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P49807

- RGS11_RAT

UniProt

P49807 - RGS11_RAT

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Protein

Regulator of G-protein signaling 11

Gene

Rgs11

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome

GO - Biological processi

  1. positive regulation of GTPase activity Source: GOC
  2. regulation of G-protein coupled receptor protein signaling pathway Source: RGD
  3. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 11
Short name:
RGS11
Gene namesi
Name:Rgs11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3563. Rgs11.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. dendrite terminus Source: Ensembl
  3. plasma membrane Source: RefGenome
  4. protein complex Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›66›66Regulator of G-protein signaling 11PRO_0000204212Add
BLAST

Proteomic databases

PaxDbiP49807.

PTM databases

PhosphoSiteiP49807.

Expressioni

Gene expression databases

ExpressionAtlasiP49807. baseline and differential.
GenevestigatoriP49807.

Interactioni

Subunit structurei

Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027763.

Structurei

3D structure databases

ProteinModelPortaliP49807.
SMRiP49807. Positions 1-66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – ›66›66RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG327614.
HOGENOMiHOG000220864.
InParanoidiP49807.
PhylomeDBiP49807.

Family and domain databases

InterProiIPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SUPFAMiSSF48097. SSF48097. 1 hit.

Sequencei

Sequence statusi: Fragment.

P49807-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
EACEELRFGG QAQVPTLVDS VYQQFLAPGA ARWINIDSRT MEWTLEGLRQ
60
PHRYVLDAAQ LHIYML
Length:66
Mass (Da):7,605
Last modified:October 1, 1996 - v1
Checksum:i5E95CA702B03F287
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei66 – 661

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32438 mRNA. Translation: AAC52375.1.
UniGeneiRn.84083.

Genome annotation databases

UCSCiRGD:3563. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32438 mRNA. Translation: AAC52375.1 .
UniGenei Rn.84083.

3D structure databases

ProteinModelPortali P49807.
SMRi P49807. Positions 1-66.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000027763.

PTM databases

PhosphoSitei P49807.

Proteomic databases

PaxDbi P49807.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:3563. rat.

Organism-specific databases

RGDi 3563. Rgs11.

Phylogenomic databases

eggNOGi NOG327614.
HOGENOMi HOG000220864.
InParanoidi P49807.
PhylomeDBi P49807.

Miscellaneous databases

PROi P49807.

Gene expression databases

ExpressionAtlasi P49807. baseline and differential.
Genevestigatori P49807.

Family and domain databases

InterProi IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SUPFAMi SSF48097. SSF48097. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins."
    Koelle M.R., Horvitz H.R.
    Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRGS11_RAT
AccessioniPrimary (citable) accession number: P49807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3