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Protein

Regulator of G-protein signaling 6

Gene

Rgs6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity.By similarity

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • protein domain specific binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 6
Short name:
RGS6
Gene namesi
Name:Rgs6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3569. Rgs6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000204194‹1 – ›66Regulator of G-protein signaling 6Add BLAST›66

Proteomic databases

PaxDbiP49801.
PRIDEiP49801.

PTM databases

PhosphoSitePlusiP49801.

Interactioni

Subunit structurei

Interacts with GNB5 (By similarity). Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5 (By similarity). Interacts with GNAI1 (By similarity).By similarity

GO - Molecular functioni

  • protein domain specific binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054984.

Structurei

3D structure databases

ProteinModelPortaliP49801.
SMRiP49801.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini‹1 – ›66RGSPROSITE-ProRule annotationAdd BLAST›66

Domaini

The RGS domain interacts avidly with Galpha and mediates the acceleration of Galpha-mediated GTP hydrolysis.By similarity

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
HOGENOMiHOG000220864.
PhylomeDBiP49801.

Family and domain databases

InterProiView protein in InterPro
IPR016137. RGS.
IPR036305. RGS_sf.
PfamiView protein in Pfam
PF00615. RGS. 1 hit.
PRINTSiPR01301. RGSPROTEIN.
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiView protein in PROSITE
PS50132. RGS. 1 hit.

Sequencei

Sequence statusi: Fragment.

P49801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LAVQDLKKQP LQDVAKRVEE IWQEFLAPGA PSAINLDSHS YEITSQNVKD
60
GGRYTFEDAQ EHIYKL
Length:66
Mass (Da):7,530
Last modified:October 1, 1996 - v1
Checksum:i2F60E18D8AA8BD66
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei661

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32436 mRNA. Translation: AAC52373.1.
UniGeneiRn.199537.

Genome annotation databases

UCSCiRGD:3569. rat.

Similar proteinsi

Entry informationi

Entry nameiRGS6_RAT
AccessioniPrimary (citable) accession number: P49801
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome