ID   RGS6_RAT                Reviewed;          66 AA.
AC   P49801;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   24-JAN-2024, entry version 127.
DE   RecName: Full=Regulator of G-protein signaling 6;
DE            Short=RGS6;
DE   Flags: Fragment;
GN   Name=Rgs6;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=8548815; DOI=10.1016/s0092-8674(00)80998-8;
RA   Koelle M.R., Horvitz H.R.;
RT   "EGL-10 regulates G protein signaling in the C. elegans nervous system and
RT   shares a conserved domain with many mammalian proteins.";
RL   Cell 84:115-125(1996).
CC   -!- FUNCTION: Regulates G protein-coupled receptor signaling cascades.
CC       Inhibits signal transduction by increasing the GTPase activity of G
CC       protein alpha subunits, thereby driving them into their inactive GDP-
CC       bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity.
CC       {ECO:0000250|UniProtKB:P49758}.
CC   -!- SUBUNIT: Interacts with GNB5 (By similarity). Interacts with RGS7BP,
CC       leading to regulate the subcellular location of the heterodimer formed
CC       with GNB5 (By similarity). Interacts with GNAI1 (By similarity).
CC       {ECO:0000250|UniProtKB:P49758, ECO:0000250|UniProtKB:Q9Z2H2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P49758}.
CC       Cytoplasm, cytosol {ECO:0000250|UniProtKB:P49758}. Membrane
CC       {ECO:0000250|UniProtKB:P49758}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P49758}. Nucleus {ECO:0000250|UniProtKB:P49758}.
CC       Cell membrane {ECO:0000250|UniProtKB:Q9Z2H2}. Note=Interaction with
CC       GNB5 mediates translocation to the nucleus.
CC       {ECO:0000250|UniProtKB:P49758}.
CC   -!- DOMAIN: The RGS domain interacts avidly with Galpha and mediates the
CC       acceleration of Galpha-mediated GTP hydrolysis. {ECO:0000250}.
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DR   EMBL; U32436; AAC52373.1; -; mRNA.
DR   AlphaFoldDB; P49801; -.
DR   SMR; P49801; -.
DR   PhosphoSitePlus; P49801; -.
DR   PaxDb; 10116-ENSRNOP00000054984; -.
DR   UCSC; RGD:3569; rat.
DR   AGR; RGD:3569; -.
DR   RGD; 3569; Rgs6.
DR   eggNOG; KOG3589; Eukaryota.
DR   InParanoid; P49801; -.
DR   PhylomeDB; P49801; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032991; C:protein-containing complex; IDA:RGD.
DR   GO; GO:0005096; F:GTPase activator activity; ISS:UniProtKB.
DR   GO; GO:0019904; F:protein domain specific binding; IPI:RGD.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; IDA:RGD.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR047016; RGS6/7/9/11.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   PANTHER; PTHR45746; LP21163P; 1.
DR   PANTHER; PTHR45746:SF2; REGULATOR OF G-PROTEIN SIGNALING 6; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Membrane; Nucleus; Reference proteome;
KW   Signal transduction inhibitor.
FT   CHAIN           <1..>66
FT                   /note="Regulator of G-protein signaling 6"
FT                   /id="PRO_0000204194"
FT   DOMAIN          <1..>66
FT                   /note="RGS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
FT   NON_TER         1
FT   NON_TER         66
SQ   SEQUENCE   66 AA;  7530 MW;  2F60E18D8AA8BD66 CRC64;
     LAVQDLKKQP LQDVAKRVEE IWQEFLAPGA PSAINLDSHS YEITSQNVKD GGRYTFEDAQ
     EHIYKL
//