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P49798

- RGS4_HUMAN

UniProt

P49798 - RGS4_HUMAN

Protein

Regulator of G-protein signaling 4

Gene

RGS4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

    GO - Molecular functioni

    1. calmodulin binding Source: ProtInc
    2. GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. inactivation of MAPK activity Source: ProtInc
    2. regulation of G-protein coupled receptor protein signaling pathway Source: ProtInc
    3. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Enzyme and pathway databases

    ReactomeiREACT_19231. G alpha (i) signalling events.
    REACT_19333. G alpha (z) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 4
    Short name:
    RGP4
    Short name:
    RGS4
    Gene namesi
    Name:RGS4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:10000. RGS4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. cytosol Source: Ensembl
    3. plasma membrane Source: RefGenome
    4. protein complex Source: Ensembl

    Pathology & Biotechi

    Involvement in diseasei

    Schizophrenia 9 (SCZD9) [MIM:604906]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.2 Publications
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

    Keywords - Diseasei

    Schizophrenia

    Organism-specific databases

    MIMi181500. phenotype.
    604906. phenotype.
    Orphaneti3140. Schizophrenia.
    PharmGKBiPA34375.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 205205Regulator of G-protein signaling 4PRO_0000204185Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21S-palmitoyl cysteine1 Publication
    Lipidationi12 – 121S-palmitoyl cysteine1 Publication
    Lipidationi95 – 951S-palmitoyl cysteine1 Publication

    Post-translational modificationi

    Palmitoylated on Cys-2 and/or Cys-12.1 Publication
    Phosphorylated by cyclic GMP-dependent protein kinase.By similarity

    Keywords - PTMi

    Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiP49798.
    PRIDEiP49798.

    PTM databases

    PhosphoSiteiP49798.

    Expressioni

    Tissue specificityi

    Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum.1 Publication

    Gene expression databases

    ArrayExpressiP49798.
    BgeeiP49798.
    CleanExiHS_RGS4.
    GenevestigatoriP49798.

    Organism-specific databases

    HPAiHPA030802.

    Interactioni

    Protein-protein interaction databases

    BioGridi111931. 13 interactions.
    DIPiDIP-59092N.
    STRINGi9606.ENSP00000397181.

    Structurei

    3D structure databases

    ProteinModelPortaliP49798.
    SMRiP49798. Positions 51-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini62 – 178117RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG318241.
    HOGENOMiHOG000233512.
    HOVERGENiHBG013233.
    InParanoidiP49798.
    KOiK16449.
    OMAiDCPSLVP.
    OrthoDBiEOG7VHSZ5.
    PhylomeDBiP49798.
    TreeFamiTF315837.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Note: May be produced by alternative promoter usage.

    Isoform 1 (identifier: P49798-1) [UniParc]FASTAAdd to Basket

    Also known as: B

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHNSSHN KKDKVVICQR    50
    VSQEEVKKWA ESLENLISHE CGLAAFKAFL KSEYSEENID FWISCEEYKK 100
    IKSPSKLSPK AKKIYNEFIS VQATKEVNLD SCTREETSRN MLEPTITCFD 150
    EAQKKIFNLM EKDSYRRFLK SRFYLDLVNP SSCGAEKQKG AKSSADCASL 200
    VPQCA 205
    Length:205
    Mass (Da):23,256
    Last modified:October 1, 1996 - v1
    Checksum:i7713F1F7496A698B
    GO
    Isoform 2 (identifier: P49798-2) [UniParc]FASTAAdd to Basket

    Also known as: A

    The sequence of this isoform differs from the canonical sequence as follows:
         173-173: F → S

    Show »
    Length:205
    Mass (Da):23,196
    Checksum:i6AA52A87496A698B
    GO
    Isoform 3 (identifier: P49798-3) [UniParc]FASTAAdd to Basket

    Also known as: C

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MYNMMLLIQK...LANSKLLNKM

    Show »
    Length:302
    Mass (Da):33,919
    Checksum:i1D058A564C79BB58
    GO
    Isoform 4 (identifier: P49798-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         72-205: GLAAFKAFLK...DCASLVPQCA → EPGFLHQGRDKPEHARAYNNLL

    Show »
    Length:93
    Mass (Da):10,556
    Checksum:i52F755864B24E3FA
    GO
    Isoform 5 (identifier: P49798-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-18: Missing.

    Show »
    Length:187
    Mass (Da):21,452
    Checksum:i33A39E66A6333B5C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti195 – 1951A → S.
    Corresponds to variant rs14665 [ dbSNP | Ensembl ].
    VAR_051795

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1818Missing in isoform 5. 2 PublicationsVSP_043854Add
    BLAST
    Alternative sequencei1 – 11M → MYNMMLLIQKRKGIGSQLLR AGEAEGDRGAGTAERSSDWL DGRSWAIKETPTGLAGRRSE DSDNIFTGEEAKYAQSRSHS SSCRISFLLANSKLLNKM in isoform 3. 2 PublicationsVSP_043853
    Alternative sequencei72 – 205134GLAAF…VPQCA → EPGFLHQGRDKPEHARAYNN LL in isoform 4. CuratedVSP_043855Add
    BLAST
    Alternative sequencei173 – 1731F → S in isoform 2. 1 PublicationVSP_043856

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U27768 mRNA. Translation: AAC50395.1.
    DQ346662 mRNA. Translation: ABC94590.1.
    DQ346663 mRNA. Translation: ABC94591.1.
    DQ346664 mRNA. Translation: ABC94592.1.
    EF054877 mRNA. Translation: ABL74968.1.
    AK093959 mRNA. No translation available.
    AK295540 mRNA. Translation: BAG58449.1.
    AK296240 mRNA. Translation: BAG58958.1.
    AK312250 mRNA. Translation: BAG35182.1.
    AF493928 mRNA. Translation: AAM12642.1.
    BT007025 mRNA. Translation: AAP35671.1.
    AL583850 Genomic DNA. Translation: CAH73766.1.
    AL583850 Genomic DNA. Translation: CAH73767.1.
    AL583850 Genomic DNA. Translation: CAH73768.1.
    CH471067 Genomic DNA. Translation: EAW90727.1.
    CH471067 Genomic DNA. Translation: EAW90728.1.
    BC000737 mRNA. Translation: AAH00737.1.
    BC051869 mRNA. Translation: AAH51869.1.
    CCDSiCCDS1243.1. [P49798-1]
    CCDS44270.1. [P49798-3]
    CCDS44271.1. [P49798-4]
    CCDS44272.1. [P49798-5]
    PIRiS78221.
    RefSeqiNP_001095915.1. NM_001102445.2. [P49798-3]
    NP_001106851.1. NM_001113380.1. [P49798-5]
    NP_001106852.1. NM_001113381.1. [P49798-4]
    NP_005604.1. NM_005613.5. [P49798-1]
    UniGeneiHs.386726.

    Genome annotation databases

    EnsembliENST00000367906; ENSP00000356882; ENSG00000117152. [P49798-5]
    ENST00000367908; ENSP00000356884; ENSG00000117152. [P49798-4]
    ENST00000367909; ENSP00000356885; ENSG00000117152. [P49798-1]
    ENST00000421743; ENSP00000397181; ENSG00000117152. [P49798-3]
    ENST00000527809; ENSP00000433261; ENSG00000117152. [P49798-5]
    GeneIDi5999.
    KEGGihsa:5999.
    UCSCiuc001gcl.4. human. [P49798-3]
    uc009wuy.3. human. [P49798-1]
    uc009wuz.3. human. [P49798-4]

    Polymorphism databases

    DMDMi1710146.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U27768 mRNA. Translation: AAC50395.1 .
    DQ346662 mRNA. Translation: ABC94590.1 .
    DQ346663 mRNA. Translation: ABC94591.1 .
    DQ346664 mRNA. Translation: ABC94592.1 .
    EF054877 mRNA. Translation: ABL74968.1 .
    AK093959 mRNA. No translation available.
    AK295540 mRNA. Translation: BAG58449.1 .
    AK296240 mRNA. Translation: BAG58958.1 .
    AK312250 mRNA. Translation: BAG35182.1 .
    AF493928 mRNA. Translation: AAM12642.1 .
    BT007025 mRNA. Translation: AAP35671.1 .
    AL583850 Genomic DNA. Translation: CAH73766.1 .
    AL583850 Genomic DNA. Translation: CAH73767.1 .
    AL583850 Genomic DNA. Translation: CAH73768.1 .
    CH471067 Genomic DNA. Translation: EAW90727.1 .
    CH471067 Genomic DNA. Translation: EAW90728.1 .
    BC000737 mRNA. Translation: AAH00737.1 .
    BC051869 mRNA. Translation: AAH51869.1 .
    CCDSi CCDS1243.1. [P49798-1 ]
    CCDS44270.1. [P49798-3 ]
    CCDS44271.1. [P49798-4 ]
    CCDS44272.1. [P49798-5 ]
    PIRi S78221.
    RefSeqi NP_001095915.1. NM_001102445.2. [P49798-3 ]
    NP_001106851.1. NM_001113380.1. [P49798-5 ]
    NP_001106852.1. NM_001113381.1. [P49798-4 ]
    NP_005604.1. NM_005613.5. [P49798-1 ]
    UniGenei Hs.386726.

    3D structure databases

    ProteinModelPortali P49798.
    SMRi P49798. Positions 51-177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111931. 13 interactions.
    DIPi DIP-59092N.
    STRINGi 9606.ENSP00000397181.

    Chemistry

    ChEMBLi CHEMBL1795091.

    PTM databases

    PhosphoSitei P49798.

    Polymorphism databases

    DMDMi 1710146.

    Proteomic databases

    PaxDbi P49798.
    PRIDEi P49798.

    Protocols and materials databases

    DNASUi 5999.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367906 ; ENSP00000356882 ; ENSG00000117152 . [P49798-5 ]
    ENST00000367908 ; ENSP00000356884 ; ENSG00000117152 . [P49798-4 ]
    ENST00000367909 ; ENSP00000356885 ; ENSG00000117152 . [P49798-1 ]
    ENST00000421743 ; ENSP00000397181 ; ENSG00000117152 . [P49798-3 ]
    ENST00000527809 ; ENSP00000433261 ; ENSG00000117152 . [P49798-5 ]
    GeneIDi 5999.
    KEGGi hsa:5999.
    UCSCi uc001gcl.4. human. [P49798-3 ]
    uc009wuy.3. human. [P49798-1 ]
    uc009wuz.3. human. [P49798-4 ]

    Organism-specific databases

    CTDi 5999.
    GeneCardsi GC01P163038.
    HGNCi HGNC:10000. RGS4.
    HPAi HPA030802.
    MIMi 181500. phenotype.
    602516. gene.
    604906. phenotype.
    neXtProti NX_P49798.
    Orphaneti 3140. Schizophrenia.
    PharmGKBi PA34375.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG318241.
    HOGENOMi HOG000233512.
    HOVERGENi HBG013233.
    InParanoidi P49798.
    KOi K16449.
    OMAi DCPSLVP.
    OrthoDBi EOG7VHSZ5.
    PhylomeDBi P49798.
    TreeFami TF315837.

    Enzyme and pathway databases

    Reactomei REACT_19231. G alpha (i) signalling events.
    REACT_19333. G alpha (z) signalling events.

    Miscellaneous databases

    GeneWikii RGS4.
    GenomeRNAii 5999.
    NextBioi 23389.
    PROi P49798.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49798.
    Bgeei P49798.
    CleanExi HS_RGS4.
    Genevestigatori P49798.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family."
      Druey K.M., Blumer K.J., Kang V.H., Kehrl J.H.
      Nature 379:742-746(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Full length cloning and expression analysis of splice variants of regulator of G-protein signaling RGS4 in human and murine brain."
      Ding L., Mychaleckyj J.C., Hegde A.N.
      Gene 401:46-60(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 5), ALTERNATIVE SPLICING (ISOFORM 4), TISSUE SPECIFICITY.
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Uterus.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 5).
      Tissue: Hippocampus, Thalamus and Trachea.
    6. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    9. "Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10."
      Tu Y., Popov S., Slaughter C., Ross E.M.
      J. Biol. Chem. 274:38260-38267(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION AT CYS-2; CYS-12 AND CYS-95.
    10. "RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz GTPase-activating protein subfamily."
      Wang J., Ducret A., Tu Y., Kozasa T., Aebersold R., Ross E.M.
      J. Biol. Chem. 273:26014-26025(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INHIBITION.
    11. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SCZD9.
    12. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SCZD9.

    Entry informationi

    Entry nameiRGS4_HUMAN
    AccessioniPrimary (citable) accession number: P49798
    Secondary accession number(s): A7XA56
    , A7XA58, A7XA59, A7YVV7, B1APZ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3