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Protein

Fms-related tyrosine kinase 3 ligand

Gene

FLT3LG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.

GO - Molecular functioni

  • receptor binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

BioCyciZFISH:ENSG00000090554-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.
SIGNORiP49771.

Names & Taxonomyi

Protein namesi
Recommended name:
Fms-related tyrosine kinase 3 ligand
Short name:
Flt3 ligand
Short name:
Flt3L
Alternative name(s):
SL cytokine
Gene namesi
Name:FLT3LG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:3766. FLT3LG.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 184ExtracellularSequence analysisAdd BLAST158
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 235CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB
  • intrinsic component of external side of plasma membrane Source: Ensembl
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2323.
OpenTargetsiENSG00000090554.
PharmGKBiPA28182.

Polymorphism and mutation databases

BioMutaiFLT3LG.
DMDMi1706818.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002128127 – 235Fms-related tyrosine kinase 3 ligandAdd BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 111
Disulfide bondi70 ↔ 153
Disulfide bondi119 ↔ 158
Glycosylationi126N-linked (GlcNAc...)Sequence analysis1
Glycosylationi149N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49771.
PeptideAtlasiP49771.
PRIDEiP49771.

Expressioni

Gene expression databases

BgeeiENSG00000090554.
CleanExiHS_FLT3LG.
ExpressionAtlasiP49771. baseline and differential.
GenevisibleiP49771. HS.

Organism-specific databases

HPAiHPA017313.

Interactioni

Subunit structurei

Homodimer (isoform 2).

GO - Molecular functioni

  • receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi108611. 2 interactors.
DIPiDIP-6220N.
IntActiP49771. 2 interactors.
MINTiMINT-1371383.
STRINGi9606.ENSP00000468977.

Structurei

Secondary structure

1235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi41 – 49Combined sources9
Beta strandi57 – 62Combined sources6
Turni68 – 70Combined sources3
Helixi71 – 87Combined sources17
Helixi92 – 105Combined sources14
Helixi106 – 110Combined sources5
Beta strandi122 – 126Combined sources5
Helixi127 – 141Combined sources15
Turni142 – 147Combined sources6
Helixi151 – 153Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ETEX-ray2.20A/B/C/D27-160[»]
3QS7X-ray4.30A/B/C/D27-160[»]
3QS9X-ray7.80A/B/C/D27-160[»]
ProteinModelPortaliP49771.
SMRiP49771.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49771.

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXDX. Eukaryota.
ENOG41118N3. LUCA.
GeneTreeiENSGT00530000064424.
HOGENOMiHOG000029239.
HOVERGENiHBG051630.
InParanoidiP49771.
KOiK05454.
OMAiSGCLELQ.
OrthoDBiEOG091G0R0Y.
PhylomeDBiP49771.
TreeFamiTF338225.

Family and domain databases

Gene3Di1.20.1250.10. 2 hits.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR004213. Flt3_lig.
[Graphical view]
PANTHERiPTHR11032. PTHR11032. 1 hit.
PfamiPF02947. Flt3_lig. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P49771-1) [UniParc]FASTAAdd to basket
Also known as: Membrane-bound

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTVLAPAWSP TTYLLLLLLL SSGLSGTQDC SFQHSPISSD FAVKIRELSD
60 70 80 90 100
YLLQDYPVTV ASNLQDEELC GGLWRLVLAQ RWMERLKTVA GSKMQGLLER
110 120 130 140 150
VNTEIHFVTK CAFQPPPSCL RFVQTNISRL LQETSEQLVA LKPWITRQNF
160 170 180 190 200
SRCLELQCQP DSSTLPPPWS PRPLEATAPT APQPPLLLLL LLPVGLLLLA
210 220 230
AAWCLHWQRT RRRTPRPGEQ VPPVPSPQDL LLVEH
Length:235
Mass (Da):26,416
Last modified:October 1, 1996 - v1
Checksum:i73B95BF693B4CECF
GO
Isoform 2 (identifier: P49771-2) [UniParc]FASTAAdd to basket
Also known as: Soluble

The sequence of this isoform differs from the canonical sequence as follows:
     161-178: DSSTLPPPWSPRPLEATA → VETVFHRVSQDGLDLLTS
     179-235: Missing.

Show »
Length:178
Mass (Da):20,142
Checksum:iD9E7D4C5FBD370D8
GO
Isoform 3 (identifier: P49771-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Show »
Length:153
Mass (Da):17,290
Checksum:i84FB972427691E35
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72G → A in AAA17999 (PubMed:8145851).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0545991 – 82Missing in isoform 3. 2 PublicationsAdd BLAST82
Alternative sequenceiVSP_004251161 – 178DSSTL…LEATA → VETVFHRVSQDGLDLLTS in isoform 2. CuratedAdd BLAST18
Alternative sequenceiVSP_004252179 – 235Missing in isoform 2. CuratedAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04806 mRNA. Translation: AAA17999.1.
U03858 mRNA. Translation: AAA19825.1.
U29874 Genomic DNA. Translation: AAA90949.1.
U29874 Genomic DNA. Translation: AAA90950.1.
AK301136 mRNA. Translation: BAG62728.1.
AC010619 Genomic DNA. No translation available.
BC028001 mRNA. Translation: AAH28001.1.
BC126293 mRNA. Translation: AAI26294.1.
BC136464 mRNA. Translation: AAI36465.1.
CCDSiCCDS12767.1. [P49771-1]
CCDS62753.1. [P49771-3]
PIRiI38440.
I39076.
RefSeqiNP_001191431.1. NM_001204502.1. [P49771-1]
NP_001191432.1. NM_001204503.1. [P49771-1]
NP_001265566.1. NM_001278637.1. [P49771-3]
NP_001265567.1. NM_001278638.1. [P49771-3]
NP_001450.2. NM_001459.3. [P49771-1]
XP_011524984.1. XM_011526682.2. [P49771-3]
UniGeneiHs.428.

Genome annotation databases

EnsembliENST00000204637; ENSP00000204637; ENSG00000090554. [P49771-3]
ENST00000594009; ENSP00000469613; ENSG00000090554. [P49771-1]
ENST00000595510; ENSP00000471226; ENSG00000090554. [P49771-3]
ENST00000597551; ENSP00000468977; ENSG00000090554. [P49771-1]
ENST00000600429; ENSP00000470453; ENSG00000090554. [P49771-1]
GeneIDi2323.
KEGGihsa:2323.
UCSCiuc002pnu.4. human. [P49771-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04806 mRNA. Translation: AAA17999.1.
U03858 mRNA. Translation: AAA19825.1.
U29874 Genomic DNA. Translation: AAA90949.1.
U29874 Genomic DNA. Translation: AAA90950.1.
AK301136 mRNA. Translation: BAG62728.1.
AC010619 Genomic DNA. No translation available.
BC028001 mRNA. Translation: AAH28001.1.
BC126293 mRNA. Translation: AAI26294.1.
BC136464 mRNA. Translation: AAI36465.1.
CCDSiCCDS12767.1. [P49771-1]
CCDS62753.1. [P49771-3]
PIRiI38440.
I39076.
RefSeqiNP_001191431.1. NM_001204502.1. [P49771-1]
NP_001191432.1. NM_001204503.1. [P49771-1]
NP_001265566.1. NM_001278637.1. [P49771-3]
NP_001265567.1. NM_001278638.1. [P49771-3]
NP_001450.2. NM_001459.3. [P49771-1]
XP_011524984.1. XM_011526682.2. [P49771-3]
UniGeneiHs.428.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ETEX-ray2.20A/B/C/D27-160[»]
3QS7X-ray4.30A/B/C/D27-160[»]
3QS9X-ray7.80A/B/C/D27-160[»]
ProteinModelPortaliP49771.
SMRiP49771.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108611. 2 interactors.
DIPiDIP-6220N.
IntActiP49771. 2 interactors.
MINTiMINT-1371383.
STRINGi9606.ENSP00000468977.

Polymorphism and mutation databases

BioMutaiFLT3LG.
DMDMi1706818.

Proteomic databases

PaxDbiP49771.
PeptideAtlasiP49771.
PRIDEiP49771.

Protocols and materials databases

DNASUi2323.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000204637; ENSP00000204637; ENSG00000090554. [P49771-3]
ENST00000594009; ENSP00000469613; ENSG00000090554. [P49771-1]
ENST00000595510; ENSP00000471226; ENSG00000090554. [P49771-3]
ENST00000597551; ENSP00000468977; ENSG00000090554. [P49771-1]
ENST00000600429; ENSP00000470453; ENSG00000090554. [P49771-1]
GeneIDi2323.
KEGGihsa:2323.
UCSCiuc002pnu.4. human. [P49771-1]

Organism-specific databases

CTDi2323.
DisGeNETi2323.
GeneCardsiFLT3LG.
H-InvDBHIX0202990.
HGNCiHGNC:3766. FLT3LG.
HPAiHPA017313.
MIMi600007. gene.
neXtProtiNX_P49771.
OpenTargetsiENSG00000090554.
PharmGKBiPA28182.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXDX. Eukaryota.
ENOG41118N3. LUCA.
GeneTreeiENSGT00530000064424.
HOGENOMiHOG000029239.
HOVERGENiHBG051630.
InParanoidiP49771.
KOiK05454.
OMAiSGCLELQ.
OrthoDBiEOG091G0R0Y.
PhylomeDBiP49771.
TreeFamiTF338225.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000090554-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.
SIGNORiP49771.

Miscellaneous databases

ChiTaRSiFLT3LG. human.
EvolutionaryTraceiP49771.
GeneWikiiFLT3LG.
GenomeRNAii2323.
PROiP49771.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000090554.
CleanExiHS_FLT3LG.
ExpressionAtlasiP49771. baseline and differential.
GenevisibleiP49771. HS.

Family and domain databases

Gene3Di1.20.1250.10. 2 hits.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR004213. Flt3_lig.
[Graphical view]
PANTHERiPTHR11032. PTHR11032. 1 hit.
PfamiPF02947. Flt3_lig. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFLT3L_HUMAN
AccessioniPrimary (citable) accession number: P49771
Secondary accession number(s): A0AVC2, B9EGH2, Q05C96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.