ID   PLGF_MOUSE              Reviewed;         158 AA.
AC   P49764;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   27-MAR-2024, entry version 159.
DE   RecName: Full=Placenta growth factor;
DE            Short=PlGF;
DE   Flags: Precursor;
GN   Name=Pgf; Synonyms=Plgf;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart;
RX   PubMed=8903720; DOI=10.1007/s003359900003;
RA   Dipalma T., Tucci M., Russo G., Maglione D., Lago C.T., Romano A.,
RA   Saccone S., della Valle G., de Gregorio L., Dragani T.A., Viglietto G.,
RA   Persico M.G.;
RT   "The placenta growth factor gene of the mouse.";
RL   Mamm. Genome 7:6-12(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=NIH Swiss;
RX   PubMed=9401819; DOI=10.3109/08977199709002113;
RA   Achen M.G., Gad J.M., Stacker S.A., Wilks A.F.;
RT   "Placenta growth factor and vascular endothelial growth factor are co-
RT   expressed during early embryonic development.";
RL   Growth Factors 15:69-80(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=129; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Growth factor active in angiogenesis and endothelial cell
CC       growth, stimulating their proliferation and migration. It binds to the
CC       receptor FLT1/VEGFR-1. Also promotes cell tumor growth (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Antiparallel homodimer; disulfide-linked. Also found as
CC       heterodimer with VEGFA/VEGF (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC       {ECO:0000305}.
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DR   EMBL; X80171; CAA56453.1; -; mRNA.
DR   EMBL; X96793; CAA65587.1; -; mRNA.
DR   EMBL; BC016567; AAH16567.1; -; mRNA.
DR   CCDS; CCDS49115.1; -.
DR   RefSeq; NP_032853.1; NM_008827.3.
DR   AlphaFoldDB; P49764; -.
DR   SMR; P49764; -.
DR   IntAct; P49764; 1.
DR   STRING; 10090.ENSMUSP00000004913; -.
DR   BindingDB; P49764; -.
DR   ChEMBL; CHEMBL1697670; -.
DR   GlyCosmos; P49764; 3 sites, No reported glycans.
DR   GlyGen; P49764; 3 sites.
DR   PhosphoSitePlus; P49764; -.
DR   PaxDb; 10090-ENSMUSP00000004913; -.
DR   PeptideAtlas; P49764; -.
DR   ProteomicsDB; 289681; -.
DR   Antibodypedia; 12927; 1065 antibodies from 44 providers.
DR   DNASU; 18654; -.
DR   Ensembl; ENSMUST00000004913.7; ENSMUSP00000004913.7; ENSMUSG00000004791.8.
DR   GeneID; 18654; -.
DR   KEGG; mmu:18654; -.
DR   UCSC; uc007ogq.2; mouse.
DR   AGR; MGI:105095; -.
DR   CTD; 5228; -.
DR   MGI; MGI:105095; Pgf.
DR   VEuPathDB; HostDB:ENSMUSG00000004791; -.
DR   eggNOG; ENOG502S2DE; Eukaryota.
DR   GeneTree; ENSGT00940000160164; -.
DR   HOGENOM; CLU_042996_3_0_1; -.
DR   InParanoid; P49764; -.
DR   OMA; KPTDCHL; -.
DR   OrthoDB; 4231319at2759; -.
DR   PhylomeDB; P49764; -.
DR   TreeFam; TF319554; -.
DR   Reactome; R-MMU-194313; VEGF ligand-receptor interactions.
DR   Reactome; R-MMU-195399; VEGF binds to VEGFR leading to receptor dimerization.
DR   BioGRID-ORCS; 18654; 2 hits in 79 CRISPR screens.
DR   ChiTaRS; Pgf; mouse.
DR   PRO; PR:P49764; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; P49764; Protein.
DR   Bgee; ENSMUSG00000004791; Expressed in decidua and 145 other cell types or tissues.
DR   ExpressionAtlas; P49764; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; ISO:MGI.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; ISS:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR   GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR   GO; GO:0005172; F:vascular endothelial growth factor receptor binding; IBA:GO_Central.
DR   GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IDA:MGI.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0010467; P:gene expression; IMP:MGI.
DR   GO; GO:0005977; P:glycogen metabolic process; IMP:MGI.
DR   GO; GO:0050930; P:induction of positive chemotaxis; IBA:GO_Central.
DR   GO; GO:0001890; P:placenta development; IMP:MGI.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; ISO:MGI.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISO:MGI.
DR   GO; GO:0060754; P:positive regulation of mast cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR   GO; GO:0008217; P:regulation of blood pressure; IMP:MGI.
DR   GO; GO:0060688; P:regulation of morphogenesis of a branching structure; IDA:MGI.
DR   GO; GO:0001666; P:response to hypoxia; IBA:GO_Central.
DR   GO; GO:0002040; P:sprouting angiogenesis; ISO:MGI.
DR   GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0038084; P:vascular endothelial growth factor signaling pathway; IBA:GO_Central.
DR   CDD; cd00135; PDGF; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR023581; PD_growth_factor_CS.
DR   InterPro; IPR000072; PDGF/VEGF_dom.
DR   PANTHER; PTHR12025:SF9; PLACENTA GROWTH FACTOR; 1.
DR   PANTHER; PTHR12025; VASCULAR ENDOTHELIAL GROWTH FACTOR; 1.
DR   Pfam; PF00341; PDGF; 1.
DR   SMART; SM00141; PDGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00249; PDGF_1; 1.
DR   PROSITE; PS50278; PDGF_2; 1.
DR   Genevisible; P49764; MM.
PE   2: Evidence at transcript level;
KW   Angiogenesis; Developmental protein; Differentiation; Disulfide bond;
KW   Glycoprotein; Growth factor; Mitogen; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000250"
FT   CHAIN           19..158
FT                   /note="Placenta growth factor"
FT                   /id="PRO_0000023421"
FT   REGION          136..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        29
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        30
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        97
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        48..90
FT                   /evidence="ECO:0000250"
FT   DISULFID        73
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
FT   DISULFID        79..125
FT                   /evidence="ECO:0000250"
FT   DISULFID        82
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
FT   DISULFID        83..127
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   158 AA;  17876 MW;  F16128BEA0790438 CRC64;
     MLVMKLFTCF LQVLAGLAVH SQGALSAGNN STEVEVVPFN EVWGRSYCRP MEKLVYILDE
     YPDEVSHIFS PSCVLLSRCS GCCGDEGLHC VPIKTANITM QILKIPPNRD PHFYVEMTFS
     QDVLCECRPI LETTKAERRK TKGKRKRSRN SQTEEPHP
//