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P49769

- PSN1_MOUSE

UniProt

P49769 - PSN1_MOUSE

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Protein

Presenilin-1

Gene

Psen1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei257 – 2571By similarity
Sitei291 – 2922Cleavage; alternateBy similarity
Sitei292 – 2932Cleavage; alternateBy similarity
Sitei298 – 2992CleavageBy similarity
Sitei345 – 3462Cleavage; by caspaseBy similarity
Active sitei385 – 3851By similarity

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: InterPro
  2. beta-catenin binding Source: RefGenome
  3. cadherin binding Source: MGI
  4. calcium channel activity Source: Ensembl
  5. endopeptidase activity Source: MGI

GO - Biological processi

  1. activation of MAPKK activity Source: MGI
  2. amyloid precursor protein catabolic process Source: MGI
  3. anagen Source: MGI
  4. autophagic vacuole assembly Source: MGI
  5. autophagy Source: MGI
  6. beta-amyloid formation Source: MGI
  7. beta-amyloid metabolic process Source: MGI
  8. blood vessel development Source: MGI
  9. brain development Source: MGI
  10. brain morphogenesis Source: MGI
  11. Cajal-Retzius cell differentiation Source: MGI
  12. calcium ion transport Source: RefGenome
  13. canonical Wnt signaling pathway Source: RefGenome
  14. cell fate specification Source: MGI
  15. cellular calcium ion homeostasis Source: MGI
  16. cellular protein metabolic process Source: MGI
  17. cellular response to DNA damage stimulus Source: MGI
  18. cerebral cortex cell migration Source: MGI
  19. cerebral cortex development Source: MGI
  20. choline transport Source: MGI
  21. dorsal/ventral neural tube patterning Source: MGI
  22. embryonic limb morphogenesis Source: MGI
  23. endoplasmic reticulum calcium ion homeostasis Source: MGI
  24. epithelial cell proliferation Source: MGI
  25. forebrain development Source: MGI
  26. heart development Source: MGI
  27. heart looping Source: MGI
  28. hematopoietic progenitor cell differentiation Source: MGI
  29. intracellular signal transduction Source: InterPro
  30. learning or memory Source: MGI
  31. L-glutamate transport Source: MGI
  32. locomotion Source: MGI
  33. membrane protein ectodomain proteolysis Source: UniProtKB
  34. memory Source: MGI
  35. mitochondrial transport Source: MGI
  36. myeloid dendritic cell differentiation Source: MGI
  37. myeloid leukocyte differentiation Source: MGI
  38. negative regulation of apoptotic process Source: MGI
  39. negative regulation of apoptotic signaling pathway Source: MGI
  40. negative regulation of axonogenesis Source: MGI
  41. negative regulation of epidermal growth factor-activated receptor activity Source: BHF-UCL
  42. negative regulation of neuron apoptotic process Source: Ensembl
  43. negative regulation of protein kinase activity Source: MGI
  44. negative regulation of protein phosphorylation Source: MGI
  45. negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: BHF-UCL
  46. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  47. negative regulation of ubiquitin-protein transferase activity Source: BHF-UCL
  48. neurogenesis Source: MGI
  49. neuron apoptotic process Source: MGI
  50. neuron development Source: MGI
  51. neuron differentiation Source: MGI
  52. neuron migration Source: MGI
  53. Notch receptor processing Source: MGI
  54. Notch signaling pathway Source: MGI
  55. positive regulation of apoptotic process Source: MGI
  56. positive regulation of catalytic activity Source: UniProtKB
  57. positive regulation of coagulation Source: MGI
  58. positive regulation of MAP kinase activity Source: MGI
  59. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
  60. positive regulation of protein kinase activity Source: MGI
  61. positive regulation of protein phosphorylation Source: MGI
  62. positive regulation of receptor recycling Source: BHF-UCL
  63. post-embryonic development Source: MGI
  64. protein glycosylation Source: MGI
  65. protein maturation Source: MGI
  66. protein processing Source: UniProtKB
  67. protein transport Source: MGI
  68. regulation of epidermal growth factor-activated receptor activity Source: MGI
  69. regulation of protein binding Source: MGI
  70. regulation of resting membrane potential Source: MGI
  71. regulation of synaptic plasticity Source: MGI
  72. regulation of synaptic transmission, glutamatergic Source: MGI
  73. response to oxidative stress Source: MGI
  74. segmentation Source: MGI
  75. single organismal cell-cell adhesion Source: MGI
  76. skeletal system morphogenesis Source: MGI
  77. skin morphogenesis Source: BHF-UCL
  78. smooth endoplasmic reticulum calcium ion homeostasis Source: MGI
  79. somitogenesis Source: MGI
  80. synaptic vesicle targeting Source: MGI
  81. T cell activation involved in immune response Source: MGI
  82. T cell receptor signaling pathway Source: MGI
  83. thymus development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Keywords - Biological processi

Apoptosis, Cell adhesion, Notch signaling pathway

Enzyme and pathway databases

ReactomeiREACT_199052. Degradation of the extracellular matrix.
REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.

Protein family/group databases

MEROPSiA22.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Presenilin-1 (EC:3.4.23.-)
Short name:
PS-1
Alternative name(s):
Protein S182
Cleaved into the following 3 chains:
Gene namesi
Name:Psen1
Synonyms:Ad3h, Psnl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1202717. Psen1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8282CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei83 – 10321HelicalSequence AnalysisAdd
BLAST
Topological domaini104 – 13229LumenalSequence AnalysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence AnalysisAdd
BLAST
Topological domaini154 – 1607CytoplasmicSequence Analysis
Transmembranei161 – 18121HelicalSequence AnalysisAdd
BLAST
Topological domaini182 – 19413LumenalSequence AnalysisAdd
BLAST
Transmembranei195 – 21521HelicalSequence AnalysisAdd
BLAST
Topological domaini216 – 2205CytoplasmicSequence Analysis
Transmembranei221 – 24121HelicalSequence AnalysisAdd
BLAST
Topological domaini242 – 2432LumenalSequence Analysis
Transmembranei244 – 26421HelicalSequence AnalysisAdd
BLAST
Topological domaini265 – 380116CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence AnalysisAdd
BLAST
Topological domaini402 – 4076LumenalSequence Analysis
Transmembranei408 – 42821HelicalSequence AnalysisAdd
BLAST
Topological domaini429 – 4324CytoplasmicSequence Analysis
Intramembranei433 – 45321HelicalSequence AnalysisAdd
BLAST
Topological domaini454 – 46714CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: RefGenome
  2. axon Source: MGI
  3. cell cortex Source: RefGenome
  4. cell surface Source: RefGenome
  5. centrosome Source: Ensembl
  6. ciliary rootlet Source: MGI
  7. cytoplasmic vesicle Source: MGI
  8. dendrite Source: MGI
  9. dendritic shaft Source: MGI
  10. endoplasmic reticulum Source: UniProtKB
  11. gamma-secretase complex Source: Ensembl
  12. Golgi apparatus Source: UniProtKB
  13. growth cone Source: MGI
  14. integral component of plasma membrane Source: UniProtKB
  15. intracellular Source: MGI
  16. kinetochore Source: Ensembl
  17. lysosomal membrane Source: RefGenome
  18. membrane Source: MGI
  19. membrane-bounded organelle Source: MGI
  20. membrane raft Source: RefGenome
  21. mitochondrial inner membrane Source: RefGenome
  22. mitochondrion Source: UniProtKB
  23. neuromuscular junction Source: RefGenome
  24. neuronal cell body Source: MGI
  25. nuclear outer membrane Source: Ensembl
  26. nucleus Source: MGI
  27. perinuclear region of cytoplasm Source: RefGenome
  28. plasma membrane Source: MGI
  29. rough endoplasmic reticulum Source: Ensembl
  30. smooth endoplasmic reticulum Source: Ensembl
  31. Z disc Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Presenilin-1 NTF subunitBy similarityPRO_0000025597Add
BLAST
Chaini299 – 467169Presenilin-1 CTF subunitBy similarityPRO_0000025598Add
BLAST
Chaini346 – 467122Presenilin-1 CTF12By similarityPRO_0000236058Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei329 – 3291Phosphoserine1 Publication
Modified residuei346 – 3461Phosphoserine; by PKCBy similarity
Modified residuei367 – 3671Phosphoserine1 Publication
Modified residuei370 – 3701Phosphothreonine1 Publication
Modified residuei371 – 3711Phosphoserine1 Publication

Post-translational modificationi

Heterogeneous proteolytic processing generates N-terminal (NTF) and C-terminal (CTF) fragments of approximately 35 and 20 kDa, respectively. During apoptosis, the C-terminal fragment (CTF) is further cleaved by caspase-3 to produce the fragment, PS1-CTF12 (By similarity).By similarity
After endoproteolysis, the C-terminal fragment (CTF) is phosphorylated on serine residues by PKA and/or PKC. Phosphorylation on Ser-346 inhibits endoproteolysis (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP49769.
PaxDbiP49769.
PRIDEiP49769.

PTM databases

PhosphoSiteiP49769.

Expressioni

Gene expression databases

BgeeiP49769.
CleanExiMM_PSEN1.
ExpressionAtlasiP49769. baseline and differential.
GenevestigatoriP49769.

Interactioni

Subunit structurei

Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity. Other components which are associated with the complex include SLC25A64, SLC5A7, PHB and PSEN1 isoform 3. Predominantly heterodimer of a N-terminal (NTF) and a C-terminal (CTF) endoproteolytical fragment. Associates with proteolytic processed C-terminal fragments C83 and C99 of the amyloid precursor protein (APP). Associates with NOTCH1. Associates with cadherin/catenin adhesion complexes through direct binding to CDH1 or CDH2. Interaction with CDH1 stabilizes the complex and stimulates cell-cell aggregation. Interaction with CDH2 is essential for trafficking of CDH2 from the endoplasmic reticulum to the plasma membrane. Interacts with CTNND2, CTNNB1, HERPUD1, FLNA, FLNB, MTCH1, PKP4 and PARL. Interacts through its N-terminus with isoform 3 of GFAP. Interacts with DOCK3 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ArcQ9WV312EBI-5260983,EBI-397779
Atp6v0a1Q9Z1G42EBI-990067,EBI-771149
CalrP142113EBI-990067,EBI-644340
Efnb1P527952EBI-990067,EBI-8107507
Erlin2Q8BFZ92EBI-990067,EBI-1635049

Protein-protein interaction databases

BioGridi202414. 18 interactions.
DIPiDIP-36237N.
IntActiP49769. 14 interactions.
MINTiMINT-193580.

Structurei

3D structure databases

ProteinModelPortaliP49769.
SMRiP49769. Positions 292-467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni322 – 450129Required for interaction with CTNNB1By similarityAdd
BLAST
Regioni372 – 39928Required for interaction with CTNND2By similarityAdd
BLAST
Regioni464 – 4674Interaction with MTCH1By similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi433 – 4353PAL

Domaini

The PAL motif is required for normal active site conformation.By similarity

Sequence similaritiesi

Belongs to the peptidase A22A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237920.
HOGENOMiHOG000240228.
HOVERGENiHBG011375.
InParanoidiP49769.
KOiK04505.
OMAiEAQRKVS.
OrthoDBiEOG7NGQBG.
PhylomeDBiP49769.
TreeFamiTF315040.

Family and domain databases

InterProiIPR002031. Pept_A22A_PS1.
IPR001108. Peptidase_A22A.
IPR006639. Preselin/SPP.
[Graphical view]
PANTHERiPTHR10202. PTHR10202. 1 hit.
PTHR10202:SF7. PTHR10202:SF7. 1 hit.
PfamiPF01080. Presenilin. 1 hit.
[Graphical view]
PRINTSiPR01072. PRESENILIN.
PR01073. PRESENILIN1.
SMARTiSM00730. PSN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P49769-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTEIPAPLSY FQNAQMSEDS HSSSAIRSQN DSQERQQQHD RQRLDNPEPI
60 70 80 90 100
SNGRPQSNSR QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI
110 120 130 140 150
KSVSFYTRKD GQLIYTPFTE DTETVGQRAL HSILNAAIMI SVIVIMTILL
160 170 180 190 200
VVLYKYRCYK VIHAWLIISS LLLLFFFSFI YLGEVFKTYN VAVDYVTVAL
210 220 230 240 250
LIWNFGVVGM IAIHWKGPLR LQQAYLIMIS ALMALVFIKY LPEWTAWLIL
260 270 280 290 300
AVISVYDLVA VLCPKGPLRM LVETAQERNE TLFPALIYSS TMVWLVNMAE
310 320 330 340 350
GDPEAQRRVP KNPKYNTQRA ERETQDSGSG NDDGGFSEEW EAQRDSHLGP
360 370 380 390 400
HRSTPESRAA VQELSGSILT SEDPEERGVK LGLGDFIFYS VLVGKASATA
410 420 430 440 450
SGDWNTTIAC FVAILIGLCL TLLLLAIFKK ALPALPISIT FGLVFYFATD
460
YLVQPFMDQL AFHQFYI
Length:467
Mass (Da):52,640
Last modified:October 1, 1996 - v1
Checksum:iD07215B4BAD2D549
GO
Isoform 2 (identifier: P49769-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     257-261: DLVAV → GKAQD
     262-467: Missing.

Note: Due to intron retention. No experimental confirmation available.

Show »
Length:261
Mass (Da):29,849
Checksum:i16FB53FBE20EA4EB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91S → T in strain: SAM P8.
Natural varianti40 – 401D → E in strain: SAM P8.
Natural varianti67 – 671E → CM in strain: SAM P8.
Natural varianti196 – 1961V → L in strain: SAM P8.
Natural varianti321 – 3222ER → RRD in strain: SAM P8.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei257 – 2615DLVAV → GKAQD in isoform 2. 1 PublicationVSP_008381
Alternative sequencei262 – 467206Missing in isoform 2. 1 PublicationVSP_008382Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42177 mRNA. Translation: AAC42094.1.
AF007560 Genomic DNA. Translation: AAB72049.1.
AF149111 mRNA. Translation: AAF73153.1.
BC014744 mRNA. Translation: AAH14744.1.
BC030409 mRNA. Translation: AAH30409.1.
BC071233 mRNA. Translation: AAH71233.1.
CCDSiCCDS26030.1. [P49769-1]
PIRiI78388.
RefSeqiNP_032969.1. NM_008943.2. [P49769-1]
XP_006515668.1. XM_006515605.1. [P49769-1]
UniGeneiMm.998.

Genome annotation databases

EnsembliENSMUST00000041806; ENSMUSP00000048363; ENSMUSG00000019969. [P49769-1]
ENSMUST00000101225; ENSMUSP00000098786; ENSMUSG00000019969. [P49769-1]
GeneIDi19164.
KEGGimmu:19164.
UCSCiuc007odo.1. mouse. [P49769-2]
uc007odp.1. mouse. [P49769-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42177 mRNA. Translation: AAC42094.1 .
AF007560 Genomic DNA. Translation: AAB72049.1 .
AF149111 mRNA. Translation: AAF73153.1 .
BC014744 mRNA. Translation: AAH14744.1 .
BC030409 mRNA. Translation: AAH30409.1 .
BC071233 mRNA. Translation: AAH71233.1 .
CCDSi CCDS26030.1. [P49769-1 ]
PIRi I78388.
RefSeqi NP_032969.1. NM_008943.2. [P49769-1 ]
XP_006515668.1. XM_006515605.1. [P49769-1 ]
UniGenei Mm.998.

3D structure databases

ProteinModelPortali P49769.
SMRi P49769. Positions 292-467.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202414. 18 interactions.
DIPi DIP-36237N.
IntActi P49769. 14 interactions.
MINTi MINT-193580.

Protein family/group databases

MEROPSi A22.001.

PTM databases

PhosphoSitei P49769.

Proteomic databases

MaxQBi P49769.
PaxDbi P49769.
PRIDEi P49769.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000041806 ; ENSMUSP00000048363 ; ENSMUSG00000019969 . [P49769-1 ]
ENSMUST00000101225 ; ENSMUSP00000098786 ; ENSMUSG00000019969 . [P49769-1 ]
GeneIDi 19164.
KEGGi mmu:19164.
UCSCi uc007odo.1. mouse. [P49769-2 ]
uc007odp.1. mouse. [P49769-1 ]

Organism-specific databases

CTDi 5663.
MGIi MGI:1202717. Psen1.

Phylogenomic databases

eggNOGi NOG237920.
HOGENOMi HOG000240228.
HOVERGENi HBG011375.
InParanoidi P49769.
KOi K04505.
OMAi EAQRKVS.
OrthoDBi EOG7NGQBG.
PhylomeDBi P49769.
TreeFami TF315040.

Enzyme and pathway databases

Reactomei REACT_199052. Degradation of the extracellular matrix.
REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.

Miscellaneous databases

NextBioi 295822.
PROi P49769.
SOURCEi Search...

Gene expression databases

Bgeei P49769.
CleanExi MM_PSEN1.
ExpressionAtlasi P49769. baseline and differential.
Genevestigatori P49769.

Family and domain databases

InterProi IPR002031. Pept_A22A_PS1.
IPR001108. Peptidase_A22A.
IPR006639. Preselin/SPP.
[Graphical view ]
PANTHERi PTHR10202. PTHR10202. 1 hit.
PTHR10202:SF7. PTHR10202:SF7. 1 hit.
Pfami PF01080. Presenilin. 1 hit.
[Graphical view ]
PRINTSi PR01072. PRESENILIN.
PR01073. PRESENILIN1.
SMARTi SM00730. PSN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Transcriptional regulation of the mouse presenilin-1 gene."
    Mitsuda N., Roses A.D., Vitek M.P.
    J. Biol. Chem. 272:23489-23497(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    Strain: 129/SvJ.
  3. "Molecular cloning and tissue distribution of presenilin-1 in senenscence accelerated mice (SAM P8) mice."
    Kumar V.B., Vyas K.C., Choudhary V., Franko M., Flood J.F., Morley J.E.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: SAM P8.
    Tissue: Hippocampus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: FVB/N.
    Tissue: Eye, Liver, Mammary gland and Retina.
  5. "Isolation and characterization of novel presenilin binding protein."
    Kashiwa A., Yoshida H., Lee S., Paladino T., Liu Y., Chen Q., Dargusch R., Schubert D., Kimura H.
    J. Neurochem. 75:109-116(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DOCK3.
    Tissue: Brain.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-367; THR-370 AND SER-371, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-329, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPSN1_MOUSE
AccessioniPrimary (citable) accession number: P49769
Secondary accession number(s): Q91WK6, Q9JLP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3