P49800 (RGS5_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of G-protein signaling 5
Short name=RGS5

Gene names

Name:

Rgs5

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha By similarity.
Subcellular location	Cytoplasm By similarity. Membrane By similarity.
Sequence similarities	Contains 1 RGS domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Molecular function	Signal transduction inhibitor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of G-protein coupled receptor protein signaling pathway Inferred from mutant phenotype PubMed 21825230. Source: RGD signal transduction Inferred from direct assay PubMed 12006602. Source: RGD termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	Regulator of G-protein signaling 5		PRO_0000204191
Regions
	Domain	64 – 180	117	RGS

Sequences

	Sequence		Length	Mass (Da)
	P49800 [UniParc]. Last modified February 21, 2001. Version 2. Checksum: 9C179CE008B82C03	FASTA	181	21,052
	10 20 30 40 50 60 MCKGLAALPH SCLERAKEIK IKLGILLQKP DSAVDLVIPY NEKPEKPAKA HKPSLEEVLQ 70 80 90 100 110 120 WRQSLDKLLQ SNYGFASFKS FLKSEFSEEN LEFWVACENY KKIKSPIKMA EKAKQIYEEF 130 140 150 160 170 180 IQTEAPKEVN IDHFTKDITM KNLVEPSPHS FDLAQKRIYA LMEKDSLPRF VRSEFYKELI N

References

[1]	Kirsch T., Lippoldt A., Wellner M., Haller H. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins." Koelle M.R., Horvitz H.R. Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 95-161. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF241259 mRNA. Translation: AAF73424.1. U32435 mRNA. Translation: AAC52372.1.
IPI	IPI00198041.
RefSeq	NP_062214.1. NM_019341.1.
UniGene	Rn.1150.
3D structure databases
ProteinModelPortal	P49800.
SMR	P49800. Positions 44-181.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	54294.
KEGG	rno:54294.
UCSC	RGD:3568. rat.
Organism-specific databases
CTD	8490.
RGD	3568. Rgs5.
Phylogenomic databases
eggNOG	NOG285261.
HOGENOM	HOG000233512.
HOVERGEN	HBG013233.
KO	K16449.
OrthoDB	EOG41RPW5.
Gene expression databases
ArrayExpress	P49800.
Genevestigator	P49800.
GermOnline	ENSRNOG00000002730. Rattus norvegicus.
Family and domain databases
Gene3D	1.10.196.10. 2 hits.
InterPro	IPR000342. Regulat_G_prot_signal. IPR024066. Regulat_G_prot_signal_dom1. IPR016137. Regulat_G_prot_signal_superfam. [Graphical view]
Pfam	PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR01301. RGSPROTEIN.
SMART	SM00315. RGS. 1 hit. [Graphical view]
SUPFAM	SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	610912.

Entry information

Entry name

RGS5_RAT

Accession

Primary (citable) accession number: P49800
Secondary accession number(s): Q9JKD7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	February 21, 2001
Last modified:	April 3, 2013
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program