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Protein

Retinoic acid receptor responder protein 1

Gene

RARRES1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle.1 Publication

GO - Biological processi

  • negative regulation of cell proliferation Source: ProtInc
Complete GO annotation...

Protein family/group databases

MEROPSiI47.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid receptor responder protein 1
Alternative name(s):
Phorbol ester-induced gene 1 protein
Short name:
PERG-1
RAR-responsive protein TIG1
Tazarotene-induced gene 1 protein
Gene namesi
Name:RARRES1
Synonyms:PEIG1, TIG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:9867. RARRES1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020LumenalSequence analysisAdd
BLAST
Transmembranei21 – 4222Helical; Signal-anchor for type III membrane proteinSequence analysisAdd
BLAST
Topological domaini43 – 294252CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34228.

Chemistry

DrugBankiDB00755. Tretinoin.

Polymorphism and mutation databases

BioMutaiRARRES1.
DMDMi57014141.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Retinoic acid receptor responder protein 1PRO_0000191346Add
BLAST

Post-translational modificationi

Not glycosylated.

Proteomic databases

PaxDbiP49788.
PeptideAtlasiP49788.
PRIDEiP49788.
TopDownProteomicsiP49788-2. [P49788-2]

PTM databases

iPTMnetiP49788.
PhosphoSiteiP49788.

Expressioni

Inductioni

By tazarotene and by all the retinoic acid receptors tested.

Gene expression databases

BgeeiENSG00000118849.
CleanExiHS_RARRES1.
GenevisibleiP49788. HS.

Organism-specific databases

HPAiHPA003892.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000237696.

Structurei

3D structure databases

ProteinModelPortaliP49788.
SMRiP49788. Positions 61-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJZ8. Eukaryota.
ENOG4111K9R. LUCA.
GeneTreeiENSGT00530000063813.
HOGENOMiHOG000137506.
HOVERGENiHBG101029.
InParanoidiP49788.
OMAiWKTNDDT.
OrthoDBiEOG091G0I8X.
PhylomeDBiP49788.
TreeFamiTF332787.

Family and domain databases

InterProiIPR009684. Prot_inh_latexin.
IPR027261. TAG1.
[Graphical view]
PfamiPF06907. Latexin. 1 hit.
[Graphical view]
PIRSFiPIRSF011132. Prot_inh_latexin. 1 hit.
PIRSF500784. TAG1. 1 hit.
ProDomiPD023134. Prot_inh_latexin. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: P49788-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQPRRQRLPA PWSGPRGPRP TAPLLALLLL LAPVAAPAGS GDPDDPGQPQ
60 70 80 90 100
DAGVPRRLLQ QAARAALHFF NFRSGSPSAL RVLAEVQEGR AWINPKEGCK
110 120 130 140 150
VHVVFSTERY NPESLLQEGE GRLGKCSARV FFKNQKPRPT INVTCTRLIE
160 170 180 190 200
KKKRQQEDYL LYKQMKQLKN PLEIVSIPDN HGHIDPSLRL IWDLAFLGSS
210 220 230 240 250
YVMWEMTTQV SHYYLAQLTS VRQWKTNDDT IDFDYTVLLH ELSTQEIIPC
260 270 280 290
RIHLVWYPGK PLKVKYHCQE LQTPEEASGT EEGSAVVPTE LSNF
Note: No experimental confirmation available.
Length:294
Mass (Da):33,285
Last modified:July 5, 2004 - v2
Checksum:iBDBA3E034F493032
GO
Isoform 1 (identifier: P49788-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-228: KTND → VRKT
     229-294: Missing.

Show »
Length:228
Mass (Da):25,812
Checksum:i36654EFCD24819EA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621A → K in AAA99722 (PubMed:8601727).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421D → G.1 Publication
Corresponds to variant rs7621322 [ dbSNP | Ensembl ].
VAR_060094
Natural varianti158 – 1581D → V.
Corresponds to variant rs11919919 [ dbSNP | Ensembl ].
VAR_053612

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei225 – 2284KTND → VRKT in isoform 1. 1 PublicationVSP_010697
Alternative sequencei229 – 29466Missing in isoform 1. 1 PublicationVSP_010698Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27185 mRNA. Translation: AAA99722.1.
BC029640 mRNA. Translation: AAH29640.1.
CCDSiCCDS3184.1. [P49788-1]
CCDS54665.1. [P49788-2]
RefSeqiNP_002879.2. NM_002888.3. [P49788-2]
NP_996846.1. NM_206963.1. [P49788-1]
UniGeneiHs.131269.

Genome annotation databases

EnsembliENST00000237696; ENSP00000237696; ENSG00000118849. [P49788-1]
ENST00000479756; ENSP00000418556; ENSG00000118849. [P49788-2]
GeneIDi5918.
KEGGihsa:5918.
UCSCiuc003fci.4. human. [P49788-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27185 mRNA. Translation: AAA99722.1.
BC029640 mRNA. Translation: AAH29640.1.
CCDSiCCDS3184.1. [P49788-1]
CCDS54665.1. [P49788-2]
RefSeqiNP_002879.2. NM_002888.3. [P49788-2]
NP_996846.1. NM_206963.1. [P49788-1]
UniGeneiHs.131269.

3D structure databases

ProteinModelPortaliP49788.
SMRiP49788. Positions 61-269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000237696.

Chemistry

DrugBankiDB00755. Tretinoin.

Protein family/group databases

MEROPSiI47.002.

PTM databases

iPTMnetiP49788.
PhosphoSiteiP49788.

Polymorphism and mutation databases

BioMutaiRARRES1.
DMDMi57014141.

Proteomic databases

PaxDbiP49788.
PeptideAtlasiP49788.
PRIDEiP49788.
TopDownProteomicsiP49788-2. [P49788-2]

Protocols and materials databases

DNASUi5918.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000237696; ENSP00000237696; ENSG00000118849. [P49788-1]
ENST00000479756; ENSP00000418556; ENSG00000118849. [P49788-2]
GeneIDi5918.
KEGGihsa:5918.
UCSCiuc003fci.4. human. [P49788-1]

Organism-specific databases

CTDi5918.
GeneCardsiRARRES1.
HGNCiHGNC:9867. RARRES1.
HPAiHPA003892.
MIMi605090. gene.
neXtProtiNX_P49788.
PharmGKBiPA34228.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJZ8. Eukaryota.
ENOG4111K9R. LUCA.
GeneTreeiENSGT00530000063813.
HOGENOMiHOG000137506.
HOVERGENiHBG101029.
InParanoidiP49788.
OMAiWKTNDDT.
OrthoDBiEOG091G0I8X.
PhylomeDBiP49788.
TreeFamiTF332787.

Miscellaneous databases

ChiTaRSiRARRES1. human.
GeneWikiiRARRES1.
GenomeRNAii5918.
PROiP49788.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118849.
CleanExiHS_RARRES1.
GenevisibleiP49788. HS.

Family and domain databases

InterProiIPR009684. Prot_inh_latexin.
IPR027261. TAG1.
[Graphical view]
PfamiPF06907. Latexin. 1 hit.
[Graphical view]
PIRSFiPIRSF011132. Prot_inh_latexin. 1 hit.
PIRSF500784. TAG1. 1 hit.
ProDomiPD023134. Prot_inh_latexin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiTIG1_HUMAN
AccessioniPrimary (citable) accession number: P49788
Secondary accession number(s): Q8N1D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.