Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P49769

- PSN1_MOUSE

UniProt

P49769 - PSN1_MOUSE

Protein

Presenilin-1

Gene

Psen1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei257 – 2571By similarity
    Sitei291 – 2922Cleavage; alternateBy similarity
    Sitei292 – 2932Cleavage; alternateBy similarity
    Sitei298 – 2992CleavageBy similarity
    Sitei345 – 3462Cleavage; by caspaseBy similarity
    Active sitei385 – 3851By similarity

    GO - Molecular functioni

    1. aspartic-type endopeptidase activity Source: InterPro
    2. beta-catenin binding Source: RefGenome
    3. cadherin binding Source: MGI
    4. calcium channel activity Source: Ensembl
    5. endopeptidase activity Source: MGI
    6. protein binding Source: IntAct

    GO - Biological processi

    1. activation of MAPKK activity Source: MGI
    2. amyloid precursor protein catabolic process Source: MGI
    3. anagen Source: MGI
    4. autophagic vacuole assembly Source: MGI
    5. autophagy Source: MGI
    6. beta-amyloid formation Source: MGI
    7. beta-amyloid metabolic process Source: MGI
    8. blood vessel development Source: MGI
    9. brain development Source: MGI
    10. brain morphogenesis Source: MGI
    11. Cajal-Retzius cell differentiation Source: MGI
    12. calcium ion transport Source: RefGenome
    13. canonical Wnt signaling pathway Source: RefGenome
    14. cell fate specification Source: MGI
    15. cellular calcium ion homeostasis Source: MGI
    16. cellular protein metabolic process Source: MGI
    17. cellular response to DNA damage stimulus Source: MGI
    18. cerebral cortex cell migration Source: MGI
    19. cerebral cortex development Source: MGI
    20. choline transport Source: MGI
    21. dorsal/ventral neural tube patterning Source: MGI
    22. embryonic limb morphogenesis Source: MGI
    23. endoplasmic reticulum calcium ion homeostasis Source: MGI
    24. epithelial cell proliferation Source: MGI
    25. forebrain development Source: MGI
    26. heart development Source: MGI
    27. heart looping Source: MGI
    28. hematopoietic progenitor cell differentiation Source: MGI
    29. intracellular signal transduction Source: InterPro
    30. learning or memory Source: MGI
    31. L-glutamate transport Source: MGI
    32. locomotion Source: MGI
    33. membrane protein ectodomain proteolysis Source: UniProtKB
    34. memory Source: MGI
    35. mitochondrial transport Source: MGI
    36. myeloid dendritic cell differentiation Source: MGI
    37. myeloid leukocyte differentiation Source: MGI
    38. negative regulation of apoptotic process Source: MGI
    39. negative regulation of apoptotic signaling pathway Source: MGI
    40. negative regulation of axonogenesis Source: MGI
    41. negative regulation of epidermal growth factor-activated receptor activity Source: BHF-UCL
    42. negative regulation of neuron apoptotic process Source: Ensembl
    43. negative regulation of protein kinase activity Source: MGI
    44. negative regulation of protein phosphorylation Source: MGI
    45. negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: BHF-UCL
    46. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    47. negative regulation of ubiquitin-protein transferase activity Source: BHF-UCL
    48. neurogenesis Source: MGI
    49. neuron apoptotic process Source: MGI
    50. neuron development Source: MGI
    51. neuron differentiation Source: MGI
    52. neuron migration Source: MGI
    53. Notch receptor processing Source: MGI
    54. Notch signaling pathway Source: MGI
    55. positive regulation of apoptotic process Source: MGI
    56. positive regulation of catalytic activity Source: UniProtKB
    57. positive regulation of coagulation Source: MGI
    58. positive regulation of MAP kinase activity Source: MGI
    59. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
    60. positive regulation of protein kinase activity Source: MGI
    61. positive regulation of protein phosphorylation Source: MGI
    62. positive regulation of receptor recycling Source: BHF-UCL
    63. post-embryonic development Source: MGI
    64. protein glycosylation Source: MGI
    65. protein maturation Source: MGI
    66. protein processing Source: UniProtKB
    67. protein transport Source: MGI
    68. regulation of epidermal growth factor-activated receptor activity Source: MGI
    69. regulation of protein binding Source: MGI
    70. regulation of resting membrane potential Source: MGI
    71. regulation of synaptic plasticity Source: MGI
    72. regulation of synaptic transmission, glutamatergic Source: MGI
    73. response to oxidative stress Source: MGI
    74. segmentation Source: MGI
    75. single organismal cell-cell adhesion Source: MGI
    76. skeletal system morphogenesis Source: MGI
    77. skin morphogenesis Source: BHF-UCL
    78. smooth endoplasmic reticulum calcium ion homeostasis Source: MGI
    79. somitogenesis Source: MGI
    80. synaptic vesicle targeting Source: MGI
    81. T cell activation involved in immune response Source: MGI
    82. T cell receptor signaling pathway Source: MGI
    83. thymus development Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis, Cell adhesion, Notch signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_199052. Degradation of the extracellular matrix.
    REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.

    Protein family/group databases

    MEROPSiA22.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Presenilin-1 (EC:3.4.23.-)
    Short name:
    PS-1
    Alternative name(s):
    Protein S182
    Cleaved into the following 3 chains:
    Gene namesi
    Name:Psen1
    Synonyms:Ad3h, Psnl1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1202717. Psen1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: RefGenome
    2. axon Source: MGI
    3. cell cortex Source: RefGenome
    4. cell surface Source: RefGenome
    5. centrosome Source: Ensembl
    6. ciliary rootlet Source: MGI
    7. cytoplasmic vesicle Source: MGI
    8. dendrite Source: MGI
    9. dendritic shaft Source: MGI
    10. endoplasmic reticulum Source: UniProtKB
    11. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    12. gamma-secretase complex Source: Ensembl
    13. Golgi apparatus Source: UniProtKB
    14. Golgi membrane Source: UniProtKB-SubCell
    15. growth cone Source: MGI
    16. integral component of plasma membrane Source: UniProtKB
    17. intracellular Source: MGI
    18. kinetochore Source: Ensembl
    19. lysosomal membrane Source: RefGenome
    20. membrane Source: MGI
    21. membrane-bounded organelle Source: MGI
    22. membrane raft Source: RefGenome
    23. mitochondrial inner membrane Source: RefGenome
    24. mitochondrion Source: UniProtKB
    25. neuromuscular junction Source: RefGenome
    26. neuronal cell body Source: MGI
    27. nuclear outer membrane Source: Ensembl
    28. nucleus Source: MGI
    29. perinuclear region of cytoplasm Source: RefGenome
    30. plasma membrane Source: MGI
    31. rough endoplasmic reticulum Source: Ensembl
    32. smooth endoplasmic reticulum Source: Ensembl
    33. Z disc Source: RefGenome

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 298298Presenilin-1 NTF subunitBy similarityPRO_0000025597Add
    BLAST
    Chaini299 – 467169Presenilin-1 CTF subunitBy similarityPRO_0000025598Add
    BLAST
    Chaini346 – 467122Presenilin-1 CTF12By similarityPRO_0000236058Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei329 – 3291Phosphoserine1 Publication
    Modified residuei346 – 3461Phosphoserine; by PKCBy similarity
    Modified residuei367 – 3671Phosphoserine1 Publication
    Modified residuei370 – 3701Phosphothreonine1 Publication
    Modified residuei371 – 3711Phosphoserine1 Publication

    Post-translational modificationi

    Heterogeneous proteolytic processing generates N-terminal (NTF) and C-terminal (CTF) fragments of approximately 35 and 20 kDa, respectively. During apoptosis, the C-terminal fragment (CTF) is further cleaved by caspase-3 to produce the fragment, PS1-CTF12 By similarity.By similarity
    After endoproteolysis, the C-terminal fragment (CTF) is phosphorylated on serine residues by PKA and/or PKC. Phosphorylation on Ser-346 inhibits endoproteolysis By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP49769.
    PaxDbiP49769.
    PRIDEiP49769.

    PTM databases

    PhosphoSiteiP49769.

    Expressioni

    Gene expression databases

    ArrayExpressiP49769.
    BgeeiP49769.
    CleanExiMM_PSEN1.
    GenevestigatoriP49769.

    Interactioni

    Subunit structurei

    Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity. Other components which are associated with the complex include SLC25A64, SLC5A7, PHB and PSEN1 isoform 3. Predominantly heterodimer of a N-terminal (NTF) and a C-terminal (CTF) endoproteolytical fragment. Associates with proteolytic processed C-terminal fragments C83 and C99 of the amyloid precursor protein (APP). Associates with NOTCH1. Associates with cadherin/catenin adhesion complexes through direct binding to CDH1 or CDH2. Interaction with CDH1 stabilizes the complex and stimulates cell-cell aggregation. Interaction with CDH2 is essential for trafficking of CDH2 from the endoplasmic reticulum to the plasma membrane. Interacts with CTNND2, CTNNB1, HERPUD1, FLNA, FLNB, MTCH1, PKP4 and PARL. Interacts through its N-terminus with isoform 3 of GFAP. Interacts with DOCK3 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ArcQ9WV312EBI-5260983,EBI-397779
    Atp6v0a1Q9Z1G42EBI-990067,EBI-771149
    CalrP142113EBI-990067,EBI-644340
    Efnb1P527952EBI-990067,EBI-8107507
    Erlin2Q8BFZ92EBI-990067,EBI-1635049

    Protein-protein interaction databases

    BioGridi202414. 17 interactions.
    DIPiDIP-36237N.
    IntActiP49769. 14 interactions.
    MINTiMINT-193580.

    Structurei

    3D structure databases

    ProteinModelPortaliP49769.
    SMRiP49769. Positions 292-467.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8282CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini104 – 13229LumenalSequence AnalysisAdd
    BLAST
    Topological domaini154 – 1607CytoplasmicSequence Analysis
    Topological domaini182 – 19413LumenalSequence AnalysisAdd
    BLAST
    Topological domaini216 – 2205CytoplasmicSequence Analysis
    Topological domaini242 – 2432LumenalSequence Analysis
    Topological domaini265 – 380116CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini402 – 4076LumenalSequence Analysis
    Topological domaini429 – 4324CytoplasmicSequence Analysis
    Topological domaini454 – 46714CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei433 – 45321HelicalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei83 – 10321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei133 – 15321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei161 – 18121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei195 – 21521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei381 – 40121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei408 – 42821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni322 – 450129Required for interaction with CTNNB1By similarityAdd
    BLAST
    Regioni372 – 39928Required for interaction with CTNND2By similarityAdd
    BLAST
    Regioni464 – 4674Interaction with MTCH1By similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi433 – 4353PAL

    Domaini

    The PAL motif is required for normal active site conformation.By similarity

    Sequence similaritiesi

    Belongs to the peptidase A22A family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG237920.
    HOGENOMiHOG000240228.
    HOVERGENiHBG011375.
    InParanoidiP49769.
    KOiK04505.
    OMAiEAQRKVS.
    OrthoDBiEOG7NGQBG.
    PhylomeDBiP49769.
    TreeFamiTF315040.

    Family and domain databases

    InterProiIPR002031. Pept_A22A_PS1.
    IPR001108. Peptidase_A22A.
    IPR006639. Preselin/SPP.
    [Graphical view]
    PANTHERiPTHR10202. PTHR10202. 1 hit.
    PTHR10202:SF7. PTHR10202:SF7. 1 hit.
    PfamiPF01080. Presenilin. 1 hit.
    [Graphical view]
    PRINTSiPR01072. PRESENILIN.
    PR01073. PRESENILIN1.
    SMARTiSM00730. PSN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P49769-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTEIPAPLSY FQNAQMSEDS HSSSAIRSQN DSQERQQQHD RQRLDNPEPI    50
    SNGRPQSNSR QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI 100
    KSVSFYTRKD GQLIYTPFTE DTETVGQRAL HSILNAAIMI SVIVIMTILL 150
    VVLYKYRCYK VIHAWLIISS LLLLFFFSFI YLGEVFKTYN VAVDYVTVAL 200
    LIWNFGVVGM IAIHWKGPLR LQQAYLIMIS ALMALVFIKY LPEWTAWLIL 250
    AVISVYDLVA VLCPKGPLRM LVETAQERNE TLFPALIYSS TMVWLVNMAE 300
    GDPEAQRRVP KNPKYNTQRA ERETQDSGSG NDDGGFSEEW EAQRDSHLGP 350
    HRSTPESRAA VQELSGSILT SEDPEERGVK LGLGDFIFYS VLVGKASATA 400
    SGDWNTTIAC FVAILIGLCL TLLLLAIFKK ALPALPISIT FGLVFYFATD 450
    YLVQPFMDQL AFHQFYI 467
    Length:467
    Mass (Da):52,640
    Last modified:October 1, 1996 - v1
    Checksum:iD07215B4BAD2D549
    GO
    Isoform 2 (identifier: P49769-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         257-261: DLVAV → GKAQD
         262-467: Missing.

    Note: Due to intron retention. No experimental confirmation available.

    Show »
    Length:261
    Mass (Da):29,849
    Checksum:i16FB53FBE20EA4EB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti9 – 91S → T in strain: SAM P8.
    Natural varianti40 – 401D → E in strain: SAM P8.
    Natural varianti67 – 671E → CM in strain: SAM P8.
    Natural varianti196 – 1961V → L in strain: SAM P8.
    Natural varianti321 – 3222ER → RRD in strain: SAM P8.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei257 – 2615DLVAV → GKAQD in isoform 2. 1 PublicationVSP_008381
    Alternative sequencei262 – 467206Missing in isoform 2. 1 PublicationVSP_008382Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42177 mRNA. Translation: AAC42094.1.
    AF007560 Genomic DNA. Translation: AAB72049.1.
    AF149111 mRNA. Translation: AAF73153.1.
    BC014744 mRNA. Translation: AAH14744.1.
    BC030409 mRNA. Translation: AAH30409.1.
    BC071233 mRNA. Translation: AAH71233.1.
    CCDSiCCDS26030.1. [P49769-1]
    PIRiI78388.
    RefSeqiNP_032969.1. NM_008943.2. [P49769-1]
    XP_006515668.1. XM_006515605.1. [P49769-1]
    UniGeneiMm.998.

    Genome annotation databases

    EnsembliENSMUST00000041806; ENSMUSP00000048363; ENSMUSG00000019969. [P49769-1]
    ENSMUST00000101225; ENSMUSP00000098786; ENSMUSG00000019969. [P49769-1]
    GeneIDi19164.
    KEGGimmu:19164.
    UCSCiuc007odo.1. mouse. [P49769-2]
    uc007odp.1. mouse. [P49769-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42177 mRNA. Translation: AAC42094.1 .
    AF007560 Genomic DNA. Translation: AAB72049.1 .
    AF149111 mRNA. Translation: AAF73153.1 .
    BC014744 mRNA. Translation: AAH14744.1 .
    BC030409 mRNA. Translation: AAH30409.1 .
    BC071233 mRNA. Translation: AAH71233.1 .
    CCDSi CCDS26030.1. [P49769-1 ]
    PIRi I78388.
    RefSeqi NP_032969.1. NM_008943.2. [P49769-1 ]
    XP_006515668.1. XM_006515605.1. [P49769-1 ]
    UniGenei Mm.998.

    3D structure databases

    ProteinModelPortali P49769.
    SMRi P49769. Positions 292-467.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202414. 17 interactions.
    DIPi DIP-36237N.
    IntActi P49769. 14 interactions.
    MINTi MINT-193580.

    Chemistry

    BindingDBi P49769.

    Protein family/group databases

    MEROPSi A22.001.

    PTM databases

    PhosphoSitei P49769.

    Proteomic databases

    MaxQBi P49769.
    PaxDbi P49769.
    PRIDEi P49769.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041806 ; ENSMUSP00000048363 ; ENSMUSG00000019969 . [P49769-1 ]
    ENSMUST00000101225 ; ENSMUSP00000098786 ; ENSMUSG00000019969 . [P49769-1 ]
    GeneIDi 19164.
    KEGGi mmu:19164.
    UCSCi uc007odo.1. mouse. [P49769-2 ]
    uc007odp.1. mouse. [P49769-1 ]

    Organism-specific databases

    CTDi 5663.
    MGIi MGI:1202717. Psen1.

    Phylogenomic databases

    eggNOGi NOG237920.
    HOGENOMi HOG000240228.
    HOVERGENi HBG011375.
    InParanoidi P49769.
    KOi K04505.
    OMAi EAQRKVS.
    OrthoDBi EOG7NGQBG.
    PhylomeDBi P49769.
    TreeFami TF315040.

    Enzyme and pathway databases

    Reactomei REACT_199052. Degradation of the extracellular matrix.
    REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.

    Miscellaneous databases

    NextBioi 295822.
    PROi P49769.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49769.
    Bgeei P49769.
    CleanExi MM_PSEN1.
    Genevestigatori P49769.

    Family and domain databases

    InterProi IPR002031. Pept_A22A_PS1.
    IPR001108. Peptidase_A22A.
    IPR006639. Preselin/SPP.
    [Graphical view ]
    PANTHERi PTHR10202. PTHR10202. 1 hit.
    PTHR10202:SF7. PTHR10202:SF7. 1 hit.
    Pfami PF01080. Presenilin. 1 hit.
    [Graphical view ]
    PRINTSi PR01072. PRESENILIN.
    PR01073. PRESENILIN1.
    SMARTi SM00730. PSN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Transcriptional regulation of the mouse presenilin-1 gene."
      Mitsuda N., Roses A.D., Vitek M.P.
      J. Biol. Chem. 272:23489-23497(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
      Strain: 129/SvJ.
    3. "Molecular cloning and tissue distribution of presenilin-1 in senenscence accelerated mice (SAM P8) mice."
      Kumar V.B., Vyas K.C., Choudhary V., Franko M., Flood J.F., Morley J.E.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: SAM P8.
      Tissue: Hippocampus.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: FVB/N.
      Tissue: Eye, Liver, Mammary gland and Retina.
    5. "Isolation and characterization of novel presenilin binding protein."
      Kashiwa A., Yoshida H., Lee S., Paladino T., Liu Y., Chen Q., Dargusch R., Schubert D., Kimura H.
      J. Neurochem. 75:109-116(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DOCK3.
      Tissue: Brain.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-367; THR-370 AND SER-371, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    8. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-329, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPSN1_MOUSE
    AccessioniPrimary (citable) accession number: P49769
    Secondary accession number(s): Q91WK6, Q9JLP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 150 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3