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Protein

Regulator of G-protein signaling 11

Gene

Rgs11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

GO - Molecular functioni

  • GTPase activator activity Source: RGD

GO - Biological processi

  • positive regulation of GTPase activity Source: GOC
  • regulation of G-protein coupled receptor protein signaling pathway Source: RGD
  • termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 11
Short name:
RGS11
Gene namesi
Name:Rgs11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3563. Rgs11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›66›66Regulator of G-protein signaling 11PRO_0000204212Add
BLAST

Proteomic databases

PaxDbiP49807.

PTM databases

PhosphoSiteiP49807.

Expressioni

Gene expression databases

ExpressionAtlasiP49807. baseline and differential.

Interactioni

Subunit structurei

Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027763.

Structurei

3D structure databases

ProteinModelPortaliP49807.
SMRiP49807. Positions 1-66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – ›66›66RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG327614.
HOGENOMiHOG000220864.
InParanoidiP49807.
PhylomeDBiP49807.

Family and domain databases

InterProiIPR016137. RGS.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SUPFAMiSSF48097. SSF48097. 1 hit.

Sequencei

Sequence statusi: Fragment.

P49807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EACEELRFGG QAQVPTLVDS VYQQFLAPGA ARWINIDSRT MEWTLEGLRQ
60
PHRYVLDAAQ LHIYML
Length:66
Mass (Da):7,605
Last modified:October 1, 1996 - v1
Checksum:i5E95CA702B03F287
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei66 – 661

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32438 mRNA. Translation: AAC52375.1.
UniGeneiRn.84083.

Genome annotation databases

UCSCiRGD:3563. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32438 mRNA. Translation: AAC52375.1.
UniGeneiRn.84083.

3D structure databases

ProteinModelPortaliP49807.
SMRiP49807. Positions 1-66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027763.

PTM databases

PhosphoSiteiP49807.

Proteomic databases

PaxDbiP49807.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3563. rat.

Organism-specific databases

RGDi3563. Rgs11.

Phylogenomic databases

eggNOGiNOG327614.
HOGENOMiHOG000220864.
InParanoidiP49807.
PhylomeDBiP49807.

Miscellaneous databases

PROiP49807.

Gene expression databases

ExpressionAtlasiP49807. baseline and differential.

Family and domain databases

InterProiIPR016137. RGS.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SUPFAMiSSF48097. SSF48097. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins."
    Koelle M.R., Horvitz H.R.
    Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRGS11_RAT
AccessioniPrimary (citable) accession number: P49807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 24, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.