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P49805

- RGS9_RAT

UniProt

P49805 - RGS9_RAT

Protein

Regulator of G-protein signaling 9

Gene

Rgs9

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 3 (30 May 2000)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(t)-alpha. Involved in phototransduction; key element in the recovery phase of visual transduction By similarity.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: RGD
    2. protein complex binding Source: RGD
    3. signal transducer activity Source: InterPro

    GO - Biological processi

    1. dopamine receptor signaling pathway Source: RGD
    2. intracellular signal transduction Source: InterPro
    3. nervous system development Source: RGD
    4. positive regulation of GTPase activity Source: RGD
    5. regulation of G-protein coupled receptor protein signaling pathway Source: RGD
    6. response to estrogen Source: RGD
    7. termination of G-protein coupled receptor signaling pathway Source: InterPro
    8. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Keywords - Biological processi

    Sensory transduction, Vision

    Enzyme and pathway databases

    ReactomeiREACT_227662. Inactivation, recovery and regulation of the phototransduction cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 9
    Short name:
    RGS9
    Gene namesi
    Name:Rgs9
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi3572. Rgs9.

    Subcellular locationi

    Membrane; Peripheral membrane protein
    Note: Targeted to the membrane via its interaction with RGS9BP.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. heterotrimeric G-protein complex Source: InterPro
    3. nucleus Source: RGD
    4. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 677677Regulator of G-protein signaling 9PRO_0000204205Add
    BLAST

    Proteomic databases

    PaxDbiP49805.
    PRIDEiP49805.

    Expressioni

    Tissue specificityi

    Expressed in the central nervous system. Isoform RGS9L is found in striatum, hypothalamus and nucleus accumbens while isoform RGS9S is expressed in retina and pineal gland.

    Gene expression databases

    GenevestigatoriP49805.

    Interactioni

    Subunit structurei

    Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5. Component of the RGS9-1-Gbeta5 complex composed of RGS9 (RGS9-1), Gbeta5 (GNB5) and RGS9BP Probable.Curated

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000005076.

    Structurei

    3D structure databases

    ProteinModelPortaliP49805.
    SMRiP49805. Positions 7-421.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 10576DEPPROSITE-ProRule annotationAdd
    BLAST
    Domaini219 – 28062G protein gammaAdd
    BLAST
    Domaini295 – 416122RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 1 G protein gamma domain.Curated
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG327614.
    GeneTreeiENSGT00700000104259.
    HOGENOMiHOG000220864.
    HOVERGENiHBG007404.
    InParanoidiP49805.
    KOiK13765.
    OMAiLVKDMQN.
    OrthoDBiEOG7BZVS5.
    PhylomeDBiP49805.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.196.10. 1 hit.
    4.10.260.10. 1 hit.
    InterProiIPR000591. DEP_dom.
    IPR015898. G-protein_gamma-like_dom.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00610. DEP. 1 hit.
    PF00631. G-gamma. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00049. DEP. 1 hit.
    SM00224. GGL. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF48670. SSF48670. 1 hit.
    PROSITEiPS50186. DEP. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform RGS9L (identifier: P49805-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTIRHQGQQY RPRMAFLQKI EALVKDMQNP ETGVRMQNQR VLVTSVPHAM    50
    TGGDVLQWII QRLWISNLEA QNLGNFIVKY GYIYPLQDPK NLVLKPDSSL 100
    YRFQTPYFWP TQQWPAEDTD YAIYLAKRNI KKKGILEEYE KENYDFLNKK 150
    INYKWDFVIM QAKEQYRTGK ERNKADRYAL DCQEKAYWLV HRSPPGMNNV 200
    LDYGLDRVTN PNEVKKQTVT AVRKEIMYYQ QALMRSTVKS SVSLGGIVKY 250
    SEQFSSNDAI MSGCLPSNPW ITDDTQFWDL NAKLVEVPTK MRVERWAFNF 300
    SELIRDPKGR QSFQYFLKKE FSGENLGFWE ACEDLKYGDQ SKVKEKAEEI 350
    YKLFLAPGAR RWINIDGKTM DITVKGLRHP HRYVLDAAQT HIYMLMKKDS 400
    YARYLKSPIY KEMLAKAIEP QETTKRSSTL PFMRRHLRSS PSPVILRQLE 450
    EEERAREAAN TVDITQPGQH LAPSPHLAVY TGTCVPPSPS SPFSPSCRSP 500
    RKPFPSPSRF IRRPSIAICP SPIRVALEGS SGLEGKGEAS WSGANPGPPV 550
    TESIETSVDR SRPHSQPRAP LKARAALSLG RFLRRGCLAS PVFARLSPKC 600
    PSVSHGKVQP LGDMGQQLPR LKPKKVANFF QIKMEMPTDS GPCLMDSDDP 650
    GAGESGDQTT EKEVICPWES LAEGKAG 677
    Length:677
    Mass (Da):77,131
    Last modified:May 30, 2000 - v3
    Checksum:i39F403E3D3C37A67
    GO
    Isoform RGS9S (identifier: P49805-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         467-677: Missing.

    Show »
    Length:466
    Mass (Da):54,808
    Checksum:iE2C79A3F16EEB6ED
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei467 – 677211Missing in isoform RGS9S. CuratedVSP_005680Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071475 mRNA. Translation: AAC64039.1.
    AB019145 mRNA. Translation: BAA34051.1.
    AF038006 mRNA. Translation: AAC01959.1.
    U32433 mRNA. Translation: AAC52370.1.
    RefSeqiNP_062097.1. NM_019224.2. [P49805-1]
    UniGeneiRn.10903.

    Genome annotation databases

    EnsembliENSRNOT00000005076; ENSRNOP00000005076; ENSRNOG00000003800. [P49805-1]
    GeneIDi29481.
    KEGGirno:29481.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071475 mRNA. Translation: AAC64039.1 .
    AB019145 mRNA. Translation: BAA34051.1 .
    AF038006 mRNA. Translation: AAC01959.1 .
    U32433 mRNA. Translation: AAC52370.1 .
    RefSeqi NP_062097.1. NM_019224.2. [P49805-1 ]
    UniGenei Rn.10903.

    3D structure databases

    ProteinModelPortali P49805.
    SMRi P49805. Positions 7-421.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000005076.

    Proteomic databases

    PaxDbi P49805.
    PRIDEi P49805.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000005076 ; ENSRNOP00000005076 ; ENSRNOG00000003800 . [P49805-1 ]
    GeneIDi 29481.
    KEGGi rno:29481.

    Organism-specific databases

    CTDi 8787.
    RGDi 3572. Rgs9.

    Phylogenomic databases

    eggNOGi NOG327614.
    GeneTreei ENSGT00700000104259.
    HOGENOMi HOG000220864.
    HOVERGENi HBG007404.
    InParanoidi P49805.
    KOi K13765.
    OMAi LVKDMQN.
    OrthoDBi EOG7BZVS5.
    PhylomeDBi P49805.

    Enzyme and pathway databases

    Reactomei REACT_227662. Inactivation, recovery and regulation of the phototransduction cascade.

    Miscellaneous databases

    NextBioi 609332.
    PROi P49805.

    Gene expression databases

    Genevestigatori P49805.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.196.10. 1 hit.
    4.10.260.10. 1 hit.
    InterProi IPR000591. DEP_dom.
    IPR015898. G-protein_gamma-like_dom.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00610. DEP. 1 hit.
    PF00631. G-gamma. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00049. DEP. 1 hit.
    SM00224. GGL. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF48670. SSF48670. 1 hit.
    PROSITEi PS50186. DEP. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of human and rat RGS9L, a novel splice variant enriched in dopamine target regions, and chromosomal localization of the RGS9 gene."
      Granneman J.G., Zhai Y., Zhu Z., Bannon M.J., Burchett S.A., Schmidt C.J., Andrade R., Cooper J.
      Mol. Pharmacol. 54:687-694(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
      Strain: Sprague-Dawley.
      Tissue: Hypothalamus.
    2. "A long form of rat regulator of G-protein signaling 9 (RGS9)."
      Zhou J., Moroi K., Homma S., Usui H., Nishiyama M., Kimura S.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RGS9L).
      Tissue: Brain.
    3. "RGS9: a regulator of G-protein signalling with specific expression in rat and mouse striatum."
      Thomas E.A., Danielson P.E., Sutcliffe J.G.
      J. Neurosci. Res. 52:118-124(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 234-677 (ISOFORM RGS9L).
      Strain: Sprague-Dawley.
      Tissue: Cerebellum, Corpus striatum and Hippocampus.
    4. "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins."
      Koelle M.R., Horvitz H.R.
      Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 330-395.
      Tissue: Brain.

    Entry informationi

    Entry nameiRGS9_RAT
    AccessioniPrimary (citable) accession number: P49805
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 113 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3