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Protein

Vascular endothelial growth factor B

Gene

Vegfb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. VEGF-B seems to be required for normal heart function in adult but is not required for proper development of the cardiovascular system either during development or for angiogenesis in adults.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Heparin-binding, Mitogen
Biological processAngiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-194313 VEGF ligand-receptor interactions
R-MMU-195399 VEGF binds to VEGFR leading to receptor dimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor B
Short name:
VEGF-B
Alternative name(s):
VEGF-related factor
Short name:
VRF
Gene namesi
Name:Vegfb
Synonyms:Vrf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:106199 Vegfb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002339922 – 207Vascular endothelial growth factor BAdd BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 89By similarity
Disulfide bondi72InterchainBy similarity
Disulfide bondi78 ↔ 122By similarity
Disulfide bondi81InterchainBy similarity
Disulfide bondi82 ↔ 124By similarity

Post-translational modificationi

VEGF-B186 is O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49766
PeptideAtlasiP49766
PRIDEiP49766

PTM databases

PhosphoSitePlusiP49766

Expressioni

Tissue specificityi

Abundantly expressed in heart, brain, kidney and skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000024962
CleanExiMM_VEGFB
GenevisibleiP49766 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Can also form heterodimer with VEGF.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP49766, 1 interactor
STRINGi10090.ENSMUSP00000025914

Structurei

3D structure databases

ProteinModelPortaliP49766
SMRiP49766
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II0A Eukaryota
ENOG410ZN1X LUCA
GeneTreeiENSGT00730000110791
HOGENOMiHOG000230896
HOVERGENiHBG000105
InParanoidiP49766
KOiK16858
OMAiTMELMGT
OrthoDBiEOG091G0G6M
PhylomeDBiP49766
TreeFamiTF319554

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform VEGF-B186 (identifier: P49766-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPLLRRLLL VALLQLARTQ APVSQFDGPS HQKKVVPWID VYARATCQPR
60 70 80 90 100
EVVVPLSMEL MGNVVKQLVP SCVTVQRCGG CCPDDGLECV PTGQHQVRMQ
110 120 130 140 150
ILMIQYPSSQ LGEMSLEEHS QCECRPKKKE SAVKPDRVAI PHHRPQPRSV
160 170 180 190 200
PGWDSTPGAS SPADIIHPTP APGSSARLAP SAVNALTPGP AAAAADAAAS

SIAKGGA
Length:207
Mass (Da):21,914
Last modified:November 16, 2001 - v2
Checksum:i4817A5E96F6960C2
GO
Isoform VEGF-B167 (identifier: P49766-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-207: RVAIPHHRPQ...AASSIAKGGA → SPRILCPPCT...DTCRCRKPRK

Show »
Length:188
Mass (Da):21,442
Checksum:iD52A055FB995E9CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69V → A in BAE28405 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004641137 – 207RVAIP…AKGGA → SPRILCPPCTQRRQRPDPRT CRCRCRRRRFLHCQGRGLEL NPDTCRCRKPRK in isoform VEGF-B167. 3 PublicationsAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43836 mRNA Translation: AAC52932.1
U43837 mRNA Translation: AAC52553.1
U52820 mRNA Translation: AAC52823.1
U48800 mRNA Translation: AAB06273.1
AK148188 mRNA Translation: BAE28405.1
BC046303 mRNA Translation: AAH46303.1
CCDSiCCDS29516.1 [P49766-1]
CCDS50373.1 [P49766-2]
PIRiJC4679
JC4680
RefSeqiNP_001172093.1, NM_001185164.1 [P49766-2]
NP_035827.1, NM_011697.3 [P49766-1]
UniGeneiMm.15607

Genome annotation databases

EnsembliENSMUST00000025914; ENSMUSP00000025914; ENSMUSG00000024962 [P49766-1]
ENSMUST00000130048; ENSMUSP00000120860; ENSMUSG00000024962 [P49766-2]
GeneIDi22340
KEGGimmu:22340
UCSCiuc008gjv.2 mouse [P49766-1]
uc008gjw.2 mouse [P49766-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVEGFB_MOUSE
AccessioniPrimary (citable) accession number: P49766
Secondary accession number(s): Q3UG04, Q5D0B1, Q64290
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 16, 2001
Last modified: March 28, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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