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Protein

Regulator of G-protein signaling 9

Gene

Rgs9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity).By similarity

GO - Molecular functioni

  • GTPase activator activity Source: RGD
  • signal transducer activity Source: InterPro

GO - Biological processi

  • dopamine receptor signaling pathway Source: RGD
  • intracellular signal transduction Source: InterPro
  • negative regulation of signal transduction Source: UniProtKB-KW
  • nervous system development Source: RGD
  • positive regulation of GTPase activity Source: RGD
  • regulation of G-protein coupled receptor protein signaling pathway Source: RGD
  • response to estrogen Source: RGD
  • visual perception Source: UniProtKB-KW

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processSensory transduction, Vision

Enzyme and pathway databases

ReactomeiR-RNO-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-RNO-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 9
Short name:
RGS9
Gene namesi
Name:Rgs9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi3572 Rgs9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042051 – 677Regulator of G-protein signaling 9Add BLAST677

Proteomic databases

PaxDbiP49805
PRIDEiP49805

PTM databases

CarbonylDBiP49805

Expressioni

Tissue specificityi

Expressed in the central nervous system. Isoform RGS9L is found in striatum, hypothalamus and nucleus accumbens while isoform RGS9S is expressed in retina and pineal gland.

Gene expression databases

BgeeiENSRNOG00000003800
GenevisibleiP49805 RN

Interactioni

Subunit structurei

Heterodimer with GNB5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5. Component of the RGS9-1-Gbeta5 complex composed of RGS9 (RGS9-1), Gbeta5 (GNB5) and RGS9BP. Interacts with PDE6G and GNAT1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005076

Structurei

3D structure databases

ProteinModelPortaliP49805
SMRiP49805
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 105DEPPROSITE-ProRule annotationAdd BLAST76
Domaini219 – 280G protein gammaAdd BLAST62
Domaini295 – 416RGSPROSITE-ProRule annotationAdd BLAST122

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142
HOGENOMiHOG000220864
HOVERGENiHBG007404
InParanoidiP49805
KOiK13765
OMAiKEVICPW
OrthoDBiEOG091G05MO
PhylomeDBiP49805

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di1.10.10.10, 1 hit
4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00631 G-gamma, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00224 GGL, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48097 SSF48097, 1 hit
SSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50132 RGS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform RGS9L (identifier: P49805-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTIRHQGQQY RPRMAFLQKI EALVKDMQNP ETGVRMQNQR VLVTSVPHAM
60 70 80 90 100
TGGDVLQWII QRLWISNLEA QNLGNFIVKY GYIYPLQDPK NLVLKPDSSL
110 120 130 140 150
YRFQTPYFWP TQQWPAEDTD YAIYLAKRNI KKKGILEEYE KENYDFLNKK
160 170 180 190 200
INYKWDFVIM QAKEQYRTGK ERNKADRYAL DCQEKAYWLV HRSPPGMNNV
210 220 230 240 250
LDYGLDRVTN PNEVKKQTVT AVRKEIMYYQ QALMRSTVKS SVSLGGIVKY
260 270 280 290 300
SEQFSSNDAI MSGCLPSNPW ITDDTQFWDL NAKLVEVPTK MRVERWAFNF
310 320 330 340 350
SELIRDPKGR QSFQYFLKKE FSGENLGFWE ACEDLKYGDQ SKVKEKAEEI
360 370 380 390 400
YKLFLAPGAR RWINIDGKTM DITVKGLRHP HRYVLDAAQT HIYMLMKKDS
410 420 430 440 450
YARYLKSPIY KEMLAKAIEP QETTKRSSTL PFMRRHLRSS PSPVILRQLE
460 470 480 490 500
EEERAREAAN TVDITQPGQH LAPSPHLAVY TGTCVPPSPS SPFSPSCRSP
510 520 530 540 550
RKPFPSPSRF IRRPSIAICP SPIRVALEGS SGLEGKGEAS WSGANPGPPV
560 570 580 590 600
TESIETSVDR SRPHSQPRAP LKARAALSLG RFLRRGCLAS PVFARLSPKC
610 620 630 640 650
PSVSHGKVQP LGDMGQQLPR LKPKKVANFF QIKMEMPTDS GPCLMDSDDP
660 670
GAGESGDQTT EKEVICPWES LAEGKAG
Length:677
Mass (Da):77,131
Last modified:May 30, 2000 - v3
Checksum:i39F403E3D3C37A67
GO
Isoform RGS9S (identifier: P49805-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     467-677: Missing.

Show »
Length:466
Mass (Da):54,808
Checksum:iE2C79A3F16EEB6ED
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005680467 – 677Missing in isoform RGS9S. CuratedAdd BLAST211

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071475 mRNA Translation: AAC64039.1
AB019145 mRNA Translation: BAA34051.1
AF038006 mRNA Translation: AAC01959.1
U32433 mRNA Translation: AAC52370.1
RefSeqiNP_062097.1, NM_019224.2 [P49805-1]
UniGeneiRn.10903

Genome annotation databases

EnsembliENSRNOT00000005076; ENSRNOP00000005076; ENSRNOG00000003800 [P49805-1]
GeneIDi29481
KEGGirno:29481

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRGS9_RAT
AccessioniPrimary (citable) accession number: P49805
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: April 25, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health