P49798 (RGS4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of G-protein signaling 4
Short name=RGP4
Short name=RGS4

Gene names

Name:

RGS4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
Post-translational modification	Palmitoylated on Cys-2 and/or Cys-12. Ref.6 Phosphorylated by cyclic GMP-dependent protein kinase By similarity.
Involvement in disease	Genetic variation in RGS4 is associated with susceptibility to schizophrenia type 9 (SCZD9) [MIM:604906]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. Ref.8 Ref.9
Sequence similarities	Contains 1 RGS domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Signal transduction inhibitor
PTM	Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	inactivation of MAPK activity Traceable author statement. Source: ProtInc regulation of G-protein coupled receptor protein signaling pathway Traceable author statement. Source: ProtInc
Cellular component	plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular function	GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome calmodulin binding Traceable author statement. Source: ProtInc signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 205	205	Regulator of G-protein signaling 4		PRO_0000204185
Regions
	Domain	62 – 178	117	RGS
Amino acid modifications
	Lipidation	2	1	S-palmitoyl cysteine Probable
	Lipidation	12	1	S-palmitoyl cysteine Probable
	Lipidation	95	1	S-palmitoyl cysteine Ref.6
Natural variations
	Natural variant	195	1	A → S. Corresponds to variant rs14665 [ dbSNP | Ensembl ].		VAR_051795

Sequences

	Sequence		Length	Mass (Da)
	P49798 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 7713F1F7496A698B	FASTA	205	23,256
	10 20 30 40 50 60 MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHNSSHN KKDKVVICQR VSQEEVKKWA 70 80 90 100 110 120 ESLENLISHE CGLAAFKAFL KSEYSEENID FWISCEEYKK IKSPSKLSPK AKKIYNEFIS 130 140 150 160 170 180 VQATKEVNLD SCTREETSRN MLEPTITCFD EAQKKIFNLM EKDSYRRFLK SRFYLDLVNP 190 200 SSCGAEKQKG AKSSADCASL VPQCA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family." Druey K.M., Blumer K.J., Kang V.H., Kehrl J.H. Nature 379:742-746(1996) [PubMed: 8602223] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Uterus.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10." Tu Y., Popov S., Slaughter C., Ross E.M. J. Biol. Chem. 274:38260-38267(1999) [PubMed: 10608901] [Abstract] Cited for: PALMITOYLATION AT CYS-2; CYS-12 AND CYS-95.
[7]	"RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz GTPase-activating protein subfamily." Wang J., Ducret A., Tu Y., Kozasa T., Aebersold R., Ross E.M. J. Biol. Chem. 273:26014-26025(1998) [PubMed: 9748280] [Abstract] Cited for: INHIBITION.
[8]	"Association and linkage analyses of RGS4 polymorphisms in schizophrenia." Chowdari K.V., Mirnics K., Semwal P., Wood J., Lawrence E., Bhatia T., Deshpande S.N., Thelma B.K., Ferrell R.E., Middleton F.A., Devlin B., Levitt P., Lewis D.A., Nimgaonkar V.L. Hum. Mol. Genet. 11:1373-1380(2002) [PubMed: 12023979] [Abstract] Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SCZD9.
[9]	"Confirming RGS4 as a susceptibility gene for schizophrenia." Morris D.W., Rodgers A., McGhee K.A., Schwaiger S., Scully P., Quinn J., Meagher D., Waddington J.L., Gill M., Corvin A.P. Am. J. Med. Genet. B Neuropsychiatr. Genet. 125:50-53(2004) [PubMed: 14755443] [Abstract] Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SCZD9.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U27768 mRNA. Translation: AAC50395.1. AF493928 mRNA. Translation: AAM12642.1. BT007025 mRNA. Translation: AAP35671.1. AL583850 Genomic DNA. Translation: CAH73767.1. BC000737 mRNA. Translation: AAH00737.1. BC051869 mRNA. Translation: AAH51869.1.
IPI	IPI00028112.
PIR	S78221.
RefSeq	NP_005604.1. NM_005613.5.
UniGene	Hs.386726.
3D structure databases
ProteinModelPortal	P49798.
SMR	P49798. Positions 51-177.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-59092N.
STRING	P49798.
PTM databases
PhosphoSite	P49798.
Polymorphism databases
DMDM	1710146.
Proteomic databases
PRIDE	P49798.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367909; ENSP00000356885; ENSG00000117152. ENST00000421743; ENSP00000397181; ENSG00000117152.
GeneID	5999.
KEGG	hsa:5999.
UCSC	uc009wuy.1. human.
Organism-specific databases
CTD	5999.
GeneCards	GC01P163038.
H-InvDB	HIX0001268.
HGNC	HGNC:10000. RGS4.
HPA	HPA030802.
MIM	181500. phenotype. 602516. gene. 604906. phenotype.
neXtProt	NX_P49798.
Orphanet	3140. Schizophrenia.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11248.
GeneTree	ENSGT00600000084388.
HOVERGEN	HBG013233.
InParanoid	P49798.
OrthoDB	EOG4PK297.
PhylomeDB	P49798.
Gene expression databases
ArrayExpress	P49798.
Bgee	P49798.
CleanEx	HS_RGS4.
Genevestigator	P49798.
GermOnline	ENSG00000117152. Homo sapiens.
Family and domain databases
InterPro	IPR000342. Regulat_G_prot_signal. IPR024066. Regulat_G_prot_signal_dom1. IPR016137. Regulat_G_prot_signal_superfam. [Graphical view]
Gene3D	G3DSA:1.10.196.10. G3DSA:1.10.196.10. 1 hit.
Pfam	PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR01301. RGSPROTEIN.
SMART	SM00315. RGS. 1 hit. [Graphical view]
SUPFAM	SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	23389.
SOURCE	Search...

Entry information

Entry name

RGS4_HUMAN

Accession

Primary (citable) accession number: P49798

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.