807

- RGS11_RAT

UniProt

P49807 - RGS11_RAT

Protein

Regulator of G-protein signaling 11

Gene

Rgs11

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. regulation of G-protein coupled receptor protein signaling pathway Source: RGD
    3. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 11
    Short name:
    RGS11
    Gene namesi
    Name:Rgs11
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3563. Rgs11.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. dendrite terminus Source: Ensembl
    3. plasma membrane Source: RefGenome
    4. protein complex Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›66›66Regulator of G-protein signaling 11PRO_0000204212Add
    BLAST

    Proteomic databases

    PaxDbiP49807.

    PTM databases

    PhosphoSiteiP49807.

    Expressioni

    Gene expression databases

    GenevestigatoriP49807.

    Interactioni

    Subunit structurei

    Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000027763.

    Structurei

    3D structure databases

    ProteinModelPortaliP49807.
    SMRiP49807. Positions 1-66.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini‹1 – ›66›66RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG327614.
    HOGENOMiHOG000220864.
    InParanoidiP49807.
    PhylomeDBiP49807.

    Family and domain databases

    InterProiIPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SUPFAMiSSF48097. SSF48097. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    P49807-1 [UniParc]FASTAAdd to Basket

    « Hide

    EACEELRFGG QAQVPTLVDS VYQQFLAPGA ARWINIDSRT MEWTLEGLRQ   50
    PHRYVLDAAQ LHIYML 66
    Length:66
    Mass (Da):7,605
    Last modified:October 1, 1996 - v1
    Checksum:i5E95CA702B03F287
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei66 – 661

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32438 mRNA. Translation: AAC52375.1.
    UniGeneiRn.84083.

    Genome annotation databases

    UCSCiRGD:3563. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32438 mRNA. Translation: AAC52375.1 .
    UniGenei Rn.84083.

    3D structure databases

    ProteinModelPortali P49807.
    SMRi P49807. Positions 1-66.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000027763.

    PTM databases

    PhosphoSitei P49807.

    Proteomic databases

    PaxDbi P49807.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:3563. rat.

    Organism-specific databases

    RGDi 3563. Rgs11.

    Phylogenomic databases

    eggNOGi NOG327614.
    HOGENOMi HOG000220864.
    InParanoidi P49807.
    PhylomeDBi P49807.

    Miscellaneous databases

    PROi P49807.

    Gene expression databases

    Genevestigatori P49807.

    Family and domain databases

    InterProi IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SUPFAMi SSF48097. SSF48097. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins."
      Koelle M.R., Horvitz H.R.
      Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiRGS11_RAT
    AccessioniPrimary (citable) accession number: P49807
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3