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Protein

Placenta growth factor

Gene

Pgf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Also promotes cell tumor growth (By similarity).By similarity

GO - Molecular functioni

  1. growth factor activity Source: UniProtKB

GO - Biological processi

  1. branching involved in ureteric bud morphogenesis Source: MGI
  2. cell differentiation Source: UniProtKB-KW
  3. cellular response to hormone stimulus Source: Ensembl
  4. female pregnancy Source: Ensembl
  5. organ regeneration Source: Ensembl
  6. positive regulation of angiogenesis Source: Ensembl
  7. positive regulation of cell division Source: UniProtKB-KW
  8. positive regulation of cell proliferation Source: UniProtKB
  9. positive regulation of endothelial cell proliferation Source: Ensembl
  10. regulation of morphogenesis of a branching structure Source: MGI
  11. response to drug Source: Ensembl
  12. response to hypoxia Source: Ensembl
  13. sprouting angiogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiREACT_293283. VEGF binds to VEGFR leading to receptor dimerization.
REACT_343634. VEGF ligand-receptor interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Placenta growth factor
Short name:
PlGF
Gene namesi
Name:Pgf
Synonyms:Plgf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:105095. Pgf.

Subcellular locationi

  1. Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: MGI
  2. extracellular space Source: Ensembl
  3. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 158140Placenta growth factorPRO_0000023421Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi48 ↔ 90By similarity
Disulfide bondi73 – 73InterchainBy similarity
Disulfide bondi79 ↔ 125By similarity
Disulfide bondi82 – 82InterchainBy similarity
Disulfide bondi83 ↔ 127By similarity
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49764.
PRIDEiP49764.

Expressioni

Gene expression databases

BgeeiP49764.
CleanExiMM_PGF.
ExpressionAtlasiP49764. baseline and differential.
GenevestigatoriP49764.

Interactioni

Subunit structurei

Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF (By similarity).By similarity

Protein-protein interaction databases

IntActiP49764. 1 interaction.
STRINGi10090.ENSMUSP00000004913.

Structurei

3D structure databases

ProteinModelPortaliP49764.
SMRiP49764. Positions 31-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG84541.
HOGENOMiHOG000230896.
HOVERGENiHBG000105.
InParanoidiP49764.
KOiK16859.
OMAiRCECRPL.
OrthoDBiEOG74R1S0.
PhylomeDBiP49764.
TreeFamiTF319554.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVMKLFTCF LQVLAGLAVH SQGALSAGNN STEVEVVPFN EVWGRSYCRP
60 70 80 90 100
MEKLVYILDE YPDEVSHIFS PSCVLLSRCS GCCGDEGLHC VPIKTANITM
110 120 130 140 150
QILKIPPNRD PHFYVEMTFS QDVLCECRPI LETTKAERRK TKGKRKRSRN

SQTEEPHP
Length:158
Mass (Da):17,876
Last modified:October 1, 1996 - v1
Checksum:iF16128BEA0790438
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80171 mRNA. Translation: CAA56453.1.
X96793 mRNA. Translation: CAA65587.1.
BC016567 mRNA. Translation: AAH16567.1.
CCDSiCCDS49115.1.
RefSeqiNP_032853.1. NM_008827.3.
UniGeneiMm.4809.

Genome annotation databases

EnsembliENSMUST00000004913; ENSMUSP00000004913; ENSMUSG00000004791.
GeneIDi18654.
KEGGimmu:18654.
UCSCiuc007ogq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80171 mRNA. Translation: CAA56453.1.
X96793 mRNA. Translation: CAA65587.1.
BC016567 mRNA. Translation: AAH16567.1.
CCDSiCCDS49115.1.
RefSeqiNP_032853.1. NM_008827.3.
UniGeneiMm.4809.

3D structure databases

ProteinModelPortaliP49764.
SMRiP49764. Positions 31-130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP49764. 1 interaction.
STRINGi10090.ENSMUSP00000004913.

Chemistry

BindingDBiP49764.
ChEMBLiCHEMBL1697670.

Proteomic databases

PaxDbiP49764.
PRIDEiP49764.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004913; ENSMUSP00000004913; ENSMUSG00000004791.
GeneIDi18654.
KEGGimmu:18654.
UCSCiuc007ogq.1. mouse.

Organism-specific databases

CTDi5228.
MGIiMGI:105095. Pgf.

Phylogenomic databases

eggNOGiNOG84541.
HOGENOMiHOG000230896.
HOVERGENiHBG000105.
InParanoidiP49764.
KOiK16859.
OMAiRCECRPL.
OrthoDBiEOG74R1S0.
PhylomeDBiP49764.
TreeFamiTF319554.

Enzyme and pathway databases

ReactomeiREACT_293283. VEGF binds to VEGFR leading to receptor dimerization.
REACT_343634. VEGF ligand-receptor interactions.

Miscellaneous databases

NextBioi294658.
PROiP49764.
SOURCEiSearch...

Gene expression databases

BgeeiP49764.
CleanExiMM_PGF.
ExpressionAtlasiP49764. baseline and differential.
GenevestigatoriP49764.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "Placenta growth factor and vascular endothelial growth factor are co-expressed during early embryonic development."
    Achen M.G., Gad J.M., Stacker S.A., Wilks A.F.
    Growth Factors 15:69-80(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NIH Swiss.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129.
    Tissue: Mammary gland.

Entry informationi

Entry nameiPLGF_MOUSE
AccessioniPrimary (citable) accession number: P49764
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 1, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.