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P49800 (RGS5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 5

Short name=RGS5
Gene names
Name:Rgs5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha By similarity.

Subcellular location

Cytoplasm By similarity. Membrane By similarity.

Sequence similarities

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 181181Regulator of G-protein signaling 5
PRO_0000204191

Regions

Domain64 – 180117RGS

Sequences

Sequence LengthMass (Da)Tools
P49800 [UniParc].

Last modified February 21, 2001. Version 2.
Checksum: 9C179CE008B82C03

FASTA18121,052
        10         20         30         40         50         60 
MCKGLAALPH SCLERAKEIK IKLGILLQKP DSAVDLVIPY NEKPEKPAKA HKPSLEEVLQ 

        70         80         90        100        110        120 
WRQSLDKLLQ SNYGFASFKS FLKSEFSEEN LEFWVACENY KKIKSPIKMA EKAKQIYEEF 

       130        140        150        160        170        180 
IQTEAPKEVN IDHFTKDITM KNLVEPSPHS FDLAQKRIYA LMEKDSLPRF VRSEFYKELI 


N 

« Hide

References

[1]Kirsch T., Lippoldt A., Wellner M., Haller H.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins."
Koelle M.R., Horvitz H.R.
Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 95-161.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF241259 mRNA. Translation: AAF73424.1.
U32435 mRNA. Translation: AAC52372.1.
RefSeqNP_062214.1. NM_019341.1.
UniGeneRn.1150.

3D structure databases

ProteinModelPortalP49800.
SMRP49800. Positions 44-181.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID54294.
KEGGrno:54294.
UCSCRGD:3568. rat.

Organism-specific databases

CTD8490.
RGD3568. Rgs5.

Phylogenomic databases

eggNOGNOG285261.
HOGENOMHOG000233512.
HOVERGENHBG013233.
KOK16449.
PhylomeDBP49800.

Gene expression databases

GenevestigatorP49800.

Family and domain databases

Gene3D1.10.196.10. 2 hits.
InterProIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamPF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
PROSITEPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio610912.
PROP49800.

Entry information

Entry nameRGS5_RAT
AccessionPrimary (citable) accession number: P49800
Secondary accession number(s): Q9JKD7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 21, 2001
Last modified: April 16, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families