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Protein

Placenta growth factor

Gene

Pgf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Also promotes cell tumor growth (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Mitogen
Biological processAngiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiR-MMU-194313 VEGF ligand-receptor interactions
R-MMU-195399 VEGF binds to VEGFR leading to receptor dimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Placenta growth factor
Short name:
PlGF
Gene namesi
Name:Pgf
Synonyms:Plgf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:105095 Pgf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1697670

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000002342119 – 158Placenta growth factorAdd BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi48 ↔ 90By similarity
Disulfide bondi73InterchainBy similarity
Disulfide bondi79 ↔ 125By similarity
Disulfide bondi82InterchainBy similarity
Disulfide bondi83 ↔ 127By similarity
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49764
PeptideAtlasiP49764
PRIDEiP49764

PTM databases

PhosphoSitePlusiP49764

Expressioni

Gene expression databases

BgeeiENSMUSG00000004791
CleanExiMM_PGF
ExpressionAtlasiP49764 baseline and differential
GenevisibleiP49764 MM

Interactioni

Subunit structurei

Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP49764, 1 interactor
STRINGi10090.ENSMUSP00000004913

Chemistry databases

BindingDBiP49764

Structurei

3D structure databases

ProteinModelPortaliP49764
SMRiP49764
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IY55 Eukaryota
ENOG410YNR0 LUCA
GeneTreeiENSGT00730000110791
HOGENOMiHOG000230896
HOVERGENiHBG000105
InParanoidiP49764
KOiK16859
OMAiRCECRPL
OrthoDBiEOG091G0G6M
PhylomeDBiP49764
TreeFamiTF319554

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVMKLFTCF LQVLAGLAVH SQGALSAGNN STEVEVVPFN EVWGRSYCRP
60 70 80 90 100
MEKLVYILDE YPDEVSHIFS PSCVLLSRCS GCCGDEGLHC VPIKTANITM
110 120 130 140 150
QILKIPPNRD PHFYVEMTFS QDVLCECRPI LETTKAERRK TKGKRKRSRN

SQTEEPHP
Length:158
Mass (Da):17,876
Last modified:October 1, 1996 - v1
Checksum:iF16128BEA0790438
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80171 mRNA Translation: CAA56453.1
X96793 mRNA Translation: CAA65587.1
BC016567 mRNA Translation: AAH16567.1
CCDSiCCDS49115.1
RefSeqiNP_032853.1, NM_008827.3
UniGeneiMm.4809

Genome annotation databases

EnsembliENSMUST00000004913; ENSMUSP00000004913; ENSMUSG00000004791
GeneIDi18654
KEGGimmu:18654
UCSCiuc007ogq.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPLGF_MOUSE
AccessioniPrimary (citable) accession number: P49764
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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