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P49798 (RGS4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 4

Short name=RGP4
Short name=RGS4
Gene names
Name:RGS4
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length205 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

Post-translational modification

Palmitoylated on Cys-2 and/or Cys-12. Ref.6

Phosphorylated by cyclic GMP-dependent protein kinase By similarity.

Involvement in disease

Genetic variation in RGS4 is associated with susceptibility to schizophrenia type 9 (SCZD9) [MIM:604906]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. Ref.8 Ref.9

Sequence similarities

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 205205Regulator of G-protein signaling 4
PRO_0000204185

Regions

Domain62 – 178117RGS

Amino acid modifications

Lipidation21S-palmitoyl cysteine Probable
Lipidation121S-palmitoyl cysteine Probable
Lipidation951S-palmitoyl cysteine Ref.6

Natural variations

Natural variant1951A → S.
Corresponds to variant rs14665 [ dbSNP | Ensembl ].
VAR_051795

Sequences

Sequence LengthMass (Da)Tools
P49798 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 7713F1F7496A698B

FASTA20523,256
        10         20         30         40         50         60 
MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHNSSHN KKDKVVICQR VSQEEVKKWA 

        70         80         90        100        110        120 
ESLENLISHE CGLAAFKAFL KSEYSEENID FWISCEEYKK IKSPSKLSPK AKKIYNEFIS 

       130        140        150        160        170        180 
VQATKEVNLD SCTREETSRN MLEPTITCFD EAQKKIFNLM EKDSYRRFLK SRFYLDLVNP 

       190        200 
SSCGAEKQKG AKSSADCASL VPQCA 

« Hide

References

« Hide 'large scale' references
[1]"Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family."
Druey K.M., Blumer K.J., Kang V.H., Kehrl J.H.
Nature 379:742-746(1996) [PubMed: 8602223] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Uterus.
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10."
Tu Y., Popov S., Slaughter C., Ross E.M.
J. Biol. Chem. 274:38260-38267(1999) [PubMed: 10608901] [Abstract]
Cited for: PALMITOYLATION AT CYS-2; CYS-12 AND CYS-95.
[7]"RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz GTPase-activating protein subfamily."
Wang J., Ducret A., Tu Y., Kozasa T., Aebersold R., Ross E.M.
J. Biol. Chem. 273:26014-26025(1998) [PubMed: 9748280] [Abstract]
Cited for: INHIBITION.
[8]"Association and linkage analyses of RGS4 polymorphisms in schizophrenia."
Chowdari K.V., Mirnics K., Semwal P., Wood J., Lawrence E., Bhatia T., Deshpande S.N., Thelma B.K., Ferrell R.E., Middleton F.A., Devlin B., Levitt P., Lewis D.A., Nimgaonkar V.L.
Hum. Mol. Genet. 11:1373-1380(2002) [PubMed: 12023979] [Abstract]
Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SCZD9.
[9]"Confirming RGS4 as a susceptibility gene for schizophrenia."
Morris D.W., Rodgers A., McGhee K.A., Schwaiger S., Scully P., Quinn J., Meagher D., Waddington J.L., Gill M., Corvin A.P.
Am. J. Med. Genet. B Neuropsychiatr. Genet. 125:50-53(2004) [PubMed: 14755443] [Abstract]
Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SCZD9.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U27768 mRNA. Translation: AAC50395.1.
AF493928 mRNA. Translation: AAM12642.1.
BT007025 mRNA. Translation: AAP35671.1.
AL583850 Genomic DNA. Translation: CAH73767.1.
BC000737 mRNA. Translation: AAH00737.1.
BC051869 mRNA. Translation: AAH51869.1.
IPIIPI00028112.
PIRS78221.
RefSeqNP_005604.1. NM_005613.5.
UniGeneHs.386726.

3D structure databases

ProteinModelPortalP49798.
SMRP49798. Positions 51-177.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-59092N.
STRINGP49798.

PTM databases

PhosphoSiteP49798.

Polymorphism databases

DMDM1710146.

Proteomic databases

PRIDEP49798.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367909; ENSP00000356885; ENSG00000117152.
ENST00000421743; ENSP00000397181; ENSG00000117152.
GeneID5999.
KEGGhsa:5999.
UCSCuc009wuy.1. human.

Organism-specific databases

CTD5999.
GeneCardsGC01P163038.
H-InvDBHIX0001268.
HGNCHGNC:10000. RGS4.
HPAHPA030802.
MIM181500. phenotype.
602516. gene.
604906. phenotype.
neXtProtNX_P49798.
Orphanet3140. Schizophrenia.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG11248.
GeneTreeENSGT00600000084388.
HOVERGENHBG013233.
InParanoidP49798.
OrthoDBEOG4PK297.
PhylomeDBP49798.

Gene expression databases

ArrayExpressP49798.
BgeeP49798.
CleanExHS_RGS4.
GenevestigatorP49798.
GermOnlineENSG00000117152. Homo sapiens.

Family and domain databases

InterProIPR000342. Regulat_G_prot_signal.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
[Graphical view]
Gene3DG3DSA:1.10.196.10. G3DSA:1.10.196.10. 1 hit.
PfamPF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITEPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio23389.
SOURCESearch...

Entry information

Entry nameRGS4_HUMAN
AccessionPrimary (citable) accession number: P49798
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 25, 2012
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families