P49804 (RGS8_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of G-protein signaling 8
Short name=RGS8

Gene names

Name:

Rgs8

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3. Ref.1
Tissue specificity	Expressed at high levels in brain. Very little expression detected in other tissues.
Developmental stage	Detected in 13-day old embryos. Expression increases gradually in later embryos and markedly in neonates to adults.
Sequence similarities	Contains 1 RGS domain.

Ontologies

Keywords
Molecular function	Signal transduction inhibitor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 180	180	Regulator of G-protein signaling 8		PRO_0000204201
Regions
	Domain	56 – 171	116	RGS

Sequences

	Sequence		Length	Mass (Da)
	P49804 [UniParc]. Last modified December 15, 1998. Version 2. Checksum: 00FC35E4C278E857	FASTA	180	20,949
	10 20 30 40 50 60 MAALLMPRRN KGMRTRLGCL SHKSDSCSDF TAILPDKPNR ALKRLSTEEA TRWADSFDVL 70 80 90 100 110 120 LSHKYGVAAF RAFLKTEFSE ENLEFWLACE EFKKTRSTAK LVTKAHRIFE EFVDVQAPRE 130 140 150 160 170 180 VNIDFQTREA TRKNMQEPSL TCFDQAQGKV HSLMEKDSYP RFLRSKMYLD LLSQSQRRLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"RGS8 accelerates G-protein-mediated modulation of K+ currents." Saitoh O., Kubo Y., Miyatani Y., Asano T., Nakata H. Nature 390:525-528(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. Tissue: Hippocampus.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins." Koelle M.R., Horvitz H.R. Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 87-153. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB006013 mRNA. Translation: BAA23680.1. BC089064 mRNA. Translation: AAH89064.1. U32432 mRNA. Translation: AAC52369.1.
IPI	IPI00198047.
RefSeq	NP_062217.1. NM_019344.2.
UniGene	Rn.89634.
3D structure databases
ProteinModelPortal	P49804.
SMR	P49804. Positions 46-176.
ModBase	Search...
PTM databases
PhosphoSite	P49804.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000003239; ENSRNOP00000003239; ENSRNOG00000002369.
GeneID	54297.
KEGG	rno:54297.
UCSC	RGD:3571. rat.
Organism-specific databases
CTD	85397.
RGD	3571. Rgs8.
Phylogenomic databases
eggNOG	NOG251235.
GeneTree	ENSGT00690000101738.
HOGENOM	HOG000233512.
HOVERGEN	HBG013233.
InParanoid	P49804.
KO	K16449.
OMA	FIDVQAP.
OrthoDB	EOG4RV2SM.
Gene expression databases
Genevestigator	P49804.
GermOnline	ENSRNOG00000002369. Rattus norvegicus.
Family and domain databases
Gene3D	1.10.196.10. 2 hits.
InterPro	IPR000342. Regulat_G_prot_signal. IPR024066. Regulat_G_prot_signal_dom1. IPR016137. Regulat_G_prot_signal_superfam. [Graphical view]
Pfam	PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR01301. RGSPROTEIN.
SMART	SM00315. RGS. 1 hit. [Graphical view]
SUPFAM	SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	610928.

Entry information

Entry name

RGS8_RAT

Accession

Primary (citable) accession number: P49804

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	December 15, 1998
Last modified:	April 3, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program