P49807 (RGS11_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of G-protein signaling 11
Short name=RGS11

Gene names

Name:

Rgs11

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	66 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
Subunit structure	Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 By similarity.
Sequence similarities	Contains 1 RGS domain.

Ontologies

Keywords
Molecular function	Signal transduction inhibitor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of G-protein coupled receptor protein signaling pathway Traceable author statement PubMed 9315921. Source: RGD termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome dendrite terminus Inferred from electronic annotation. Source: Compara plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome protein complex Inferred from electronic annotation. Source: Compara
Molecular_function	GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›66	›66	Regulator of G-protein signaling 11		PRO_0000204212
Regions
	Domain	‹1 – ›66	›66	RGS
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	66	1

Sequences

	Sequence		Length	Mass (Da)
	P49807 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 5E95CA702B03F287	FASTA	66	7,605
	10 20 30 40 50 60 EACEELRFGG QAQVPTLVDS VYQQFLAPGA ARWINIDSRT MEWTLEGLRQ PHRYVLDAAQ LHIYML

References

[1]	"EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins." Koelle M.R., Horvitz H.R. Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U32438 mRNA. Translation: AAC52375.1.
IPI	IPI00957698.
UniGene	Rn.84083.
3D structure databases
ProteinModelPortal	P49807.
SMR	P49807. Positions 1-66.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000027763.
PTM databases
PhosphoSite	P49807.
Proteomic databases
PaxDb	P49807.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:3563. rat.
Organism-specific databases
RGD	3563. Rgs11.
Phylogenomic databases
eggNOG	NOG327614.
HOGENOM	HOG000220864.
InParanoid	P49807.
OrthoDB	EOG44XJGT.
Gene expression databases
Genevestigator	P49807.
Family and domain databases
InterPro	IPR000342. Regulat_G_prot_signal. IPR016137. Regulat_G_prot_signal_superfam. [Graphical view]
Pfam	PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR01301. RGSPROTEIN.
SUPFAM	SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS50132. RGS. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RGS11_RAT

Accession

Primary (citable) accession number: P49807

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program