P49801 (RGS6_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of G-protein signaling 6
Short name=RGS6

Gene names

Name:

Rgs6

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	66 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer By similarity.
Subunit structure	Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 By similarity.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.
Sequence similarities	Contains 1 RGS domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Molecular function	Signal transduction inhibitor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of G-protein coupled receptor protein signaling pathway Non-traceable author statement PubMed 12140291. Source: RGD positive regulation of neuron differentiation Inferred from direct assay PubMed 12140291. Source: RGD termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›66	›66	Regulator of G-protein signaling 6		PRO_0000204194
Regions
	Domain	‹1 – ›66	›66	RGS
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	66	1

Sequences

	Sequence		Length	Mass (Da)
	P49801 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 2F60E18D8AA8BD66	FASTA	66	7,530
	10 20 30 40 50 60 LAVQDLKKQP LQDVAKRVEE IWQEFLAPGA PSAINLDSHS YEITSQNVKD GGRYTFEDAQ EHIYKL

References

[1]	"EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins." Koelle M.R., Horvitz H.R. Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U32436 mRNA. Translation: AAC52373.1.
IPI	IPI00764686.
UniGene	Rn.232716.
3D structure databases
ProteinModelPortal	P49801.
SMR	P49801. Positions 1-66.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000054984.
Protein family/group databases
TCDB	1.A.71.1.2. brain acid-soluble protein channel (BASP1 Channel) family.
PTM databases
PhosphoSite	P49801.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:3569. rat.
Organism-specific databases
RGD	3569. Rgs6.
Phylogenomic databases
eggNOG	NOG327614.
HOGENOM	HOG000220864.
InParanoid	P49801.
OrthoDB	EOG41ZF9K.
Gene expression databases
ArrayExpress	P49801.
Genevestigator	P49801.
Family and domain databases
InterPro	IPR000342. Regulat_G_prot_signal. IPR016137. Regulat_G_prot_signal_superfam. [Graphical view]
Pfam	PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR01301. RGSPROTEIN.
SUPFAM	SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RGS6_RAT

Accession

Primary (citable) accession number: P49801

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program