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P49806

- RGS10_RAT

UniProt

P49806 - RGS10_RAT

Protein

Regulator of G-protein signaling 10

Gene

Rgs10

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein By similarity.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. regulation of G-protein coupled receptor protein signaling pathway Source: RGD
    3. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 10
    Short name:
    RGS10
    Gene namesi
    Name:Rgs10
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3562. Rgs10.

    Subcellular locationi

    GO - Cellular componenti

    1. axon terminus Source: RGD
    2. cytoplasm Source: RefGenome
    3. dendritic spine Source: RGD
    4. neuronal cell body Source: RGD
    5. nucleus Source: RGD
    6. plasma membrane Source: RefGenome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›66›66Regulator of G-protein signaling 10PRO_0000204209Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi3 – 31S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP49806.

    Expressioni

    Gene expression databases

    GenevestigatoriP49806.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000027375.

    Structurei

    3D structure databases

    ProteinModelPortaliP49806.
    SMRiP49806. Positions 1-66.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini‹1 – ›66›66RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG271158.
    HOGENOMiHOG000233512.

    Family and domain databases

    InterProiIPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P49806-1 [UniParc]FASTAAdd to Basket

    « Hide

    LACEDFKKTE DKKQMQEKAK KIYMTFLSNK ASSQVNVEGQ SRLTEKILEE   50
    PHPLMFQKLQ DQIFNL 66
    Length:66
    Mass (Da):7,776
    Last modified:October 1, 1996 - v1
    Checksum:i052DBC45DA024251
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei66 – 661

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32437 mRNA. Translation: AAC52374.1.
    UniGeneiRn.23957.

    Genome annotation databases

    UCSCiRGD:3562. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32437 mRNA. Translation: AAC52374.1 .
    UniGenei Rn.23957.

    3D structure databases

    ProteinModelPortali P49806.
    SMRi P49806. Positions 1-66.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000027375.

    Proteomic databases

    PRIDEi P49806.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:3562. rat.

    Organism-specific databases

    RGDi 3562. Rgs10.

    Phylogenomic databases

    eggNOGi NOG271158.
    HOGENOMi HOG000233512.

    Miscellaneous databases

    PROi P49806.

    Gene expression databases

    Genevestigatori P49806.

    Family and domain databases

    InterProi IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins."
      Koelle M.R., Horvitz H.R.
      Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiRGS10_RAT
    AccessioniPrimary (citable) accession number: P49806
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3