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Protein

Regulator of G-protein signaling 4

Gene

RGS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

GO - Molecular functioni

  1. calmodulin binding Source: ProtInc
  2. GTPase activator activity Source: GO_Central

GO - Biological processi

  1. inactivation of MAPK activity Source: ProtInc
  2. regulation of G-protein coupled receptor protein signaling pathway Source: ProtInc
  3. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiREACT_19231. G alpha (i) signalling events.
REACT_19333. G alpha (z) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 4
Short name:
RGP4
Short name:
RGS4
Gene namesi
Name:RGS4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10000. RGS4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. cytosol Source: Ensembl
  3. plasma membrane Source: GO_Central
  4. protein complex Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Schizophrenia 92 Publications

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.

See also OMIM:604906

Keywords - Diseasei

Schizophrenia

Organism-specific databases

MIMi181500. phenotype.
604906. phenotype.
Orphaneti3140. Schizophrenia.
PharmGKBiPA34375.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Regulator of G-protein signaling 4PRO_0000204185Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21S-palmitoyl cysteine1 Publication
Lipidationi12 – 121S-palmitoyl cysteine1 Publication
Lipidationi95 – 951S-palmitoyl cysteine1 Publication

Post-translational modificationi

Palmitoylated on Cys-2 and/or Cys-12.1 Publication
Phosphorylated by cyclic GMP-dependent protein kinase.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP49798.
PRIDEiP49798.

PTM databases

PhosphoSiteiP49798.

Expressioni

Tissue specificityi

Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum.1 Publication

Gene expression databases

BgeeiP49798.
CleanExiHS_RGS4.
ExpressionAtlasiP49798. baseline and differential.
GenevestigatoriP49798.

Organism-specific databases

HPAiHPA030802.

Interactioni

Protein-protein interaction databases

BioGridi111931. 13 interactions.
DIPiDIP-59092N.
IntActiP49798. 1 interaction.
STRINGi9606.ENSP00000397181.

Structurei

3D structure databases

ProteinModelPortaliP49798.
SMRiP49798. Positions 51-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 178117RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG318241.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiP49798.
KOiK16449.
OMAiVCQRVSQ.
OrthoDBiEOG7VHSZ5.
PhylomeDBiP49798.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: May be produced by alternative promoter usage.

Isoform 1 (identifier: P49798-1) [UniParc]FASTAAdd to basket

Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHNSSHN KKDKVVICQR
60 70 80 90 100
VSQEEVKKWA ESLENLISHE CGLAAFKAFL KSEYSEENID FWISCEEYKK
110 120 130 140 150
IKSPSKLSPK AKKIYNEFIS VQATKEVNLD SCTREETSRN MLEPTITCFD
160 170 180 190 200
EAQKKIFNLM EKDSYRRFLK SRFYLDLVNP SSCGAEKQKG AKSSADCASL

VPQCA
Length:205
Mass (Da):23,256
Last modified:October 1, 1996 - v1
Checksum:i7713F1F7496A698B
GO
Isoform 2 (identifier: P49798-2) [UniParc]FASTAAdd to basket

Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     173-173: F → S

Show »
Length:205
Mass (Da):23,196
Checksum:i6AA52A87496A698B
GO
Isoform 3 (identifier: P49798-3) [UniParc]FASTAAdd to basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MYNMMLLIQK...LANSKLLNKM

Show »
Length:302
Mass (Da):33,919
Checksum:i1D058A564C79BB58
GO
Isoform 4 (identifier: P49798-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-205: GLAAFKAFLK...DCASLVPQCA → EPGFLHQGRDKPEHARAYNNLL

Show »
Length:93
Mass (Da):10,556
Checksum:i52F755864B24E3FA
GO
Isoform 5 (identifier: P49798-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.

Show »
Length:187
Mass (Da):21,452
Checksum:i33A39E66A6333B5C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti195 – 1951A → S.
Corresponds to variant rs14665 [ dbSNP | Ensembl ].
VAR_051795

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1818Missing in isoform 5. 2 PublicationsVSP_043854Add
BLAST
Alternative sequencei1 – 11M → MYNMMLLIQKRKGIGSQLLR AGEAEGDRGAGTAERSSDWL DGRSWAIKETPTGLAGRRSE DSDNIFTGEEAKYAQSRSHS SSCRISFLLANSKLLNKM in isoform 3. 2 PublicationsVSP_043853
Alternative sequencei72 – 205134GLAAF…VPQCA → EPGFLHQGRDKPEHARAYNN LL in isoform 4. CuratedVSP_043855Add
BLAST
Alternative sequencei173 – 1731F → S in isoform 2. 1 PublicationVSP_043856

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27768 mRNA. Translation: AAC50395.1.
DQ346662 mRNA. Translation: ABC94590.1.
DQ346663 mRNA. Translation: ABC94591.1.
DQ346664 mRNA. Translation: ABC94592.1.
EF054877 mRNA. Translation: ABL74968.1.
AK093959 mRNA. No translation available.
AK295540 mRNA. Translation: BAG58449.1.
AK296240 mRNA. Translation: BAG58958.1.
AK312250 mRNA. Translation: BAG35182.1.
AF493928 mRNA. Translation: AAM12642.1.
BT007025 mRNA. Translation: AAP35671.1.
AL583850 Genomic DNA. Translation: CAH73766.1.
AL583850 Genomic DNA. Translation: CAH73767.1.
AL583850 Genomic DNA. Translation: CAH73768.1.
CH471067 Genomic DNA. Translation: EAW90727.1.
CH471067 Genomic DNA. Translation: EAW90728.1.
BC000737 mRNA. Translation: AAH00737.1.
BC051869 mRNA. Translation: AAH51869.1.
CCDSiCCDS1243.1. [P49798-1]
CCDS44270.1. [P49798-3]
CCDS44271.1. [P49798-4]
CCDS44272.1. [P49798-5]
PIRiS78221.
RefSeqiNP_001095915.1. NM_001102445.2. [P49798-3]
NP_001106851.1. NM_001113380.1. [P49798-5]
NP_001106852.1. NM_001113381.1. [P49798-4]
NP_005604.1. NM_005613.5. [P49798-1]
UniGeneiHs.386726.

Genome annotation databases

EnsembliENST00000367906; ENSP00000356882; ENSG00000117152. [P49798-5]
ENST00000367908; ENSP00000356884; ENSG00000117152. [P49798-4]
ENST00000367909; ENSP00000356885; ENSG00000117152. [P49798-1]
ENST00000421743; ENSP00000397181; ENSG00000117152. [P49798-3]
ENST00000527809; ENSP00000433261; ENSG00000117152. [P49798-5]
GeneIDi5999.
KEGGihsa:5999.
UCSCiuc001gcl.4. human. [P49798-3]
uc009wuy.3. human. [P49798-1]
uc009wuz.3. human. [P49798-4]

Polymorphism databases

DMDMi1710146.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27768 mRNA. Translation: AAC50395.1.
DQ346662 mRNA. Translation: ABC94590.1.
DQ346663 mRNA. Translation: ABC94591.1.
DQ346664 mRNA. Translation: ABC94592.1.
EF054877 mRNA. Translation: ABL74968.1.
AK093959 mRNA. No translation available.
AK295540 mRNA. Translation: BAG58449.1.
AK296240 mRNA. Translation: BAG58958.1.
AK312250 mRNA. Translation: BAG35182.1.
AF493928 mRNA. Translation: AAM12642.1.
BT007025 mRNA. Translation: AAP35671.1.
AL583850 Genomic DNA. Translation: CAH73766.1.
AL583850 Genomic DNA. Translation: CAH73767.1.
AL583850 Genomic DNA. Translation: CAH73768.1.
CH471067 Genomic DNA. Translation: EAW90727.1.
CH471067 Genomic DNA. Translation: EAW90728.1.
BC000737 mRNA. Translation: AAH00737.1.
BC051869 mRNA. Translation: AAH51869.1.
CCDSiCCDS1243.1. [P49798-1]
CCDS44270.1. [P49798-3]
CCDS44271.1. [P49798-4]
CCDS44272.1. [P49798-5]
PIRiS78221.
RefSeqiNP_001095915.1. NM_001102445.2. [P49798-3]
NP_001106851.1. NM_001113380.1. [P49798-5]
NP_001106852.1. NM_001113381.1. [P49798-4]
NP_005604.1. NM_005613.5. [P49798-1]
UniGeneiHs.386726.

3D structure databases

ProteinModelPortaliP49798.
SMRiP49798. Positions 51-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111931. 13 interactions.
DIPiDIP-59092N.
IntActiP49798. 1 interaction.
STRINGi9606.ENSP00000397181.

Chemistry

BindingDBiP49798.
ChEMBLiCHEMBL1795091.

PTM databases

PhosphoSiteiP49798.

Polymorphism databases

DMDMi1710146.

Proteomic databases

PaxDbiP49798.
PRIDEiP49798.

Protocols and materials databases

DNASUi5999.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367906; ENSP00000356882; ENSG00000117152. [P49798-5]
ENST00000367908; ENSP00000356884; ENSG00000117152. [P49798-4]
ENST00000367909; ENSP00000356885; ENSG00000117152. [P49798-1]
ENST00000421743; ENSP00000397181; ENSG00000117152. [P49798-3]
ENST00000527809; ENSP00000433261; ENSG00000117152. [P49798-5]
GeneIDi5999.
KEGGihsa:5999.
UCSCiuc001gcl.4. human. [P49798-3]
uc009wuy.3. human. [P49798-1]
uc009wuz.3. human. [P49798-4]

Organism-specific databases

CTDi5999.
GeneCardsiGC01P163038.
HGNCiHGNC:10000. RGS4.
HPAiHPA030802.
MIMi181500. phenotype.
602516. gene.
604906. phenotype.
neXtProtiNX_P49798.
Orphaneti3140. Schizophrenia.
PharmGKBiPA34375.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG318241.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiP49798.
KOiK16449.
OMAiVCQRVSQ.
OrthoDBiEOG7VHSZ5.
PhylomeDBiP49798.
TreeFamiTF315837.

Enzyme and pathway databases

ReactomeiREACT_19231. G alpha (i) signalling events.
REACT_19333. G alpha (z) signalling events.

Miscellaneous databases

ChiTaRSiRGS4. human.
GeneWikiiRGS4.
GenomeRNAii5999.
NextBioi23389.
PROiP49798.
SOURCEiSearch...

Gene expression databases

BgeeiP49798.
CleanExiHS_RGS4.
ExpressionAtlasiP49798. baseline and differential.
GenevestigatoriP49798.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family."
    Druey K.M., Blumer K.J., Kang V.H., Kehrl J.H.
    Nature 379:742-746(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Full length cloning and expression analysis of splice variants of regulator of G-protein signaling RGS4 in human and murine brain."
    Ding L., Mychaleckyj J.C., Hegde A.N.
    Gene 401:46-60(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 5), ALTERNATIVE SPLICING (ISOFORM 4), TISSUE SPECIFICITY.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Uterus.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 5).
    Tissue: Hippocampus, Thalamus and Trachea.
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  9. "Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10."
    Tu Y., Popov S., Slaughter C., Ross E.M.
    J. Biol. Chem. 274:38260-38267(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-2; CYS-12 AND CYS-95.
  10. "RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz GTPase-activating protein subfamily."
    Wang J., Ducret A., Tu Y., Kozasa T., Aebersold R., Ross E.M.
    J. Biol. Chem. 273:26014-26025(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INHIBITION.
  11. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SCZD9.
  12. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SCZD9.

Entry informationi

Entry nameiRGS4_HUMAN
AccessioniPrimary (citable) accession number: P49798
Secondary accession number(s): A7XA56
, A7XA58, A7XA59, A7YVV7, B1APZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 4, 2015
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.