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Reviewed, UniProtKB/Swiss-Prot P49788 (TIG1_HUMAN)

Last modified November 4, 2008. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Retinoic acid receptor responder protein 1
Alternative name(s):
    RAR-responsive protein TIG1
    Tazarotene-induced gene 1 protein
Gene names
Name: RARRES1
Synonyms: TIG1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Subcellular location

Membrane; Single-pass type II membrane proteinPotential.

Induction

By tazarotene and by all the retinoic acid receptors tested.

Sequence similarities

Belongs to the protease inhibitor I47 (latexin) family. [View classification]

Ontologies

Keywords

   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainSignal-anchor
Transmembrane
   PTMGlycoprotein

Gene Ontology (GO)

   Biological processnegative regulation of cell proliferation

Traceable author statement. Source: ProtInc

   Cellular componentGolgi apparatus

Inferred from direct assay. Source: HPA

integral to membrane Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 2 (identifier: P49788-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Notes: No experimental confirmation available.
Isoform 1 (identifier: P49788-2)

The sequence of this isoform differs from the canonical sequence as follows:
     225-228: KTND → VRKT
     229-294: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294Retinoic acid receptor responder protein 1
PRO_0000191346

Regions

Topological domain1 – 2020Cytoplasmic Potential
Transmembrane21 – 4222Signal-anchor for type II membrane protein Potential
Topological domain43 – 294252Extracellular Potential

Amino acid modifications

Glycosylation1421N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence225 – 2284KTND → VRKT in isoform 1.
VSP_010697
Alternative sequence229 – 29466Missing in isoform 1.
VSP_010698

Experimental info

Sequence conflict421D → G in AAA99722. Ref.1
Sequence conflict621A → K in AAA99722. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 2 [UniParc].

Last modified July 5, 2004. Version 2.
Checksum: BDBA3E034F493032

FASTA29433,285
        10         20         30         40         50         60 
MQPRRQRLPA PWSGPRGPRP TAPLLALLLL LAPVAAPAGS GDPDDPGQPQ DAGVPRRLLQ 

        70         80         90        100        110        120 
QAARAALHFF NFRSGSPSAL RVLAEVQEGR AWINPKEGCK VHVVFSTERY NPESLLQEGE 

       130        140        150        160        170        180 
GRLGKCSARV FFKNQKPRPT INVTCTRLIE KKKRQQEDYL LYKQMKQLKN PLEIVSIPDN 

       190        200        210        220        230        240 
HGHIDPSLRL IWDLAFLGSS YVMWEMTTQV SHYYLAQLTS VRQWKTNDDT IDFDYTVLLH 

       250        260        270        280        290 
ELSTQEIIPC RIHLVWYPGK PLKVKYHCQE LQTPEEASGT EEGSAVVPTE LSNF 

« Hide

Isoform 1 [UniParc].

Checksum: 36654EFCD24819EA
Show »

22825,812

References

« Hide 'large scale' references
[1]"Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin."
Nagpal S., Patel S., Asano A.T., Johnson A.T., Duvic M., Chandraratna R.A.S.
J. Invest. Dermatol. 106:269-274(1996) [PubMed: 8601727] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Skin.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

U27185 mRNA. Translation: AAA99722.1.
BC029640 mRNA. Translation: AAH29640.1.
RefSeqNP_002879.2.
NP_996846.1.
UniGeneHs.131269

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSG00000118849. Homo sapiens. [Contig view]
GeneID5918.
KEGGhsa:5918.

Organism-specific databases

H-InvDBHIX0003808.
HGNCHGNC:9867. RARRES1.
HPAHPA003892.
MIM605090. gene.
PharmGKBPA34228.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP49788.
HOVERGENP49788.

Gene expression databases

ArrayExpressP49788.
CleanExHS_RARRES1.
GermOnlineENSG00000118849. Homo sapiens.

Family and domain databases

InterProIPR009684. Prot_inh_latexin.
[Graphical view]
PfamPF06907. Latexin. 1 hit.
[Graphical view]
PIRSFPIRSF011132. Prot_inh_latexin. 1 hit.
BLOCKSSearch...
ProtoNetSearch...

Other Resources

DrugBankDB00755. Tretinoin.
NextBio23042.
SOURCESearch...

Entry information

Entry nameTIG1_HUMAN
AccessionPrimary (citable) accession number: P49788
Secondary accession number(s): Q8N1D7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 5, 2004
Last modified: November 4, 2008
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents