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Protein

Retinoic acid receptor responder protein 1

Gene

RARRES1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle.1 Publication

GO - Biological processi

  • negative regulation of cell proliferation Source: ProtInc

Enzyme and pathway databases

SIGNORiP49788.

Protein family/group databases

MEROPSiI47.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid receptor responder protein 1
Alternative name(s):
Phorbol ester-induced gene 1 protein
Short name:
PERG-1
RAR-responsive protein TIG1
Tazarotene-induced gene 1 protein
Gene namesi
Name:RARRES1
Synonyms:PEIG1, TIG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000118849.9.
HGNCiHGNC:9867. RARRES1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20LumenalSequence analysisAdd BLAST20
Transmembranei21 – 42Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST22
Topological domaini43 – 294CytoplasmicSequence analysisAdd BLAST252

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5918.
OpenTargetsiENSG00000118849.
PharmGKBiPA34228.

Chemistry databases

DrugBankiDB00755. Tretinoin.

Polymorphism and mutation databases

BioMutaiRARRES1.
DMDMi57014141.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913461 – 294Retinoic acid receptor responder protein 1Add BLAST294

Post-translational modificationi

Not glycosylated.

Proteomic databases

PaxDbiP49788.
PeptideAtlasiP49788.
PRIDEiP49788.
TopDownProteomicsiP49788-2. [P49788-2]

PTM databases

iPTMnetiP49788.
PhosphoSitePlusiP49788.

Expressioni

Inductioni

By tazarotene and by all the retinoic acid receptors tested.

Gene expression databases

BgeeiENSG00000118849.
CleanExiHS_RARRES1.
GenevisibleiP49788. HS.

Organism-specific databases

HPAiHPA003892.

Interactioni

Protein-protein interaction databases

BioGridi111853. 1 interactor.
STRINGi9606.ENSP00000237696.

Structurei

3D structure databases

ProteinModelPortaliP49788.
SMRiP49788.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJZ8. Eukaryota.
ENOG4111K9R. LUCA.
GeneTreeiENSGT00530000063813.
HOGENOMiHOG000137506.
HOVERGENiHBG101029.
InParanoidiP49788.
OMAiQWKTNDD.
OrthoDBiEOG091G0I8X.
PhylomeDBiP49788.
TreeFamiTF332787.

Family and domain databases

InterProiView protein in InterPro
IPR009684. Prot_inh_latexin.
IPR027261. TAG1.
PANTHERiPTHR28591. PTHR28591. 1 hit.
PfamiView protein in Pfam
PF06907. Latexin. 1 hit.
PIRSFiPIRSF011132. Prot_inh_latexin. 1 hit.
PIRSF500784. TAG1. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD023134. Prot_inh_latexin. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: P49788-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQPRRQRLPA PWSGPRGPRP TAPLLALLLL LAPVAAPAGS GDPDDPGQPQ
60 70 80 90 100
DAGVPRRLLQ QAARAALHFF NFRSGSPSAL RVLAEVQEGR AWINPKEGCK
110 120 130 140 150
VHVVFSTERY NPESLLQEGE GRLGKCSARV FFKNQKPRPT INVTCTRLIE
160 170 180 190 200
KKKRQQEDYL LYKQMKQLKN PLEIVSIPDN HGHIDPSLRL IWDLAFLGSS
210 220 230 240 250
YVMWEMTTQV SHYYLAQLTS VRQWKTNDDT IDFDYTVLLH ELSTQEIIPC
260 270 280 290
RIHLVWYPGK PLKVKYHCQE LQTPEEASGT EEGSAVVPTE LSNF
Note: No experimental confirmation available.
Length:294
Mass (Da):33,285
Last modified:July 5, 2004 - v2
Checksum:iBDBA3E034F493032
GO
Isoform 1 (identifier: P49788-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-228: KTND → VRKT
     229-294: Missing.

Show »
Length:228
Mass (Da):25,812
Checksum:i36654EFCD24819EA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62A → K in AAA99722 (PubMed:8601727).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06009442D → G1 PublicationCorresponds to variant dbSNP:rs7621322Ensembl.1
Natural variantiVAR_053612158D → V. Corresponds to variant dbSNP:rs11919919Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010697225 – 228KTND → VRKT in isoform 1. 1 Publication4
Alternative sequenceiVSP_010698229 – 294Missing in isoform 1. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27185 mRNA. Translation: AAA99722.1.
BC029640 mRNA. Translation: AAH29640.1.
CCDSiCCDS3184.1. [P49788-1]
CCDS54665.1. [P49788-2]
RefSeqiNP_002879.2. NM_002888.3. [P49788-2]
NP_996846.1. NM_206963.1. [P49788-1]
UniGeneiHs.131269.

Genome annotation databases

EnsembliENST00000237696; ENSP00000237696; ENSG00000118849. [P49788-1]
ENST00000479756; ENSP00000418556; ENSG00000118849. [P49788-2]
GeneIDi5918.
KEGGihsa:5918.
UCSCiuc003fci.4. human. [P49788-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTIG1_HUMAN
AccessioniPrimary (citable) accession number: P49788
Secondary accession number(s): Q8N1D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families