P49758 (RGS6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of G-protein signaling 6
Short name=RGS6

Alternative name(s):
S914

Gene names

Name:

RGS6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	472 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer. Ref.3
Subunit structure	Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 By similarity.
Subcellular location	Cytoplasm. Membrane; Peripheral membrane protein.
Sequence similarities	Contains 1 DEP domain. Contains 1 G protein gamma domain. Contains 1 RGS domain.
Sequence caution	The sequence AAC42001.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing
Molecular function	Signal transduction inhibitor
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro intracellular signal transduction Inferred from electronic annotation. Source: InterPro positive regulation of neuron differentiation Inferred from electronic annotation. Source: Compara regulation of G-protein coupled receptor protein signaling pathway Non-traceable author statement. Source: UniProtKB termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome heterotrimeric G-protein complex Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HSP90AB1	P08238	2	EBI-6426927,EBI-352572

Alternative products

This entry describes 11 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P49758-4)

Also known as: RGS6Lalpha2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P49758-2)

Also known as: RGS6Lgamma1;

The sequence of this isoform differs from the canonical sequence as follows:
     457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVLYSNTPLAKRP

Isoform 3 (identifier: P49758-3)

Also known as: RGS6Lalpha1;

The sequence of this isoform differs from the canonical sequence as follows:
     456-456: K → KPESEQGRRTSLEKFTRSV

Isoform 5 (identifier: P49758-5)

Also known as: RGS6Lbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     457-472: GKSLAGKRLTGLMQSS → KVSKVVELP

Isoform 6 (identifier: P49758-6)

Also known as: RGS6Lbeta-GGL;

The sequence of this isoform differs from the canonical sequence as follows:
     285-321: Missing.
     457-472: GKSLAGKRLTGLMQSS → KVSKVVELP

Isoform 7 (identifier: P49758-7)

Also known as: RGS6Lalpha2-GGL;

The sequence of this isoform differs from the canonical sequence as follows:
     285-321: Missing.

Isoform 8 (identifier: P49758-8)

Also known as: RGS6Lgamma2;

The sequence of this isoform differs from the canonical sequence as follows:
     457-472: GKSLAGKRLTGLMQSS → LYSNTPLAKRP

Isoform 9 (identifier: P49758-9)

Also known as: RGS6Lalpha1-GGL;

The sequence of this isoform differs from the canonical sequence as follows:
     285-321: Missing.
     456-456: K → KPESEQGRRTSLEKFTRSV

Isoform 10 (identifier: P49758-10)

Also known as: RGS6Lgamma1-GGL;

The sequence of this isoform differs from the canonical sequence as follows:
     285-321: Missing.
     457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVLYSNTPLAKRP

Isoform 11 (identifier: P49758-11)

Also known as: RGS6Lgamma2-GGL;

The sequence of this isoform differs from the canonical sequence as follows:
     285-321: Missing.
     457-472: GKSLAGKRLTGLMQSS → LYSNTPLAKRP

Isoform 12 (identifier: P49758-12)

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.
     457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVLYSNTPLAKRP

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 472

472

Regulator of G-protein signaling 6

PRO_0000204192

Regions

Domain

40 – 115

76

DEP

Domain

261 – 330

70

G protein gamma

Domain

336 – 441

106

RGS

Natural variations

Alternative sequence

1 – 139

139

Missing in isoform 12.

VSP_035845

Alternative sequence

285 – 321

37

Missing in isoform 6, isoform 7, isoform 9, isoform 10 and isoform 11.

VSP_035846

Alternative sequence

456

1

K → KPESEQGRRTSLEKFTRSV in isoform 3 and isoform 9.

VSP_035847

Alternative sequence

457 – 472

16

GKSLA…LMQSS → PESEQGRRTSLEKFTRSVLY SNTPLAKRP in isoform 2, isoform 10 and isoform 12.

VSP_035848

Alternative sequence

457 – 472

16

GKSLA…LMQSS → KVSKVVELP in isoform 5 and isoform 6.

VSP_035849

Alternative sequence

457 – 472

16

GKSLA…LMQSS → LYSNTPLAKRP in isoform 8 and isoform 11.

VSP_035850

Experimental info

Mutagenesis

297

1

D → A: Loss of interaction with Gbeta5. Ref.2

Mutagenesis

309

1

W → F: Diminishes interaction with Gbeta5. Ref.2

Sequence conflict

165

1

R → K in AAC26049. Ref.1

Sequence conflict

165

1

R → K in AAM03004. Ref.1

Sequence conflict

165

1

R → K in AAM03005. Ref.1

Sequence conflict

165

1

R → K in AAM03006. Ref.1

Sequence conflict

165

1

R → K in AAM03007. Ref.1

Sequence conflict

165

1

R → K in AAM03008. Ref.1

Sequence conflict

165

1

R → K in AAM03009. Ref.1

Sequence conflict

165

1

R → K in AAM03010. Ref.1

Sequence conflict

165

1

R → K in AAM03011. Ref.1

Sequence conflict

165

1

R → K in AAM03012. Ref.1

Sequence conflict

165

1

R → K in AAM03013. Ref.1

Sequence conflict

210

1

V → L in AAC26049. Ref.1

Sequence conflict

210

1

V → L in AAM03004. Ref.1

Sequence conflict

210

1

V → L in AAM03005. Ref.1

Sequence conflict

210

1

V → L in AAM03006. Ref.1

Sequence conflict

210

1

V → L in AAM03007. Ref.1

Sequence conflict

210

1

V → L in AAM03008. Ref.1

Sequence conflict

210

1

V → L in AAM03009. Ref.1

Sequence conflict

210

1

V → L in AAM03010. Ref.1

Sequence conflict

210

1

V → L in AAM03011. Ref.1

Sequence conflict

210

1

V → L in AAM03012. Ref.1

Sequence conflict

210

1

V → L in AAM03013. Ref.1

Sequence conflict

312 – 313

2

DD → EE in AAC26049. Ref.1

Sequence conflict

312 – 313

2

DD → EE in AAM03004. Ref.1

Sequence conflict

312 – 313

2

DD → EE in AAM03005. Ref.1

Sequence conflict

312 – 313

2

DD → EE in AAM03006. Ref.1

Sequence conflict

312 – 313

2

DD → EE in AAM03009. Ref.1

Sequence conflict

312 – 313

2

DD → EE in AAM03010. Ref.1

Sequence conflict

324

1

E → D in AAC26049. Ref.1

Sequence conflict

324

1

E → D in AAM03004. Ref.1

Sequence conflict

324

1

E → D in AAM03005. Ref.1

Sequence conflict

324

1

E → D in AAM03006. Ref.1

Sequence conflict

324

1

E → D in AAM03007. Ref.1

Sequence conflict

324

1

E → D in AAM03008. Ref.1

Sequence conflict

324

1

E → D in AAM03009. Ref.1

Sequence conflict

324

1

E → D in AAM03010. Ref.1

Sequence conflict

324

1

E → D in AAM03011. Ref.1

Sequence conflict

324

1

E → D in AAM03012. Ref.1

Sequence conflict

324

1

E → D in AAM03013. Ref.1

Sequence conflict

465

1

L → C in AAC42001. Ref.5

Secondary structure

1

.

.

.

.

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.

.

.

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472

Helix Strand Turn

Details...

Helix

327 – 333

7

Helix

337 – 342

6

Helix

344 – 356

13

Helix

360 – 373

14

Helix

377 – 379

3

Helix

380 – 391

12

Helix

404 – 416

13

Turn

417 – 422

6

Helix

423 – 436

14

Helix

438 – 443

6

Helix

445 – 448

4

Turn

449 – 451

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (RGS6Lalpha2) [UniParc]. Last modified November 25, 2008. Version 5. Checksum: 1424518EA697CD76	FASTA	472	54,423
	10 20 30 40 50 60 MAQGSGDQRA VGVADPEESS PNMIVYCKIE DIITKMQDDK TGGVPIRTVK SFLSKIPSVV 70 80 90 100 110 120 TGTDIVQWLM KNLSIEDPVE AIHLGSLIAA QGYIFPISDH VLTMKDDGTF YRFQAPYFWP 130 140 150 160 170 180 SNCWEPENTD YAIYLCKRTM QNKARLELAD YEAENLARLQ RAFARKWEFI FMQAEAQVKI 190 200 210 220 230 240 DRKKDKTERK ILDSQERAFW DVHRPVPGCV NTTEMDIRKC RRLKNPQKVK KSVYGVTEES 250 260 270 280 290 300 QAQSPVHVLS QPIRKTTKED IRKQITFLNA QIDRHCLKMS KVAESLIAYT EQYVEYDPLI 310 320 330 340 350 360 TPAEPSNPWI SDDVALWDIE MSKEPSQQRV KRWGFSFDEI LKDQVGRDQF LRFLESEFSS 370 380 390 400 410 420 ENLRFWLAVQ DLKKQPLQDV AKRVEEIWQE FLAPGAPSAI NLDSHSYEIT SQNVKDGGRY 430 440 450 460 470 TFEDAQEHIY KLMKSDSYAR FLRSNAYQDL LLAKKKGKSL AGKRLTGLMQ SS
	Isoform 2 (RGS6Lgamma1) [UniParc]. Checksum: 06D282213979376C	FASTA	485	56,138
	10 20 30 40 50 60 MAQGSGDQRA VGVADPEESS PNMIVYCKIE DIITKMQDDK TGGVPIRTVK SFLSKIPSVV 70 80 90 100 110 120 TGTDIVQWLM KNLSIEDPVE AIHLGSLIAA QGYIFPISDH VLTMKDDGTF YRFQAPYFWP 130 140 150 160 170 180 SNCWEPENTD YAIYLCKRTM QNKARLELAD YEAENLARLQ RAFARKWEFI FMQAEAQVKI 190 200 210 220 230 240 DRKKDKTERK ILDSQERAFW DVHRPVPGCV NTTEMDIRKC RRLKNPQKVK KSVYGVTEES 250 260 270 280 290 300 QAQSPVHVLS QPIRKTTKED IRKQITFLNA QIDRHCLKMS KVAESLIAYT EQYVEYDPLI 310 320 330 340 350 360 TPAEPSNPWI SDDVALWDIE MSKEPSQQRV KRWGFSFDEI LKDQVGRDQF LRFLESEFSS 370 380 390 400 410 420 ENLRFWLAVQ DLKKQPLQDV AKRVEEIWQE FLAPGAPSAI NLDSHSYEIT SQNVKDGGRY 430 440 450 460 470 480 TFEDAQEHIY KLMKSDSYAR FLRSNAYQDL LLAKKKPESE QGRRTSLEKF TRSVLYSNTP LAKRP
	Isoform 3 (RGS6Lalpha1) [UniParc]. Checksum: C8BD1254D593D1F5	FASTA	490	56,512
	10 20 30 40 50 60 MAQGSGDQRA VGVADPEESS PNMIVYCKIE DIITKMQDDK TGGVPIRTVK SFLSKIPSVV 70 80 90 100 110 120 TGTDIVQWLM KNLSIEDPVE AIHLGSLIAA QGYIFPISDH VLTMKDDGTF YRFQAPYFWP 130 140 150 160 170 180 SNCWEPENTD YAIYLCKRTM QNKARLELAD YEAENLARLQ RAFARKWEFI FMQAEAQVKI 190 200 210 220 230 240 DRKKDKTERK ILDSQERAFW DVHRPVPGCV NTTEMDIRKC RRLKNPQKVK KSVYGVTEES 250 260 270 280 290 300 QAQSPVHVLS QPIRKTTKED IRKQITFLNA QIDRHCLKMS KVAESLIAYT EQYVEYDPLI 310 320 330 340 350 360 TPAEPSNPWI SDDVALWDIE MSKEPSQQRV KRWGFSFDEI LKDQVGRDQF LRFLESEFSS 370 380 390 400 410 420 ENLRFWLAVQ DLKKQPLQDV AKRVEEIWQE FLAPGAPSAI NLDSHSYEIT SQNVKDGGRY 430 440 450 460 470 480 TFEDAQEHIY KLMKSDSYAR FLRSNAYQDL LLAKKKPESE QGRRTSLEKF TRSVGKSLAG 490 KRLTGLMQSS
	Isoform 5 (RGS6Lbeta) [UniParc]. Checksum: 2027294E5EF69596	FASTA	465	53,787
	10 20 30 40 50 60 MAQGSGDQRA VGVADPEESS PNMIVYCKIE DIITKMQDDK TGGVPIRTVK SFLSKIPSVV 70 80 90 100 110 120 TGTDIVQWLM KNLSIEDPVE AIHLGSLIAA QGYIFPISDH VLTMKDDGTF YRFQAPYFWP 130 140 150 160 170 180 SNCWEPENTD YAIYLCKRTM QNKARLELAD YEAENLARLQ RAFARKWEFI FMQAEAQVKI 190 200 210 220 230 240 DRKKDKTERK ILDSQERAFW DVHRPVPGCV NTTEMDIRKC RRLKNPQKVK KSVYGVTEES 250 260 270 280 290 300 QAQSPVHVLS QPIRKTTKED IRKQITFLNA QIDRHCLKMS KVAESLIAYT EQYVEYDPLI 310 320 330 340 350 360 TPAEPSNPWI SDDVALWDIE MSKEPSQQRV KRWGFSFDEI LKDQVGRDQF LRFLESEFSS 370 380 390 400 410 420 ENLRFWLAVQ DLKKQPLQDV AKRVEEIWQE FLAPGAPSAI NLDSHSYEIT SQNVKDGGRY 430 440 450 460 TFEDAQEHIY KLMKSDSYAR FLRSNAYQDL LLAKKKKVSK VVELP
	Isoform 6 (RGS6Lbeta-GGL) [UniParc]. Checksum: A2C52E54E4569178	FASTA	428	49,520
	10 20 30 40 50 60 MAQGSGDQRA VGVADPEESS PNMIVYCKIE DIITKMQDDK TGGVPIRTVK SFLSKIPSVV 70 80 90 100 110 120 TGTDIVQWLM KNLSIEDPVE AIHLGSLIAA QGYIFPISDH VLTMKDDGTF YRFQAPYFWP 130 140 150 160 170 180 SNCWEPENTD YAIYLCKRTM QNKARLELAD YEAENLARLQ RAFARKWEFI FMQAEAQVKI 190 200 210 220 230 240 DRKKDKTERK ILDSQERAFW DVHRPVPGCV NTTEMDIRKC RRLKNPQKVK KSVYGVTEES 250 260 270 280 290 300 QAQSPVHVLS QPIRKTTKED IRKQITFLNA QIDRHCLKMS KVAESKEPSQ QRVKRWGFSF 310 320 330 340 350 360 DEILKDQVGR DQFLRFLESE FSSENLRFWL AVQDLKKQPL QDVAKRVEEI WQEFLAPGAP 370 380 390 400 410 420 SAINLDSHSY EITSQNVKDG GRYTFEDAQE HIYKLMKSDS YARFLRSNAY QDLLLAKKKK VSKVVELP
	Isoform 7 (RGS6Lalpha2-GGL) [UniParc]. Checksum: 95405495A89187D4	FASTA	435	50,155
	10 20 30 40 50 60 MAQGSGDQRA VGVADPEESS PNMIVYCKIE DIITKMQDDK TGGVPIRTVK SFLSKIPSVV 70 80 90 100 110 120 TGTDIVQWLM KNLSIEDPVE AIHLGSLIAA QGYIFPISDH VLTMKDDGTF YRFQAPYFWP 130 140 150 160 170 180 SNCWEPENTD YAIYLCKRTM QNKARLELAD YEAENLARLQ RAFARKWEFI FMQAEAQVKI 190 200 210 220 230 240 DRKKDKTERK ILDSQERAFW DVHRPVPGCV NTTEMDIRKC RRLKNPQKVK KSVYGVTEES 250 260 270 280 290 300 QAQSPVHVLS QPIRKTTKED IRKQITFLNA QIDRHCLKMS KVAESKEPSQ QRVKRWGFSF 310 320 330 340 350 360 DEILKDQVGR DQFLRFLESE FSSENLRFWL AVQDLKKQPL QDVAKRVEEI WQEFLAPGAP 370 380 390 400 410 420 SAINLDSHSY EITSQNVKDG GRYTFEDAQE HIYKLMKSDS YARFLRSNAY QDLLLAKKKG 430 KSLAGKRLTG LMQSS
	Isoform 8 (RGS6Lgamma2) [UniParc]. Checksum: F2CE01A6D57BFD91	FASTA	467	54,049
	10 20 30 40 50 60 MAQGSGDQRA VGVADPEESS PNMIVYCKIE DIITKMQDDK TGGVPIRTVK SFLSKIPSVV 70 80 90 100 110 120 TGTDIVQWLM KNLSIEDPVE AIHLGSLIAA QGYIFPISDH VLTMKDDGTF YRFQAPYFWP 130 140 150 160 170 180 SNCWEPENTD YAIYLCKRTM QNKARLELAD YEAENLARLQ RAFARKWEFI FMQAEAQVKI 190 200 210 220 230 240 DRKKDKTERK ILDSQERAFW DVHRPVPGCV NTTEMDIRKC RRLKNPQKVK KSVYGVTEES 250 260 270 280 290 300 QAQSPVHVLS QPIRKTTKED IRKQITFLNA QIDRHCLKMS KVAESLIAYT EQYVEYDPLI 310 320 330 340 350 360 TPAEPSNPWI SDDVALWDIE MSKEPSQQRV KRWGFSFDEI LKDQVGRDQF LRFLESEFSS 370 380 390 400 410 420 ENLRFWLAVQ DLKKQPLQDV AKRVEEIWQE FLAPGAPSAI NLDSHSYEIT SQNVKDGGRY 430 440 450 460 TFEDAQEHIY KLMKSDSYAR FLRSNAYQDL LLAKKKLYSN TPLAKRP
	Isoform 9 (RGS6Lalpha1-GGL) [UniParc]. Checksum: 78F9B10D25DF6B44	FASTA	453	52,245
	10 20 30 40 50 60 MAQGSGDQRA VGVADPEESS PNMIVYCKIE DIITKMQDDK TGGVPIRTVK SFLSKIPSVV 70 80 90 100 110 120 TGTDIVQWLM KNLSIEDPVE AIHLGSLIAA QGYIFPISDH VLTMKDDGTF YRFQAPYFWP 130 140 150 160 170 180 SNCWEPENTD YAIYLCKRTM QNKARLELAD YEAENLARLQ RAFARKWEFI FMQAEAQVKI 190 200 210 220 230 240 DRKKDKTERK ILDSQERAFW DVHRPVPGCV NTTEMDIRKC RRLKNPQKVK KSVYGVTEES 250 260 270 280 290 300 QAQSPVHVLS QPIRKTTKED IRKQITFLNA QIDRHCLKMS KVAESKEPSQ QRVKRWGFSF 310 320 330 340 350 360 DEILKDQVGR DQFLRFLESE FSSENLRFWL AVQDLKKQPL QDVAKRVEEI WQEFLAPGAP 370 380 390 400 410 420 SAINLDSHSY EITSQNVKDG GRYTFEDAQE HIYKLMKSDS YARFLRSNAY QDLLLAKKKP 430 440 450 ESEQGRRTSL EKFTRSVGKS LAGKRLTGLM QSS
	Isoform 10 (RGS6Lgamma1-GGL) [UniParc]. Checksum: 5A6833E6530ADBAB	FASTA	448	51,870
	10 20 30 40 50 60 MAQGSGDQRA VGVADPEESS PNMIVYCKIE DIITKMQDDK TGGVPIRTVK SFLSKIPSVV 70 80 90 100 110 120 TGTDIVQWLM KNLSIEDPVE AIHLGSLIAA QGYIFPISDH VLTMKDDGTF YRFQAPYFWP 130 140 150 160 170 180 SNCWEPENTD YAIYLCKRTM QNKARLELAD YEAENLARLQ RAFARKWEFI FMQAEAQVKI 190 200 210 220 230 240 DRKKDKTERK ILDSQERAFW DVHRPVPGCV NTTEMDIRKC RRLKNPQKVK KSVYGVTEES 250 260 270 280 290 300 QAQSPVHVLS QPIRKTTKED IRKQITFLNA QIDRHCLKMS KVAESKEPSQ QRVKRWGFSF 310 320 330 340 350 360 DEILKDQVGR DQFLRFLESE FSSENLRFWL AVQDLKKQPL QDVAKRVEEI WQEFLAPGAP 370 380 390 400 410 420 SAINLDSHSY EITSQNVKDG GRYTFEDAQE HIYKLMKSDS YARFLRSNAY QDLLLAKKKP 430 440 ESEQGRRTSL EKFTRSVLYS NTPLAKRP
	Isoform 11 (RGS6Lgamma2-GGL) [UniParc]. Checksum: F484A344D2614731	FASTA	430	49,781
	10 20 30 40 50 60 MAQGSGDQRA VGVADPEESS PNMIVYCKIE DIITKMQDDK TGGVPIRTVK SFLSKIPSVV 70 80 90 100 110 120 TGTDIVQWLM KNLSIEDPVE AIHLGSLIAA QGYIFPISDH VLTMKDDGTF YRFQAPYFWP 130 140 150 160 170 180 SNCWEPENTD YAIYLCKRTM QNKARLELAD YEAENLARLQ RAFARKWEFI FMQAEAQVKI 190 200 210 220 230 240 DRKKDKTERK ILDSQERAFW DVHRPVPGCV NTTEMDIRKC RRLKNPQKVK KSVYGVTEES 250 260 270 280 290 300 QAQSPVHVLS QPIRKTTKED IRKQITFLNA QIDRHCLKMS KVAESKEPSQ QRVKRWGFSF 310 320 330 340 350 360 DEILKDQVGR DQFLRFLESE FSSENLRFWL AVQDLKKQPL QDVAKRVEEI WQEFLAPGAP 370 380 390 400 410 420 SAINLDSHSY EITSQNVKDG GRYTFEDAQE HIYKLMKSDS YARFLRSNAY QDLLLAKKKL 430 YSNTPLAKRP
	Isoform 12 [UniParc]. Checksum: A0462F5A1DBDC9EA	FASTA	346	40,588
	10 20 30 40 50 60 MQNKARLELA DYEAENLARL QRAFARKWEF IFMQAEAQVK IDRKKDKTER KILDSQERAF 70 80 90 100 110 120 WDVHRPVPGC VNTTEMDIRK CRRLKNPQKV KKSVYGVTEE SQAQSPVHVL SQPIRKTTKE 130 140 150 160 170 180 DIRKQITFLN AQIDRHCLKM SKVAESLIAY TEQYVEYDPL ITPAEPSNPW ISDDVALWDI 190 200 210 220 230 240 EMSKEPSQQR VKRWGFSFDE ILKDQVGRDQ FLRFLESEFS SENLRFWLAV QDLKKQPLQD 250 260 270 280 290 300 VAKRVEEIWQ EFLAPGAPSA INLDSHSYEI TSQNVKDGGR YTFEDAQEHI YKLMKSDSYA 310 320 330 340 RFLRSNAYQD LLLAKKKPES EQGRRTSLEK FTRSVLYSNT PLAKRP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants." Chatterjee T.K., Liu Z., Fisher R.A. J. Biol. Chem. 278:30261-30271(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 5; 6; 7; 8; 9; 10; 11 AND 12).
[2]	"Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11." Snow B.E., Betts L., Mangion J., Sondek J., Siderovski D.P. Proc. Natl. Acad. Sci. U.S.A. 96:6489-6494(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), MUTAGENESIS OF ASP-297 AND TRP-309. Tissue: Brain.
[3]	"Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways." Posner B.A., Gilman A.G., Harris B.A. J. Biol. Chem. 274:31087-31093(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
[4]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease." Sherrington R., Rogaev E.I., Liang Y., Rogaeva E.A., Levesque G., Ikeda M., Chi H., Lin C., Li G., Holman K., Tsuda T., Mar L., Foncin J.-F., Bruni A.C., Montesi M.P., Sorbi S., Rainero I., Pinessi L. , Nee L., Chumakov I., Pollen D., Brookes A., Sanseau P., Polinsky R.J., Wasco W., da Silva H.A.R., Haines J.L., Pericak-Vance M.A., Tanzi R.E., Roses A.D., Fraser P.E., Rommens J.M., St George-Hyslop P.H. Nature 375:754-760(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 362-472 (ISOFORM 1). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF073920 mRNA. Translation: AAC26049.2.
AF073921 mRNA. Translation: AAC26050.1.
AF465727 , AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725, AF465726 Genomic DNA. Translation: AAM03004.1.
AF465727 , AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725, AF465726 Genomic DNA. Translation: AAM03005.1.
AF465726 , AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725 Genomic DNA. Translation: AAM03006.1.
AF465727 , AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725, AF465726 Genomic DNA. Translation: AAM03007.1.
AF465727 , AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725, AF465726 Genomic DNA. Translation: AAM03008.1.
AF465727 , AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725 Genomic DNA. Translation: AAM03009.1.
AF465727 , AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725 Genomic DNA. Translation: AAM03010.1.
AF465727 , AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725 Genomic DNA. Translation: AAM03011.1.
AF465727 , AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725 Genomic DNA. Translation: AAM03012.1.
AF465726 , AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725 Genomic DNA. Translation: AAM03013.1.
AF107619 mRNA. Translation: AAD34717.1.
AF107620 mRNA. Translation: AAD34718.1.
AF156932 mRNA. Translation: AAD40183.1.
AC004828 Genomic DNA. No translation available.
AC005157 Genomic DNA. Translation: AAC83180.1.
AC005226 Genomic DNA. No translation available.
AC005227 Genomic DNA. No translation available.
AC005477 Genomic DNA. Translation: AAD05031.1.
AC005533 Genomic DNA. No translation available.
AC005857 Genomic DNA. No translation available.
AC005993 Genomic DNA. No translation available.
L40394 mRNA. Translation: AAC42001.1. Frameshift.

IPI

IPI00216322.
IPI00216323.
IPI00216324.
IPI00216325.
IPI00216326.
IPI00216327.
IPI00216328.
IPI00216329.
IPI00218951.
IPI00218952.
IPI00942997.

RefSeq

NP_001191345.1. NM_001204416.1.
NP_001191346.1. NM_001204417.1.
NP_001191347.1. NM_001204418.1.
NP_001191348.1. NM_001204419.1.
NP_001191349.1. NM_001204420.1.
NP_001191350.1. NM_001204421.1.
NP_001191351.1. NM_001204422.1.
NP_001191352.1. NM_001204423.1.
NP_001191353.1. NM_001204424.1.
NP_004287.3. NM_004296.5.

UniGene

Hs.509872.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2ES0	X-ray	2.10	A	325-470	[»]

ProteinModelPortal

P49758.

ModBase

Search...

Protein-protein interaction databases

IntAct

P49758. 1 interaction.

PTM databases

PhosphoSite

P49758.

Polymorphism databases

DMDM

215274268.

Proteomic databases

PaxDb

P49758.

PRIDE

P49758.

Protocols and materials databases

DNASU

9628.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000343854; ENSP00000341199; ENSG00000182732.
ENST00000402788; ENSP00000383953; ENSG00000182732.
ENST00000553525; ENSP00000451030; ENSG00000182732.
ENST00000553530; ENSP00000452331; ENSG00000182732.
ENST00000554474; ENSP00000450858; ENSG00000182732.
ENST00000554782; ENSP00000451912; ENSG00000182732.
ENST00000555571; ENSP00000450936; ENSG00000182732.
ENST00000556437; ENSP00000451855; ENSG00000182732.

GeneID

9628.

KEGG

hsa:9628.

UCSC

uc001xmx.4. human.
uc001xmy.4. human.
uc021rvw.1. human.
uc021rvx.1. human.
uc021rvy.1. human.
uc021rvz.1. human.
uc021rwa.1. human.
uc021rwb.1. human.
uc021rwc.1. human.

Organism-specific databases

CTD

9628.

GeneCards

GC14P072399.

HGNC

HGNC:10002. RGS6.

HPA

HPA003067.

MIM

603894. gene.

neXtProt

NX_P49758.

PharmGKB

PA34377.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG327614.

HOVERGEN

HBG007404.

InParanoid

P49758.

KO

K16449.

OMA

NEQGRRT.

OrthoDB

EOG41ZF9K.

Gene expression databases

ArrayExpress

P49758.

Bgee

P49758.

Genevestigator

P49758.

Family and domain databases

Gene3D

1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.

InterPro

IPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR000342. Regulat_G_prot_signal.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]

Pfam

PF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]

PRINTS

PR01301. RGSPROTEIN.

SMART

SM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]

SUPFAM

SSF48670. G-protein_gamma-like. 1 hit.
SSF48097. Regulat_G_prot_signal_superfam. 1 hit.

PROSITE

PS50186. DEP. 1 hit.
PS50058. G_PROTEIN_GAMMA. False negative.
PS50132. RGS. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P49758.

GenomeRNAi

9628.

NextBio

36131.

SOURCE

Search...

Entry information

Entry name

RGS6_HUMAN

Accession

Primary (citable) accession number: P49758
Secondary accession number(s): O75576 , O75577, Q8TE13, Q8TE14, Q8TE15, Q8TE16, Q8TE17, Q8TE18, Q8TE19, Q8TE20, Q8TE21, Q8TE22, Q9UDS8, Q9UDT0, Q9Y245, Q9Y647

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 128 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.