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P49800

- RGS5_RAT

UniProt

P49800 - RGS5_RAT

Protein

Regulator of G-protein signaling 5

Gene

Rgs5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (21 Feb 2001)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha By similarity.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. negative regulation of G-protein coupled receptor protein signaling pathway Source: RGD
    2. positive regulation of GTPase activity Source: GOC
    3. signal transduction Source: RGD
    4. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 5
    Short name:
    RGS5
    Gene namesi
    Name:Rgs5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3568. Rgs5.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 181181Regulator of G-protein signaling 5PRO_0000204191Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP49800.

    Structurei

    3D structure databases

    ProteinModelPortaliP49800.
    SMRiP49800. Positions 44-181.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini64 – 180117RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG285261.
    HOGENOMiHOG000233512.
    HOVERGENiHBG013233.
    KOiK16449.
    PhylomeDBiP49800.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P49800-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCKGLAALPH SCLERAKEIK IKLGILLQKP DSAVDLVIPY NEKPEKPAKA    50
    HKPSLEEVLQ WRQSLDKLLQ SNYGFASFKS FLKSEFSEEN LEFWVACENY 100
    KKIKSPIKMA EKAKQIYEEF IQTEAPKEVN IDHFTKDITM KNLVEPSPHS 150
    FDLAQKRIYA LMEKDSLPRF VRSEFYKELI N 181
    Length:181
    Mass (Da):21,052
    Last modified:February 21, 2001 - v2
    Checksum:i9C179CE008B82C03
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF241259 mRNA. Translation: AAF73424.1.
    U32435 mRNA. Translation: AAC52372.1.
    RefSeqiNP_062214.1. NM_019341.1.
    UniGeneiRn.1150.

    Genome annotation databases

    GeneIDi54294.
    KEGGirno:54294.
    UCSCiRGD:3568. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF241259 mRNA. Translation: AAF73424.1 .
    U32435 mRNA. Translation: AAC52372.1 .
    RefSeqi NP_062214.1. NM_019341.1.
    UniGenei Rn.1150.

    3D structure databases

    ProteinModelPortali P49800.
    SMRi P49800. Positions 44-181.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 54294.
    KEGGi rno:54294.
    UCSCi RGD:3568. rat.

    Organism-specific databases

    CTDi 8490.
    RGDi 3568. Rgs5.

    Phylogenomic databases

    eggNOGi NOG285261.
    HOGENOMi HOG000233512.
    HOVERGENi HBG013233.
    KOi K16449.
    PhylomeDBi P49800.

    Miscellaneous databases

    NextBioi 610912.
    PROi P49800.

    Gene expression databases

    Genevestigatori P49800.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Kirsch T., Lippoldt A., Wellner M., Haller H.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins."
      Koelle M.R., Horvitz H.R.
      Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 95-161.
      Tissue: Brain.

    Entry informationi

    Entry nameiRGS5_RAT
    AccessioniPrimary (citable) accession number: P49800
    Secondary accession number(s): Q9JKD7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: February 21, 2001
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3