P49764 (PLGF_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Placenta growth factor
Short name=PlGF

Gene names

Name:	Pgf
Synonyms:	Plgf

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Also promotes cell tumor growth By similarity.
Subunit structure	Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the PDGF/VEGF growth factor family.

Ontologies

Keywords
Biological process	Angiogenesis Differentiation
Cellular component	Secreted
Domain	Signal
Molecular function	Developmental protein Growth factor Mitogen
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	branching involved in ureteric bud morphogenesis Inferred from direct assay PubMed 13678594. Source: MGI cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW cellular response to hormone stimulus Inferred from electronic annotation. Source: Compara female pregnancy Inferred from electronic annotation. Source: Compara organ regeneration Inferred from electronic annotation. Source: Compara positive regulation of angiogenesis Inferred from electronic annotation. Source: Compara positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of endothelial cell proliferation Inferred from electronic annotation. Source: Compara regulation of morphogenesis of a branching structure Inferred from direct assay PubMed 13678594. Source: MGI response to drug Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara sprouting angiogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular region Inferred from sequence orthology PubMed 10575000. Source: MGI extracellular space Inferred from electronic annotation. Source: Compara membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	growth factor activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	By similarity
	Chain	19 – 158	140	Placenta growth factor		PRO_0000023421
Amino acid modifications
	Glycosylation	29	1	N-linked (GlcNAc...) Potential
	Glycosylation	30	1	N-linked (GlcNAc...) Potential
	Glycosylation	97	1	N-linked (GlcNAc...) Potential
	Disulfide bond	48 ↔ 90		By similarity
	Disulfide bond	73		Interchain By similarity
	Disulfide bond	79 ↔ 125		By similarity
	Disulfide bond	82		Interchain By similarity
	Disulfide bond	83 ↔ 127		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P49764 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: F16128BEA0790438	FASTA	158	17,876
	10 20 30 40 50 60 MLVMKLFTCF LQVLAGLAVH SQGALSAGNN STEVEVVPFN EVWGRSYCRP MEKLVYILDE 70 80 90 100 110 120 YPDEVSHIFS PSCVLLSRCS GCCGDEGLHC VPIKTANITM QILKIPPNRD PHFYVEMTFS 130 140 150 QDVLCECRPI LETTKAERRK TKGKRKRSRN SQTEEPHP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The placenta growth factor gene of the mouse." Dipalma T., Tucci M., Russo G., Maglione D., Lago C.T., Romano A., Saccone S., della Valle G., de Gregorio L., Dragani T.A., Viglietto G., Persico M.G. Mamm. Genome 7:6-12(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[2]	"Placenta growth factor and vascular endothelial growth factor are co-expressed during early embryonic development." Achen M.G., Gad J.M., Stacker S.A., Wilks A.F. Growth Factors 15:69-80(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: NIH Swiss.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: 129. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X80171 mRNA. Translation: CAA56453.1. X96793 mRNA. Translation: CAA65587.1. BC016567 mRNA. Translation: AAH16567.1.
IPI	IPI00309442.
RefSeq	NP_032853.1. NM_008827.3.
UniGene	Mm.4809.
3D structure databases
ProteinModelPortal	P49764.
SMR	P49764. Positions 31-130.
ModBase	Search...
Protein-protein interaction databases
IntAct	P49764. 1 interaction.
STRING	10090.ENSMUSP00000004913.
Proteomic databases
PaxDb	P49764.
PRIDE	P49764.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000004913; ENSMUSP00000004913; ENSMUSG00000004791.
GeneID	18654.
KEGG	mmu:18654.
UCSC	uc007ogq.1. mouse.
Organism-specific databases
CTD	5228.
MGI	MGI:105095. Pgf.
Phylogenomic databases
eggNOG	NOG84541.
HOGENOM	HOG000230896.
HOVERGEN	HBG000105.
InParanoid	P49764.
KO	K16859.
OMA	CECRPLR.
OrthoDB	EOG444KM7.
Gene expression databases
ArrayExpress	P49764.
Bgee	P49764.
CleanEx	MM_PGF.
Genevestigator	P49764.
Family and domain databases
InterPro	IPR000072. PD_growth_factor. IPR023581. PD_growth_factor_CS. [Graphical view]
Pfam	PF00341. PDGF. 1 hit. [Graphical view]
SMART	SM00141. PDGF. 1 hit. [Graphical view]
PROSITE	PS00249. PDGF_1. 1 hit. PS50278. PDGF_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P49764.
ChEMBL	CHEMBL1697670.
NextBio	294658.
SOURCE	Search...

Entry information

Entry name

PLGF_MOUSE

Accession

Primary (citable) accession number: P49764

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 29, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program