Reviewed,
UniProtKB/Swiss-Prot P49788 (TIG1_HUMAN)
Last modified
November 3, 2009.
Version 67.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Retinoic acid receptor responder protein 1 Alternative name(s): RAR-responsive protein TIG1 Tazarotene-induced gene 1 protein | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 294 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Subcellular location | Membrane; Single-pass type II membrane protein Potential. |
| Induction | By tazarotene and by all the retinoic acid receptors tested. |
| Sequence similarities | Belongs to the protease inhibitor I47 (latexin) family. [View classification] |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Signal-anchor Transmembrane |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | negative regulation of cell proliferation Traceable author statement. Source: ProtInc |
| Cellular component | integral to membrane Ref.1 Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 2 (identifier: P49788-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 1 (identifier: P49788-2) The sequence of this isoform differs from the canonical sequence as follows: 225-228: KTND → VRKT 229-294: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 294 | 294 | Retinoic acid receptor responder protein 1 | PRO_0000191346 | |||||
Regions | |||||||||
| Topological domain | 1 – 20 | 20 | Cytoplasmic Potential | ||||||
| Transmembrane | 21 – 42 | 22 | Signal-anchor for type II membrane protein Potential | ||||||
| Topological domain | 43 – 294 | 252 | Extracellular Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 142 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 225 – 228 | 4 | KTND → VRKT in isoform 1. | VSP_010697 | |||||
| Alternative sequence | 229 – 294 | 66 | Missing in isoform 1. | VSP_010698 | |||||
| Natural variant | 42 | 1 | D → G: dbSNP rs7621322. Ref.1 | VAR_060094 | |||||
| Natural variant | 158 | 1 | D → V: dbSNP rs11919919. | VAR_053612 | |||||
Experimental info | |||||||||
| Sequence conflict | 62 | 1 | A → K in AAA99722. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin." Nagpal S., Patel S., Asano A.T., Johnson A.T., Duvic M., Chandraratna R.A.S. J. Invest. Dermatol. 106:269-274(1996) [PubMed: 8601727] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLY-42. Tissue: Skin. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Skin. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U27185 mRNA. Translation: AAA99722.1. BC029640 mRNA. Translation: AAH29640.1. | |
| IPI | IPI00410240. IPI00410377. |
| RefSeq | NP_002879.2. NP_996846.1. |
| UniGene | Hs.131269 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P49788. |
Proteomic databases | |
| PRIDE | P49788. |
Genome annotation databases | |
| Ensembl | ENST00000237696; ENSP00000237696; ENSG00000118849; Homo sapiens. [Genome view] |
| GeneID | 5918. |
| KEGG | hsa:5918. |
| UCSC | uc003fci.1. human. uc003fcj.1. human. |
Organism-specific databases | |
| CTD | 5918. |
| GeneCards | GC03M159897. |
| H-InvDB | HIX0003808. |
| HGNC | HGNC:9867. RARRES1. |
| HPA | HPA003892. |
| MIM | 605090. gene. |
| PharmGKB | PA34228. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P49788. |
| HOVERGEN | P49788. |
| OMA | TIDFDYT. |
Gene expression databases | |
| ArrayExpress | P49788. |
| Bgee | P49788. |
| CleanEx | HS_RARRES1. |
| Genevestigator | P49788. |
| GermOnline | ENSG00000118849. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR009684. Prot_inh_latexin. [Graphical view] |
| Pfam | PF06907. Latexin. 1 hit. [Graphical view] |
| PIRSF | PIRSF011132. Prot_inh_latexin. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| DrugBank | DB00755. Tretinoin. |
| NextBio | 23042. |
| SOURCE | Search... |
Entry information
| Entry name | TIG1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P49788 Secondary accession number(s): Q8N1D7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


