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P49766

- VEGFB_MOUSE

UniProt

P49766 - VEGFB_MOUSE

Protein

Vascular endothelial growth factor B

Gene

Vegfb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (16 Nov 2001)
      Previous versions | rss
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    Functioni

    Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. VEGF-B seems to be required for normal heart function in adult but is not required for proper development of the cardiovascular system either during development or for angiogenesis in adults.1 Publication

    GO - Molecular functioni

    1. chemoattractant activity Source: Ensembl
    2. heparin binding Source: UniProtKB-KW
    3. protein heterodimerization activity Source: MGI
    4. protein homodimerization activity Source: MGI

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. cardiac muscle contraction Source: MGI
    3. cell differentiation Source: UniProtKB-KW
    4. coronary vasculature development Source: MGI
    5. heart development Source: MGI
    6. induction of positive chemotaxis Source: Ensembl
    7. negative regulation of gene expression Source: Ensembl
    8. negative regulation of neuron apoptotic process Source: Ensembl
    9. positive regulation of cell division Source: UniProtKB-KW
    10. positive regulation of endothelial cell proliferation Source: Ensembl
    11. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    12. positive regulation of mast cell chemotaxis Source: Ensembl
    13. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    14. positive regulation of protein kinase B signaling Source: Ensembl
    15. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: Ensembl
    16. positive regulation of vascular wound healing Source: Ensembl
    17. protein O-linked glycosylation Source: MGI
    18. response to drug Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Growth factor, Mitogen

    Keywords - Biological processi

    Angiogenesis, Differentiation

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_205099. VEGF binds to VEGFR leading to receptor dimerization.
    REACT_224551. VEGF ligand-receptor interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vascular endothelial growth factor B
    Short name:
    VEGF-B
    Alternative name(s):
    VEGF-related factor
    Short name:
    VRF
    Gene namesi
    Name:Vegfb
    Synonyms:Vrf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:106199. Vegfb.

    Subcellular locationi

    Secreted
    Note: Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.

    GO - Cellular componenti

    1. extracellular region Source: MGI
    2. extracellular space Source: Ensembl
    3. intracellular Source: MGI
    4. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 207186Vascular endothelial growth factor BPRO_0000023399Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi47 ↔ 89By similarity
    Disulfide bondi72 – 72InterchainBy similarity
    Disulfide bondi78 ↔ 122By similarity
    Disulfide bondi81 – 81InterchainBy similarity
    Disulfide bondi82 ↔ 124By similarity

    Post-translational modificationi

    VEGF-B186 is O-glycosylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP49766.

    Expressioni

    Tissue specificityi

    Abundantly expressed in heart, brain, kidney and skeletal muscle.

    Gene expression databases

    BgeeiP49766.
    CleanExiMM_VEGFB.
    GenevestigatoriP49766.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Can also form heterodimer with VEGF.

    Protein-protein interaction databases

    IntActiP49766. 1 interaction.
    MINTiMINT-1573475.

    Structurei

    3D structure databases

    ProteinModelPortaliP49766.
    SMRiP49766. Positions 34-128.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PDGF/VEGF growth factor family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG77417.
    GeneTreeiENSGT00730000110791.
    HOGENOMiHOG000230896.
    HOVERGENiHBG000105.
    InParanoidiP49766.
    KOiK16858.
    OMAiASTPHHR.
    OrthoDBiEOG74R1S0.
    PhylomeDBiP49766.
    TreeFamiTF319554.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR023581. PD_growth_factor_CS.
    IPR000072. PDGF/VEGF_dom.
    [Graphical view]
    PfamiPF00341. PDGF. 1 hit.
    [Graphical view]
    SMARTiSM00141. PDGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00249. PDGF_1. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform VEGF-B186 (identifier: P49766-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSPLLRRLLL VALLQLARTQ APVSQFDGPS HQKKVVPWID VYARATCQPR    50
    EVVVPLSMEL MGNVVKQLVP SCVTVQRCGG CCPDDGLECV PTGQHQVRMQ 100
    ILMIQYPSSQ LGEMSLEEHS QCECRPKKKE SAVKPDRVAI PHHRPQPRSV 150
    PGWDSTPGAS SPADIIHPTP APGSSARLAP SAVNALTPGP AAAAADAAAS 200
    SIAKGGA 207
    Length:207
    Mass (Da):21,914
    Last modified:November 16, 2001 - v2
    Checksum:i4817A5E96F6960C2
    GO
    Isoform VEGF-B167 (identifier: P49766-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         137-207: RVAIPHHRPQ...AASSIAKGGA → SPRILCPPCT...DTCRCRKPRK

    Show »
    Length:188
    Mass (Da):21,442
    Checksum:iD52A055FB995E9CA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti69 – 691V → A in BAE28405. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei137 – 20771RVAIP…AKGGA → SPRILCPPCTQRRQRPDPRT CRCRCRRRRFLHCQGRGLEL NPDTCRCRKPRK in isoform VEGF-B167. 3 PublicationsVSP_004641Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43836 mRNA. Translation: AAC52932.1.
    U43837 mRNA. Translation: AAC52553.1.
    U52820 mRNA. Translation: AAC52823.1.
    U48800 mRNA. Translation: AAB06273.1.
    AK148188 mRNA. Translation: BAE28405.1.
    BC046303 mRNA. Translation: AAH46303.1.
    CCDSiCCDS29516.1. [P49766-1]
    CCDS50373.1. [P49766-2]
    PIRiJC4679.
    JC4680.
    RefSeqiNP_001172093.1. NM_001185164.1. [P49766-2]
    NP_035827.1. NM_011697.3. [P49766-1]
    UniGeneiMm.15607.

    Genome annotation databases

    EnsembliENSMUST00000025914; ENSMUSP00000025914; ENSMUSG00000024962. [P49766-1]
    ENSMUST00000130048; ENSMUSP00000120860; ENSMUSG00000024962. [P49766-2]
    GeneIDi22340.
    KEGGimmu:22340.
    UCSCiuc008gjv.2. mouse. [P49766-1]
    uc008gjw.2. mouse. [P49766-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43836 mRNA. Translation: AAC52932.1 .
    U43837 mRNA. Translation: AAC52553.1 .
    U52820 mRNA. Translation: AAC52823.1 .
    U48800 mRNA. Translation: AAB06273.1 .
    AK148188 mRNA. Translation: BAE28405.1 .
    BC046303 mRNA. Translation: AAH46303.1 .
    CCDSi CCDS29516.1. [P49766-1 ]
    CCDS50373.1. [P49766-2 ]
    PIRi JC4679.
    JC4680.
    RefSeqi NP_001172093.1. NM_001185164.1. [P49766-2 ]
    NP_035827.1. NM_011697.3. [P49766-1 ]
    UniGenei Mm.15607.

    3D structure databases

    ProteinModelPortali P49766.
    SMRi P49766. Positions 34-128.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P49766. 1 interaction.
    MINTi MINT-1573475.

    Proteomic databases

    PRIDEi P49766.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025914 ; ENSMUSP00000025914 ; ENSMUSG00000024962 . [P49766-1 ]
    ENSMUST00000130048 ; ENSMUSP00000120860 ; ENSMUSG00000024962 . [P49766-2 ]
    GeneIDi 22340.
    KEGGi mmu:22340.
    UCSCi uc008gjv.2. mouse. [P49766-1 ]
    uc008gjw.2. mouse. [P49766-2 ]

    Organism-specific databases

    CTDi 7423.
    MGIi MGI:106199. Vegfb.

    Phylogenomic databases

    eggNOGi NOG77417.
    GeneTreei ENSGT00730000110791.
    HOGENOMi HOG000230896.
    HOVERGENi HBG000105.
    InParanoidi P49766.
    KOi K16858.
    OMAi ASTPHHR.
    OrthoDBi EOG74R1S0.
    PhylomeDBi P49766.
    TreeFami TF319554.

    Enzyme and pathway databases

    Reactomei REACT_205099. VEGF binds to VEGFR leading to receptor dimerization.
    REACT_224551. VEGF ligand-receptor interactions.

    Miscellaneous databases

    NextBioi 302601.
    PROi P49766.
    SOURCEi Search...

    Gene expression databases

    Bgeei P49766.
    CleanExi MM_VEGFB.
    Genevestigatori P49766.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR023581. PD_growth_factor_CS.
    IPR000072. PDGF/VEGF_dom.
    [Graphical view ]
    Pfami PF00341. PDGF. 1 hit.
    [Graphical view ]
    SMARTi SM00141. PDGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00249. PDGF_1. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS VEGF-B186 AND VEGF-B167).
      Tissue: Brain.
    2. "Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform."
      Olofsson B., Pajusola K., von Euler G., Chilov D., Alitalo K., Eriksson U.
      J. Biol. Chem. 271:19310-19317(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF-B186).
      Tissue: Heart.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF-B167).
      Tissue: Heart.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM VEGF-B186).
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM VEGF-B167).
      Tissue: Eye.
    6. "Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect."
      Aase K., von Euler G., Li X., Ponten A., Thoren P., Cao R., Cao Y., Olofsson B., Gebre-Medhin S., Pekny M., Alitalo K., Betsholtz C., Eriksson U.
      Circulation 104:358-364(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiVEGFB_MOUSE
    AccessioniPrimary (citable) accession number: P49766
    Secondary accession number(s): Q3UG04, Q5D0B1, Q64290
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 16, 2001
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3