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Protein

Regulator of G-protein signaling 4

Gene

Rgs4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

GO - Molecular functioni

  • G-protein alpha-subunit binding Source: RGD
  • GTPase activator activity Source: RGD

GO - Biological processi

  • negative regulation of G-protein coupled receptor protein signaling pathway Source: RGD
  • positive regulation of GTPase activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 4
Short name:
RGP4
Short name:
RGS4
Gene namesi
Name:Rgs4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi3567. Rgs4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • cytosol Source: RGD
  • membrane Source: RGD
  • nucleus Source: Ensembl
  • plasma membrane Source: RGD
  • protein complex Source: RGD
Complete GO annotation...

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi2811.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041871 – 205Regulator of G-protein signaling 4Add BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2S-palmitoyl cysteineBy similarity1
Lipidationi12S-palmitoyl cysteineBy similarity1
Lipidationi95S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Either Cys-2 or Cys-12 or both are palmitoylated.By similarity
Phosphorylated by cyclic GMP-dependent protein kinase.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP49799.
PRIDEiP49799.

PTM databases

PhosphoSitePlusiP49799.
SwissPalmiP49799.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002773.
GenevisibleiP49799. RN.

Interactioni

GO - Molecular functioni

  • G-protein alpha-subunit binding Source: RGD

Protein-protein interaction databases

DIPiDIP-6074N.
IntActiP49799. 3 interactors.
MINTiMINT-8049194.
STRINGi10116.ENSRNOP00000003774.

Structurei

Secondary structure

1205
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi53 – 59Combined sources7
Helixi63 – 68Combined sources6
Helixi70 – 82Combined sources13
Helixi87 – 100Combined sources14
Turni104 – 106Combined sources3
Helixi107 – 118Combined sources12
Helixi131 – 140Combined sources10
Turni146 – 149Combined sources4
Helixi150 – 162Combined sources13
Helixi164 – 168Combined sources5
Helixi172 – 175Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AGRX-ray2.80E/H1-205[»]
1EZTNMR-A51-205[»]
1EZYNMR-A51-205[»]
DisProtiDP00063.
ProteinModelPortaliP49799.
SMRiP49799.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49799.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 178RGSPROSITE-ProRule annotationAdd BLAST117

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiP49799.
KOiK16449.
OMAiVCQRVSQ.
OrthoDBiEOG091G0BDG.
PhylomeDBiP49799.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49799-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHSSSHS KKDKVVTCQR
60 70 80 90 100
VSQEEVKKWA ESLENLINHE CGLAAFKAFL KSEYSEENID FWISCEEYKK
110 120 130 140 150
IKSPSKLSPK AKKIYNEFIS VQATKEVNLD SCTREETSRN MLEPTITCFD
160 170 180 190 200
EAQKKIFNLM EKDSYRRFLK SRFYLDLTNP SSCGAEKQKG AKSSADCTSL

VPQCA
Length:205
Mass (Da):23,249
Last modified:October 1, 1996 - v1
Checksum:i9647C0EC909D0F6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27767 mRNA. Translation: AAC52440.1.
AF117211 mRNA. Translation: AAD12065.1.
U32327 mRNA. Translation: AAC52367.1.
RefSeqiNP_058910.1. NM_017214.1.
UniGeneiRn.11065.

Genome annotation databases

EnsembliENSRNOT00000003774; ENSRNOP00000003774; ENSRNOG00000002773.
GeneIDi29480.
KEGGirno:29480.
UCSCiRGD:3567. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27767 mRNA. Translation: AAC52440.1.
AF117211 mRNA. Translation: AAD12065.1.
U32327 mRNA. Translation: AAC52367.1.
RefSeqiNP_058910.1. NM_017214.1.
UniGeneiRn.11065.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AGRX-ray2.80E/H1-205[»]
1EZTNMR-A51-205[»]
1EZYNMR-A51-205[»]
DisProtiDP00063.
ProteinModelPortaliP49799.
SMRiP49799.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6074N.
IntActiP49799. 3 interactors.
MINTiMINT-8049194.
STRINGi10116.ENSRNOP00000003774.

Chemistry databases

GuidetoPHARMACOLOGYi2811.

PTM databases

PhosphoSitePlusiP49799.
SwissPalmiP49799.

Proteomic databases

PaxDbiP49799.
PRIDEiP49799.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003774; ENSRNOP00000003774; ENSRNOG00000002773.
GeneIDi29480.
KEGGirno:29480.
UCSCiRGD:3567. rat.

Organism-specific databases

CTDi5999.
RGDi3567. Rgs4.

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiP49799.
KOiK16449.
OMAiVCQRVSQ.
OrthoDBiEOG091G0BDG.
PhylomeDBiP49799.
TreeFamiTF315837.

Miscellaneous databases

EvolutionaryTraceiP49799.
PROiP49799.

Gene expression databases

BgeeiENSRNOG00000002773.
GenevisibleiP49799. RN.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGS4_RAT
AccessioniPrimary (citable) accession number: P49799
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.