P49777 (ABP1_SCHPO) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 93.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: ARS-binding protein 1 | ||||
| Gene names |
| ||||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | ||||
| Taxonomic identifier | 284812 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 522 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Binds, preferentially, to the Maundrell ARS consensus sequence within ARS3002. |
| Subunit structure | Interacts with mcm10. Ref.3 |
| Subcellular location | |
| Sequence similarities | Contains 1 HTH CENPB-type DNA-binding domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Nucleus |
| Ligand | DNA-binding |
| PTM | Phosphoprotein |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | DNA-dependent DNA replication initiation Inferred from mutant phenotype. Source: GeneDB_Spombe chromatin silencing at centromereInferred from mutant phenotype. Source: GeneDB_Spombe histone modificationInferred from mutant phenotype. Source: GeneDB_Spombe mitotic sister chromatid segregationInferred from genetic interaction. Source: GeneDB_Spombe |
| Cellular component | condensed nuclear chromosome, centromeric region Inferred from direct assay. Source: GeneDB_Spombe nuclear chromatinInferred by curator. Source: GeneDB_Spombe |
| Molecular function | centromeric DNA binding Inferred from direct assay. Source: GeneDB_Spombe protein dimerization activityNon-traceable author statement. Source: GeneDB_Spombe |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 522 | 522 | ARS-binding protein 1 | PRO_0000126133 | |||||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||||
| Domain | 70 – 144 | 75 | HTH CENPB-type | ||||||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||||||
| Modified residue | 460 | 1 | Phosphothreonine Ref.4 | ||||||||||||||||||||||||||||
Experimental info | |||||||||||||||||||||||||||||||
| Sequence conflict | 336 | 1 | C → S in AAB01537. Ref.1 | ||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||
| Beta strand | 5 – 7 | 3 | |||||||||||||||||||||||||||||
| Helix | 12 – 22 | 11 | |||||||||||||||||||||||||||||
| Beta strand | 23 – 26 | 4 | |||||||||||||||||||||||||||||
| Helix | 30 – 41 | 12 | |||||||||||||||||||||||||||||
| Beta strand | 46 – 49 | 4 | |||||||||||||||||||||||||||||
| Helix | 52 – 60 | 9 | |||||||||||||||||||||||||||||
| Turn | 61 – 63 | 3 | |||||||||||||||||||||||||||||
| Beta strand | 66 – 72 | 7 | |||||||||||||||||||||||||||||
| Helix | 80 – 92 | 13 | |||||||||||||||||||||||||||||
| Helix | 102 – 114 | 13 | |||||||||||||||||||||||||||||
| Beta strand | 116 – 119 | 4 | |||||||||||||||||||||||||||||
| Helix | 129 – 137 | 9 | |||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification, purification, and molecular cloning of autonomously replicating sequence-binding protein 1 from fission yeast Schizosaccharomyces pombe." Murakami Y., Huberman J.A., Hurwitz J. Proc. Natl. Acad. Sci. U.S.A. 93:502-507(1996) [PubMed: 8552670] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 972 / ATCC 24843. |
| [2] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843. |
| [3] | "The CENP-B homolog, Abp1, interacts with the initiation protein Cdc23 (MCM10) and is required for efficient DNA replication in fission yeast." Locovei A.M., Spiga M.-G., Tanaka K., Murakami Y., D'Urso G. Cell Div. 1:27-27(2006) [PubMed: 17112379] [Abstract] Cited for: INTERACTION WITH ABP1. |
| [4] | "Phosphoproteome analysis of fission yeast." Wilson-Grady J.T., Villen J., Gygi S.P. J. Proteome Res. 7:1088-1097(2008) [PubMed: 18257517] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-460, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | U39079 Genomic DNA. Translation: AAB01537.1. CU329671 Genomic DNA. Translation: CAB50967.1. | ||||||||||||
| PIR | T39281. | ||||||||||||
| RefSeq | NP_596460.1. NM_001022379.1. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ProteinModelPortal | P49777. | ||||||||||||
| SMR | P49777. Positions 1-141. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | P49777. 2 interactions. | ||||||||||||
| STRING | P49777. | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| EnsemblFungi | SPBC1105.04c.1; SPBC1105.04c.1:pep; SPBC1105.04c. | ||||||||||||
| GeneID | 2539971. | ||||||||||||
| GenomeReviews | Gene locus abp1 in contig CU329671_GR. | ||||||||||||
| KEGG | spo:SPBC1105.04c. | ||||||||||||
| NMPDR | fig|4896.1.peg.2326. | ||||||||||||
Organism-specific databases | |||||||||||||
| GeneDB_Spombe | SPBC1105.04c. | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | fuNOG05144. | ||||||||||||
| GeneTree | EFGT00050000007452. | ||||||||||||
| HOGENOM | HBG207912. | ||||||||||||
| OMA | ANTHARM. | ||||||||||||
| OrthoDB | EOG4DRDN0. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-004461-MONOMER. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P49777. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR004875. DDE_SF_endonuclease_CENPB-like. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. IPR006600. Pogo/CenpB/PDC2_DNA-bd_HTH. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:1.10.10.60. Homeodomain-rel. 2 hits. | ||||||||||||
| Pfam | PF03184. DDE_1. 1 hit. PF03221. HTH_Tnp_Tc5. 1 hit. [Graphical view] | ||||||||||||
| SMART | SM00674. CENPB. 1 hit. [Graphical view] | ||||||||||||
| SUPFAM | SSF46689. Homeodomain_like. 2 hits. | ||||||||||||
| PROSITE | PS51253. HTH_CENPB. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Entry information
| Entry name | ABP1_SCHPO | ||||||||
| Accession | Primary (citable) accession number: P49777 Secondary accession number(s): Q9URU7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

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