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P49806 (RGS10_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 10

Short name=RGS10
Gene names
Name:Rgs10
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length66 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein By similarity.

Sequence similarities

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›66›66Regulator of G-protein signaling 10
PRO_0000204209

Regions

Domain‹1 – ›66›66RGS

Amino acid modifications

Lipidation31S-palmitoyl cysteine By similarity

Experimental info

Non-terminal residue11
Non-terminal residue661

Sequences

Sequence LengthMass (Da)Tools
P49806 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 052DBC45DA024251

FASTA667,776
        10         20         30         40         50         60 
LACEDFKKTE DKKQMQEKAK KIYMTFLSNK ASSQVNVEGQ SRLTEKILEE PHPLMFQKLQ 


DQIFNL 

« Hide

References

[1]"EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins."
Koelle M.R., Horvitz H.R.
Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U32437 mRNA. Translation: AAC52374.1.
UniGeneRn.23957.

3D structure databases

ProteinModelPortalP49806.
SMRP49806. Positions 1-66.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000027375.

Proteomic databases

PRIDEP49806.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:3562. rat.

Organism-specific databases

RGD3562. Rgs10.

Phylogenomic databases

eggNOGNOG271158.
HOGENOMHOG000233512.

Gene expression databases

GenevestigatorP49806.

Family and domain databases

InterProIPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamPF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SUPFAMSSF48097. SSF48097. 1 hit.
PROSITEPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP49806.

Entry information

Entry nameRGS10_RAT
AccessionPrimary (citable) accession number: P49806
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families