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Protein

Regulator of G-protein signaling 11

Gene

Rgs11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

GO - Molecular functioni

  • GTPase activator activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 11
Short name:
RGS11
Gene namesi
Name:Rgs11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3563. Rgs11.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000204212‹1 – ›66Regulator of G-protein signaling 11Add BLAST›66

Proteomic databases

PaxDbiP49807.

PTM databases

PhosphoSitePlusiP49807.

Interactioni

Subunit structurei

Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027763.

Structurei

3D structure databases

ProteinModelPortaliP49807.
SMRiP49807.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini‹1 – ›66RGSPROSITE-ProRule annotationAdd BLAST›66

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
HOGENOMiHOG000220864.
InParanoidiP49807.
PhylomeDBiP49807.

Family and domain databases

InterProiView protein in InterPro
IPR016137. RGS.
PfamiView protein in Pfam
PF00615. RGS. 1 hit.
PRINTSiPR01301. RGSPROTEIN.
SUPFAMiSSF48097. SSF48097. 1 hit.

Sequencei

Sequence statusi: Fragment.

P49807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EACEELRFGG QAQVPTLVDS VYQQFLAPGA ARWINIDSRT MEWTLEGLRQ
60
PHRYVLDAAQ LHIYML
Length:66
Mass (Da):7,605
Last modified:October 1, 1996 - v1
Checksum:i5E95CA702B03F287
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei661

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32438 mRNA. Translation: AAC52375.1.
UniGeneiRn.84083.

Genome annotation databases

UCSCiRGD:3563. rat.

Similar proteinsi

Entry informationi

Entry nameiRGS11_RAT
AccessioniPrimary (citable) accession number: P49807
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: August 30, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome