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P49806

- RGS10_RAT

UniProt

P49806 - RGS10_RAT

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Protein
Regulator of G-protein signaling 10
Gene
Rgs10
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein By similarity.

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome

GO - Biological processi

  1. positive regulation of GTPase activity Source: GOC
  2. regulation of G-protein coupled receptor protein signaling pathway Source: RGD
  3. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 10
Short name:
RGS10
Gene namesi
Name:Rgs10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3562. Rgs10.

Subcellular locationi

GO - Cellular componenti

  1. axon terminus Source: RGD
  2. cytoplasm Source: RefGenome
  3. dendritic spine Source: RGD
  4. neuronal cell body Source: RGD
  5. nucleus Source: RGD
  6. plasma membrane Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›66›66Regulator of G-protein signaling 10
PRO_0000204209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi3 – 31S-palmitoyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRIDEiP49806.

Expressioni

Gene expression databases

GenevestigatoriP49806.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027375.

Structurei

3D structure databases

ProteinModelPortaliP49806.
SMRiP49806. Positions 1-66.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – ›66›66RGS
Add
BLAST

Sequence similaritiesi

Contains 1 RGS domain.

Phylogenomic databases

eggNOGiNOG271158.
HOGENOMiHOG000233512.

Family and domain databases

InterProiIPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P49806-1 [UniParc]FASTAAdd to Basket

« Hide

LACEDFKKTE DKKQMQEKAK KIYMTFLSNK ASSQVNVEGQ SRLTEKILEE   50
PHPLMFQKLQ DQIFNL 66
Length:66
Mass (Da):7,776
Last modified:October 1, 1996 - v1
Checksum:i052DBC45DA024251
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei66 – 661

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32437 mRNA. Translation: AAC52374.1.
UniGeneiRn.23957.

Genome annotation databases

UCSCiRGD:3562. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32437 mRNA. Translation: AAC52374.1 .
UniGenei Rn.23957.

3D structure databases

ProteinModelPortali P49806.
SMRi P49806. Positions 1-66.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000027375.

Proteomic databases

PRIDEi P49806.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:3562. rat.

Organism-specific databases

RGDi 3562. Rgs10.

Phylogenomic databases

eggNOGi NOG271158.
HOGENOMi HOG000233512.

Miscellaneous databases

PROi P49806.

Gene expression databases

Genevestigatori P49806.

Family and domain databases

InterProi IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SUPFAMi SSF48097. SSF48097. 1 hit.
PROSITEi PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins."
    Koelle M.R., Horvitz H.R.
    Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRGS10_RAT
AccessioniPrimary (citable) accession number: P49806
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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