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P49771

- FLT3L_HUMAN

UniProt

P49771 - FLT3L_HUMAN

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Protein

Fms-related tyrosine kinase 3 ligand

Gene

FLT3LG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.

GO - Molecular functioni

  1. receptor binding Source: ProtInc

GO - Biological processi

  1. embryonic hemopoiesis Source: DFLAT
  2. lymphocyte differentiation Source: Ensembl
  3. positive regulation of cell proliferation Source: UniProtKB
  4. positive regulation of natural killer cell differentiation Source: Ensembl
  5. positive regulation of protein phosphorylation Source: Ensembl
  6. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Fms-related tyrosine kinase 3 ligand
Short name:
Flt3 ligand
Short name:
Flt3L
Alternative name(s):
SL cytokine
Gene namesi
Name:FLT3LG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:3766. FLT3LG.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB
  3. intrinsic component of external side of plasma membrane Source: Ensembl
  4. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28182.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 235209Fms-related tyrosine kinase 3 ligandPRO_0000021281Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 111
Disulfide bondi70 ↔ 153
Disulfide bondi119 ↔ 158
Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP49771.

Expressioni

Gene expression databases

BgeeiP49771.
CleanExiHS_FLT3LG.
GenevestigatoriP49771.

Organism-specific databases

HPAiHPA017313.

Interactioni

Subunit structurei

Homodimer (isoform 2).

Protein-protein interaction databases

BioGridi108611. 1 interaction.
DIPiDIP-6220N.
IntActiP49771. 2 interactions.
MINTiMINT-1371383.
STRINGi9606.ENSP00000204637.

Structurei

Secondary structure

1
235
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi41 – 499Combined sources
Beta strandi57 – 626Combined sources
Turni68 – 703Combined sources
Helixi71 – 8717Combined sources
Helixi92 – 10514Combined sources
Helixi106 – 1105Combined sources
Beta strandi122 – 1265Combined sources
Helixi127 – 14115Combined sources
Turni142 – 1476Combined sources
Helixi151 – 1533Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ETEX-ray2.20A/B/C/D27-160[»]
3QS7X-ray4.30A/B/C/D27-160[»]
3QS9X-ray7.80A/B/C/D27-160[»]
ProteinModelPortaliP49771.
SMRiP49771. Positions 27-159.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49771.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 184158ExtracellularSequence AnalysisAdd
BLAST
Topological domaini206 – 23530CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei185 – 20521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44664.
GeneTreeiENSGT00530000064424.
HOGENOMiHOG000029239.
HOVERGENiHBG051630.
InParanoidiP49771.
KOiK05454.
OMAiAVNTEIH.
OrthoDBiEOG7HTHJG.
PhylomeDBiP49771.
TreeFamiTF338225.

Family and domain databases

Gene3Di1.20.1250.10. 2 hits.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR004213. Flt3_lig.
[Graphical view]
PANTHERiPTHR11032. PTHR11032. 1 hit.
PfamiPF02947. Flt3_lig. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P49771-1) [UniParc]FASTAAdd to Basket

Also known as: Membrane-bound

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTVLAPAWSP TTYLLLLLLL SSGLSGTQDC SFQHSPISSD FAVKIRELSD
60 70 80 90 100
YLLQDYPVTV ASNLQDEELC GGLWRLVLAQ RWMERLKTVA GSKMQGLLER
110 120 130 140 150
VNTEIHFVTK CAFQPPPSCL RFVQTNISRL LQETSEQLVA LKPWITRQNF
160 170 180 190 200
SRCLELQCQP DSSTLPPPWS PRPLEATAPT APQPPLLLLL LLPVGLLLLA
210 220 230
AAWCLHWQRT RRRTPRPGEQ VPPVPSPQDL LLVEH
Length:235
Mass (Da):26,416
Last modified:October 1, 1996 - v1
Checksum:i73B95BF693B4CECF
GO
Isoform 2 (identifier: P49771-2) [UniParc]FASTAAdd to Basket

Also known as: Soluble

The sequence of this isoform differs from the canonical sequence as follows:
     161-178: DSSTLPPPWSPRPLEATA → VETVFHRVSQDGLDLLTS
     179-235: Missing.

Show »
Length:178
Mass (Da):20,142
Checksum:iD9E7D4C5FBD370D8
GO
Isoform 3 (identifier: P49771-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Show »
Length:153
Mass (Da):17,290
Checksum:i84FB972427691E35
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti72 – 721G → A in AAA17999. (PubMed:8145851)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8282Missing in isoform 3. 2 PublicationsVSP_054599Add
BLAST
Alternative sequencei161 – 17818DSSTL…LEATA → VETVFHRVSQDGLDLLTS in isoform 2. CuratedVSP_004251Add
BLAST
Alternative sequencei179 – 23557Missing in isoform 2. CuratedVSP_004252Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04806 mRNA. Translation: AAA17999.1.
U03858 mRNA. Translation: AAA19825.1.
U29874 Genomic DNA. Translation: AAA90949.1.
U29874 Genomic DNA. Translation: AAA90950.1.
AK301136 mRNA. Translation: BAG62728.1.
AC010619 Genomic DNA. No translation available.
BC028001 mRNA. Translation: AAH28001.1.
BC126293 mRNA. Translation: AAI26294.1.
BC136464 mRNA. Translation: AAI36465.1.
CCDSiCCDS12767.1. [P49771-1]
CCDS62753.1. [P49771-3]
PIRiI38440.
I39076.
RefSeqiNP_001191431.1. NM_001204502.1. [P49771-1]
NP_001191432.1. NM_001204503.1. [P49771-1]
NP_001265566.1. NM_001278637.1. [P49771-3]
NP_001265567.1. NM_001278638.1. [P49771-3]
NP_001450.2. NM_001459.3. [P49771-1]
UniGeneiHs.428.

Genome annotation databases

EnsembliENST00000204637; ENSP00000204637; ENSG00000090554. [P49771-3]
ENST00000594009; ENSP00000469613; ENSG00000090554. [P49771-1]
ENST00000595510; ENSP00000471226; ENSG00000090554. [P49771-3]
ENST00000597551; ENSP00000468977; ENSG00000090554. [P49771-1]
ENST00000600429; ENSP00000470453; ENSG00000090554. [P49771-1]
GeneIDi2323.
KEGGihsa:2323.
UCSCiuc002pnu.3. human. [P49771-1]

Polymorphism databases

DMDMi1706818.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04806 mRNA. Translation: AAA17999.1 .
U03858 mRNA. Translation: AAA19825.1 .
U29874 Genomic DNA. Translation: AAA90949.1 .
U29874 Genomic DNA. Translation: AAA90950.1 .
AK301136 mRNA. Translation: BAG62728.1 .
AC010619 Genomic DNA. No translation available.
BC028001 mRNA. Translation: AAH28001.1 .
BC126293 mRNA. Translation: AAI26294.1 .
BC136464 mRNA. Translation: AAI36465.1 .
CCDSi CCDS12767.1. [P49771-1 ]
CCDS62753.1. [P49771-3 ]
PIRi I38440.
I39076.
RefSeqi NP_001191431.1. NM_001204502.1. [P49771-1 ]
NP_001191432.1. NM_001204503.1. [P49771-1 ]
NP_001265566.1. NM_001278637.1. [P49771-3 ]
NP_001265567.1. NM_001278638.1. [P49771-3 ]
NP_001450.2. NM_001459.3. [P49771-1 ]
UniGenei Hs.428.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ETE X-ray 2.20 A/B/C/D 27-160 [» ]
3QS7 X-ray 4.30 A/B/C/D 27-160 [» ]
3QS9 X-ray 7.80 A/B/C/D 27-160 [» ]
ProteinModelPortali P49771.
SMRi P49771. Positions 27-159.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108611. 1 interaction.
DIPi DIP-6220N.
IntActi P49771. 2 interactions.
MINTi MINT-1371383.
STRINGi 9606.ENSP00000204637.

Polymorphism databases

DMDMi 1706818.

Proteomic databases

PRIDEi P49771.

Protocols and materials databases

DNASUi 2323.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000204637 ; ENSP00000204637 ; ENSG00000090554 . [P49771-3 ]
ENST00000594009 ; ENSP00000469613 ; ENSG00000090554 . [P49771-1 ]
ENST00000595510 ; ENSP00000471226 ; ENSG00000090554 . [P49771-3 ]
ENST00000597551 ; ENSP00000468977 ; ENSG00000090554 . [P49771-1 ]
ENST00000600429 ; ENSP00000470453 ; ENSG00000090554 . [P49771-1 ]
GeneIDi 2323.
KEGGi hsa:2323.
UCSCi uc002pnu.3. human. [P49771-1 ]

Organism-specific databases

CTDi 2323.
GeneCardsi GC19P049977.
H-InvDB HIX0202990.
HGNCi HGNC:3766. FLT3LG.
HPAi HPA017313.
MIMi 600007. gene.
neXtProti NX_P49771.
PharmGKBi PA28182.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44664.
GeneTreei ENSGT00530000064424.
HOGENOMi HOG000029239.
HOVERGENi HBG051630.
InParanoidi P49771.
KOi K05454.
OMAi AVNTEIH.
OrthoDBi EOG7HTHJG.
PhylomeDBi P49771.
TreeFami TF338225.

Miscellaneous databases

ChiTaRSi FLT3LG. human.
EvolutionaryTracei P49771.
GeneWikii FLT3LG.
GenomeRNAii 2323.
NextBioi 13608020.
PROi P49771.
SOURCEi Search...

Gene expression databases

Bgeei P49771.
CleanExi HS_FLT3LG.
Genevestigatori P49771.

Family and domain databases

Gene3Di 1.20.1250.10. 2 hits.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR004213. Flt3_lig.
[Graphical view ]
PANTHERi PTHR11032. PTHR11032. 1 hit.
Pfami PF02947. Flt3_lig. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells."
    Lyman S.D., James L., Johnson L., Brasel K., de Vries P., Escobar S.S., Downey H., Splett R.R., Beckmann M.P., McKenna H.J.
    Blood 83:2795-2801(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Structural analysis of human and murine flt3 ligand genomic loci."
    Lyman S.D., Stocking K., Davison B., Fletcher F., Johnson L., Escobar S.
    Oncogene 11:1165-1172(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Spleen.
  5. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain.
  7. "Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots."
    Savvides S.N., Boone T., Karplus P.A.
    Nat. Struct. Biol. 7:486-491(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).

Entry informationi

Entry nameiFLT3L_HUMAN
AccessioniPrimary (citable) accession number: P49771
Secondary accession number(s): A0AVC2, B9EGH2, Q05C96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3