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P49803

- RGS7_RAT

UniProt

P49803 - RGS7_RAT

Protein

Regulator of G-protein signaling 7

Gene

Rgs7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (21 Feb 2001)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer By similarity. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations. May play a role in synaptic vesicle exocytosis.By similarity1 Publication

    GO - Molecular functioni

    1. G-protein beta-subunit binding Source: RGD
    2. GTPase activator activity Source: RefGenome
    3. protein binding Source: RGD
    4. signal transducer activity Source: InterPro

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: InterPro
    2. intracellular signal transduction Source: InterPro
    3. positive regulation of GTPase activity Source: GOC
    4. regulation of G-protein coupled receptor protein signaling pathway Source: RGD
    5. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 7
    Short name:
    RGS7
    Gene namesi
    Name:Rgs7
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3570. Rgs7.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. cytosol Source: RGD
    3. dendrite terminus Source: Ensembl
    4. heterotrimeric G-protein complex Source: InterPro
    5. nucleus Source: Ensembl
    6. plasma membrane Source: RGD
    7. protein complex Source: RGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 477477Regulator of G-protein signaling 7PRO_0000204198Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei434 – 4341PhosphoserineBy similarity

    Post-translational modificationi

    Palmitoylated.By similarity
    Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity.By similarity

    Keywords - PTMi

    Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PRIDEiP49803.

    PTM databases

    PhosphoSiteiP49803.

    Expressioni

    Tissue specificityi

    Brain-specific. Predominantly cerebellar granule cells.2 Publications

    Gene expression databases

    GenevestigatoriP49803.

    Interactioni

    Subunit structurei

    Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5. Interacts with SNAPIN By similarity.By similarity

    Protein-protein interaction databases

    BioGridi248516. 1 interaction.
    STRINGi10116.ENSRNOP00000046013.

    Structurei

    3D structure databases

    ProteinModelPortaliP49803.
    SMRiP49803. Positions 320-450.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 11276DEPPROSITE-ProRule annotationAdd
    BLAST
    Domaini255 – 31662G protein gammaAdd
    BLAST
    Domaini333 – 448116RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 1 G protein gamma domain.Curated
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG327614.
    HOGENOMiHOG000220864.
    HOVERGENiHBG007404.
    InParanoidiP49803.
    KOiK16449.
    PhylomeDBiP49803.
    TreeFamiTF351956.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.196.10. 1 hit.
    4.10.260.10. 1 hit.
    InterProiIPR000591. DEP_dom.
    IPR015898. G-protein_gamma-like_dom.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00610. DEP. 1 hit.
    PF00631. G-gamma. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00049. DEP. 1 hit.
    SM00224. GGL. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF48670. SSF48670. 1 hit.
    PROSITEiPS50186. DEP. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P49803-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQGNNYGQT SNGVAEESPN MLVYRKMEDV IARMQDEKNG IPIRTVKSFL    50
    SKIPSVFSGS DIVQWLIKNL TIEDPVEALH LGTLMAAHGY FFPISDHVLT 100
    LKDDGTFYRF QTPYFWPSNC WEPENTDYAV YLCKRTMQNK ARLELADYEA 150
    ESLARLQRAF ARKWEFIFMQ AEAQAKVDKK RDKIERKILD SQERAFWDVH 200
    RPVPGCVNTT EVDIKKSSRM RNPHKTRKSV YGLQNDIRSH SPTHTPTPET 250
    KPPTEDELHR QIKYWQIQLD RHRLKMSKVA DSLLSYTEQY VEYDPFLVPP 300
    DPSNPWLSDD TTFWELEASK EPSQQRVKRW GFGMDEALKD PVGREQFLKF 350
    LESEFSSENL RFWLAVEDLK KRPIREVPSR VQEIWQEFLA PGAPSAINLD 400
    SKSYDKTTQN VKEPGRYTFE DAQEHIYKLM KSDSYPRFIR SSAYQELLQA 450
    KRKGRNIPIF PCHKNCTPTL RASTNLL 477
    Length:477
    Mass (Da):55,691
    Last modified:February 21, 2001 - v2
    Checksum:i4BA05410865DDC4A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB024398 mRNA. Translation: BAA75635.1.
    U32328 mRNA. Translation: AAC52368.1.
    RefSeqiNP_062216.1. NM_019343.1.
    UniGeneiRn.204219.

    Genome annotation databases

    GeneIDi54296.
    KEGGirno:54296.
    UCSCiRGD:3570. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB024398 mRNA. Translation: BAA75635.1 .
    U32328 mRNA. Translation: AAC52368.1 .
    RefSeqi NP_062216.1. NM_019343.1.
    UniGenei Rn.204219.

    3D structure databases

    ProteinModelPortali P49803.
    SMRi P49803. Positions 320-450.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248516. 1 interaction.
    STRINGi 10116.ENSRNOP00000046013.

    PTM databases

    PhosphoSitei P49803.

    Proteomic databases

    PRIDEi P49803.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 54296.
    KEGGi rno:54296.
    UCSCi RGD:3570. rat.

    Organism-specific databases

    CTDi 6000.
    RGDi 3570. Rgs7.

    Phylogenomic databases

    eggNOGi NOG327614.
    HOGENOMi HOG000220864.
    HOVERGENi HBG007404.
    InParanoidi P49803.
    KOi K16449.
    PhylomeDBi P49803.
    TreeFami TF351956.

    Miscellaneous databases

    NextBioi 610924.
    PROi P49803.

    Gene expression databases

    Genevestigatori P49803.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.196.10. 1 hit.
    4.10.260.10. 1 hit.
    InterProi IPR000591. DEP_dom.
    IPR015898. G-protein_gamma-like_dom.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00610. DEP. 1 hit.
    PF00631. G-gamma. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00049. DEP. 1 hit.
    SM00224. GGL. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF48670. SSF48670. 1 hit.
    PROSITEi PS50186. DEP. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents."
      Saitoh O., Kubo Y., Odagiri M., Ichikawa M., Yamagata K., Sekine T.
      J. Biol. Chem. 274:9899-9904(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    2. "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins."
      Koelle M.R., Horvitz H.R.
      Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 364-429.
      Tissue: Brain.
    3. "Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain."
      Gold S.J., Ni Y.G., Dohlman H.G., Nestler E.J.
      J. Neurosci. 17:8024-8037(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiRGS7_RAT
    AccessioniPrimary (citable) accession number: P49803
    Secondary accession number(s): Q9R0R0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: February 21, 2001
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3