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Protein

Regulator of G-protein signaling 5

Gene

Rgs5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of G-protein coupled receptor protein signaling pathway Source: RGD
  • signal transduction Source: RGD

Keywordsi

Molecular functionSignal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 5
Short name:
RGS5
Gene namesi
Name:Rgs5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3568. Rgs5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041911 – 181Regulator of G-protein signaling 5Add BLAST181

Proteomic databases

PaxDbiP49800.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003705.

Structurei

3D structure databases

ProteinModelPortaliP49800.
SMRiP49800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 180RGSPROSITE-ProRule annotationAdd BLAST117

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiP49800.
KOiK16449.
PhylomeDBiP49800.

Family and domain databases

CDDicd08717. RGS_RGS5. 1 hit.
Gene3Di1.10.196.10. 2 hits.
InterProiView protein in InterPro
IPR016137. RGS.
IPR034955. RGS5.
IPR034956. RGS_RGS5.
IPR036305. RGS_sf.
IPR024066. RGS_subdom1.
PANTHERiPTHR10845:SF42. PTHR10845:SF42. 1 hit.
PfamiView protein in Pfam
PF00615. RGS. 1 hit.
PRINTSiPR01301. RGSPROTEIN.
SMARTiView protein in SMART
SM00315. RGS. 1 hit.
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiView protein in PROSITE
PS50132. RGS. 1 hit.

Sequencei

Sequence statusi: Complete.

P49800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCKGLAALPH SCLERAKEIK IKLGILLQKP DSAVDLVIPY NEKPEKPAKA
60 70 80 90 100
HKPSLEEVLQ WRQSLDKLLQ SNYGFASFKS FLKSEFSEEN LEFWVACENY
110 120 130 140 150
KKIKSPIKMA EKAKQIYEEF IQTEAPKEVN IDHFTKDITM KNLVEPSPHS
160 170 180
FDLAQKRIYA LMEKDSLPRF VRSEFYKELI N
Length:181
Mass (Da):21,052
Last modified:February 21, 2001 - v2
Checksum:i9C179CE008B82C03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241259 mRNA. Translation: AAF73424.1.
U32435 mRNA. Translation: AAC52372.1.
RefSeqiNP_062214.1. NM_019341.1.
UniGeneiRn.1150.

Genome annotation databases

GeneIDi54294.
KEGGirno:54294.
UCSCiRGD:3568. rat.

Similar proteinsi

Entry informationi

Entry nameiRGS5_RAT
AccessioniPrimary (citable) accession number: P49800
Secondary accession number(s): Q9JKD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 21, 2001
Last modified: October 25, 2017
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome