Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Regulator of G-protein signaling 8

Gene

Rgs8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling.2 Publications

GO - Molecular functioni

  • G-protein alpha-subunit binding Source: UniProtKB
  • GTPase activator activity Source: UniProtKB

GO - Biological processi

  • G-protein coupled acetylcholine receptor signaling pathway Source: UniProtKB
  • negative regulation of signal transduction Source: UniProtKB-KW
  • positive regulation of GTPase activity Source: UniProtKB
  • regulation of dopamine receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 8
Short name:
RGS8
Gene namesi
Name:Rgs8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi3571. Rgs8.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • dendrite Source: UniProtKB
  • extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
  • neuronal cell body membrane Source: UniProtKB
  • nucleus Source: UniProtKB
  • perikaryon Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042011 – 180Regulator of G-protein signaling 8Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP49804.
PRIDEiP49804.

PTM databases

iPTMnetiP49804.
PhosphoSitePlusiP49804.
SwissPalmiP49804.

Expressioni

Tissue specificityi

Expressed at high levels in brain. Very little expression detected in other tissues (PubMed:9394004). Detected in Purkinje cells in the cerebellum (PubMed:12880183).2 Publications

Developmental stagei

Detected in 13-day old embryos. Expression increases gradually in later embryos and markedly in neonates to adults.1 Publication

Gene expression databases

BgeeiENSRNOG00000002369.
ExpressionAtlasiP49804. baseline and differential.
GenevisibleiP49804. RN.

Interactioni

Subunit structurei

Interacts with GNAO1 and GNAI3.1 Publication

GO - Molecular functioni

  • G-protein alpha-subunit binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003239.

Structurei

3D structure databases

ProteinModelPortaliP49804.
SMRiP49804.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 171RGSPROSITE-ProRule annotationAdd BLAST116

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiP49804.
KOiK16449.
OMAiSHKSDSY.
PhylomeDBiP49804.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49804-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALLMPRRN KGMRTRLGCL SHKSDSCSDF TAILPDKPNR ALKRLSTEEA
60 70 80 90 100
TRWADSFDVL LSHKYGVAAF RAFLKTEFSE ENLEFWLACE EFKKTRSTAK
110 120 130 140 150
LVTKAHRIFE EFVDVQAPRE VNIDFQTREA TRKNMQEPSL TCFDQAQGKV
160 170 180
HSLMEKDSYP RFLRSKMYLD LLSQSQRRLS
Length:180
Mass (Da):20,949
Last modified:December 15, 1998 - v2
Checksum:i00FC35E4C278E857
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006013 mRNA. Translation: BAA23680.1.
BC089064 mRNA. Translation: AAH89064.1.
U32432 mRNA. Translation: AAC52369.1.
RefSeqiNP_062217.1. NM_019344.2.
XP_006250078.1. XM_006250016.3.
UniGeneiRn.89634.

Genome annotation databases

EnsembliENSRNOT00000003239; ENSRNOP00000003239; ENSRNOG00000002369.
ENSRNOT00000088329; ENSRNOP00000074194; ENSRNOG00000002369.
GeneIDi54297.
KEGGirno:54297.
UCSCiRGD:3571. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006013 mRNA. Translation: BAA23680.1.
BC089064 mRNA. Translation: AAH89064.1.
U32432 mRNA. Translation: AAC52369.1.
RefSeqiNP_062217.1. NM_019344.2.
XP_006250078.1. XM_006250016.3.
UniGeneiRn.89634.

3D structure databases

ProteinModelPortaliP49804.
SMRiP49804.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003239.

PTM databases

iPTMnetiP49804.
PhosphoSitePlusiP49804.
SwissPalmiP49804.

Proteomic databases

PaxDbiP49804.
PRIDEiP49804.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003239; ENSRNOP00000003239; ENSRNOG00000002369.
ENSRNOT00000088329; ENSRNOP00000074194; ENSRNOG00000002369.
GeneIDi54297.
KEGGirno:54297.
UCSCiRGD:3571. rat.

Organism-specific databases

CTDi85397.
RGDi3571. Rgs8.

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiP49804.
KOiK16449.
OMAiSHKSDSY.
PhylomeDBiP49804.
TreeFamiTF315837.

Miscellaneous databases

PROiP49804.

Gene expression databases

BgeeiENSRNOG00000002369.
ExpressionAtlasiP49804. baseline and differential.
GenevisibleiP49804. RN.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGS8_RAT
AccessioniPrimary (citable) accession number: P49804
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 15, 1998
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.