P49796 (RGS3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of G-protein signaling 3
Short name=RGP3
Short name=RGS3

Gene names

Name:

RGS3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1198 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. Ref.1 Ref.9 Ref.10 Ref.11
Subunit structure	Binds EFNB1 and EFNB2 By similarity. Binds the GNB1-GNG2 heterodimer.
Subcellular location	Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein Potential. Note: Long isoforms are cytoplasmic and associated with the plasma membrane. Short isoforms are nuclear. Ref.9 Ref.10 Ref.11
Post-translational modification	Phosphorylated by cyclic GMP-dependent protein kinase By similarity. ISGylated Probable. Ref.12
Sequence similarities	Contains 1 C2 domain. Contains 1 PDZ (DHR) domain. Contains 1 RGS domain.
Sequence caution	The sequence AAM33254.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Signal transduction inhibitor
PTM	Phosphoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	inactivation of MAPK activity Traceable author statement Ref.1. Source: ProtInc regulation of G-protein coupled receptor protein signaling pathway Traceable author statement Ref.9. Source: ProtInc termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cytosol Traceable author statement Ref.9. Source: ProtInc nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 3 (identifier: P49796-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: P49796-1)

The sequence of this isoform differs from the canonical sequence as follows:
     1-679: Missing.

Isoform 2 (identifier: P49796-2)

Also known as: RGS3T;

The sequence of this isoform differs from the canonical sequence as follows:
     1-992: Missing.

Note: Nuclear.

Isoform 4 (identifier: P49796-4)

Also known as: 1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-281: Missing.
     282-299: PLLRMPGGGDTENGKKLK → MNRFNGLCKVCSERRYRQ

Isoform 5 (identifier: P49796-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.
     113-138: ALPRRDEWTQTSPARKRITHAKVQGA → MERSLHRVSLGSRRAHPDLSFYLTTF
     680-714: MFETEADEKREMALEEGKGPGAEDSPPSKEPSPGQ → KLHPFGSLQQEMGPVNSTNATQDRSFTSPGQTLIG
     715-1198: Missing.

Isoform 6 (identifier: P49796-6)

Also known as: C2PA-RGS3;

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1198

1198

Regulator of G-protein signaling 3

PRO_0000204182

Regions

Domain

137 – 239

103

C2

Domain

299 – 376

78

PDZ

Domain

1073 – 1198

126

RGS

Compositional bias

705 – 819

115

Pro-rich

Amino acid modifications

Modified residue

943

1

Phosphoserine By similarity

Modified residue

946

1

Phosphoserine By similarity

Natural variations

Alternative sequence

1 – 992

992

Missing in isoform 2.

VSP_005662

Alternative sequence

1 – 679

679

Missing in isoform 1.

VSP_013958

Alternative sequence

1 – 281

281

Missing in isoform 4.

VSP_013959

Alternative sequence

1 – 112

112

Missing in isoform 5.

VSP_013961

Alternative sequence

1 – 104

104

Missing in isoform 6.

VSP_013960

Alternative sequence

113 – 138

26

ALPRR…KVQGA → MERSLHRVSLGSRRAHPDLS FYLTTF in isoform 5.

VSP_013962

Alternative sequence

282 – 299

18

PLLRM…GKKLK → MNRFNGLCKVCSERRYRQ in isoform 4.

VSP_013963

Alternative sequence

680 – 714

35

MFETE…PSPGQ → KLHPFGSLQQEMGPVNSTNA TQDRSFTSPGQTLIG in isoform 5.

VSP_013964

Alternative sequence

715 – 1198

484

Missing in isoform 5.

VSP_013965

Natural variant

129

1

R → K.
Corresponds to variant rs16933949 [ dbSNP | Ensembl ].

VAR_051794

Natural variant

809

1

R → Q.
Corresponds to variant rs41305473 [ dbSNP | Ensembl ].

VAR_061769

Experimental info

Sequence conflict

170

1

C → W in AAM33254. Ref.2

Sequence conflict

206

1

F → S in BAC11328. Ref.3

Sequence conflict

266

1

T → A in AAM33254. Ref.2

Sequence conflict

462

1

A → V in AAL68829. Ref.4

Sequence conflict

585

1

A → V in AAM33255. Ref.2

Sequence conflict

632

1

C → R in BAC11328. Ref.3

Sequence conflict

705

1

Missing in AAM33254. Ref.2

Sequence conflict

725

1

N → S in AAH42555. Ref.8

Sequence conflict

873

1

Q → H in AAM33254. Ref.2

Sequence conflict

883 – 884

2

EE → KQ in AAM33254. Ref.2

Sequence conflict

984

1

K → R in AAM12641. Ref.5

Secondary structure

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1198

Helix Strand Turn

Details...

Beta strand

140 – 161

22

Beta strand

166 – 168

3

Beta strand

172 – 180

9

Beta strand

200 – 208

9

Helix

211 – 213

3

Beta strand

216 – 224

9

Helix

229 – 231

3

Beta strand

233 – 241

9

Helix

242 – 245

4

Beta strand

252 – 257

6

Helix

263 – 265

3

Beta strand

300 – 303

4

Beta strand

310 – 314

5

Beta strand

316 – 318

3

Beta strand

320 – 324

5

Helix

329 – 333

5

Beta strand

340 – 344

5

Helix

354 – 362

9

Beta strand

365 – 374

10

Helix

1066 – 1070

5

Helix

1074 – 1078

5

Helix

1081 – 1093

13

Helix

1097 – 1109

13

Helix

1115 – 1129

15

Helix

1142 – 1150

9

Turn

1157 – 1160

4

Helix

1161 – 1173

13

Helix

1175 – 1181

7

Helix

1183 – 1186

4

Turn

1187 – 1189

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 3 [UniParc]. Last modified June 7, 2005. Version 2. Checksum: E615DA49022EFFE4	FASTA	1,198	132,336
	10 20 30 40 50 60 MPVIPALWEV EMGRSQGQEI ETILANRSHS DSTPLPNFLS GSHRPECCTC RLLTASGAQD 70 80 90 100 110 120 SLPFGRRLYS GPWRSCEEVC HVSVLSVLST SCGLSLSLPI FPGWMEWLSP DIALPRRDEW 130 140 150 160 170 180 TQTSPARKRI THAKVQGAGQ LRLSIDAQDR VLLLHIIEGK GLISKQPGTC DPYVKISLIP 190 200 210 220 230 240 EDSRLRHQKT QTVPDCRDPA FHEHFFFPVQ EEDDQKRLLV TVWNRASQSR QSGLIGCMSF 250 260 270 280 290 300 GVKSLLTPDK EISGWYYLLG EHLGRTKHLK VARRRLRPLR DPLLRMPGGG DTENGKKLKI 310 320 330 340 350 360 TIPRGKDGFG FTICCDSPVR VQAVDSGGPA ERAGLQQLDT VLQLNERPVE HWKCVELAHE 370 380 390 400 410 420 IRSCPSEIIL LVWRMVPQVK PGPDGGVLRR ASCKSTHDLQ SPPNKREKNC THGVQARPEQ 430 440 450 460 470 480 RHSCHLVCDS SDGLLLGGWE RYTEVAKRGG QHTLPALSRA TAPTDPNYII LAPLNPGSQL 490 500 510 520 530 540 LRPVYQEDTI PEESGSPSKG KSYTGLGKKS RLMKTVQTMK GHGNYQNCPV VRPHATHSSY 550 560 570 580 590 600 GTYVTLAPKV LVFPVFVQPL DLCNPARTLL LSEELLLYEG RNKAAEVTLF AYSDLLLFTK 610 620 630 640 650 660 EDEPGRCDVL RNPLYLQSVK LQEGSSEDLK FCVLYLAEKA ECLFTLEAHS QEQKKRVCWC 670 680 690 700 710 720 LSENIAKQQQ LAASPPDSKM FETEADEKRE MALEEGKGPG AEDSPPSKEP SPGQELPPGQ 730 740 750 760 770 780 DLPPNKDSPS GQEPAPSQEP LSSKDSATSE GSPPGPDAPP SKDVPPCQEP PPAQDLSPCQ 790 800 810 820 830 840 DLPAGQEPLP HQDPLLTKDL PAIQESPTRD LPPCQDLPPS QVSLPAKALT EDTMSSGDLL 850 860 870 880 890 900 AATGDPPAAP RPAFVIPEVR LDSTYSQKAG AEQGCSGDEE DAEEAEEVEE GEEGEEDEDE 910 920 930 940 950 960 DTSDDNYGER SEAKRSSMIE TGQGAEGGLS LRVQNSLRRR THSEGSLLQE PRGPCFASDT 970 980 990 1000 1010 1020 TLHCSDGEGA ASTWGMPSPS TLKKELGRNG GSMHHLSLFF TGHRKMSGAD TVGDDDEASR 1030 1040 1050 1060 1070 1080 KRKSKNLAKD MKNKLGIFRR RNESPGAPPA GKADKMMKSF KPTSEEALKW GESLEKLLVH 1090 1100 1110 1120 1130 1140 KYGLAVFQAF LRTEFSEENL EFWLACEDFK KVKSQSKMAS KAKKIFAEYI AIQACKEVNL 1150 1160 1170 1180 1190 DSYTREHTKD NLQSVTRGCF DLAQKRIFGL MEKDSYPRFL RSDLYLDLIN QKKMSPPL
	Isoform 1 [UniParc]. Checksum: F1CFE3F27D4673A0	FASTA	519	56,602
	10 20 30 40 50 60 MFETEADEKR EMALEEGKGP GAEDSPPSKE PSPGQELPPG QDLPPNKDSP SGQEPAPSQE 70 80 90 100 110 120 PLSSKDSATS EGSPPGPDAP PSKDVPPCQE PPPAQDLSPC QDLPAGQEPL PHQDPLLTKD 130 140 150 160 170 180 LPAIQESPTR DLPPCQDLPP SQVSLPAKAL TEDTMSSGDL LAATGDPPAA PRPAFVIPEV 190 200 210 220 230 240 RLDSTYSQKA GAEQGCSGDE EDAEEAEEVE EGEEGEEDED EDTSDDNYGE RSEAKRSSMI 250 260 270 280 290 300 ETGQGAEGGL SLRVQNSLRR RTHSEGSLLQ EPRGPCFASD TTLHCSDGEG AASTWGMPSP 310 320 330 340 350 360 STLKKELGRN GGSMHHLSLF FTGHRKMSGA DTVGDDDEAS RKRKSKNLAK DMKNKLGIFR 370 380 390 400 410 420 RRNESPGAPP AGKADKMMKS FKPTSEEALK WGESLEKLLV HKYGLAVFQA FLRTEFSEEN 430 440 450 460 470 480 LEFWLACEDF KKVKSQSKMA SKAKKIFAEY IAIQACKEVN LDSYTREHTK DNLQSVTRGC 490 500 510 FDLAQKRIFG LMEKDSYPRF LRSDLYLDLI NQKKMSPPL
	Isoform 2 (RGS3T) [UniParc]. Checksum: E24047B4952692D4	FASTA	206	23,725
	10 20 30 40 50 60 MHHLSLFFTG HRKMSGADTV GDDDEASRKR KSKNLAKDMK NKLGIFRRRN ESPGAPPAGK 70 80 90 100 110 120 ADKMMKSFKP TSEEALKWGE SLEKLLVHKY GLAVFQAFLR TEFSEENLEF WLACEDFKKV 130 140 150 160 170 180 KSQSKMASKA KKIFAEYIAI QACKEVNLDS YTREHTKDNL QSVTRGCFDL AQKRIFGLME 190 200 KDSYPRFLRS DLYLDLINQK KMSPPL
	Isoform 4 (1) [UniParc]. Checksum: 17D77BE23D0A1C52	FASTA	917	100,948
	10 20 30 40 50 60 MNRFNGLCKV CSERRYRQIT IPRGKDGFGF TICCDSPVRV QAVDSGGPAE RAGLQQLDTV 70 80 90 100 110 120 LQLNERPVEH WKCVELAHEI RSCPSEIILL VWRMVPQVKP GPDGGVLRRA SCKSTHDLQS 130 140 150 160 170 180 PPNKREKNCT HGVQARPEQR HSCHLVCDSS DGLLLGGWER YTEVAKRGGQ HTLPALSRAT 190 200 210 220 230 240 APTDPNYIIL APLNPGSQLL RPVYQEDTIP EESGSPSKGK SYTGLGKKSR LMKTVQTMKG 250 260 270 280 290 300 HGNYQNCPVV RPHATHSSYG TYVTLAPKVL VFPVFVQPLD LCNPARTLLL SEELLLYEGR 310 320 330 340 350 360 NKAAEVTLFA YSDLLLFTKE DEPGRCDVLR NPLYLQSVKL QEGSSEDLKF CVLYLAEKAE 370 380 390 400 410 420 CLFTLEAHSQ EQKKRVCWCL SENIAKQQQL AASPPDSKMF ETEADEKREM ALEEGKGPGA 430 440 450 460 470 480 EDSPPSKEPS PGQELPPGQD LPPNKDSPSG QEPAPSQEPL SSKDSATSEG SPPGPDAPPS 490 500 510 520 530 540 KDVPPCQEPP PAQDLSPCQD LPAGQEPLPH QDPLLTKDLP AIQESPTRDL PPCQDLPPSQ 550 560 570 580 590 600 VSLPAKALTE DTMSSGDLLA ATGDPPAAPR PAFVIPEVRL DSTYSQKAGA EQGCSGDEED 610 620 630 640 650 660 AEEAEEVEEG EEGEEDEDED TSDDNYGERS EAKRSSMIET GQGAEGGLSL RVQNSLRRRT 670 680 690 700 710 720 HSEGSLLQEP RGPCFASDTT LHCSDGEGAA STWGMPSPST LKKELGRNGG SMHHLSLFFT 730 740 750 760 770 780 GHRKMSGADT VGDDDEASRK RKSKNLAKDM KNKLGIFRRR NESPGAPPAG KADKMMKSFK 790 800 810 820 830 840 PTSEEALKWG ESLEKLLVHK YGLAVFQAFL RTEFSEENLE FWLACEDFKK VKSQSKMASK 850 860 870 880 890 900 AKKIFAEYIA IQACKEVNLD SYTREHTKDN LQSVTRGCFD LAQKRIFGLM EKDSYPRFLR 910 SDLYLDLINQ KKMSPPL
	Isoform 5 [UniParc]. Checksum: 1976A77C3FC3933F	FASTA	602	67,282
	10 20 30 40 50 60 MERSLHRVSL GSRRAHPDLS FYLTTFGQLR LSIDAQDRVL LLHIIEGKGL ISKQPGTCDP 70 80 90 100 110 120 YVKISLIPED SRLRHQKTQT VPDCRDPAFH EHFFFPVQEE DDQKRLLVTV WNRASQSRQS 130 140 150 160 170 180 GLIGCMSFGV KSLLTPDKEI SGWYYLLGEH LGRTKHLKVA RRRLRPLRDP LLRMPGGGDT 190 200 210 220 230 240 ENGKKLKITI PRGKDGFGFT ICCDSPVRVQ AVDSGGPAER AGLQQLDTVL QLNERPVEHW 250 260 270 280 290 300 KCVELAHEIR SCPSEIILLV WRMVPQVKPG PDGGVLRRAS CKSTHDLQSP PNKREKNCTH 310 320 330 340 350 360 GVQARPEQRH SCHLVCDSSD GLLLGGWERY TEVAKRGGQH TLPALSRATA PTDPNYIILA 370 380 390 400 410 420 PLNPGSQLLR PVYQEDTIPE ESGSPSKGKS YTGLGKKSRL MKTVQTMKGH GNYQNCPVVR 430 440 450 460 470 480 PHATHSSYGT YVTLAPKVLV FPVFVQPLDL CNPARTLLLS EELLLYEGRN KAAEVTLFAY 490 500 510 520 530 540 SDLLLFTKED EPGRCDVLRN PLYLQSVKLQ EGSSEDLKFC VLYLAEKAEC LFTLEAHSQE 550 560 570 580 590 600 QKKRVCWCLS ENIAKQQQLA ASPPDSKKLH PFGSLQQEMG PVNSTNATQD RSFTSPGQTL IG
	Isoform 6 (C2PA-RGS3) [UniParc]. Checksum: 9465608DAA6F95B6	FASTA	1,094	121,008
	10 20 30 40 50 60 MEWLSPDIAL PRRDEWTQTS PARKRITHAK VQGAGQLRLS IDAQDRVLLL HIIEGKGLIS 70 80 90 100 110 120 KQPGTCDPYV KISLIPEDSR LRHQKTQTVP DCRDPAFHEH FFFPVQEEDD QKRLLVTVWN 130 140 150 160 170 180 RASQSRQSGL IGCMSFGVKS LLTPDKEISG WYYLLGEHLG RTKHLKVARR RLRPLRDPLL 190 200 210 220 230 240 RMPGGGDTEN GKKLKITIPR GKDGFGFTIC CDSPVRVQAV DSGGPAERAG LQQLDTVLQL 250 260 270 280 290 300 NERPVEHWKC VELAHEIRSC PSEIILLVWR MVPQVKPGPD GGVLRRASCK STHDLQSPPN 310 320 330 340 350 360 KREKNCTHGV QARPEQRHSC HLVCDSSDGL LLGGWERYTE VAKRGGQHTL PALSRATAPT 370 380 390 400 410 420 DPNYIILAPL NPGSQLLRPV YQEDTIPEES GSPSKGKSYT GLGKKSRLMK TVQTMKGHGN 430 440 450 460 470 480 YQNCPVVRPH ATHSSYGTYV TLAPKVLVFP VFVQPLDLCN PARTLLLSEE LLLYEGRNKA 490 500 510 520 530 540 AEVTLFAYSD LLLFTKEDEP GRCDVLRNPL YLQSVKLQEG SSEDLKFCVL YLAEKAECLF 550 560 570 580 590 600 TLEAHSQEQK KRVCWCLSEN IAKQQQLAAS PPDSKMFETE ADEKREMALE EGKGPGAEDS 610 620 630 640 650 660 PPSKEPSPGQ ELPPGQDLPP NKDSPSGQEP APSQEPLSSK DSATSEGSPP GPDAPPSKDV 670 680 690 700 710 720 PPCQEPPPAQ DLSPCQDLPA GQEPLPHQDP LLTKDLPAIQ ESPTRDLPPC QDLPPSQVSL 730 740 750 760 770 780 PAKALTEDTM SSGDLLAATG DPPAAPRPAF VIPEVRLDST YSQKAGAEQG CSGDEEDAEE 790 800 810 820 830 840 AEEVEEGEEG EEDEDEDTSD DNYGERSEAK RSSMIETGQG AEGGLSLRVQ NSLRRRTHSE 850 860 870 880 890 900 GSLLQEPRGP CFASDTTLHC SDGEGAASTW GMPSPSTLKK ELGRNGGSMH HLSLFFTGHR 910 920 930 940 950 960 KMSGADTVGD DDEASRKRKS KNLAKDMKNK LGIFRRRNES PGAPPAGKAD KMMKSFKPTS 970 980 990 1000 1010 1020 EEALKWGESL EKLLVHKYGL AVFQAFLRTE FSEENLEFWL ACEDFKKVKS QSKMASKAKK 1030 1040 1050 1060 1070 1080 IFAEYIAIQA CKEVNLDSYT REHTKDNLQS VTRGCFDLAQ KRIFGLMEKD SYPRFLRSDL 1090 YLDLINQKKM SPPL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family." Druey K.M., Blumer K.J., Kang V.H., Kehrl J.H. Nature 379:742-746(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
[2]	"Additional 5' exons in the RGS3 locus generate multiple mRNA transcripts, one of which accounts for the origin of human PDZ-RGS3." Kehrl J.H., Srikumar D., Harrison K., Wilson G.L., Shi C.S. Genomics 79:860-868(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 6), NUCLEOTIDE SEQUENCE [MRNA] OF 105-1198 (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 5). Tissue: Amygdala and Testis.
[4]	"Human PDZ-RGS3." Chatterjee T.K., Fisher R.A. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 4).
[5]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain.
[6]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Brain.
[9]	"RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11." Dulin N.O., Sorokin A., Reed E., Elliott S., Kehrl J.H., Dunn M.J. Mol. Cell. Biol. 19:714-723(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH GNA11 AND GNA13, SUBCELLULAR LOCATION.
[10]	"Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis." Dulin N.O., Pratt P., Tiruppathi C., Niu J., Voyno-Yasenetskaya T., Dunn M.J. J. Biol. Chem. 275:21317-21323(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[11]	"Regulator of G-protein signaling 3 (RGS3) inhibits G-beta1/gamma2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation." Shi C.-S., Lee S.B., Sinnarajah S., Dessauer C.W., Rhee S.G., Kehrl J.H. J. Biol. Chem. 276:24293-24300(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH HETERODIMERIC GNB1-GNG2, SUBCELLULAR LOCATION.
[12]	"Identification and Herc5-mediated ISGylation of novel target proteins." Takeuchi T., Inoue S., Yokosawa H. Biochem. Biophys. Res. Commun. 348:473-477(2006) [PubMed] [Europe PMC] [Abstract] Cited for: ISGYLATION.
[13]	"Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line." Giorgianni F., Zhao Y., Desiderio D.M., Beranova-Giorgianni S. Electrophoresis 28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Prostate cancer.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U27655 mRNA. Translation: AAC50394.1.
AF490839 mRNA. Translation: AAM33254.1. Different initiation.
AF490840 mRNA. Translation: AAM33255.1.
AK074977 mRNA. Translation: BAC11328.1.
AK128127 mRNA. Translation: BAC87285.1.
AK289666 mRNA. Translation: BAF82355.1.
AF493927 mRNA. Translation: AAM12641.1.
AF493941 mRNA. Translation: AAM12655.1.
AY585192 mRNA. Translation: AAT79495.1.
AF463495 Genomic DNA. Translation: AAL68829.1.
AL162727 Genomic DNA. Translation: CAC78977.1.
AL162727, AL359455 Genomic DNA. Translation: CAH70841.1.
AL162727, AL137066, AL359455 Genomic DNA. Translation: CAH70843.1.
AL137066, AL162727, AL359455 Genomic DNA. Translation: CAH70102.1.
AL137066, AL359455 Genomic DNA. Translation: CAH70103.1.
AL359455, AL137066 Genomic DNA. Translation: CAH73880.1.
AL359455, AL162727 Genomic DNA. Translation: CAH73877.1.
AL359455, AL137066, AL162727 Genomic DNA. Translation: CAH73879.1.
CH471090 Genomic DNA. Translation: EAW87391.1.
CH471090 Genomic DNA. Translation: EAW87393.1.
BC042555 mRNA. Translation: AAH42555.1.

IPI

IPI00181533.
IPI00328216.
IPI00385923.
IPI00418780.
IPI00473078.
IPI00604741.

PIR

S78089.

RefSeq

NP_001263189.1. NM_001276260.1.
NP_060260.3. NM_017790.4.
NP_066929.1. NM_021106.3.
NP_570613.2. NM_130795.3.
NP_652759.3. NM_144488.5.

UniGene

Hs.494875.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2F5Y	X-ray	2.39	A/B	300-384	[»]
2OJ4	X-ray	2.30	A	1064-1190	[»]
3FBK	X-ray	2.00	A/B	134-276	[»]

ProteinModelPortal

P49796.

ModBase

Search...

Protein-protein interaction databases

IntAct

P49796. 13 interactions.

MINT

MINT-136831.

PTM databases

PhosphoSite

P49796.

Polymorphism databases

DMDM

67477383.

Proteomic databases

PaxDb

P49796.

PRIDE

P49796.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000317613; ENSP00000312844; ENSG00000138835.
ENST00000343817; ENSP00000340284; ENSG00000138835.
ENST00000350696; ENSP00000259406; ENSG00000138835.
ENST00000374134; ENSP00000363249; ENSG00000138835.
ENST00000374140; ENSP00000363255; ENSG00000138835.
ENST00000462143; ENSP00000420356; ENSG00000138835.

GeneID

5998.

KEGG

hsa:5998.

UCSC

uc004bhq.3. human.
uc004bhr.3. human.
uc004bht.3. human.
uc004bhv.3. human.
uc004bhw.3. human.

Organism-specific databases

CTD

5998.

GeneCards

GC09P116207.

HGNC

HGNC:9999. RGS3.

HPA

CAB032507.

MIM

602189. gene.

neXtProt

NX_P49796.

PharmGKB

PA34374.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG266213.

HOVERGEN

HBG013233.

InParanoid

P49796.

KO

K07524.

OMA

FTGHRKM.

OrthoDB

EOG4GB76T.

Enzyme and pathway databases

Pathway_Interaction_DB

ephrinbrevpathway. Ephrin B reverse signaling.

Gene expression databases

ArrayExpress

P49796.

Bgee

P49796.

Genevestigator

P49796.

GermOnline

ENSG00000138835. Homo sapiens.

Family and domain databases

Gene3D

1.10.196.10. 2 hits.
2.30.29.30. 1 hit.

InterPro

IPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR018029. C2_membr_targeting.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR000342. Regulat_G_prot_signal.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
[Graphical view]

Pfam

PF00168. C2. 1 hit.
PF00595. PDZ. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]

PRINTS

PR01301. RGSPROTEIN.

SMART

SM00239. C2. 1 hit.
SM00228. PDZ. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]

SUPFAM

SSF49562. C2_CaLB. 1 hit.
SSF50156. PDZ. 1 hit.
SSF48097. Regulat_G_prot_signal_superfam. 1 hit.

PROSITE

PS50004. C2. 1 hit.
PS50106. PDZ. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

RGS3. human.

EvolutionaryTrace

P49796.

GenomeRNAi

5998.

NextBio

23375.

SOURCE

Search...

Entry information

Entry name

RGS3_HUMAN

Accession

Primary (citable) accession number: P49796
Secondary accession number(s): A6NHA0 , A8K0V1, Q5VXB8, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	June 7, 2005
Last modified:	May 1, 2013
This is version 139 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.