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P49800

- RGS5_RAT

UniProt

P49800 - RGS5_RAT

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Protein

Regulator of G-protein signaling 5

Gene

Rgs5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).By similarity

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome

GO - Biological processi

  1. negative regulation of G-protein coupled receptor protein signaling pathway Source: RGD
  2. positive regulation of GTPase activity Source: GOC
  3. signal transduction Source: RGD
  4. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 5
Short name:
RGS5
Gene namesi
Name:Rgs5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3568. Rgs5.

Subcellular locationi

Cytoplasm By similarity. Membrane By similarity

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Regulator of G-protein signaling 5PRO_0000204191Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiP49800. baseline and differential.
GenevestigatoriP49800.

Structurei

3D structure databases

ProteinModelPortaliP49800.
SMRiP49800. Positions 44-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 180117RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG285261.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiP49800.
KOiK16449.
PhylomeDBiP49800.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49800-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCKGLAALPH SCLERAKEIK IKLGILLQKP DSAVDLVIPY NEKPEKPAKA
60 70 80 90 100
HKPSLEEVLQ WRQSLDKLLQ SNYGFASFKS FLKSEFSEEN LEFWVACENY
110 120 130 140 150
KKIKSPIKMA EKAKQIYEEF IQTEAPKEVN IDHFTKDITM KNLVEPSPHS
160 170 180
FDLAQKRIYA LMEKDSLPRF VRSEFYKELI N
Length:181
Mass (Da):21,052
Last modified:February 21, 2001 - v2
Checksum:i9C179CE008B82C03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241259 mRNA. Translation: AAF73424.1.
U32435 mRNA. Translation: AAC52372.1.
RefSeqiNP_062214.1. NM_019341.1.
UniGeneiRn.1150.

Genome annotation databases

GeneIDi54294.
KEGGirno:54294.
UCSCiRGD:3568. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241259 mRNA. Translation: AAF73424.1 .
U32435 mRNA. Translation: AAC52372.1 .
RefSeqi NP_062214.1. NM_019341.1.
UniGenei Rn.1150.

3D structure databases

ProteinModelPortali P49800.
SMRi P49800. Positions 44-181.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 54294.
KEGGi rno:54294.
UCSCi RGD:3568. rat.

Organism-specific databases

CTDi 8490.
RGDi 3568. Rgs5.

Phylogenomic databases

eggNOGi NOG285261.
HOGENOMi HOG000233512.
HOVERGENi HBG013233.
InParanoidi P49800.
KOi K16449.
PhylomeDBi P49800.

Miscellaneous databases

NextBioi 610912.
PROi P49800.

Gene expression databases

ExpressionAtlasi P49800. baseline and differential.
Genevestigatori P49800.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
PROSITEi PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Kirsch T., Lippoldt A., Wellner M., Haller H.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins."
    Koelle M.R., Horvitz H.R.
    Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 95-161.
    Tissue: Brain.

Entry informationi

Entry nameiRGS5_RAT
AccessioniPrimary (citable) accession number: P49800
Secondary accession number(s): Q9JKD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 21, 2001
Last modified: October 29, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3