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P49758

- RGS6_HUMAN

UniProt

P49758 - RGS6_HUMAN

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Protein

Regulator of G-protein signaling 6

Gene

RGS6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer.1 Publication

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome
  2. signal transducer activity Source: InterPro

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: InterPro
  2. intracellular signal transduction Source: InterPro
  3. positive regulation of GTPase activity Source: GOC
  4. positive regulation of neuron differentiation Source: Ensembl
  5. regulation of G-protein coupled receptor protein signaling pathway Source: ProtInc
  6. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiREACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 6
Short name:
RGS6
Alternative name(s):
S914
Gene namesi
Name:RGS6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:10002. RGS6.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. heterotrimeric G-protein complex Source: InterPro
  3. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi297 – 2971D → A: Loss of interaction with Gbeta5. 1 Publication
Mutagenesisi309 – 3091W → F: Diminishes interaction with Gbeta5. 1 Publication

Organism-specific databases

PharmGKBiPA34377.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Regulator of G-protein signaling 6PRO_0000204192Add
BLAST

Proteomic databases

PaxDbiP49758.
PRIDEiP49758.

PTM databases

PhosphoSiteiP49758.

Expressioni

Gene expression databases

BgeeiP49758.
ExpressionAtlasiP49758. baseline and differential.
GenevestigatoriP49758.

Organism-specific databases

HPAiHPA003067.

Interactioni

Subunit structurei

Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP90AB1P082382EBI-6426927,EBI-352572

Protein-protein interaction databases

BioGridi114987. 9 interactions.
IntActiP49758. 4 interactions.
MINTiMINT-242744.

Structurei

Secondary structure

1
472
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi327 – 3337Combined sources
Helixi337 – 3426Combined sources
Helixi344 – 35613Combined sources
Helixi360 – 37314Combined sources
Helixi377 – 3793Combined sources
Helixi380 – 39112Combined sources
Helixi404 – 41613Combined sources
Turni417 – 4226Combined sources
Helixi423 – 43614Combined sources
Helixi438 – 4436Combined sources
Helixi445 – 4484Combined sources
Turni449 – 4513Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ES0X-ray2.10A325-470[»]
ProteinModelPortaliP49758.
SMRiP49758. Positions 17-452.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49758.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 11576DEPPROSITE-ProRule annotationAdd
BLAST
Domaini261 – 33070G protein gammaAdd
BLAST
Domaini336 – 441106RGSPROSITE-ProRule annotationAdd
BLAST

Domaini

The RGS domain interacts avidly with Galpha and mediates the acceleration of Galpha-mediated GTP hydrolysis.1 Publication

Sequence similaritiesi

Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 G protein gamma domain.Curated
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG327614.
GeneTreeiENSGT00760000119142.
HOVERGENiHBG007404.
InParanoidiP49758.
KOiK16449.
OMAiEDAQDHI.
OrthoDBiEOG7BZVS5.
PhylomeDBiP49758.
TreeFamiTF351956.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequences (15)i

Sequence statusi: Complete.

This entry describes 15 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P49758-4) [UniParc]FASTAAdd to Basket

Also known as: RGS6Lalpha2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQGSGDQRA VGVADPEESS PNMIVYCKIE DIITKMQDDK TGGVPIRTVK
60 70 80 90 100
SFLSKIPSVV TGTDIVQWLM KNLSIEDPVE AIHLGSLIAA QGYIFPISDH
110 120 130 140 150
VLTMKDDGTF YRFQAPYFWP SNCWEPENTD YAIYLCKRTM QNKARLELAD
160 170 180 190 200
YEAENLARLQ RAFARKWEFI FMQAEAQVKI DRKKDKTERK ILDSQERAFW
210 220 230 240 250
DVHRPVPGCV NTTEMDIRKC RRLKNPQKVK KSVYGVTEES QAQSPVHVLS
260 270 280 290 300
QPIRKTTKED IRKQITFLNA QIDRHCLKMS KVAESLIAYT EQYVEYDPLI
310 320 330 340 350
TPAEPSNPWI SDDVALWDIE MSKEPSQQRV KRWGFSFDEI LKDQVGRDQF
360 370 380 390 400
LRFLESEFSS ENLRFWLAVQ DLKKQPLQDV AKRVEEIWQE FLAPGAPSAI
410 420 430 440 450
NLDSHSYEIT SQNVKDGGRY TFEDAQEHIY KLMKSDSYAR FLRSNAYQDL
460 470
LLAKKKGKSL AGKRLTGLMQ SS
Length:472
Mass (Da):54,423
Last modified:November 25, 2008 - v5
Checksum:i1424518EA697CD76
GO
Isoform 2 (identifier: P49758-2) [UniParc]FASTAAdd to Basket

Also known as: RGS6Lgamma1

The sequence of this isoform differs from the canonical sequence as follows:
     457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVLYSNTPLAKRP

Show »
Length:485
Mass (Da):56,138
Checksum:i06D282213979376C
GO
Isoform 3 (identifier: P49758-3) [UniParc]FASTAAdd to Basket

Also known as: RGS6Lalpha1

The sequence of this isoform differs from the canonical sequence as follows:
     456-456: K → KPESEQGRRTSLEKFTRSV

Show »
Length:490
Mass (Da):56,512
Checksum:iC8BD1254D593D1F5
GO
Isoform 5 (identifier: P49758-5) [UniParc]FASTAAdd to Basket

Also known as: RGS6Lbeta

The sequence of this isoform differs from the canonical sequence as follows:
     457-472: GKSLAGKRLTGLMQSS → KVSKVVELP

Show »
Length:465
Mass (Da):53,787
Checksum:i2027294E5EF69596
GO
Isoform 6 (identifier: P49758-6) [UniParc]FASTAAdd to Basket

Also known as: RGS6Lbeta-GGL

The sequence of this isoform differs from the canonical sequence as follows:
     285-321: Missing.
     457-472: GKSLAGKRLTGLMQSS → KVSKVVELP

Show »
Length:428
Mass (Da):49,520
Checksum:iA2C52E54E4569178
GO
Isoform 7 (identifier: P49758-7) [UniParc]FASTAAdd to Basket

Also known as: RGS6Lalpha2-GGL

The sequence of this isoform differs from the canonical sequence as follows:
     285-321: Missing.

Show »
Length:435
Mass (Da):50,155
Checksum:i95405495A89187D4
GO
Isoform 8 (identifier: P49758-8) [UniParc]FASTAAdd to Basket

Also known as: RGS6Lgamma2

The sequence of this isoform differs from the canonical sequence as follows:
     457-472: GKSLAGKRLTGLMQSS → LYSNTPLAKRP

Show »
Length:467
Mass (Da):54,049
Checksum:iF2CE01A6D57BFD91
GO
Isoform 9 (identifier: P49758-9) [UniParc]FASTAAdd to Basket

Also known as: RGS6Lalpha1-GGL

The sequence of this isoform differs from the canonical sequence as follows:
     285-321: Missing.
     456-456: K → KPESEQGRRTSLEKFTRSV

Show »
Length:453
Mass (Da):52,245
Checksum:i78F9B10D25DF6B44
GO
Isoform 10 (identifier: P49758-10) [UniParc]FASTAAdd to Basket

Also known as: RGS6Lgamma1-GGL

The sequence of this isoform differs from the canonical sequence as follows:
     285-321: Missing.
     457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVLYSNTPLAKRP

Show »
Length:448
Mass (Da):51,870
Checksum:i5A6833E6530ADBAB
GO
Isoform 11 (identifier: P49758-11) [UniParc]FASTAAdd to Basket

Also known as: RGS6Lgamma2-GGL

The sequence of this isoform differs from the canonical sequence as follows:
     285-321: Missing.
     457-472: GKSLAGKRLTGLMQSS → LYSNTPLAKRP

Show »
Length:430
Mass (Da):49,781
Checksum:iF484A344D2614731
GO
Isoform 12 (identifier: P49758-12) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.
     457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVLYSNTPLAKRP

Show »
Length:346
Mass (Da):40,588
Checksum:iA0462F5A1DBDC9EA
GO
Isoform 13 (identifier: P49758-13) [UniParc]FASTAAdd to Basket

Also known as: RGS6Lepsilon

The sequence of this isoform differs from the canonical sequence as follows:
     457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVG

Show »
Length:475
Mass (Da):54,953
Checksum:iDBD7BC0ADF638F51
GO
Isoform 14 (identifier: P49758-14) [UniParc]FASTAAdd to Basket

Also known as: RGS6Ldelta

The sequence of this isoform differs from the canonical sequence as follows:
     457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVLLF

Show »
Length:477
Mass (Da):55,270
Checksum:iB8212487BC0ADF63
GO
Isoform 15 (identifier: P49758-15) [UniParc]FASTAAdd to Basket

Also known as: RGS6Lgamma

The sequence of this isoform differs from the canonical sequence as follows:
     457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVCLQLLF

Show »
Length:480
Mass (Da):55,614
Checksum:i6781EF37312D17BC
GO
Isoform 16 (identifier: P49758-16) [UniParc]FASTAAdd to Basket

Also known as: RGS6Leta

The sequence of this isoform differs from the canonical sequence as follows:
     457-472: GKSLAGKRLTGLMQSS → VWLL

Show »
Length:460
Mass (Da):53,319
Checksum:i829707C9624AD2A3
GO

Sequence cautioni

The sequence AAC42001.1 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti165 – 1651R → K in AAC26049. (PubMed:12761221)Curated
Sequence conflicti165 – 1651R → K in AAM03004. (PubMed:12761221)Curated
Sequence conflicti165 – 1651R → K in AAM03005. (PubMed:12761221)Curated
Sequence conflicti165 – 1651R → K in AAM03006. (PubMed:12761221)Curated
Sequence conflicti165 – 1651R → K in AAM03007. (PubMed:12761221)Curated
Sequence conflicti165 – 1651R → K in AAM03008. (PubMed:12761221)Curated
Sequence conflicti165 – 1651R → K in AAM03009. (PubMed:12761221)Curated
Sequence conflicti165 – 1651R → K in AAM03010. (PubMed:12761221)Curated
Sequence conflicti165 – 1651R → K in AAM03011. (PubMed:12761221)Curated
Sequence conflicti165 – 1651R → K in AAM03012. (PubMed:12761221)Curated
Sequence conflicti165 – 1651R → K in AAM03013. (PubMed:12761221)Curated
Sequence conflicti210 – 2101V → L in AAC26049. (PubMed:12761221)Curated
Sequence conflicti210 – 2101V → L in AAM03004. (PubMed:12761221)Curated
Sequence conflicti210 – 2101V → L in AAM03005. (PubMed:12761221)Curated
Sequence conflicti210 – 2101V → L in AAM03006. (PubMed:12761221)Curated
Sequence conflicti210 – 2101V → L in AAM03007. (PubMed:12761221)Curated
Sequence conflicti210 – 2101V → L in AAM03008. (PubMed:12761221)Curated
Sequence conflicti210 – 2101V → L in AAM03009. (PubMed:12761221)Curated
Sequence conflicti210 – 2101V → L in AAM03010. (PubMed:12761221)Curated
Sequence conflicti210 – 2101V → L in AAM03011. (PubMed:12761221)Curated
Sequence conflicti210 – 2101V → L in AAM03012. (PubMed:12761221)Curated
Sequence conflicti210 – 2101V → L in AAM03013. (PubMed:12761221)Curated
Sequence conflicti312 – 3132DD → EE in AAC26049. (PubMed:12761221)Curated
Sequence conflicti312 – 3132DD → EE in AAM03004. (PubMed:12761221)Curated
Sequence conflicti312 – 3132DD → EE in AAM03005. (PubMed:12761221)Curated
Sequence conflicti312 – 3132DD → EE in AAM03006. (PubMed:12761221)Curated
Sequence conflicti312 – 3132DD → EE in AAM03009. (PubMed:12761221)Curated
Sequence conflicti312 – 3132DD → EE in AAM03010. (PubMed:12761221)Curated
Sequence conflicti324 – 3241E → D in AAC26049. (PubMed:12761221)Curated
Sequence conflicti324 – 3241E → D in AAM03004. (PubMed:12761221)Curated
Sequence conflicti324 – 3241E → D in AAM03005. (PubMed:12761221)Curated
Sequence conflicti324 – 3241E → D in AAM03006. (PubMed:12761221)Curated
Sequence conflicti324 – 3241E → D in AAM03007. (PubMed:12761221)Curated
Sequence conflicti324 – 3241E → D in AAM03008. (PubMed:12761221)Curated
Sequence conflicti324 – 3241E → D in AAM03009. (PubMed:12761221)Curated
Sequence conflicti324 – 3241E → D in AAM03010. (PubMed:12761221)Curated
Sequence conflicti324 – 3241E → D in AAM03011. (PubMed:12761221)Curated
Sequence conflicti324 – 3241E → D in AAM03012. (PubMed:12761221)Curated
Sequence conflicti324 – 3241E → D in AAM03013. (PubMed:12761221)Curated
Sequence conflicti465 – 4651L → C in AAC42001. (PubMed:7596406)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 139139Missing in isoform 12. 1 PublicationVSP_035845Add
BLAST
Alternative sequencei285 – 32137Missing in isoform 6, isoform 7, isoform 9, isoform 10 and isoform 11. 1 PublicationVSP_035846Add
BLAST
Alternative sequencei456 – 4561K → KPESEQGRRTSLEKFTRSV in isoform 3 and isoform 9. 2 PublicationsVSP_035847
Alternative sequencei457 – 47216GKSLA…LMQSS → PESEQGRRTSLEKFTRSVG in isoform 13. 1 PublicationVSP_047806Add
BLAST
Alternative sequencei457 – 47216GKSLA…LMQSS → PESEQGRRTSLEKFTRSVLL F in isoform 14. 1 PublicationVSP_047807Add
BLAST
Alternative sequencei457 – 47216GKSLA…LMQSS → PESEQGRRTSLEKFTRSVCL QLLF in isoform 15. 1 PublicationVSP_047808Add
BLAST
Alternative sequencei457 – 47216GKSLA…LMQSS → VWLL in isoform 16. 1 PublicationVSP_047809Add
BLAST
Alternative sequencei457 – 47216GKSLA…LMQSS → PESEQGRRTSLEKFTRSVLY SNTPLAKRP in isoform 2, isoform 10 and isoform 12. 1 PublicationVSP_035848Add
BLAST
Alternative sequencei457 – 47216GKSLA…LMQSS → KVSKVVELP in isoform 5 and isoform 6. 1 PublicationVSP_035849Add
BLAST
Alternative sequencei457 – 47216GKSLA…LMQSS → LYSNTPLAKRP in isoform 8 and isoform 11. 1 PublicationVSP_035850Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073920 mRNA. Translation: AAC26049.2.
AF073921 mRNA. Translation: AAC26050.1.
AY309097 mRNA. Translation: AAP74386.1.
AY309098 mRNA. Translation: AAP74387.1.
AY309099 mRNA. Translation: AAP74388.1.
AY309100 mRNA. Translation: AAP74389.1.
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725, AF465726 Genomic DNA. Translation: AAM03004.1.
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725, AF465726 Genomic DNA. Translation: AAM03005.1.
AF465726
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725 Genomic DNA. Translation: AAM03006.1.
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725, AF465726 Genomic DNA. Translation: AAM03007.1.
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725, AF465726 Genomic DNA. Translation: AAM03008.1.
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725 Genomic DNA. Translation: AAM03009.1.
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725 Genomic DNA. Translation: AAM03010.1.
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725 Genomic DNA. Translation: AAM03011.1.
AF465727
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725 Genomic DNA. Translation: AAM03012.1.
AF465726
, AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725 Genomic DNA. Translation: AAM03013.1.
AF107619 mRNA. Translation: AAD34717.1.
AF107620 mRNA. Translation: AAD34718.1.
AF156932 mRNA. Translation: AAD40183.1.
AC004828 Genomic DNA. No translation available.
AC005157 Genomic DNA. Translation: AAC83180.1.
AC005226 Genomic DNA. No translation available.
AC005227 Genomic DNA. No translation available.
AC005477 Genomic DNA. Translation: AAD05031.1.
AC005533 Genomic DNA. No translation available.
AC005857 Genomic DNA. No translation available.
AC005993 Genomic DNA. No translation available.
L40394 mRNA. Translation: AAC42001.1. Frameshift.
CCDSiCCDS55924.1. [P49758-3]
CCDS9808.1. [P49758-4]
RefSeqiNP_001191345.1. NM_001204416.1. [P49758-3]
NP_001191346.1. NM_001204417.1. [P49758-2]
NP_001191347.1. NM_001204418.1. [P49758-8]
NP_001191348.1. NM_001204419.1. [P49758-9]
NP_001191349.1. NM_001204420.1. [P49758-7]
NP_001191350.1. NM_001204421.1. [P49758-10]
NP_001191351.1. NM_001204422.1. [P49758-11]
NP_001191352.1. NM_001204423.1.
NP_001191353.1. NM_001204424.1. [P49758-3]
NP_004287.3. NM_004296.5. [P49758-4]
XP_005268291.1. XM_005268234.1. [P49758-2]
XP_005268292.1. XM_005268235.2. [P49758-13]
XP_005268293.1. XM_005268236.1. [P49758-4]
XP_006720391.1. XM_006720328.1. [P49758-5]
XP_006720392.1. XM_006720329.1. [P49758-5]
XP_006720393.1. XM_006720330.1. [P49758-5]
XP_006720394.1. XM_006720331.1. [P49758-9]
XP_006720395.1. XM_006720332.1. [P49758-10]
XP_006720396.1. XM_006720333.1. [P49758-7]
UniGeneiHs.509872.

Genome annotation databases

EnsembliENST00000355512; ENSP00000347699; ENSG00000182732. [P49758-16]
ENST00000404301; ENSP00000385243; ENSG00000182732. [P49758-15]
ENST00000406236; ENSP00000384218; ENSG00000182732. [P49758-13]
ENST00000407322; ENSP00000384612; ENSG00000182732. [P49758-14]
ENST00000553525; ENSP00000451030; ENSG00000182732. [P49758-3]
ENST00000553530; ENSP00000452331; ENSG00000182732. [P49758-4]
ENST00000554474; ENSP00000450858; ENSG00000182732. [P49758-5]
ENST00000554782; ENSP00000451912; ENSG00000182732. [P49758-12]
ENST00000555571; ENSP00000450936; ENSG00000182732. [P49758-4]
ENST00000556437; ENSP00000451855; ENSG00000182732. [P49758-3]
GeneIDi9628.
KEGGihsa:9628.
UCSCiuc001xmx.4. human. [P49758-4]
uc001xmy.4. human. [P49758-3]
uc021rvw.1. human. [P49758-2]
uc021rvx.1. human. [P49758-8]
uc021rvy.1. human. [P49758-10]
uc021rvz.1. human. [P49758-11]
uc021rwa.1. human. [P49758-9]
uc021rwb.1. human. [P49758-7]
uc021rwc.1. human. [P49758-12]

Polymorphism databases

DMDMi215274268.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073920 mRNA. Translation: AAC26049.2 .
AF073921 mRNA. Translation: AAC26050.1 .
AY309097 mRNA. Translation: AAP74386.1 .
AY309098 mRNA. Translation: AAP74387.1 .
AY309099 mRNA. Translation: AAP74388.1 .
AY309100 mRNA. Translation: AAP74389.1 .
AF465727
, AF465711 , AF465712 , AF465713 , AF465714 , AF465715 , AF465716 , AF465717 , AF465718 , AF465719 , AF465720 , AF465721 , AF465722 , AF465723 , AF465724 , AF465725 , AF465726 Genomic DNA. Translation: AAM03004.1 .
AF465727
, AF465711 , AF465712 , AF465713 , AF465714 , AF465715 , AF465716 , AF465717 , AF465718 , AF465719 , AF465720 , AF465721 , AF465722 , AF465723 , AF465724 , AF465725 , AF465726 Genomic DNA. Translation: AAM03005.1 .
AF465726
, AF465711 , AF465712 , AF465713 , AF465714 , AF465715 , AF465716 , AF465717 , AF465718 , AF465719 , AF465720 , AF465721 , AF465722 , AF465723 , AF465724 , AF465725 Genomic DNA. Translation: AAM03006.1 .
AF465727
, AF465711 , AF465712 , AF465713 , AF465714 , AF465715 , AF465716 , AF465717 , AF465718 , AF465719 , AF465720 , AF465721 , AF465723 , AF465724 , AF465725 , AF465726 Genomic DNA. Translation: AAM03007.1 .
AF465727
, AF465711 , AF465712 , AF465713 , AF465714 , AF465715 , AF465716 , AF465717 , AF465718 , AF465719 , AF465720 , AF465721 , AF465723 , AF465724 , AF465725 , AF465726 Genomic DNA. Translation: AAM03008.1 .
AF465727
, AF465711 , AF465712 , AF465713 , AF465714 , AF465715 , AF465716 , AF465717 , AF465718 , AF465719 , AF465720 , AF465721 , AF465722 , AF465723 , AF465724 , AF465725 Genomic DNA. Translation: AAM03009.1 .
AF465727
, AF465711 , AF465712 , AF465713 , AF465714 , AF465715 , AF465716 , AF465717 , AF465718 , AF465719 , AF465720 , AF465721 , AF465722 , AF465723 , AF465724 , AF465725 Genomic DNA. Translation: AAM03010.1 .
AF465727
, AF465711 , AF465712 , AF465713 , AF465714 , AF465715 , AF465716 , AF465717 , AF465718 , AF465719 , AF465720 , AF465721 , AF465723 , AF465724 , AF465725 Genomic DNA. Translation: AAM03011.1 .
AF465727
, AF465711 , AF465712 , AF465713 , AF465714 , AF465715 , AF465716 , AF465717 , AF465718 , AF465719 , AF465720 , AF465721 , AF465723 , AF465724 , AF465725 Genomic DNA. Translation: AAM03012.1 .
AF465726
, AF465711 , AF465712 , AF465713 , AF465714 , AF465715 , AF465716 , AF465717 , AF465718 , AF465719 , AF465720 , AF465721 , AF465723 , AF465724 , AF465725 Genomic DNA. Translation: AAM03013.1 .
AF107619 mRNA. Translation: AAD34717.1 .
AF107620 mRNA. Translation: AAD34718.1 .
AF156932 mRNA. Translation: AAD40183.1 .
AC004828 Genomic DNA. No translation available.
AC005157 Genomic DNA. Translation: AAC83180.1 .
AC005226 Genomic DNA. No translation available.
AC005227 Genomic DNA. No translation available.
AC005477 Genomic DNA. Translation: AAD05031.1 .
AC005533 Genomic DNA. No translation available.
AC005857 Genomic DNA. No translation available.
AC005993 Genomic DNA. No translation available.
L40394 mRNA. Translation: AAC42001.1 . Frameshift.
CCDSi CCDS55924.1. [P49758-3 ]
CCDS9808.1. [P49758-4 ]
RefSeqi NP_001191345.1. NM_001204416.1. [P49758-3 ]
NP_001191346.1. NM_001204417.1. [P49758-2 ]
NP_001191347.1. NM_001204418.1. [P49758-8 ]
NP_001191348.1. NM_001204419.1. [P49758-9 ]
NP_001191349.1. NM_001204420.1. [P49758-7 ]
NP_001191350.1. NM_001204421.1. [P49758-10 ]
NP_001191351.1. NM_001204422.1. [P49758-11 ]
NP_001191352.1. NM_001204423.1.
NP_001191353.1. NM_001204424.1. [P49758-3 ]
NP_004287.3. NM_004296.5. [P49758-4 ]
XP_005268291.1. XM_005268234.1. [P49758-2 ]
XP_005268292.1. XM_005268235.2. [P49758-13 ]
XP_005268293.1. XM_005268236.1. [P49758-4 ]
XP_006720391.1. XM_006720328.1. [P49758-5 ]
XP_006720392.1. XM_006720329.1. [P49758-5 ]
XP_006720393.1. XM_006720330.1. [P49758-5 ]
XP_006720394.1. XM_006720331.1. [P49758-9 ]
XP_006720395.1. XM_006720332.1. [P49758-10 ]
XP_006720396.1. XM_006720333.1. [P49758-7 ]
UniGenei Hs.509872.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2ES0 X-ray 2.10 A 325-470 [» ]
ProteinModelPortali P49758.
SMRi P49758. Positions 17-452.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114987. 9 interactions.
IntActi P49758. 4 interactions.
MINTi MINT-242744.

PTM databases

PhosphoSitei P49758.

Polymorphism databases

DMDMi 215274268.

Proteomic databases

PaxDbi P49758.
PRIDEi P49758.

Protocols and materials databases

DNASUi 9628.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355512 ; ENSP00000347699 ; ENSG00000182732 . [P49758-16 ]
ENST00000404301 ; ENSP00000385243 ; ENSG00000182732 . [P49758-15 ]
ENST00000406236 ; ENSP00000384218 ; ENSG00000182732 . [P49758-13 ]
ENST00000407322 ; ENSP00000384612 ; ENSG00000182732 . [P49758-14 ]
ENST00000553525 ; ENSP00000451030 ; ENSG00000182732 . [P49758-3 ]
ENST00000553530 ; ENSP00000452331 ; ENSG00000182732 . [P49758-4 ]
ENST00000554474 ; ENSP00000450858 ; ENSG00000182732 . [P49758-5 ]
ENST00000554782 ; ENSP00000451912 ; ENSG00000182732 . [P49758-12 ]
ENST00000555571 ; ENSP00000450936 ; ENSG00000182732 . [P49758-4 ]
ENST00000556437 ; ENSP00000451855 ; ENSG00000182732 . [P49758-3 ]
GeneIDi 9628.
KEGGi hsa:9628.
UCSCi uc001xmx.4. human. [P49758-4 ]
uc001xmy.4. human. [P49758-3 ]
uc021rvw.1. human. [P49758-2 ]
uc021rvx.1. human. [P49758-8 ]
uc021rvy.1. human. [P49758-10 ]
uc021rvz.1. human. [P49758-11 ]
uc021rwa.1. human. [P49758-9 ]
uc021rwb.1. human. [P49758-7 ]
uc021rwc.1. human. [P49758-12 ]

Organism-specific databases

CTDi 9628.
GeneCardsi GC14P072399.
HGNCi HGNC:10002. RGS6.
HPAi HPA003067.
MIMi 603894. gene.
neXtProti NX_P49758.
PharmGKBi PA34377.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327614.
GeneTreei ENSGT00760000119142.
HOVERGENi HBG007404.
InParanoidi P49758.
KOi K16449.
OMAi EDAQDHI.
OrthoDBi EOG7BZVS5.
PhylomeDBi P49758.
TreeFami TF351956.

Enzyme and pathway databases

Reactomei REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSi RGS6. human.
EvolutionaryTracei P49758.
GeneWikii RGS6.
GenomeRNAii 9628.
NextBioi 36131.
PROi P49758.
SOURCEi Search...

Gene expression databases

Bgeei P49758.
ExpressionAtlasi P49758. baseline and differential.
Genevestigatori P49758.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProi IPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEi PS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants."
    Chatterjee T.K., Liu Z., Fisher R.A.
    J. Biol. Chem. 278:30261-30271(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15 AND 16).
  2. "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11."
    Snow B.E., Betts L., Mangion J., Sondek J., Siderovski D.P.
    Proc. Natl. Acad. Sci. U.S.A. 96:6489-6494(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), MUTAGENESIS OF ASP-297 AND TRP-309.
    Tissue: Brain.
  3. "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways."
    Posner B.A., Gilman A.G., Harris B.A.
    J. Biol. Chem. 274:31087-31093(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 362-472 (ISOFORM 1).
    Tissue: Brain.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 325-470, DOMAIN RGS.

Entry informationi

Entry nameiRGS6_HUMAN
AccessioniPrimary (citable) accession number: P49758
Secondary accession number(s): C9JE95
, F8W7W5, O75576, O75577, Q7Z4K3, Q7Z4K4, Q7Z4K5, Q7Z4K6, Q8TE13, Q8TE14, Q8TE15, Q8TE16, Q8TE17, Q8TE18, Q8TE19, Q8TE20, Q8TE21, Q8TE22, Q9UDS8, Q9UDT0, Q9Y245, Q9Y647
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 25, 2008
Last modified: November 26, 2014
This is version 144 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3