Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Regulator of G-protein signaling 19

Gene

RGS19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Keywords - Biological processi

Autophagy

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171700-MONOMER.
ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
SignaLinkiP49795.
SIGNORiP49795.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 19
Short name:
RGS19
Alternative name(s):
G-alpha-interacting protein
Short name:
GAIP
Gene namesi
Name:RGS19
Synonyms:GAIP, GNAI3IP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:13735. RGS19.

Subcellular locationi

GO - Cellular componenti

  • beta-catenin destruction complex Source: GO_Central
  • brush border Source: Ensembl
  • cell cortex Source: GO_Central
  • clathrin-coated vesicle Source: Ensembl
  • cytoplasmic, membrane-bounded vesicle Source: GO_Central
  • cytoplasmic microtubule Source: GO_Central
  • Golgi apparatus Source: ProtInc
  • membrane Source: ProtInc
  • membrane raft Source: Ensembl
  • postsynaptic density Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi151S → A: Diminishes gap activity towards G(i)-alpha3 and autophagy in colon cancer cells. 1 Publication1

Organism-specific databases

DisGeNETi10287.
OpenTargetsiENSG00000171700.
PharmGKBiPA34370.

Polymorphism and mutation databases

BioMutaiRGS19.
DMDMi1730186.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042291 – 217Regulator of G-protein signaling 19Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineBy similarity1
Modified residuei97PhosphoserineCombined sources1
Modified residuei151Phosphoserine; by MAPK1 and MAPK31 Publication1

Post-translational modificationi

Fatty acylated. Heavily palmitoylated in the cysteine string motif.1 Publication
Phosphorylated, mainly on serine residues.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiP49795.
MaxQBiP49795.
PaxDbiP49795.
PeptideAtlasiP49795.
PRIDEiP49795.

PTM databases

iPTMnetiP49795.
PhosphoSitePlusiP49795.
SwissPalmiP49795.

Expressioni

Tissue specificityi

Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.

Gene expression databases

BgeeiENSG00000171700.
CleanExiHS_RGS19.
GenevisibleiP49795. HS.

Organism-specific databases

HPAiCAB031925.

Interactioni

Subunit structurei

Interacts with GIPC PDZ domain.

Binary interactionsi

WithEntry#Exp.IntActNotes
Gnai3P087534EBI-874907,EBI-874897From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115576. 13 interactors.
IntActiP49795. 10 interactors.
MINTiMINT-3017930.
STRINGi9606.ENSP00000333194.

Chemistry databases

BindingDBiP49795.

Structurei

Secondary structure

1217
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi81 – 87Combined sources7
Helixi92 – 95Combined sources4
Helixi98 – 111Combined sources14
Helixi115 – 125Combined sources11
Helixi126 – 128Combined sources3
Helixi133 – 145Combined sources13
Turni146 – 148Combined sources3
Beta strandi150 – 152Combined sources3
Helixi160 – 168Combined sources9
Beta strandi169 – 171Combined sources3
Helixi178 – 191Combined sources14
Helixi193 – 196Combined sources4
Helixi200 – 203Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CMZNMR-A76-217[»]
ProteinModelPortaliP49795.
SMRiP49795.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49795.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 206RGSPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni207 – 217Interaction with GIPCAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 49Poly-CysAdd BLAST11

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233513.
HOVERGENiHBG013233.
InParanoidiP49795.
KOiK16449.
OMAiGINKKMQ.
OrthoDBiEOG091G0BDG.
PhylomeDBiP49795.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTPHEAEKQ ITGPEEADRP PSMSSHDTAS PAAPSRNPCC LCWCCCCSCS
60 70 80 90 100
WNQERRRAWQ ASRESKLQPL PSCEVCATPS PEEVQSWAQS FDKLMHSPAG
110 120 130 140 150
RSVFRAFLRT EYSEENMLFW LACEELKAEA NQHVVDEKAR LIYEDYVSIL
160 170 180 190 200
SPKEVSLDSR VREGINKKMQ EPSAHTFDDA QLQIYTLMHR DSYPRFLSSP
210
TYRALLLQGP SQSSSEA
Length:217
Mass (Da):24,636
Last modified:October 1, 1996 - v1
Checksum:i925A5687DC222CBD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204A → V in AAM12653 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91809 mRNA. Translation: CAA62919.1.
AF493939 mRNA. Translation: AAM12653.1.
AY585188 mRNA. Translation: AAS94232.1.
BT009804 mRNA. Translation: AAP88806.1.
AK290081 mRNA. Translation: BAF82770.1.
AL590548 Genomic DNA. Translation: CAD11902.1.
CH471077 Genomic DNA. Translation: EAW75166.1.
CH471077 Genomic DNA. Translation: EAW75167.1.
BC001318 mRNA. Translation: AAH01318.1.
BC054337 mRNA. Translation: AAH54337.1.
BC063010 mRNA. Translation: AAH63010.1.
CCDSiCCDS13555.1.
RefSeqiNP_001034556.1. NM_001039467.1.
NP_005864.1. NM_005873.2.
XP_011526787.1. XM_011528485.2.
XP_011526788.1. XM_011528486.2.
UniGeneiHs.422336.

Genome annotation databases

EnsembliENST00000332298; ENSP00000333194; ENSG00000171700.
ENST00000395042; ENSP00000378483; ENSG00000171700.
GeneIDi10287.
KEGGihsa:10287.
UCSCiuc002yhy.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91809 mRNA. Translation: CAA62919.1.
AF493939 mRNA. Translation: AAM12653.1.
AY585188 mRNA. Translation: AAS94232.1.
BT009804 mRNA. Translation: AAP88806.1.
AK290081 mRNA. Translation: BAF82770.1.
AL590548 Genomic DNA. Translation: CAD11902.1.
CH471077 Genomic DNA. Translation: EAW75166.1.
CH471077 Genomic DNA. Translation: EAW75167.1.
BC001318 mRNA. Translation: AAH01318.1.
BC054337 mRNA. Translation: AAH54337.1.
BC063010 mRNA. Translation: AAH63010.1.
CCDSiCCDS13555.1.
RefSeqiNP_001034556.1. NM_001039467.1.
NP_005864.1. NM_005873.2.
XP_011526787.1. XM_011528485.2.
XP_011526788.1. XM_011528486.2.
UniGeneiHs.422336.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CMZNMR-A76-217[»]
ProteinModelPortaliP49795.
SMRiP49795.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115576. 13 interactors.
IntActiP49795. 10 interactors.
MINTiMINT-3017930.
STRINGi9606.ENSP00000333194.

Chemistry databases

BindingDBiP49795.

PTM databases

iPTMnetiP49795.
PhosphoSitePlusiP49795.
SwissPalmiP49795.

Polymorphism and mutation databases

BioMutaiRGS19.
DMDMi1730186.

Proteomic databases

EPDiP49795.
MaxQBiP49795.
PaxDbiP49795.
PeptideAtlasiP49795.
PRIDEiP49795.

Protocols and materials databases

DNASUi10287.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332298; ENSP00000333194; ENSG00000171700.
ENST00000395042; ENSP00000378483; ENSG00000171700.
GeneIDi10287.
KEGGihsa:10287.
UCSCiuc002yhy.4. human.

Organism-specific databases

CTDi10287.
DisGeNETi10287.
GeneCardsiRGS19.
HGNCiHGNC:13735. RGS19.
HPAiCAB031925.
MIMi605071. gene.
neXtProtiNX_P49795.
OpenTargetsiENSG00000171700.
PharmGKBiPA34370.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233513.
HOVERGENiHBG013233.
InParanoidiP49795.
KOiK16449.
OMAiGINKKMQ.
OrthoDBiEOG091G0BDG.
PhylomeDBiP49795.
TreeFamiTF315837.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171700-MONOMER.
ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
SignaLinkiP49795.
SIGNORiP49795.

Miscellaneous databases

ChiTaRSiRGS19. human.
EvolutionaryTraceiP49795.
GeneWikiiRGS19.
GenomeRNAii10287.
PROiP49795.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171700.
CleanExiHS_RGS19.
GenevisibleiP49795. HS.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGS19_HUMAN
AccessioniPrimary (citable) accession number: P49795
Secondary accession number(s): A8K216
, E1P5G9, Q53XN0, Q8TD60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 167 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.