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P49801

- RGS6_RAT

UniProt

P49801 - RGS6_RAT

Protein

Regulator of G-protein signaling 6

Gene

Rgs6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer By similarity.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome
    2. protein domain specific binding Source: RGD

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. positive regulation of neuron differentiation Source: RGD
    3. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 6
    Short name:
    RGS6
    Gene namesi
    Name:Rgs6
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3569. Rgs6.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. Golgi apparatus Source: RGD
    3. plasma membrane Source: RefGenome
    4. protein complex Source: RGD

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›66›66Regulator of G-protein signaling 6PRO_0000204194Add
    BLAST

    PTM databases

    PhosphoSiteiP49801.

    Expressioni

    Gene expression databases

    GenevestigatoriP49801.

    Interactioni

    Subunit structurei

    Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000054984.

    Structurei

    3D structure databases

    ProteinModelPortaliP49801.
    SMRiP49801. Positions 1-66.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini‹1 – ›66›66RGSPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The RGS domain interacts avidly with Galpha and mediates the acceleration of Galpha-mediated GTP hydrolysis.By similarity

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG327614.
    HOGENOMiHOG000220864.
    InParanoidiP49801.
    PhylomeDBiP49801.

    Family and domain databases

    InterProiIPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P49801-1 [UniParc]FASTAAdd to Basket

    « Hide

    LAVQDLKKQP LQDVAKRVEE IWQEFLAPGA PSAINLDSHS YEITSQNVKD   50
    GGRYTFEDAQ EHIYKL 66
    Length:66
    Mass (Da):7,530
    Last modified:October 1, 1996 - v1
    Checksum:i2F60E18D8AA8BD66
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei66 – 661

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32436 mRNA. Translation: AAC52373.1.
    UniGeneiRn.199537.

    Genome annotation databases

    UCSCiRGD:3569. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32436 mRNA. Translation: AAC52373.1 .
    UniGenei Rn.199537.

    3D structure databases

    ProteinModelPortali P49801.
    SMRi P49801. Positions 1-66.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000054984.

    PTM databases

    PhosphoSitei P49801.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:3569. rat.

    Organism-specific databases

    RGDi 3569. Rgs6.

    Phylogenomic databases

    eggNOGi NOG327614.
    HOGENOMi HOG000220864.
    InParanoidi P49801.
    PhylomeDBi P49801.

    Miscellaneous databases

    PROi P49801.

    Gene expression databases

    Genevestigatori P49801.

    Family and domain databases

    InterProi IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins."
      Koelle M.R., Horvitz H.R.
      Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiRGS6_RAT
    AccessioniPrimary (citable) accession number: P49801
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3