Reviewed, UniProtKB/Swiss-Prot P49788 (TIG1_HUMAN)

Names and origin

Protein names

Recommended name:
    Retinoic acid receptor responder protein 1
Alternative name(s):
    RAR-responsive protein TIG1
    Tazarotene-induced gene 1 protein

Gene names

Name:	RARRES1
Synonyms:	TIG1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass type II membrane proteinPotential.
Induction	By tazarotene and by all the retinoic acid receptors tested.
Sequence similarities	Belongs to the protease inhibitor I47 (latexin) family. [View classification]

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Signal-anchor Transmembrane
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	negative regulation of cell proliferation Traceable author statement. Source: ProtInc
Cellular component	Golgi apparatus Inferred from direct assay. Source: HPA integral to membrane Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 2 (identifier: P49788-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Notes: No experimental confirmation available.

Isoform 1 (identifier: P49788-2)

The sequence of this isoform differs from the canonical sequence as follows:
     225-228: KTND → VRKT
     229-294: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Retinoic acid receptor responder protein 1		PRO_0000191346
Regions
	Topological domain	1 – 20	20	Cytoplasmic Potential
	Transmembrane	21 – 42	22	Signal-anchor for type II membrane protein Potential
	Topological domain	43 – 294	252	Extracellular Potential
Amino acid modifications
	Glycosylation	142	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	225 – 228	4	KTND → VRKT in isoform 1.		VSP_010697
	Alternative sequence	229 – 294	66	Missing in isoform 1.		VSP_010698
Experimental info
	Sequence conflict	42	1	D → G in AAA99722. Ref.1
	Sequence conflict	62	1	A → K in AAA99722. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 [UniParc]. Last modified July 5, 2004. Version 2. Checksum: BDBA3E034F493032	FASTA	294	33,285
	10 20 30 40 50 60 MQPRRQRLPA PWSGPRGPRP TAPLLALLLL LAPVAAPAGS GDPDDPGQPQ DAGVPRRLLQ 70 80 90 100 110 120 QAARAALHFF NFRSGSPSAL RVLAEVQEGR AWINPKEGCK VHVVFSTERY NPESLLQEGE 130 140 150 160 170 180 GRLGKCSARV FFKNQKPRPT INVTCTRLIE KKKRQQEDYL LYKQMKQLKN PLEIVSIPDN 190 200 210 220 230 240 HGHIDPSLRL IWDLAFLGSS YVMWEMTTQV SHYYLAQLTS VRQWKTNDDT IDFDYTVLLH 250 260 270 280 290 ELSTQEIIPC RIHLVWYPGK PLKVKYHCQE LQTPEEASGT EEGSAVVPTE LSNF
	Isoform 1 [UniParc]. Checksum: 36654EFCD24819EA		228	25,812
	10 20 30 40 50 60 MQPRRQRLPA PWSGPRGPRP TAPLLALLLL LAPVAAPAGS GDPDDPGQPQ DAGVPRRLLQ 70 80 90 100 110 120 QAARAALHFF NFRSGSPSAL RVLAEVQEGR AWINPKEGCK VHVVFSTERY NPESLLQEGE 130 140 150 160 170 180 GRLGKCSARV FFKNQKPRPT INVTCTRLIE KKKRQQEDYL LYKQMKQLKN PLEIVSIPDN 190 200 210 220 HGHIDPSLRL IWDLAFLGSS YVMWEMTTQV SHYYLAQLTS VRQWVRKT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin." Nagpal S., Patel S., Asano A.T., Johnson A.T., Duvic M., Chandraratna R.A.S. J. Invest. Dermatol. 106:269-274(1996) [PubMed: 8601727] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Skin.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Skin.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	U27185 mRNA. Translation: AAA99722.1. BC029640 mRNA. Translation: AAH29640.1.
RefSeq	NP_002879.2. NP_996846.1.
UniGene	Hs.131269
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000118849. Homo sapiens. [Contig view]
GeneID	5918.
KEGG	hsa:5918.
Organism-specific databases
H-InvDB	HIX0003808.
HGNC	HGNC:9867. RARRES1.
HPA	HPA003892.
MIM	605090. gene.
PharmGKB	PA34228.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P49788.
HOVERGEN	P49788.
Gene expression databases
ArrayExpress	P49788.
CleanEx	HS_RARRES1.
GermOnline	ENSG00000118849. Homo sapiens.
Family and domain databases
InterPro	IPR009684. Prot_inh_latexin. [Graphical view]
Pfam	PF06907. Latexin. 1 hit. [Graphical view]
PIRSF	PIRSF011132. Prot_inh_latexin. 1 hit.
BLOCKS	Search...
ProtoNet	Search...
Other Resources
DrugBank	DB00755. Tretinoin.
NextBio	23042.
SOURCE	Search...

Entry information

Entry name

TIG1_HUMAN

Accession

Primary (citable) accession number: P49788
Secondary accession number(s): Q8N1D7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	July 5, 2004
Last modified:	November 4, 2008
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)