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P49764 (PLGF_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Placenta growth factor

Short name=PlGF
Gene names
Name:Pgf
Synonyms:Plgf
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length158 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Also promotes cell tumor growth By similarity.

Subunit structure

Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the PDGF/VEGF growth factor family.

Ontologies

Keywords
   Biological processAngiogenesis
Differentiation
   Cellular componentSecreted
   DomainSignal
   Molecular functionDevelopmental protein
Growth factor
Mitogen
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbranching involved in ureteric bud morphogenesis

Inferred from direct assay PubMed 13678594. Source: MGI

cell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

cellular response to hormone stimulus

Inferred from electronic annotation. Source: Ensembl

female pregnancy

Inferred from electronic annotation. Source: Ensembl

organ regeneration

Inferred from electronic annotation. Source: Ensembl

positive regulation of angiogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell division

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of endothelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

regulation of morphogenesis of a branching structure

Inferred from direct assay PubMed 13678594. Source: MGI

response to drug

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

sprouting angiogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular region

Inferred from sequence orthology PubMed 10575000. Source: MGI

extracellular space

Inferred from electronic annotation. Source: Ensembl

membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functiongrowth factor activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 By similarity
Chain19 – 158140Placenta growth factor
PRO_0000023421

Amino acid modifications

Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation301N-linked (GlcNAc...) Potential
Glycosylation971N-linked (GlcNAc...) Potential
Disulfide bond48 ↔ 90 By similarity
Disulfide bond73Interchain By similarity
Disulfide bond79 ↔ 125 By similarity
Disulfide bond82Interchain By similarity
Disulfide bond83 ↔ 127 By similarity

Sequences

Sequence LengthMass (Da)Tools
P49764 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: F16128BEA0790438

FASTA15817,876
        10         20         30         40         50         60 
MLVMKLFTCF LQVLAGLAVH SQGALSAGNN STEVEVVPFN EVWGRSYCRP MEKLVYILDE 

        70         80         90        100        110        120 
YPDEVSHIFS PSCVLLSRCS GCCGDEGLHC VPIKTANITM QILKIPPNRD PHFYVEMTFS 

       130        140        150 
QDVLCECRPI LETTKAERRK TKGKRKRSRN SQTEEPHP 

« Hide

References

« Hide 'large scale' references
[1]"The placenta growth factor gene of the mouse."
Dipalma T., Tucci M., Russo G., Maglione D., Lago C.T., Romano A., Saccone S., della Valle G., de Gregorio L., Dragani T.A., Viglietto G., Persico M.G.
Mamm. Genome 7:6-12(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[2]"Placenta growth factor and vascular endothelial growth factor are co-expressed during early embryonic development."
Achen M.G., Gad J.M., Stacker S.A., Wilks A.F.
Growth Factors 15:69-80(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: NIH Swiss.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: 129.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X80171 mRNA. Translation: CAA56453.1.
X96793 mRNA. Translation: CAA65587.1.
BC016567 mRNA. Translation: AAH16567.1.
RefSeqNP_032853.1. NM_008827.3.
UniGeneMm.4809.

3D structure databases

ProteinModelPortalP49764.
SMRP49764. Positions 31-130.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP49764. 1 interaction.
STRING10090.ENSMUSP00000004913.

Chemistry

BindingDBP49764.
ChEMBLCHEMBL1697670.

Proteomic databases

PaxDbP49764.
PRIDEP49764.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000004913; ENSMUSP00000004913; ENSMUSG00000004791.
GeneID18654.
KEGGmmu:18654.
UCSCuc007ogq.1. mouse.

Organism-specific databases

CTD5228.
MGIMGI:105095. Pgf.

Phylogenomic databases

eggNOGNOG84541.
HOGENOMHOG000230896.
HOVERGENHBG000105.
InParanoidP49764.
KOK16859.
OMARCECRPL.
OrthoDBEOG74R1S0.
PhylomeDBP49764.
TreeFamTF319554.

Gene expression databases

ArrayExpressP49764.
BgeeP49764.
CleanExMM_PGF.
GenevestigatorP49764.

Family and domain databases

InterProIPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamPF00341. PDGF. 1 hit.
[Graphical view]
SMARTSM00141. PDGF. 1 hit.
[Graphical view]
PROSITEPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio294658.
PROP49764.
SOURCESearch...

Entry information

Entry namePLGF_MOUSE
AccessionPrimary (citable) accession number: P49764
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot