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P49786 (BCCP_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Biotin carboxyl carrier protein of acetyl-CoA carboxylase

Short name=BCCP
Gene names
Name:accB
Synonyms:fabE, yqhW
Ordered Locus Names:BSU24350
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length159 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homodimer By similarity.

Sequence similarities

Contains 1 biotinyl-binding domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 159159Biotin carboxyl carrier protein of acetyl-CoA carboxylase
PRO_0000146801

Regions

Domain82 – 15675Biotinyl-binding

Amino acid modifications

Modified residue1231N6-biotinyllysine By similarity

Experimental info

Sequence conflict64 – 652AQ → GE in AAB00182. Ref.1
Sequence conflict1261N → I in AAB00182. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P49786 [UniParc].

Last modified August 4, 2003. Version 2.
Checksum: 7A185B5B3703A07F

FASTA15917,229
        10         20         30         40         50         60 
MLNIKEIHEL IKAIDESTID EFVYENEGVS LKLKKHEAGT VQVMQQAPAA PVQAQAPQAV 

        70         80         90        100        110        120 
QPQAQQAAAP AQEAPKQDEN LHKITSPMVG TFYASSSPEA GPYVTAGSKV NENTVVCIVE 

       130        140        150 
AMKLFNEIEA EVKGEIVEVL VENGQLVEYG QPLFLVKAE 

« Hide

References

« Hide 'large scale' references
[1]"The genes encoding the biotin carboxyl carrier protein and biotin carboxylase subunits of Bacillus subtilis acetyl coenzyme A carboxylase, the first enzyme of fatty acid synthesis."
Marini P.E., Li S.J., Gardiol D., Cronan J.E. Jr., de Mendoza D.
J. Bacteriol. 177:7003-7006(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes."
Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M., Kobayashi Y.
Microbiology 142:3103-3111(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / JH642.
[3]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[4]Guerout-Fleury A.M., Gonzy-Treboul G., Stragier P.
Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-124.
Strain: 168 / JH642.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U36245 Genomic DNA. Translation: AAB00182.1.
D84432 Genomic DNA. Translation: BAA12568.1.
AL009126 Genomic DNA. Translation: CAB14366.1.
U35252 Genomic DNA. Translation: AAA76728.1.
PIRH69580.
RefSeqNP_390315.1. NC_000964.3.

3D structure databases

ProteinModelPortalP49786.
SMRP49786. Positions 78-157.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU24350.

Proteomic databases

PaxDbP49786.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB14366; CAB14366; BSU24350.
GeneID938587.
KEGGbsu:BSU24350.
PATRIC18976704. VBIBacSub10457_2542.

Organism-specific databases

GenoListBSU24350. [Micado]

Phylogenomic databases

eggNOGCOG0511.
HOGENOMHOG000008876.
KOK02160.
OMAEVEYPCK.
OrthoDBEOG6CVV6Z.
ProtClustDBPRK06302.

Enzyme and pathway databases

BioCycBSUB:BSU24350-MONOMER.
UniPathwayUPA00094.

Family and domain databases

InterProIPR001249. AcCoA_biotinCC.
IPR001882. Biotin_BS.
IPR000089. Biotin_lipoyl.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamPF00364. Biotin_lipoyl. 1 hit.
[Graphical view]
PRINTSPR01071. ACOABIOTINCC.
SUPFAMSSF51230. SSF51230. 1 hit.
TIGRFAMsTIGR00531. BCCP. 1 hit.
PROSITEPS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBCCP_BACSU
AccessionPrimary (citable) accession number: P49786
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 4, 2003
Last modified: November 13, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList