P49802 (RGS7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of G-protein signaling 7
Short name=RGS7

Gene names

Name:

RGS7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations By similarity.
Subunit structure	Heterodimer with GNG5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 By similarity. Interacts with 14-3-3 protein Tau and SNAPIN. Ref.7 Ref.8 Ref.9
Post-translational modification	Palmitoylated By similarity. Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity.
Sequence similarities	Contains 1 DEP domain. Contains 1 G protein gamma domain. Contains 1 RGS domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Signal transduction inhibitor
PTM	Lipoprotein Palmitate Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro intracellular signal transduction Inferred from electronic annotation. Source: InterPro regulation of G-protein coupled receptor protein signaling pathway Non-traceable author statement. Source: UniProtKB termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome cytosol Inferred from electronic annotation. Source: Compara dendrite terminus Inferred from electronic annotation. Source: Compara heterotrimeric G-protein complex Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: Compara plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P49802-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P49802-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     454-495: SGNSMDRRTSFEKFAQNVGRNIPIFPCHKNCTPTLRASTNLL → GKSLTSKRLTSLAQSY

Isoform 3 (identifier: P49802-3)

The sequence of this isoform differs from the canonical sequence as follows:
     454-471: Missing.

Isoform 4 (identifier: P49802-4)

The sequence of this isoform differs from the canonical sequence as follows:
     76-128: Missing.
     454-471: Missing.

Isoform 5 (identifier: P49802-5)

The sequence of this isoform differs from the canonical sequence as follows:
     473-495: RNIPIFPCHKNCTPTLRASTNLL → KSLTSKRLTSLAQSY

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 495

495

Regulator of G-protein signaling 7

PRO_0000204196

Regions

Domain

37 – 112

76

DEP

Domain

255 – 316

62

G protein gamma

Domain

333 – 448

116

RGS

Amino acid modifications

Modified residue

229

1

Phosphoserine By similarity

Modified residue

434

1

Phosphoserine

Natural variations

Alternative sequence

76 – 128

53

Missing in isoform 4.

VSP_005671

Alternative sequence

454 – 495

42

SGNSM…STNLL → GKSLTSKRLTSLAQSY in isoform 2.

VSP_005672

Alternative sequence

454 – 471

18

Missing in isoform 3 and isoform 4.

VSP_005673

Alternative sequence

473 – 495

23

RNIPI…STNLL → KSLTSKRLTSLAQSY in isoform 5.

VSP_038388

Natural variant

137

1

M → L.
Corresponds to variant rs12746550 [ dbSNP | Ensembl ].

VAR_057153

Natural variant

409

1

Q → H. Ref.6
Corresponds to variant rs17851953 [ dbSNP | Ensembl ].

VAR_060604

Experimental info

Mutagenesis

306

1

W → F: Diminishes interaction with Gbeta5. Ref.7

Sequence conflict

26

1

K → R in AAM12645. Ref.3

Sequence conflict

234

1

Q → R in AAM12644. Ref.3

Secondary structure

1

.

.

.

.

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.

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.

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.

.

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.

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495

Helix Strand Turn

Details...

Helix

324 – 329

6

Helix

330 – 332

3

Helix

334 – 339

6

Helix

341 – 353

13

Helix

358 – 369

12

Helix

374 – 376

3

Helix

377 – 388

12

Helix

401 – 412

12

Turn

414 – 419

6

Helix

420 – 432

13

Helix

434 – 440

7

Helix

442 – 449

8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (A) [UniParc]. Last modified October 18, 2001. Version 3. Checksum: 1FCC2D60622675DE	FASTA	495	57,668
	10 20 30 40 50 60 MAQGNNYGQT SNGVADESPN MLVYRKMEDV IARMQDEKNG IPIRTVKSFL SKIPSVFSGS 70 80 90 100 110 120 DIVQWLIKNL TIEDPVEALH LGTLMAAHGY FFPISDHVLT LKDDGTFYRF QTPYFWPSNC 130 140 150 160 170 180 WEPENTDYAV YLCKRTMQNK ARLELADYEA ESLARLQRAF ARKWEFIFMQ AEAQAKVDKK 190 200 210 220 230 240 RDKIERKILD SQERAFWDVH RPVPGCVNTT EVDIKKSSRM RNPHKTRKSV YGLQNDIRSH 250 260 270 280 290 300 SPTHTPTPET KPPTEDELQQ QIKYWQIQLD RHRLKMSKVA DSLLSYTEQY LEYDPFLLPP 310 320 330 340 350 360 DPSNPWLSDD TTFWELEASK EPSQQRVKRW GFGMDEALKD PVGREQFLKF LESEFSSENL 370 380 390 400 410 420 RFWLAVEDLK KRPIKEVPSR VQEIWQEFLA PGAPSAINLD SKSYDKTTQN VKEPGRYTFE 430 440 450 460 470 480 DAQEHIYKLM KSDSYPRFIR SSAYQELLQA KKKSGNSMDR RTSFEKFAQN VGRNIPIFPC 490 HKNCTPTLRA STNLL
	Isoform 2 (B) [UniParc]. Checksum: 993C1209EDD884EC	FASTA	469	54,685
	10 20 30 40 50 60 MAQGNNYGQT SNGVADESPN MLVYRKMEDV IARMQDEKNG IPIRTVKSFL SKIPSVFSGS 70 80 90 100 110 120 DIVQWLIKNL TIEDPVEALH LGTLMAAHGY FFPISDHVLT LKDDGTFYRF QTPYFWPSNC 130 140 150 160 170 180 WEPENTDYAV YLCKRTMQNK ARLELADYEA ESLARLQRAF ARKWEFIFMQ AEAQAKVDKK 190 200 210 220 230 240 RDKIERKILD SQERAFWDVH RPVPGCVNTT EVDIKKSSRM RNPHKTRKSV YGLQNDIRSH 250 260 270 280 290 300 SPTHTPTPET KPPTEDELQQ QIKYWQIQLD RHRLKMSKVA DSLLSYTEQY LEYDPFLLPP 310 320 330 340 350 360 DPSNPWLSDD TTFWELEASK EPSQQRVKRW GFGMDEALKD PVGREQFLKF LESEFSSENL 370 380 390 400 410 420 RFWLAVEDLK KRPIKEVPSR VQEIWQEFLA PGAPSAINLD SKSYDKTTQN VKEPGRYTFE 430 440 450 460 DAQEHIYKLM KSDSYPRFIR SSAYQELLQA KKKGKSLTSK RLTSLAQSY
	Isoform 3 [UniParc]. Checksum: A7252A838E1881A9	FASTA	477	55,612
	10 20 30 40 50 60 MAQGNNYGQT SNGVADESPN MLVYRKMEDV IARMQDEKNG IPIRTVKSFL SKIPSVFSGS 70 80 90 100 110 120 DIVQWLIKNL TIEDPVEALH LGTLMAAHGY FFPISDHVLT LKDDGTFYRF QTPYFWPSNC 130 140 150 160 170 180 WEPENTDYAV YLCKRTMQNK ARLELADYEA ESLARLQRAF ARKWEFIFMQ AEAQAKVDKK 190 200 210 220 230 240 RDKIERKILD SQERAFWDVH RPVPGCVNTT EVDIKKSSRM RNPHKTRKSV YGLQNDIRSH 250 260 270 280 290 300 SPTHTPTPET KPPTEDELQQ QIKYWQIQLD RHRLKMSKVA DSLLSYTEQY LEYDPFLLPP 310 320 330 340 350 360 DPSNPWLSDD TTFWELEASK EPSQQRVKRW GFGMDEALKD PVGREQFLKF LESEFSSENL 370 380 390 400 410 420 RFWLAVEDLK KRPIKEVPSR VQEIWQEFLA PGAPSAINLD SKSYDKTTQN VKEPGRYTFE 430 440 450 460 470 DAQEHIYKLM KSDSYPRFIR SSAYQELLQA KKKGRNIPIF PCHKNCTPTL RASTNLL
	Isoform 4 [UniParc]. Checksum: 25A8A2F507C07E87	FASTA	424	49,387
	10 20 30 40 50 60 MAQGNNYGQT SNGVADESPN MLVYRKMEDV IARMQDEKNG IPIRTVKSFL SKIPSVFSGS 70 80 90 100 110 120 DIVQWLIKNL TIEDPAVYLC KRTMQNKARL ELADYEAESL ARLQRAFARK WEFIFMQAEA 130 140 150 160 170 180 QAKVDKKRDK IERKILDSQE RAFWDVHRPV PGCVNTTEVD IKKSSRMRNP HKTRKSVYGL 190 200 210 220 230 240 QNDIRSHSPT HTPTPETKPP TEDELQQQIK YWQIQLDRHR LKMSKVADSL LSYTEQYLEY 250 260 270 280 290 300 DPFLLPPDPS NPWLSDDTTF WELEASKEPS QQRVKRWGFG MDEALKDPVG REQFLKFLES 310 320 330 340 350 360 EFSSENLRFW LAVEDLKKRP IKEVPSRVQE IWQEFLAPGA PSAINLDSKS YDKTTQNVKE 370 380 390 400 410 420 PGRYTFEDAQ EHIYKLMKSD SYPRFIRSSA YQELLQAKKK GRNIPIFPCH KNCTPTLRAS TNLL
	Isoform 5 [UniParc]. Checksum: 50BDD0E8896444BC	FASTA	487	56,741
	10 20 30 40 50 60 MAQGNNYGQT SNGVADESPN MLVYRKMEDV IARMQDEKNG IPIRTVKSFL SKIPSVFSGS 70 80 90 100 110 120 DIVQWLIKNL TIEDPVEALH LGTLMAAHGY FFPISDHVLT LKDDGTFYRF QTPYFWPSNC 130 140 150 160 170 180 WEPENTDYAV YLCKRTMQNK ARLELADYEA ESLARLQRAF ARKWEFIFMQ AEAQAKVDKK 190 200 210 220 230 240 RDKIERKILD SQERAFWDVH RPVPGCVNTT EVDIKKSSRM RNPHKTRKSV YGLQNDIRSH 250 260 270 280 290 300 SPTHTPTPET KPPTEDELQQ QIKYWQIQLD RHRLKMSKVA DSLLSYTEQY LEYDPFLLPP 310 320 330 340 350 360 DPSNPWLSDD TTFWELEASK EPSQQRVKRW GFGMDEALKD PVGREQFLKF LESEFSSENL 370 380 390 400 410 420 RFWLAVEDLK KRPIKEVPSR VQEIWQEFLA PGAPSAINLD SKSYDKTTQN VKEPGRYTFE 430 440 450 460 470 480 DAQEHIYKLM KSDSYPRFIR SSAYQELLQA KKKSGNSMDR RTSFEKFAQN VGKSLTSKRL TSLAQSY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Interaction between RGS7 and polycystin." Kim E., Arnould T., Sellin L., Benzing T., Comella N., Kocher O., Tsiokas L., Sukhatme V.P., Walz G. Proc. Natl. Acad. Sci. U.S.A. 96:6371-6376(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Brain.
[2]	"EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins." Koelle M.R., Horvitz H.R. Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4). Tissue: Brain.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), VARIANT HIS-409. Tissue: Testis.
[7]	"Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11." Snow B.E., Betts L., Mangion J., Sondek J., Siderovski D.P. Proc. Natl. Acad. Sci. U.S.A. 96:6489-6494(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH GBETA5, MUTAGENESIS OF TRP-306. Tissue: Brain.
[8]	"14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity." Benzing T., Yaffe M.B., Arnould T., Sellin L., Schermer B., Schilling B., Schreiber R., Kunzelmann K., Leparc G.G., Kim E., Walz G. J. Biol. Chem. 275:28167-28172(2000) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION, INTERACTION WITH 14-3-3 PROTEINS.
[9]	"Snapin interacts with the N-terminus of regulator of G protein signaling 7." Hunt R.A., Edris W., Chanda P.K., Nieuwenhuijsen B., Young K.H. Biochem. Biophys. Res. Commun. 303:594-599(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SNAPIN.
[10]	"Solution structure of the RGS domain of regulator of G-protein signaling 7." RIKEN structural genomics initiative (RSGI) Submitted (DEC-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 323-448.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF090116 mRNA. Translation: AAD34290.1.
AF090117 mRNA. Translation: AAD34291.1.
U32439 mRNA. Translation: AAC50351.1.
AF493930 mRNA. Translation: AAM12644.1.
AF493931 mRNA. Translation: AAM12645.1.
AY587875 mRNA. Translation: AAT52231.1.
AL512307 , AL359764, AL365184, AL590682 Genomic DNA. Translation: CAH71987.1.
AL512307 , AL359764, AL365184, AL590682 Genomic DNA. Translation: CAH71988.1.
AL512307 , AL359764, AL365184, AL590682 Genomic DNA. Translation: CAH71989.1.
AL512307 , AL359764, AL365184, AL590682 Genomic DNA. Translation: CAH71990.1.
AL590682 , AL359764, AL365184, AL512307 Genomic DNA. Translation: CAH73809.1.
AL590682 , AL359764, AL365184, AL512307 Genomic DNA. Translation: CAH73810.1.
AL590682 , AL359764, AL365184, AL512307 Genomic DNA. Translation: CAH73811.1.
AL590682 , AL359764, AL365184, AL512307 Genomic DNA. Translation: CAH73812.1.
AL359764 , AL365184, AL512307, AL590682 Genomic DNA. Translation: CAI15140.1.
AL359764 , AL365184, AL512307, AL590682 Genomic DNA. Translation: CAI15141.1.
AL359764 , AL365184, AL512307, AL590682 Genomic DNA. Translation: CAI15142.1.
AL359764 , AL365184, AL512307, AL590682 Genomic DNA. Translation: CAI15143.1.
AL365184 , AL359764, AL512307, AL590682 Genomic DNA. Translation: CAI16818.1.
AL365184 , AL359764, AL512307, AL590682 Genomic DNA. Translation: CAI16819.1.
AL365184 , AL359764, AL512307, AL590682 Genomic DNA. Translation: CAI16820.1.
AL365184 , AL359764, AL512307, AL590682 Genomic DNA. Translation: CAI16821.1.
CH471098 Genomic DNA. Translation: EAW70086.1.
BC022009 mRNA. Translation: AAH22009.1.

IPI

IPI00028457.
IPI00220660.
IPI00220661.
IPI00257291.
IPI00874132.

RefSeq

NP_002915.3. NM_002924.4.

UniGene

Hs.655739.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2A72	X-ray	2.00	A/B	320-463	[»]
2D9J	NMR	-	A	323-448	[»]

ProteinModelPortal

P49802.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-40869N.

IntAct

P49802. 4 interactions.

MINT

MINT-136910.

STRING

9606.ENSP00000355520.

PTM databases

PhosphoSite

P49802.

Polymorphism databases

DMDM

17380284.

Proteomic databases

PaxDb

P49802.

PRIDE

P49802.

Protocols and materials databases

DNASU

6000.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000348120; ENSP00000341242; ENSG00000182901.
ENST00000366562; ENSP00000355520; ENSG00000182901.
ENST00000366563; ENSP00000355521; ENSG00000182901.
ENST00000366564; ENSP00000355522; ENSG00000182901.
ENST00000366565; ENSP00000355523; ENSG00000182901.
ENST00000401882; ENSP00000385508; ENSG00000182901.
ENST00000407727; ENSP00000384428; ENSG00000182901.

GeneID

6000.

KEGG

hsa:6000.

UCSC

uc001hyt.2. human.
uc001hyu.2. human.
uc001hyv.2. human.
uc001hyw.2. human.
uc009xgn.1. human.

Organism-specific databases

CTD

6000.

GeneCards

GC01M240938.

HGNC

HGNC:10003. RGS7.

HPA

CAB017561.
HPA000688.

MIM

602517. gene.

neXtProt

NX_P49802.

PharmGKB

PA34378.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG327614.

HOVERGEN

HBG007404.

InParanoid

P49802.

KO

K16449.

OMA

AHVYHLM.

PhylomeDB

P49802.

Gene expression databases

ArrayExpress

P49802.

Bgee

P49802.

CleanEx

HS_RGS7.

Genevestigator

P49802.

GermOnline

ENSG00000182901. Homo sapiens.

Family and domain databases

Gene3D

1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.

InterPro

IPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR000342. Regulat_G_prot_signal.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]

Pfam

PF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]

PRINTS

PR01301. RGSPROTEIN.

SMART

SM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]

SUPFAM

SSF48670. G-protein_gamma-like. 1 hit.
SSF48097. Regulat_G_prot_signal_superfam. 1 hit.

PROSITE

PS50186. DEP. 1 hit.
PS50058. G_PROTEIN_GAMMA. False negative.
PS50132. RGS. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

RGS7. human.

EvolutionaryTrace

P49802.

GenomeRNAi

6000.

NextBio

23395.

SOURCE

Search...

Entry information

Entry name

RGS7_HUMAN

Accession

Primary (citable) accession number: P49802
Secondary accession number(s): Q5T3H4 , Q8TD66, Q8TD67, Q8WW09, Q9UNU7, Q9Y6B9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 18, 2001
Last modified:	May 1, 2013
This is version 135 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.