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P49764

- PLGF_MOUSE

UniProt

P49764 - PLGF_MOUSE

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Protein

Placenta growth factor

Gene

Pgf

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Also promotes cell tumor growth (By similarity).By similarity

GO - Molecular functioni

  1. growth factor activity Source: UniProtKB

GO - Biological processi

  1. branching involved in ureteric bud morphogenesis Source: MGI
  2. cell differentiation Source: UniProtKB-KW
  3. cellular response to hormone stimulus Source: Ensembl
  4. female pregnancy Source: Ensembl
  5. organ regeneration Source: Ensembl
  6. positive regulation of angiogenesis Source: Ensembl
  7. positive regulation of cell division Source: UniProtKB-KW
  8. positive regulation of cell proliferation Source: UniProtKB
  9. positive regulation of endothelial cell proliferation Source: Ensembl
  10. regulation of morphogenesis of a branching structure Source: MGI
  11. response to drug Source: Ensembl
  12. response to hypoxia Source: Ensembl
  13. sprouting angiogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiREACT_205099. VEGF binds to VEGFR leading to receptor dimerization.
REACT_224551. VEGF ligand-receptor interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Placenta growth factor
Short name:
PlGF
Gene namesi
Name:Pgf
Synonyms:Plgf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:105095. Pgf.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: MGI
  2. extracellular space Source: Ensembl
  3. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 158140Placenta growth factorPRO_0000023421Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi48 ↔ 90By similarity
Disulfide bondi73 – 73InterchainBy similarity
Disulfide bondi79 ↔ 125By similarity
Disulfide bondi82 – 82InterchainBy similarity
Disulfide bondi83 ↔ 127By similarity
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49764.
PRIDEiP49764.

Expressioni

Gene expression databases

BgeeiP49764.
CleanExiMM_PGF.
ExpressionAtlasiP49764. baseline and differential.
GenevestigatoriP49764.

Interactioni

Subunit structurei

Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF (By similarity).By similarity

Protein-protein interaction databases

IntActiP49764. 1 interaction.
STRINGi10090.ENSMUSP00000004913.

Structurei

3D structure databases

ProteinModelPortaliP49764.
SMRiP49764. Positions 31-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG84541.
HOGENOMiHOG000230896.
HOVERGENiHBG000105.
InParanoidiP49764.
KOiK16859.
OMAiHIIKERA.
OrthoDBiEOG74R1S0.
PhylomeDBiP49764.
TreeFamiTF319554.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49764-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLVMKLFTCF LQVLAGLAVH SQGALSAGNN STEVEVVPFN EVWGRSYCRP
60 70 80 90 100
MEKLVYILDE YPDEVSHIFS PSCVLLSRCS GCCGDEGLHC VPIKTANITM
110 120 130 140 150
QILKIPPNRD PHFYVEMTFS QDVLCECRPI LETTKAERRK TKGKRKRSRN

SQTEEPHP
Length:158
Mass (Da):17,876
Last modified:October 1, 1996 - v1
Checksum:iF16128BEA0790438
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80171 mRNA. Translation: CAA56453.1.
X96793 mRNA. Translation: CAA65587.1.
BC016567 mRNA. Translation: AAH16567.1.
CCDSiCCDS49115.1.
RefSeqiNP_032853.1. NM_008827.3.
UniGeneiMm.4809.

Genome annotation databases

EnsembliENSMUST00000004913; ENSMUSP00000004913; ENSMUSG00000004791.
GeneIDi18654.
KEGGimmu:18654.
UCSCiuc007ogq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80171 mRNA. Translation: CAA56453.1 .
X96793 mRNA. Translation: CAA65587.1 .
BC016567 mRNA. Translation: AAH16567.1 .
CCDSi CCDS49115.1.
RefSeqi NP_032853.1. NM_008827.3.
UniGenei Mm.4809.

3D structure databases

ProteinModelPortali P49764.
SMRi P49764. Positions 31-130.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P49764. 1 interaction.
STRINGi 10090.ENSMUSP00000004913.

Chemistry

BindingDBi P49764.
ChEMBLi CHEMBL1697670.

Proteomic databases

PaxDbi P49764.
PRIDEi P49764.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004913 ; ENSMUSP00000004913 ; ENSMUSG00000004791 .
GeneIDi 18654.
KEGGi mmu:18654.
UCSCi uc007ogq.1. mouse.

Organism-specific databases

CTDi 5228.
MGIi MGI:105095. Pgf.

Phylogenomic databases

eggNOGi NOG84541.
HOGENOMi HOG000230896.
HOVERGENi HBG000105.
InParanoidi P49764.
KOi K16859.
OMAi HIIKERA.
OrthoDBi EOG74R1S0.
PhylomeDBi P49764.
TreeFami TF319554.

Enzyme and pathway databases

Reactomei REACT_205099. VEGF binds to VEGFR leading to receptor dimerization.
REACT_224551. VEGF ligand-receptor interactions.

Miscellaneous databases

NextBioi 294658.
PROi P49764.
SOURCEi Search...

Gene expression databases

Bgeei P49764.
CleanExi MM_PGF.
ExpressionAtlasi P49764. baseline and differential.
Genevestigatori P49764.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view ]
Pfami PF00341. PDGF. 1 hit.
[Graphical view ]
SMARTi SM00141. PDGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "Placenta growth factor and vascular endothelial growth factor are co-expressed during early embryonic development."
    Achen M.G., Gad J.M., Stacker S.A., Wilks A.F.
    Growth Factors 15:69-80(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NIH Swiss.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129.
    Tissue: Mammary gland.

Entry informationi

Entry nameiPLGF_MOUSE
AccessioniPrimary (citable) accession number: P49764
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3