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P49805

- RGS9_RAT

UniProt

P49805 - RGS9_RAT

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Protein

Regulator of G-protein signaling 9

Gene

Rgs9

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(t)-alpha. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity).By similarity

GO - Molecular functioni

  1. GTPase activator activity Source: RGD
  2. protein complex binding Source: RGD
  3. signal transducer activity Source: InterPro

GO - Biological processi

  1. dopamine receptor signaling pathway Source: RGD
  2. intracellular signal transduction Source: InterPro
  3. nervous system development Source: RGD
  4. positive regulation of GTPase activity Source: RGD
  5. regulation of G-protein coupled receptor protein signaling pathway Source: RGD
  6. response to estrogen Source: RGD
  7. termination of G-protein coupled receptor signaling pathway Source: InterPro
  8. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Keywords - Biological processi

Sensory transduction, Vision

Enzyme and pathway databases

ReactomeiREACT_227662. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 9
Short name:
RGS9
Gene namesi
Name:Rgs9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi3572. Rgs9.

Subcellular locationi

Membrane; Peripheral membrane protein
Note: Targeted to the membrane via its interaction with RGS9BP.By similarity

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. heterotrimeric G-protein complex Source: InterPro
  3. nucleus Source: RGD
  4. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 677677Regulator of G-protein signaling 9PRO_0000204205Add
BLAST

Proteomic databases

PaxDbiP49805.
PRIDEiP49805.

Expressioni

Tissue specificityi

Expressed in the central nervous system. Isoform RGS9L is found in striatum, hypothalamus and nucleus accumbens while isoform RGS9S is expressed in retina and pineal gland.

Gene expression databases

ExpressionAtlasiP49805. baseline.
GenevestigatoriP49805.

Interactioni

Subunit structurei

Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5. Component of the RGS9-1-Gbeta5 complex composed of RGS9 (RGS9-1), Gbeta5 (GNB5) and RGS9BP (Probable).Curated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005076.

Structurei

3D structure databases

ProteinModelPortaliP49805.
SMRiP49805. Positions 7-421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 10576DEPPROSITE-ProRule annotationAdd
BLAST
Domaini219 – 28062G protein gammaAdd
BLAST
Domaini295 – 416122RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 G protein gamma domain.Curated
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG327614.
GeneTreeiENSGT00760000119142.
HOGENOMiHOG000220864.
HOVERGENiHBG007404.
InParanoidiP49805.
KOiK13765.
OMAiLVKDMQN.
OrthoDBiEOG7BZVS5.
PhylomeDBiP49805.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform RGS9L (identifier: P49805-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTIRHQGQQY RPRMAFLQKI EALVKDMQNP ETGVRMQNQR VLVTSVPHAM
60 70 80 90 100
TGGDVLQWII QRLWISNLEA QNLGNFIVKY GYIYPLQDPK NLVLKPDSSL
110 120 130 140 150
YRFQTPYFWP TQQWPAEDTD YAIYLAKRNI KKKGILEEYE KENYDFLNKK
160 170 180 190 200
INYKWDFVIM QAKEQYRTGK ERNKADRYAL DCQEKAYWLV HRSPPGMNNV
210 220 230 240 250
LDYGLDRVTN PNEVKKQTVT AVRKEIMYYQ QALMRSTVKS SVSLGGIVKY
260 270 280 290 300
SEQFSSNDAI MSGCLPSNPW ITDDTQFWDL NAKLVEVPTK MRVERWAFNF
310 320 330 340 350
SELIRDPKGR QSFQYFLKKE FSGENLGFWE ACEDLKYGDQ SKVKEKAEEI
360 370 380 390 400
YKLFLAPGAR RWINIDGKTM DITVKGLRHP HRYVLDAAQT HIYMLMKKDS
410 420 430 440 450
YARYLKSPIY KEMLAKAIEP QETTKRSSTL PFMRRHLRSS PSPVILRQLE
460 470 480 490 500
EEERAREAAN TVDITQPGQH LAPSPHLAVY TGTCVPPSPS SPFSPSCRSP
510 520 530 540 550
RKPFPSPSRF IRRPSIAICP SPIRVALEGS SGLEGKGEAS WSGANPGPPV
560 570 580 590 600
TESIETSVDR SRPHSQPRAP LKARAALSLG RFLRRGCLAS PVFARLSPKC
610 620 630 640 650
PSVSHGKVQP LGDMGQQLPR LKPKKVANFF QIKMEMPTDS GPCLMDSDDP
660 670
GAGESGDQTT EKEVICPWES LAEGKAG
Length:677
Mass (Da):77,131
Last modified:May 30, 2000 - v3
Checksum:i39F403E3D3C37A67
GO
Isoform RGS9S (identifier: P49805-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     467-677: Missing.

Show »
Length:466
Mass (Da):54,808
Checksum:iE2C79A3F16EEB6ED
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei467 – 677211Missing in isoform RGS9S. CuratedVSP_005680Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071475 mRNA. Translation: AAC64039.1.
AB019145 mRNA. Translation: BAA34051.1.
AF038006 mRNA. Translation: AAC01959.1.
U32433 mRNA. Translation: AAC52370.1.
RefSeqiNP_062097.1. NM_019224.2. [P49805-1]
UniGeneiRn.10903.

Genome annotation databases

EnsembliENSRNOT00000005076; ENSRNOP00000005076; ENSRNOG00000003800. [P49805-1]
GeneIDi29481.
KEGGirno:29481.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071475 mRNA. Translation: AAC64039.1 .
AB019145 mRNA. Translation: BAA34051.1 .
AF038006 mRNA. Translation: AAC01959.1 .
U32433 mRNA. Translation: AAC52370.1 .
RefSeqi NP_062097.1. NM_019224.2. [P49805-1 ]
UniGenei Rn.10903.

3D structure databases

ProteinModelPortali P49805.
SMRi P49805. Positions 7-421.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000005076.

Proteomic databases

PaxDbi P49805.
PRIDEi P49805.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000005076 ; ENSRNOP00000005076 ; ENSRNOG00000003800 . [P49805-1 ]
GeneIDi 29481.
KEGGi rno:29481.

Organism-specific databases

CTDi 8787.
RGDi 3572. Rgs9.

Phylogenomic databases

eggNOGi NOG327614.
GeneTreei ENSGT00760000119142.
HOGENOMi HOG000220864.
HOVERGENi HBG007404.
InParanoidi P49805.
KOi K13765.
OMAi LVKDMQN.
OrthoDBi EOG7BZVS5.
PhylomeDBi P49805.

Enzyme and pathway databases

Reactomei REACT_227662. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

NextBioi 609332.
PROi P49805.

Gene expression databases

ExpressionAtlasi P49805. baseline.
Genevestigatori P49805.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProi IPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEi PS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of human and rat RGS9L, a novel splice variant enriched in dopamine target regions, and chromosomal localization of the RGS9 gene."
    Granneman J.G., Zhai Y., Zhu Z., Bannon M.J., Burchett S.A., Schmidt C.J., Andrade R., Cooper J.
    Mol. Pharmacol. 54:687-694(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
    Strain: Sprague-Dawley.
    Tissue: Hypothalamus.
  2. "A long form of rat regulator of G-protein signaling 9 (RGS9)."
    Zhou J., Moroi K., Homma S., Usui H., Nishiyama M., Kimura S.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RGS9L).
    Tissue: Brain.
  3. "RGS9: a regulator of G-protein signalling with specific expression in rat and mouse striatum."
    Thomas E.A., Danielson P.E., Sutcliffe J.G.
    J. Neurosci. Res. 52:118-124(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 234-677 (ISOFORM RGS9L).
    Strain: Sprague-Dawley.
    Tissue: Cerebellum, Corpus striatum and Hippocampus.
  4. "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins."
    Koelle M.R., Horvitz H.R.
    Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 330-395.
    Tissue: Brain.

Entry informationi

Entry nameiRGS9_RAT
AccessioniPrimary (citable) accession number: P49805
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: October 29, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3