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P49801

- RGS6_RAT

UniProt

P49801 - RGS6_RAT

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Protein

Regulator of G-protein signaling 6

Gene

Rgs6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer (By similarity).By similarity

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome
  2. protein domain specific binding Source: RGD

GO - Biological processi

  1. positive regulation of GTPase activity Source: GOC
  2. positive regulation of neuron differentiation Source: RGD
  3. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 6
Short name:
RGS6
Gene namesi
Name:Rgs6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3569. Rgs6.

Subcellular locationi

Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. Golgi apparatus Source: RGD
  3. plasma membrane Source: RefGenome
  4. protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›66›66Regulator of G-protein signaling 6PRO_0000204194Add
BLAST

PTM databases

PhosphoSiteiP49801.

Expressioni

Gene expression databases

ExpressionAtlasiP49801. baseline and differential.
GenevestigatoriP49801.

Interactioni

Subunit structurei

Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054984.

Structurei

3D structure databases

ProteinModelPortaliP49801.
SMRiP49801. Positions 1-66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – ›66›66RGSPROSITE-ProRule annotationAdd
BLAST

Domaini

The RGS domain interacts avidly with Galpha and mediates the acceleration of Galpha-mediated GTP hydrolysis.By similarity

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG327614.
HOGENOMiHOG000220864.
PhylomeDBiP49801.

Family and domain databases

InterProiIPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P49801 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
LAVQDLKKQP LQDVAKRVEE IWQEFLAPGA PSAINLDSHS YEITSQNVKD
60
GGRYTFEDAQ EHIYKL
Length:66
Mass (Da):7,530
Last modified:October 1, 1996 - v1
Checksum:i2F60E18D8AA8BD66
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei66 – 661

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32436 mRNA. Translation: AAC52373.1.
UniGeneiRn.199537.

Genome annotation databases

UCSCiRGD:3569. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32436 mRNA. Translation: AAC52373.1 .
UniGenei Rn.199537.

3D structure databases

ProteinModelPortali P49801.
SMRi P49801. Positions 1-66.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000054984.

PTM databases

PhosphoSitei P49801.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:3569. rat.

Organism-specific databases

RGDi 3569. Rgs6.

Phylogenomic databases

eggNOGi NOG327614.
HOGENOMi HOG000220864.
PhylomeDBi P49801.

Miscellaneous databases

PROi P49801.

Gene expression databases

ExpressionAtlasi P49801. baseline and differential.
Genevestigatori P49801.

Family and domain databases

InterProi IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SUPFAMi SSF48097. SSF48097. 1 hit.
PROSITEi PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins."
    Koelle M.R., Horvitz H.R.
    Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRGS6_RAT
AccessioniPrimary (citable) accession number: P49801
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3