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Protein

Biotin carboxylase 1

Gene

accC1

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.By similarity

Caution

Leu-235 is present instead of the conserved His which is expected to bind ATP.Curated

Catalytic activityi

ATP + [biotin carboxyl-carrier protein]-biotin-N6-L-lysine + hydrogencarbonate- = ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine.
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.
Proteins known to be involved in this subpathway in this organism are:
  1. Biotin carboxylase 2 (accC2), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Biotin carboxylase 1 (accC1), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116ATPBy similarity1
Binding sitei200ATPBy similarity1
Active sitei293By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Biotin, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU24340-MONOMER
UniPathwayiUPA00655; UER00711

Names & Taxonomyi

Protein namesi
Recommended name:
Biotin carboxylase 1 (EC:6.3.4.14)
Alternative name(s):
Acetyl-CoA carboxylase subunit A 1 (EC:6.4.1.2)
Short name:
ACC 1
Gene namesi
Name:accC1
Synonyms:accC, yqhX
Ordered Locus Names:BSU24340
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001467891 – 450Biotin carboxylase 1Add BLAST450

Proteomic databases

PaxDbiP49787
PRIDEiP49787

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.By similarity

Protein-protein interaction databases

IntActiP49787, 1 interactor
MINTiP49787
STRINGi224308.Bsubs1_010100013351

Structurei

3D structure databases

ProteinModelPortaliP49787
SMRiP49787
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 447Biotin carboxylationAdd BLAST447
Domaini120 – 318ATP-graspPROSITE-ProRule annotationAdd BLAST199

Phylogenomic databases

eggNOGiENOG4105CER Bacteria
COG0439 LUCA
HOGENOMiHOG000008988
InParanoidiP49787
KOiK01961
OMAiFVEICSH
PhylomeDBiP49787

Family and domain databases

InterProiView protein in InterPro
IPR004549 Acetyl_CoA_COase_biotin_COase
IPR011761 ATP-grasp
IPR005481 BC-like_N
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR016185 PreATP-grasp_dom_sf
IPR011054 Rudment_hybrid_motif
PfamiView protein in Pfam
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF02786 CPSase_L_D2, 1 hit
SMARTiView protein in SMART
SM00878 Biotin_carb_C, 1 hit
SUPFAMiSSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR00514 accC, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00866 CPSASE_1, 1 hit
PS00867 CPSASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P49787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKKLLIANR GEIAVRIIRA CRELGIETVA VYSEADKDAL HVQMADEAFC
60 70 80 90 100
IGPKASKDSY LNVTNIVSVA KLTGTDAIHP GYGFLAENAD FAELCEEVNV
110 120 130 140 150
TFVGPSADAI SKMGTKDVAR ETMKQAGVPI VPGSQGIIEN VEEAVSLANE
160 170 180 190 200
IGYPVIIKAT AGGGGKGIRV ARTEEELING IKITQQEAAT AFGNPGVYIE
210 220 230 240 250
KYIEDFRHVE IQVLADNYGN TIHLGERDCS IQRRLQKLLE ESPSPALDSE
260 270 280 290 300
IREQMGDAAV KAAKAVGYTG AGTVEFIYDY NEQRYYFMEM NTRIQVEHPV
310 320 330 340 350
TEMVTGTDLI KEQIKVASGM ELSLKQEDVE FEGWAIECRI NAENPSKNFM
360 370 380 390 400
PSPGEIKMYL PPGGLGVRVD SAAYPGYSIP PYYDSMIAKV ITYGKTRDEA
410 420 430 440 450
IARMKRALSE FVIEGIETTI PFHLKLLEHE TFVSGEFNTK FLETYDVMGS
Length:450
Mass (Da):49,452
Last modified:July 7, 2009 - v3
Checksum:i2F93B3E793478334
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107A → P in BAA12569 (PubMed:8969508).Curated1
Sequence conflicti193G → R in BAA12569 (PubMed:8969508).Curated1
Sequence conflicti240E → G in AAB00183 (PubMed:7592499).Curated1
Sequence conflicti248D → G in AAB00183 (PubMed:7592499).Curated1
Sequence conflicti344 – 348NPSKN → TQVK in AAB00183 (PubMed:7592499).Curated5
Sequence conflicti357 – 362KMYLPP → NVPAS in AAB00183 (PubMed:7592499).Curated6
Sequence conflicti409 – 410SE → QQ in AAB00183 (PubMed:7592499).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36245 Genomic DNA Translation: AAB00183.1
D84432 Genomic DNA Translation: BAA12569.1
AL009126 Genomic DNA Translation: CAB14365.2
PIRiA69581
RefSeqiNP_390314.2, NC_000964.3
WP_003230253.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14365; CAB14365; BSU24340
GeneIDi938588
KEGGibsu:BSU24340
PATRICifig|224308.179.peg.2652

Similar proteinsi

Entry informationi

Entry nameiACCC1_BACSU
AccessioniPrimary (citable) accession number: P49787
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 7, 2009
Last modified: April 25, 2018
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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