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P49803 (RGS7_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 7
Short name=RGS7
Gene names
Name:Rgs7
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length477 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer By similarity. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations. May play a role in synaptic vesicle exocytosis. Ref.1

Subunit structure

Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5. Interacts with SNAPIN By similarity.

Tissue specificity

Brain-specific. Predominantly cerebellar granule cells. Ref.1 Ref.3

Post-translational modification

Palmitoylated By similarity.

Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity By similarity.

Sequence similarities

Contains 1 DEP domain.

Contains 1 G protein gamma domain.

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 477477Regulator of G-protein signaling 7
PRO_0000204198

Regions

Domain37 – 11276DEP
Domain255 – 31662G protein gamma
Domain333 – 448116RGS

Amino acid modifications

Modified residue2291Phosphoserine By similarity
Modified residue4341Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P49803 [UniParc].

Last modified February 21, 2001. Version 2.
Checksum: 4BA05410865DDC4A

FASTA47755,691
        10         20         30         40         50         60 
MAQGNNYGQT SNGVAEESPN MLVYRKMEDV IARMQDEKNG IPIRTVKSFL SKIPSVFSGS 

        70         80         90        100        110        120 
DIVQWLIKNL TIEDPVEALH LGTLMAAHGY FFPISDHVLT LKDDGTFYRF QTPYFWPSNC 

       130        140        150        160        170        180 
WEPENTDYAV YLCKRTMQNK ARLELADYEA ESLARLQRAF ARKWEFIFMQ AEAQAKVDKK 

       190        200        210        220        230        240 
RDKIERKILD SQERAFWDVH RPVPGCVNTT EVDIKKSSRM RNPHKTRKSV YGLQNDIRSH 

       250        260        270        280        290        300 
SPTHTPTPET KPPTEDELHR QIKYWQIQLD RHRLKMSKVA DSLLSYTEQY VEYDPFLVPP 

       310        320        330        340        350        360 
DPSNPWLSDD TTFWELEASK EPSQQRVKRW GFGMDEALKD PVGREQFLKF LESEFSSENL 

       370        380        390        400        410        420 
RFWLAVEDLK KRPIREVPSR VQEIWQEFLA PGAPSAINLD SKSYDKTTQN VKEPGRYTFE 

       430        440        450        460        470 
DAQEHIYKLM KSDSYPRFIR SSAYQELLQA KRKGRNIPIF PCHKNCTPTL RASTNLL

« Hide

References

[1]"RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents."
Saitoh O., Kubo Y., Odagiri M., Ichikawa M., Yamagata K., Sekine T.
J. Biol. Chem. 274:9899-9904(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]"EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins."
Koelle M.R., Horvitz H.R.
Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 364-429.
Tissue: Brain.
[3]"Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain."
Gold S.J., Ni Y.G., Dohlman H.G., Nestler E.J.
J. Neurosci. 17:8024-8037(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB024398 mRNA. Translation: BAA75635.1.
U32328 mRNA. Translation: AAC52368.1.
IPIIPI00198046.
RefSeqNP_062216.1. NM_019343.1.
UniGeneRn.204219.

3D structure databases

ProteinModelPortalP49803.
SMRP49803. Positions 320-450.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000046013.

PTM databases

PhosphoSiteP49803.

Proteomic databases

PRIDEP49803.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID54296.
KEGGrno:54296.
UCSCRGD:3570. rat.

Organism-specific databases

CTD6000.
RGD3570. Rgs7.

Phylogenomic databases

eggNOGNOG327614.
HOGENOMHOG000220864.
HOVERGENHBG007404.
InParanoidP49803.
KOK16449.

Gene expression databases

ArrayExpressP49803.
GenevestigatorP49803.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR000342. Regulat_G_prot_signal.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48670. G-protein_gamma-like. 1 hit.
SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITEPS50186. DEP. 1 hit.
PS50058. G_PROTEIN_GAMMA. False negative.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio610924.

Entry information

Entry nameRGS7_RAT
AccessionPrimary (citable) accession number: P49803
Secondary accession number(s): Q9R0R0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 21, 2001
Last modified: May 1, 2013
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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