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P49806

- RGS10_RAT

UniProt

P49806 - RGS10_RAT

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Protein

Regulator of G-protein signaling 10

Gene

Rgs10

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein (By similarity).By similarity

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome

GO - Biological processi

  1. positive regulation of GTPase activity Source: GOC
  2. regulation of G-protein coupled receptor protein signaling pathway Source: RGD
  3. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 10
Short name:
RGS10
Gene namesi
Name:Rgs10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3562. Rgs10.

Subcellular locationi

GO - Cellular componenti

  1. axon terminus Source: RGD
  2. cytoplasm Source: RefGenome
  3. dendritic spine Source: RGD
  4. neuronal cell body Source: RGD
  5. nucleus Source: RGD
  6. plasma membrane Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›66›66Regulator of G-protein signaling 10PRO_0000204209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi3 – 31S-palmitoyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRIDEiP49806.

Expressioni

Gene expression databases

ExpressionAtlasiP49806. baseline and differential.
GenevestigatoriP49806.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027375.

Structurei

3D structure databases

ProteinModelPortaliP49806.
SMRiP49806. Positions 1-66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – ›66›66RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG271158.
HOGENOMiHOG000233512.
InParanoidiP49806.

Family and domain databases

InterProiIPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P49806-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
LACEDFKKTE DKKQMQEKAK KIYMTFLSNK ASSQVNVEGQ SRLTEKILEE
60
PHPLMFQKLQ DQIFNL
Length:66
Mass (Da):7,776
Last modified:October 1, 1996 - v1
Checksum:i052DBC45DA024251
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei66 – 661

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32437 mRNA. Translation: AAC52374.1.
UniGeneiRn.23957.

Genome annotation databases

UCSCiRGD:3562. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32437 mRNA. Translation: AAC52374.1 .
UniGenei Rn.23957.

3D structure databases

ProteinModelPortali P49806.
SMRi P49806. Positions 1-66.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000027375.

Proteomic databases

PRIDEi P49806.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:3562. rat.

Organism-specific databases

RGDi 3562. Rgs10.

Phylogenomic databases

eggNOGi NOG271158.
HOGENOMi HOG000233512.
InParanoidi P49806.

Miscellaneous databases

PROi P49806.

Gene expression databases

ExpressionAtlasi P49806. baseline and differential.
Genevestigatori P49806.

Family and domain databases

InterProi IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SUPFAMi SSF48097. SSF48097. 1 hit.
PROSITEi PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins."
    Koelle M.R., Horvitz H.R.
    Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRGS10_RAT
AccessioniPrimary (citable) accession number: P49806
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3