Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P49766

- VEGFB_MOUSE

UniProt

P49766 - VEGFB_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Vascular endothelial growth factor B

Gene

Vegfb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. VEGF-B seems to be required for normal heart function in adult but is not required for proper development of the cardiovascular system either during development or for angiogenesis in adults.1 Publication

GO - Molecular functioni

  1. chemoattractant activity Source: Ensembl
  2. heparin binding Source: UniProtKB-KW
  3. protein heterodimerization activity Source: MGI
  4. protein homodimerization activity Source: MGI

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. cardiac muscle contraction Source: MGI
  3. cell differentiation Source: UniProtKB-KW
  4. coronary vasculature development Source: MGI
  5. heart development Source: MGI
  6. induction of positive chemotaxis Source: Ensembl
  7. negative regulation of gene expression Source: Ensembl
  8. negative regulation of neuron apoptotic process Source: Ensembl
  9. positive regulation of cell division Source: UniProtKB-KW
  10. positive regulation of endothelial cell proliferation Source: Ensembl
  11. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  12. positive regulation of mast cell chemotaxis Source: Ensembl
  13. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  14. positive regulation of protein kinase B signaling Source: Ensembl
  15. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: Ensembl
  16. positive regulation of vascular wound healing Source: Ensembl
  17. protein O-linked glycosylation Source: MGI
  18. response to drug Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_205099. VEGF binds to VEGFR leading to receptor dimerization.
REACT_224551. VEGF ligand-receptor interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor B
Short name:
VEGF-B
Alternative name(s):
VEGF-related factor
Short name:
VRF
Gene namesi
Name:Vegfb
Synonyms:Vrf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:106199. Vegfb.

Subcellular locationi

Secreted
Note: Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.

GO - Cellular componenti

  1. extracellular region Source: MGI
  2. extracellular space Source: Ensembl
  3. intracellular Source: MGI
  4. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 207186Vascular endothelial growth factor BPRO_0000023399Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 89By similarity
Disulfide bondi72 – 72InterchainBy similarity
Disulfide bondi78 ↔ 122By similarity
Disulfide bondi81 – 81InterchainBy similarity
Disulfide bondi82 ↔ 124By similarity

Post-translational modificationi

VEGF-B186 is O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP49766.

Expressioni

Tissue specificityi

Abundantly expressed in heart, brain, kidney and skeletal muscle.

Gene expression databases

BgeeiP49766.
CleanExiMM_VEGFB.
GenevestigatoriP49766.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Can also form heterodimer with VEGF.

Protein-protein interaction databases

IntActiP49766. 1 interaction.
MINTiMINT-1573475.

Structurei

3D structure databases

ProteinModelPortaliP49766.
SMRiP49766. Positions 34-128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG77417.
GeneTreeiENSGT00730000110791.
HOGENOMiHOG000230896.
HOVERGENiHBG000105.
InParanoidiP49766.
KOiK16858.
OMAiASTPHHR.
OrthoDBiEOG74R1S0.
PhylomeDBiP49766.
TreeFamiTF319554.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform VEGF-B186 (identifier: P49766-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPLLRRLLL VALLQLARTQ APVSQFDGPS HQKKVVPWID VYARATCQPR
60 70 80 90 100
EVVVPLSMEL MGNVVKQLVP SCVTVQRCGG CCPDDGLECV PTGQHQVRMQ
110 120 130 140 150
ILMIQYPSSQ LGEMSLEEHS QCECRPKKKE SAVKPDRVAI PHHRPQPRSV
160 170 180 190 200
PGWDSTPGAS SPADIIHPTP APGSSARLAP SAVNALTPGP AAAAADAAAS

SIAKGGA
Length:207
Mass (Da):21,914
Last modified:November 16, 2001 - v2
Checksum:i4817A5E96F6960C2
GO
Isoform VEGF-B167 (identifier: P49766-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-207: RVAIPHHRPQ...AASSIAKGGA → SPRILCPPCT...DTCRCRKPRK

Show »
Length:188
Mass (Da):21,442
Checksum:iD52A055FB995E9CA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691V → A in BAE28405. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei137 – 20771RVAIP…AKGGA → SPRILCPPCTQRRQRPDPRT CRCRCRRRRFLHCQGRGLEL NPDTCRCRKPRK in isoform VEGF-B167. 3 PublicationsVSP_004641Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43836 mRNA. Translation: AAC52932.1.
U43837 mRNA. Translation: AAC52553.1.
U52820 mRNA. Translation: AAC52823.1.
U48800 mRNA. Translation: AAB06273.1.
AK148188 mRNA. Translation: BAE28405.1.
BC046303 mRNA. Translation: AAH46303.1.
CCDSiCCDS29516.1. [P49766-1]
CCDS50373.1. [P49766-2]
PIRiJC4679.
JC4680.
RefSeqiNP_001172093.1. NM_001185164.1. [P49766-2]
NP_035827.1. NM_011697.3. [P49766-1]
UniGeneiMm.15607.

Genome annotation databases

EnsembliENSMUST00000025914; ENSMUSP00000025914; ENSMUSG00000024962. [P49766-1]
ENSMUST00000130048; ENSMUSP00000120860; ENSMUSG00000024962. [P49766-2]
GeneIDi22340.
KEGGimmu:22340.
UCSCiuc008gjv.2. mouse. [P49766-1]
uc008gjw.2. mouse. [P49766-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43836 mRNA. Translation: AAC52932.1 .
U43837 mRNA. Translation: AAC52553.1 .
U52820 mRNA. Translation: AAC52823.1 .
U48800 mRNA. Translation: AAB06273.1 .
AK148188 mRNA. Translation: BAE28405.1 .
BC046303 mRNA. Translation: AAH46303.1 .
CCDSi CCDS29516.1. [P49766-1 ]
CCDS50373.1. [P49766-2 ]
PIRi JC4679.
JC4680.
RefSeqi NP_001172093.1. NM_001185164.1. [P49766-2 ]
NP_035827.1. NM_011697.3. [P49766-1 ]
UniGenei Mm.15607.

3D structure databases

ProteinModelPortali P49766.
SMRi P49766. Positions 34-128.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P49766. 1 interaction.
MINTi MINT-1573475.

Proteomic databases

PRIDEi P49766.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025914 ; ENSMUSP00000025914 ; ENSMUSG00000024962 . [P49766-1 ]
ENSMUST00000130048 ; ENSMUSP00000120860 ; ENSMUSG00000024962 . [P49766-2 ]
GeneIDi 22340.
KEGGi mmu:22340.
UCSCi uc008gjv.2. mouse. [P49766-1 ]
uc008gjw.2. mouse. [P49766-2 ]

Organism-specific databases

CTDi 7423.
MGIi MGI:106199. Vegfb.

Phylogenomic databases

eggNOGi NOG77417.
GeneTreei ENSGT00730000110791.
HOGENOMi HOG000230896.
HOVERGENi HBG000105.
InParanoidi P49766.
KOi K16858.
OMAi ASTPHHR.
OrthoDBi EOG74R1S0.
PhylomeDBi P49766.
TreeFami TF319554.

Enzyme and pathway databases

Reactomei REACT_205099. VEGF binds to VEGFR leading to receptor dimerization.
REACT_224551. VEGF ligand-receptor interactions.

Miscellaneous databases

ChiTaRSi Vegfb. mouse.
NextBioi 302601.
PROi P49766.
SOURCEi Search...

Gene expression databases

Bgeei P49766.
CleanExi MM_VEGFB.
Genevestigatori P49766.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view ]
Pfami PF00341. PDGF. 1 hit.
[Graphical view ]
SMARTi SM00141. PDGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS VEGF-B186 AND VEGF-B167).
    Tissue: Brain.
  2. "Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform."
    Olofsson B., Pajusola K., von Euler G., Chilov D., Alitalo K., Eriksson U.
    J. Biol. Chem. 271:19310-19317(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF-B186).
    Tissue: Heart.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF-B167).
    Tissue: Heart.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM VEGF-B186).
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM VEGF-B167).
    Tissue: Eye.
  6. "Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect."
    Aase K., von Euler G., Li X., Ponten A., Thoren P., Cao R., Cao Y., Olofsson B., Gebre-Medhin S., Pekny M., Alitalo K., Betsholtz C., Eriksson U.
    Circulation 104:358-364(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiVEGFB_MOUSE
AccessioniPrimary (citable) accession number: P49766
Secondary accession number(s): Q3UG04, Q5D0B1, Q64290
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 16, 2001
Last modified: November 26, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3