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Protein

Vascular endothelial growth factor B

Gene

Vegfb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. VEGF-B seems to be required for normal heart function in adult but is not required for proper development of the cardiovascular system either during development or for angiogenesis in adults.1 Publication

GO - Molecular functioni

  • growth factor activity Source: GO_Central
  • heparin binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI
  • vascular endothelial growth factor receptor 1 binding Source: GO_Central

GO - Biological processi

  • angiogenesis Source: GO_Central
  • cardiac muscle contraction Source: MGI
  • cell differentiation Source: UniProtKB-KW
  • coronary vasculature development Source: MGI
  • heart development Source: MGI
  • induction of positive chemotaxis Source: GO_Central
  • positive regulation of angiogenesis Source: GO_Central
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of endothelial cell proliferation Source: GO_Central
  • positive regulation of mast cell chemotaxis Source: GO_Central
  • protein O-linked glycosylation Source: MGI
  • response to drug Source: Ensembl
  • response to hypoxia Source: GO_Central
  • vascular endothelial growth factor receptor signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-194313. VEGF ligand-receptor interactions.
R-MMU-195399. VEGF binds to VEGFR leading to receptor dimerization.

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor B
Short name:
VEGF-B
Alternative name(s):
VEGF-related factor
Short name:
VRF
Gene namesi
Name:Vegfb
Synonyms:Vrf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:106199. Vegfb.

Subcellular locationi

  • Secreted

  • Note: Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.

GO - Cellular componenti

  • extracellular region Source: MGI
  • extracellular space Source: GO_Central
  • intracellular Source: MGI
  • membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002339922 – 207Vascular endothelial growth factor BAdd BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 89By similarity
Disulfide bondi72InterchainBy similarity
Disulfide bondi78 ↔ 122By similarity
Disulfide bondi81InterchainBy similarity
Disulfide bondi82 ↔ 124By similarity

Post-translational modificationi

VEGF-B186 is O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49766.
PeptideAtlasiP49766.
PRIDEiP49766.

PTM databases

PhosphoSitePlusiP49766.

Expressioni

Tissue specificityi

Abundantly expressed in heart, brain, kidney and skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000024962.
CleanExiMM_VEGFB.
GenevisibleiP49766. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Can also form heterodimer with VEGF.

GO - Molecular functioni

  • growth factor activity Source: GO_Central
  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI
  • vascular endothelial growth factor receptor 1 binding Source: GO_Central

Protein-protein interaction databases

IntActiP49766. 1 interactor.
MINTiMINT-1573475.
STRINGi10090.ENSMUSP00000025914.

Structurei

3D structure databases

ProteinModelPortaliP49766.
SMRiP49766.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II0A. Eukaryota.
ENOG410ZN1X. LUCA.
GeneTreeiENSGT00730000110791.
HOGENOMiHOG000230896.
HOVERGENiHBG000105.
InParanoidiP49766.
KOiK16858.
OMAiTMELMGT.
OrthoDBiEOG091G0G6M.
PhylomeDBiP49766.
TreeFamiTF319554.

Family and domain databases

CDDicd00135. PDGF. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform VEGF-B186 (identifier: P49766-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPLLRRLLL VALLQLARTQ APVSQFDGPS HQKKVVPWID VYARATCQPR
60 70 80 90 100
EVVVPLSMEL MGNVVKQLVP SCVTVQRCGG CCPDDGLECV PTGQHQVRMQ
110 120 130 140 150
ILMIQYPSSQ LGEMSLEEHS QCECRPKKKE SAVKPDRVAI PHHRPQPRSV
160 170 180 190 200
PGWDSTPGAS SPADIIHPTP APGSSARLAP SAVNALTPGP AAAAADAAAS

SIAKGGA
Length:207
Mass (Da):21,914
Last modified:November 16, 2001 - v2
Checksum:i4817A5E96F6960C2
GO
Isoform VEGF-B167 (identifier: P49766-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-207: RVAIPHHRPQ...AASSIAKGGA → SPRILCPPCT...DTCRCRKPRK

Show »
Length:188
Mass (Da):21,442
Checksum:iD52A055FB995E9CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69V → A in BAE28405 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004641137 – 207RVAIP…AKGGA → SPRILCPPCTQRRQRPDPRT CRCRCRRRRFLHCQGRGLEL NPDTCRCRKPRK in isoform VEGF-B167. 3 PublicationsAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43836 mRNA. Translation: AAC52932.1.
U43837 mRNA. Translation: AAC52553.1.
U52820 mRNA. Translation: AAC52823.1.
U48800 mRNA. Translation: AAB06273.1.
AK148188 mRNA. Translation: BAE28405.1.
BC046303 mRNA. Translation: AAH46303.1.
CCDSiCCDS29516.1. [P49766-1]
CCDS50373.1. [P49766-2]
PIRiJC4679.
JC4680.
RefSeqiNP_001172093.1. NM_001185164.1. [P49766-2]
NP_035827.1. NM_011697.3. [P49766-1]
UniGeneiMm.15607.

Genome annotation databases

EnsembliENSMUST00000025914; ENSMUSP00000025914; ENSMUSG00000024962. [P49766-1]
ENSMUST00000130048; ENSMUSP00000120860; ENSMUSG00000024962. [P49766-2]
GeneIDi22340.
KEGGimmu:22340.
UCSCiuc008gjv.2. mouse. [P49766-1]
uc008gjw.2. mouse. [P49766-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43836 mRNA. Translation: AAC52932.1.
U43837 mRNA. Translation: AAC52553.1.
U52820 mRNA. Translation: AAC52823.1.
U48800 mRNA. Translation: AAB06273.1.
AK148188 mRNA. Translation: BAE28405.1.
BC046303 mRNA. Translation: AAH46303.1.
CCDSiCCDS29516.1. [P49766-1]
CCDS50373.1. [P49766-2]
PIRiJC4679.
JC4680.
RefSeqiNP_001172093.1. NM_001185164.1. [P49766-2]
NP_035827.1. NM_011697.3. [P49766-1]
UniGeneiMm.15607.

3D structure databases

ProteinModelPortaliP49766.
SMRiP49766.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP49766. 1 interactor.
MINTiMINT-1573475.
STRINGi10090.ENSMUSP00000025914.

PTM databases

PhosphoSitePlusiP49766.

Proteomic databases

PaxDbiP49766.
PeptideAtlasiP49766.
PRIDEiP49766.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025914; ENSMUSP00000025914; ENSMUSG00000024962. [P49766-1]
ENSMUST00000130048; ENSMUSP00000120860; ENSMUSG00000024962. [P49766-2]
GeneIDi22340.
KEGGimmu:22340.
UCSCiuc008gjv.2. mouse. [P49766-1]
uc008gjw.2. mouse. [P49766-2]

Organism-specific databases

CTDi7423.
MGIiMGI:106199. Vegfb.

Phylogenomic databases

eggNOGiENOG410II0A. Eukaryota.
ENOG410ZN1X. LUCA.
GeneTreeiENSGT00730000110791.
HOGENOMiHOG000230896.
HOVERGENiHBG000105.
InParanoidiP49766.
KOiK16858.
OMAiTMELMGT.
OrthoDBiEOG091G0G6M.
PhylomeDBiP49766.
TreeFamiTF319554.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-194313. VEGF ligand-receptor interactions.
R-MMU-195399. VEGF binds to VEGFR leading to receptor dimerization.

Miscellaneous databases

ChiTaRSiVegfb. mouse.
PROiP49766.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024962.
CleanExiMM_VEGFB.
GenevisibleiP49766. MM.

Family and domain databases

CDDicd00135. PDGF. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVEGFB_MOUSE
AccessioniPrimary (citable) accession number: P49766
Secondary accession number(s): Q3UG04, Q5D0B1, Q64290
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 16, 2001
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.