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P49769

- PSN1_MOUSE

UniProt

P49769 - PSN1_MOUSE

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Protein
Presenilin-1
Gene
Psen1, Ad3h, Psnl1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei257 – 2571 By similarity
Sitei291 – 2922Cleavage; alternate By similarity
Sitei292 – 2932Cleavage; alternate By similarity
Sitei298 – 2992Cleavage By similarity
Sitei345 – 3462Cleavage; by caspase By similarity
Active sitei385 – 3851 By similarity

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: InterPro
  2. cadherin binding Source: MGI
  3. calcium channel activity Source: Ensembl
  4. endopeptidase activity Source: MGI
  5. protein binding Source: IntAct

GO - Biological processi

  1. Cajal-Retzius cell differentiation Source: MGI
  2. L-glutamate transport Source: MGI
  3. Notch receptor processing Source: MGI
  4. Notch signaling pathway Source: MGI
  5. T cell activation involved in immune response Source: MGI
  6. T cell receptor signaling pathway Source: MGI
  7. activation of MAPKK activity Source: MGI
  8. amyloid precursor protein catabolic process Source: MGI
  9. anagen Source: MGI
  10. autophagic vacuole assembly Source: MGI
  11. autophagy Source: MGI
  12. beta-amyloid formation Source: MGI
  13. beta-amyloid metabolic process Source: MGI
  14. blood vessel development Source: MGI
  15. brain development Source: MGI
  16. brain morphogenesis Source: MGI
  17. calcium ion transport Source: RefGenome
  18. cell fate specification Source: MGI
  19. cellular calcium ion homeostasis Source: MGI
  20. cellular protein metabolic process Source: MGI
  21. cellular response to DNA damage stimulus Source: MGI
  22. cerebral cortex cell migration Source: MGI
  23. cerebral cortex development Source: MGI
  24. choline transport Source: MGI
  25. dorsal/ventral neural tube patterning Source: MGI
  26. embryonic limb morphogenesis Source: MGI
  27. endoplasmic reticulum calcium ion homeostasis Source: MGI
  28. epithelial cell proliferation Source: MGI
  29. forebrain development Source: MGI
  30. heart development Source: MGI
  31. heart looping Source: MGI
  32. hematopoietic progenitor cell differentiation Source: MGI
  33. intracellular signal transduction Source: InterPro
  34. learning or memory Source: MGI
  35. locomotion Source: MGI
  36. membrane protein ectodomain proteolysis Source: UniProtKB
  37. memory Source: MGI
  38. mitochondrial transport Source: MGI
  39. myeloid leukocyte differentiation Source: MGI
  40. negative regulation of apoptotic process Source: MGI
  41. negative regulation of apoptotic signaling pathway Source: MGI
  42. negative regulation of axonogenesis Source: MGI
  43. negative regulation of epidermal growth factor-activated receptor activity Source: BHF-UCL
  44. negative regulation of neuron apoptotic process Source: Ensembl
  45. negative regulation of protein kinase activity Source: MGI
  46. negative regulation of protein phosphorylation Source: MGI
  47. negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: BHF-UCL
  48. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  49. negative regulation of ubiquitin-protein transferase activity Source: BHF-UCL
  50. neurogenesis Source: MGI
  51. neuron apoptotic process Source: MGI
  52. neuron development Source: MGI
  53. neuron differentiation Source: MGI
  54. neuron migration Source: MGI
  55. positive regulation of MAP kinase activity Source: MGI
  56. positive regulation of apoptotic process Source: MGI
  57. positive regulation of catalytic activity Source: UniProtKB
  58. positive regulation of coagulation Source: MGI
  59. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
  60. positive regulation of protein kinase activity Source: MGI
  61. positive regulation of protein phosphorylation Source: MGI
  62. positive regulation of receptor recycling Source: BHF-UCL
  63. post-embryonic development Source: MGI
  64. protein glycosylation Source: MGI
  65. protein maturation Source: MGI
  66. protein processing Source: UniProtKB
  67. protein transport Source: MGI
  68. regulation of epidermal growth factor-activated receptor activity Source: MGI
  69. regulation of protein binding Source: MGI
  70. regulation of resting membrane potential Source: MGI
  71. regulation of synaptic plasticity Source: MGI
  72. regulation of synaptic transmission, glutamatergic Source: MGI
  73. response to oxidative stress Source: MGI
  74. segmentation Source: MGI
  75. single organismal cell-cell adhesion Source: MGI
  76. skeletal system morphogenesis Source: MGI
  77. skin morphogenesis Source: BHF-UCL
  78. smooth endoplasmic reticulum calcium ion homeostasis Source: MGI
  79. somitogenesis Source: MGI
  80. synaptic vesicle targeting Source: MGI
  81. thymus development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Keywords - Biological processi

Apoptosis, Cell adhesion, Notch signaling pathway

Enzyme and pathway databases

ReactomeiREACT_199052. Degradation of the extracellular matrix.
REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.

Protein family/group databases

MEROPSiA22.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Presenilin-1 (EC:3.4.23.-)
Short name:
PS-1
Alternative name(s):
Protein S182
Cleaved into the following 3 chains:
Gene namesi
Name:Psen1
Synonyms:Ad3h, Psnl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1202717. Psen1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8282Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei83 – 10321Helical; Reviewed prediction
Add
BLAST
Topological domaini104 – 13229Lumenal Reviewed prediction
Add
BLAST
Transmembranei133 – 15321Helical; Reviewed prediction
Add
BLAST
Topological domaini154 – 1607Cytoplasmic Reviewed prediction
Transmembranei161 – 18121Helical; Reviewed prediction
Add
BLAST
Topological domaini182 – 19413Lumenal Reviewed prediction
Add
BLAST
Transmembranei195 – 21521Helical; Reviewed prediction
Add
BLAST
Topological domaini216 – 2205Cytoplasmic Reviewed prediction
Transmembranei221 – 24121Helical; Reviewed prediction
Add
BLAST
Topological domaini242 – 2432Lumenal Reviewed prediction
Transmembranei244 – 26421Helical; Reviewed prediction
Add
BLAST
Topological domaini265 – 380116Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei381 – 40121Helical; Reviewed prediction
Add
BLAST
Topological domaini402 – 4076Lumenal Reviewed prediction
Transmembranei408 – 42821Helical; Reviewed prediction
Add
BLAST
Topological domaini429 – 4324Cytoplasmic Reviewed prediction
Intramembranei433 – 45321Helical; Reviewed prediction
Add
BLAST
Topological domaini454 – 46714Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. Golgi membrane Source: UniProtKB-SubCell
  3. Z disc Source: RefGenome
  4. apical plasma membrane Source: RefGenome
  5. axon Source: MGI
  6. cell cortex Source: RefGenome
  7. cell surface Source: RefGenome
  8. centrosome Source: Ensembl
  9. ciliary rootlet Source: MGI
  10. cytoplasmic vesicle Source: MGI
  11. dendrite Source: MGI
  12. dendritic shaft Source: MGI
  13. endoplasmic reticulum Source: UniProtKB
  14. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  15. gamma-secretase complex Source: Ensembl
  16. growth cone Source: MGI
  17. integral component of plasma membrane Source: UniProtKB
  18. intracellular Source: MGI
  19. kinetochore Source: Ensembl
  20. lysosomal membrane Source: RefGenome
  21. membrane Source: MGI
  22. membrane raft Source: RefGenome
  23. membrane-bounded organelle Source: MGI
  24. mitochondrial inner membrane Source: RefGenome
  25. mitochondrion Source: UniProtKB
  26. neuromuscular junction Source: RefGenome
  27. neuronal cell body Source: MGI
  28. nuclear outer membrane Source: Ensembl
  29. nucleus Source: MGI
  30. perinuclear region of cytoplasm Source: RefGenome
  31. plasma membrane Source: MGI
  32. rough endoplasmic reticulum Source: Ensembl
  33. smooth endoplasmic reticulum Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Presenilin-1 NTF subunit By similarity
PRO_0000025597Add
BLAST
Chaini299 – 467169Presenilin-1 CTF subunit By similarity
PRO_0000025598Add
BLAST
Chaini346 – 467122Presenilin-1 CTF12 By similarity
PRO_0000236058Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei329 – 3291Phosphoserine1 Publication
Modified residuei346 – 3461Phosphoserine; by PKC By similarity
Modified residuei367 – 3671Phosphoserine1 Publication
Modified residuei370 – 3701Phosphothreonine1 Publication
Modified residuei371 – 3711Phosphoserine1 Publication

Post-translational modificationi

Heterogeneous proteolytic processing generates N-terminal (NTF) and C-terminal (CTF) fragments of approximately 35 and 20 kDa, respectively. During apoptosis, the C-terminal fragment (CTF) is further cleaved by caspase-3 to produce the fragment, PS1-CTF12 By similarity.
After endoproteolysis, the C-terminal fragment (CTF) is phosphorylated on serine residues by PKA and/or PKC. Phosphorylation on Ser-346 inhibits endoproteolysis By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP49769.
PaxDbiP49769.
PRIDEiP49769.

PTM databases

PhosphoSiteiP49769.

Expressioni

Gene expression databases

ArrayExpressiP49769.
BgeeiP49769.
CleanExiMM_PSEN1.
GenevestigatoriP49769.

Interactioni

Subunit structurei

Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity. Other components which are associated with the complex include SLC25A64, SLC5A7, PHB and PSEN1 isoform 3. Predominantly heterodimer of a N-terminal (NTF) and a C-terminal (CTF) endoproteolytical fragment. Associates with proteolytic processed C-terminal fragments C83 and C99 of the amyloid precursor protein (APP). Associates with NOTCH1. Associates with cadherin/catenin adhesion complexes through direct binding to CDH1 or CDH2. Interaction with CDH1 stabilizes the complex and stimulates cell-cell aggregation. Interaction with CDH2 is essential for trafficking of CDH2 from the endoplasmic reticulum to the plasma membrane. Interacts with CTNND2, CTNNB1, HERPUD1, FLNA, FLNB, MTCH1, PKP4 and PARL. Interacts through its N-terminus with isoform 3 of GFAP. Interacts with DOCK3 By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ArcQ9WV312EBI-5260983,EBI-397779
Atp6v0a1Q9Z1G42EBI-990067,EBI-771149
CalrP142113EBI-990067,EBI-644340
Efnb1P527952EBI-990067,EBI-8107507
Erlin2Q8BFZ92EBI-990067,EBI-1635049

Protein-protein interaction databases

BioGridi202414. 17 interactions.
DIPiDIP-36237N.
IntActiP49769. 14 interactions.
MINTiMINT-193580.

Structurei

3D structure databases

ProteinModelPortaliP49769.
SMRiP49769. Positions 292-467.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni322 – 450129Required for interaction with CTNNB1 By similarity
Add
BLAST
Regioni372 – 39928Required for interaction with CTNND2 By similarity
Add
BLAST
Regioni464 – 4674Interaction with MTCH1 By similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi433 – 4353PAL

Domaini

The PAL motif is required for normal active site conformation By similarity.

Sequence similaritiesi

Belongs to the peptidase A22A family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237920.
HOGENOMiHOG000240228.
HOVERGENiHBG011375.
InParanoidiP49769.
KOiK04505.
OMAiEAQRKVS.
OrthoDBiEOG7NGQBG.
PhylomeDBiP49769.
TreeFamiTF315040.

Family and domain databases

InterProiIPR002031. Pept_A22A_PS1.
IPR001108. Peptidase_A22A.
IPR006639. Preselin/SPP.
[Graphical view]
PANTHERiPTHR10202. PTHR10202. 1 hit.
PTHR10202:SF7. PTHR10202:SF7. 1 hit.
PfamiPF01080. Presenilin. 1 hit.
[Graphical view]
PRINTSiPR01072. PRESENILIN.
PR01073. PRESENILIN1.
SMARTiSM00730. PSN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P49769-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTEIPAPLSY FQNAQMSEDS HSSSAIRSQN DSQERQQQHD RQRLDNPEPI    50
SNGRPQSNSR QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI 100
KSVSFYTRKD GQLIYTPFTE DTETVGQRAL HSILNAAIMI SVIVIMTILL 150
VVLYKYRCYK VIHAWLIISS LLLLFFFSFI YLGEVFKTYN VAVDYVTVAL 200
LIWNFGVVGM IAIHWKGPLR LQQAYLIMIS ALMALVFIKY LPEWTAWLIL 250
AVISVYDLVA VLCPKGPLRM LVETAQERNE TLFPALIYSS TMVWLVNMAE 300
GDPEAQRRVP KNPKYNTQRA ERETQDSGSG NDDGGFSEEW EAQRDSHLGP 350
HRSTPESRAA VQELSGSILT SEDPEERGVK LGLGDFIFYS VLVGKASATA 400
SGDWNTTIAC FVAILIGLCL TLLLLAIFKK ALPALPISIT FGLVFYFATD 450
YLVQPFMDQL AFHQFYI 467
Length:467
Mass (Da):52,640
Last modified:October 1, 1996 - v1
Checksum:iD07215B4BAD2D549
GO
Isoform 2 (identifier: P49769-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     257-261: DLVAV → GKAQD
     262-467: Missing.

Note: Due to intron retention. No experimental confirmation available.

Show »
Length:261
Mass (Da):29,849
Checksum:i16FB53FBE20EA4EB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91S → T in strain: SAM P8.
Natural varianti40 – 401D → E in strain: SAM P8.
Natural varianti67 – 671E → CM in strain: SAM P8.
Natural varianti196 – 1961V → L in strain: SAM P8.
Natural varianti321 – 3222ER → RRD in strain: SAM P8.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei257 – 2615DLVAV → GKAQD in isoform 2.
VSP_008381
Alternative sequencei262 – 467206Missing in isoform 2.
VSP_008382Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42177 mRNA. Translation: AAC42094.1.
AF007560 Genomic DNA. Translation: AAB72049.1.
AF149111 mRNA. Translation: AAF73153.1.
BC014744 mRNA. Translation: AAH14744.1.
BC030409 mRNA. Translation: AAH30409.1.
BC071233 mRNA. Translation: AAH71233.1.
CCDSiCCDS26030.1. [P49769-1]
PIRiI78388.
RefSeqiNP_032969.1. NM_008943.2. [P49769-1]
XP_006515668.1. XM_006515605.1. [P49769-1]
UniGeneiMm.998.

Genome annotation databases

EnsembliENSMUST00000041806; ENSMUSP00000048363; ENSMUSG00000019969. [P49769-1]
ENSMUST00000101225; ENSMUSP00000098786; ENSMUSG00000019969. [P49769-1]
GeneIDi19164.
KEGGimmu:19164.
UCSCiuc007odo.1. mouse. [P49769-2]
uc007odp.1. mouse. [P49769-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42177 mRNA. Translation: AAC42094.1 .
AF007560 Genomic DNA. Translation: AAB72049.1 .
AF149111 mRNA. Translation: AAF73153.1 .
BC014744 mRNA. Translation: AAH14744.1 .
BC030409 mRNA. Translation: AAH30409.1 .
BC071233 mRNA. Translation: AAH71233.1 .
CCDSi CCDS26030.1. [P49769-1 ]
PIRi I78388.
RefSeqi NP_032969.1. NM_008943.2. [P49769-1 ]
XP_006515668.1. XM_006515605.1. [P49769-1 ]
UniGenei Mm.998.

3D structure databases

ProteinModelPortali P49769.
SMRi P49769. Positions 292-467.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202414. 17 interactions.
DIPi DIP-36237N.
IntActi P49769. 14 interactions.
MINTi MINT-193580.

Chemistry

BindingDBi P49769.

Protein family/group databases

MEROPSi A22.001.

PTM databases

PhosphoSitei P49769.

Proteomic databases

MaxQBi P49769.
PaxDbi P49769.
PRIDEi P49769.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000041806 ; ENSMUSP00000048363 ; ENSMUSG00000019969 . [P49769-1 ]
ENSMUST00000101225 ; ENSMUSP00000098786 ; ENSMUSG00000019969 . [P49769-1 ]
GeneIDi 19164.
KEGGi mmu:19164.
UCSCi uc007odo.1. mouse. [P49769-2 ]
uc007odp.1. mouse. [P49769-1 ]

Organism-specific databases

CTDi 5663.
MGIi MGI:1202717. Psen1.

Phylogenomic databases

eggNOGi NOG237920.
HOGENOMi HOG000240228.
HOVERGENi HBG011375.
InParanoidi P49769.
KOi K04505.
OMAi EAQRKVS.
OrthoDBi EOG7NGQBG.
PhylomeDBi P49769.
TreeFami TF315040.

Enzyme and pathway databases

Reactomei REACT_199052. Degradation of the extracellular matrix.
REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.

Miscellaneous databases

NextBioi 295822.
PROi P49769.
SOURCEi Search...

Gene expression databases

ArrayExpressi P49769.
Bgeei P49769.
CleanExi MM_PSEN1.
Genevestigatori P49769.

Family and domain databases

InterProi IPR002031. Pept_A22A_PS1.
IPR001108. Peptidase_A22A.
IPR006639. Preselin/SPP.
[Graphical view ]
PANTHERi PTHR10202. PTHR10202. 1 hit.
PTHR10202:SF7. PTHR10202:SF7. 1 hit.
Pfami PF01080. Presenilin. 1 hit.
[Graphical view ]
PRINTSi PR01072. PRESENILIN.
PR01073. PRESENILIN1.
SMARTi SM00730. PSN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Transcriptional regulation of the mouse presenilin-1 gene."
    Mitsuda N., Roses A.D., Vitek M.P.
    J. Biol. Chem. 272:23489-23497(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    Strain: 129/SvJ.
  3. "Molecular cloning and tissue distribution of presenilin-1 in senenscence accelerated mice (SAM P8) mice."
    Kumar V.B., Vyas K.C., Choudhary V., Franko M., Flood J.F., Morley J.E.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: SAM P8.
    Tissue: Hippocampus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: FVB/N.
    Tissue: Eye, Liver, Mammary gland and Retina.
  5. "Isolation and characterization of novel presenilin binding protein."
    Kashiwa A., Yoshida H., Lee S., Paladino T., Liu Y., Chen Q., Dargusch R., Schubert D., Kimura H.
    J. Neurochem. 75:109-116(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DOCK3.
    Tissue: Brain.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-367; THR-370 AND SER-371, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-329, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPSN1_MOUSE
AccessioniPrimary (citable) accession number: P49769
Secondary accession number(s): Q91WK6, Q9JLP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi