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P49801 (RGS6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 6

Short name=RGS6
Gene names
Name:Rgs6
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length66 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer By similarity.

Subunit structure

Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 By similarity.

Subcellular location

Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.

Domain

The RGS domain interacts avidly with Galpha and mediates the acceleration of Galpha-mediated GTP hydrolysis By similarity.

Sequence similarities

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›66›66Regulator of G-protein signaling 6
PRO_0000204194

Regions

Domain‹1 – ›66›66RGS

Experimental info

Non-terminal residue11
Non-terminal residue661

Sequences

Sequence LengthMass (Da)Tools
P49801 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 2F60E18D8AA8BD66

FASTA667,530
        10         20         30         40         50         60 
LAVQDLKKQP LQDVAKRVEE IWQEFLAPGA PSAINLDSHS YEITSQNVKD GGRYTFEDAQ 


EHIYKL 

« Hide

References

[1]"EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins."
Koelle M.R., Horvitz H.R.
Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U32436 mRNA. Translation: AAC52373.1.
UniGeneRn.199537.

3D structure databases

ProteinModelPortalP49801.
SMRP49801. Positions 1-66.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000054984.

PTM databases

PhosphoSiteP49801.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:3569. rat.

Organism-specific databases

RGD3569. Rgs6.

Phylogenomic databases

eggNOGNOG327614.
HOGENOMHOG000220864.
InParanoidP49801.
PhylomeDBP49801.

Gene expression databases

GenevestigatorP49801.

Family and domain databases

InterProIPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamPF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SUPFAMSSF48097. SSF48097. 1 hit.
PROSITEPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP49801.

Entry information

Entry nameRGS6_RAT
AccessionPrimary (citable) accession number: P49801
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families