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P49764

- PLGF_MOUSE

UniProt

P49764 - PLGF_MOUSE

Protein

Placenta growth factor

Gene

Pgf

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Also promotes cell tumor growth By similarity.By similarity

    GO - Molecular functioni

    1. growth factor activity Source: UniProtKB

    GO - Biological processi

    1. branching involved in ureteric bud morphogenesis Source: MGI
    2. cell differentiation Source: UniProtKB-KW
    3. cellular response to hormone stimulus Source: Ensembl
    4. female pregnancy Source: Ensembl
    5. organ regeneration Source: Ensembl
    6. positive regulation of angiogenesis Source: Ensembl
    7. positive regulation of cell division Source: UniProtKB-KW
    8. positive regulation of cell proliferation Source: UniProtKB
    9. positive regulation of endothelial cell proliferation Source: Ensembl
    10. regulation of morphogenesis of a branching structure Source: MGI
    11. response to drug Source: Ensembl
    12. response to hypoxia Source: Ensembl
    13. sprouting angiogenesis Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Growth factor, Mitogen

    Keywords - Biological processi

    Angiogenesis, Differentiation

    Enzyme and pathway databases

    ReactomeiREACT_205099. VEGF binds to VEGFR leading to receptor dimerization.
    REACT_224551. VEGF ligand-receptor interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Placenta growth factor
    Short name:
    PlGF
    Gene namesi
    Name:Pgf
    Synonyms:Plgf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:105095. Pgf.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: MGI
    2. extracellular space Source: Ensembl
    3. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818By similarityAdd
    BLAST
    Chaini19 – 158140Placenta growth factorPRO_0000023421Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi48 ↔ 90By similarity
    Disulfide bondi73 – 73InterchainBy similarity
    Disulfide bondi79 ↔ 125By similarity
    Disulfide bondi82 – 82InterchainBy similarity
    Disulfide bondi83 ↔ 127By similarity
    Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP49764.
    PRIDEiP49764.

    Expressioni

    Gene expression databases

    ArrayExpressiP49764.
    BgeeiP49764.
    CleanExiMM_PGF.
    GenevestigatoriP49764.

    Interactioni

    Subunit structurei

    Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF By similarity.By similarity

    Protein-protein interaction databases

    IntActiP49764. 1 interaction.
    STRINGi10090.ENSMUSP00000004913.

    Structurei

    3D structure databases

    ProteinModelPortaliP49764.
    SMRiP49764. Positions 31-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PDGF/VEGF growth factor family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG84541.
    HOGENOMiHOG000230896.
    HOVERGENiHBG000105.
    InParanoidiP49764.
    KOiK16859.
    OMAiHIIKERA.
    OrthoDBiEOG74R1S0.
    PhylomeDBiP49764.
    TreeFamiTF319554.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR023581. PD_growth_factor_CS.
    IPR000072. PDGF/VEGF_dom.
    [Graphical view]
    PfamiPF00341. PDGF. 1 hit.
    [Graphical view]
    SMARTiSM00141. PDGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00249. PDGF_1. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49764-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLVMKLFTCF LQVLAGLAVH SQGALSAGNN STEVEVVPFN EVWGRSYCRP    50
    MEKLVYILDE YPDEVSHIFS PSCVLLSRCS GCCGDEGLHC VPIKTANITM 100
    QILKIPPNRD PHFYVEMTFS QDVLCECRPI LETTKAERRK TKGKRKRSRN 150
    SQTEEPHP 158
    Length:158
    Mass (Da):17,876
    Last modified:October 1, 1996 - v1
    Checksum:iF16128BEA0790438
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80171 mRNA. Translation: CAA56453.1.
    X96793 mRNA. Translation: CAA65587.1.
    BC016567 mRNA. Translation: AAH16567.1.
    CCDSiCCDS49115.1.
    RefSeqiNP_032853.1. NM_008827.3.
    UniGeneiMm.4809.

    Genome annotation databases

    EnsembliENSMUST00000004913; ENSMUSP00000004913; ENSMUSG00000004791.
    GeneIDi18654.
    KEGGimmu:18654.
    UCSCiuc007ogq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80171 mRNA. Translation: CAA56453.1 .
    X96793 mRNA. Translation: CAA65587.1 .
    BC016567 mRNA. Translation: AAH16567.1 .
    CCDSi CCDS49115.1.
    RefSeqi NP_032853.1. NM_008827.3.
    UniGenei Mm.4809.

    3D structure databases

    ProteinModelPortali P49764.
    SMRi P49764. Positions 31-130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P49764. 1 interaction.
    STRINGi 10090.ENSMUSP00000004913.

    Chemistry

    BindingDBi P49764.
    ChEMBLi CHEMBL1697670.

    Proteomic databases

    PaxDbi P49764.
    PRIDEi P49764.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004913 ; ENSMUSP00000004913 ; ENSMUSG00000004791 .
    GeneIDi 18654.
    KEGGi mmu:18654.
    UCSCi uc007ogq.1. mouse.

    Organism-specific databases

    CTDi 5228.
    MGIi MGI:105095. Pgf.

    Phylogenomic databases

    eggNOGi NOG84541.
    HOGENOMi HOG000230896.
    HOVERGENi HBG000105.
    InParanoidi P49764.
    KOi K16859.
    OMAi HIIKERA.
    OrthoDBi EOG74R1S0.
    PhylomeDBi P49764.
    TreeFami TF319554.

    Enzyme and pathway databases

    Reactomei REACT_205099. VEGF binds to VEGFR leading to receptor dimerization.
    REACT_224551. VEGF ligand-receptor interactions.

    Miscellaneous databases

    NextBioi 294658.
    PROi P49764.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49764.
    Bgeei P49764.
    CleanExi MM_PGF.
    Genevestigatori P49764.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR023581. PD_growth_factor_CS.
    IPR000072. PDGF/VEGF_dom.
    [Graphical view ]
    Pfami PF00341. PDGF. 1 hit.
    [Graphical view ]
    SMARTi SM00141. PDGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00249. PDGF_1. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. "Placenta growth factor and vascular endothelial growth factor are co-expressed during early embryonic development."
      Achen M.G., Gad J.M., Stacker S.A., Wilks A.F.
      Growth Factors 15:69-80(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: NIH Swiss.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: 129.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiPLGF_MOUSE
    AccessioniPrimary (citable) accession number: P49764
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3