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P49758

- RGS6_HUMAN

UniProt

P49758 - RGS6_HUMAN

Protein

Regulator of G-protein signaling 6

Gene

RGS6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 5 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer.1 Publication

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome
    2. protein binding Source: IntAct
    3. signal transducer activity Source: InterPro

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: InterPro
    2. intracellular signal transduction Source: InterPro
    3. positive regulation of GTPase activity Source: GOC
    4. positive regulation of neuron differentiation Source: Ensembl
    5. regulation of G-protein coupled receptor protein signaling pathway Source: ProtInc
    6. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Enzyme and pathway databases

    ReactomeiREACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 6
    Short name:
    RGS6
    Alternative name(s):
    S914
    Gene namesi
    Name:RGS6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:10002. RGS6.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. heterotrimeric G-protein complex Source: InterPro
    3. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi297 – 2971D → A: Loss of interaction with Gbeta5. 1 Publication
    Mutagenesisi309 – 3091W → F: Diminishes interaction with Gbeta5. 1 Publication

    Organism-specific databases

    PharmGKBiPA34377.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 472472Regulator of G-protein signaling 6PRO_0000204192Add
    BLAST

    Proteomic databases

    PaxDbiP49758.
    PRIDEiP49758.

    PTM databases

    PhosphoSiteiP49758.

    Expressioni

    Gene expression databases

    ArrayExpressiP49758.
    BgeeiP49758.
    GenevestigatoriP49758.

    Organism-specific databases

    HPAiHPA003067.

    Interactioni

    Subunit structurei

    Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HSP90AB1P082382EBI-6426927,EBI-352572

    Protein-protein interaction databases

    BioGridi114987. 9 interactions.
    IntActiP49758. 4 interactions.
    MINTiMINT-242744.

    Structurei

    Secondary structure

    1
    472
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi327 – 3337
    Helixi337 – 3426
    Helixi344 – 35613
    Helixi360 – 37314
    Helixi377 – 3793
    Helixi380 – 39112
    Helixi404 – 41613
    Turni417 – 4226
    Helixi423 – 43614
    Helixi438 – 4436
    Helixi445 – 4484
    Turni449 – 4513

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ES0X-ray2.10A325-470[»]
    ProteinModelPortaliP49758.
    SMRiP49758. Positions 17-452.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP49758.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini40 – 11576DEPPROSITE-ProRule annotationAdd
    BLAST
    Domaini261 – 33070G protein gammaAdd
    BLAST
    Domaini336 – 441106RGSPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The RGS domain interacts avidly with Galpha and mediates the acceleration of Galpha-mediated GTP hydrolysis.1 Publication

    Sequence similaritiesi

    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 1 G protein gamma domain.Curated
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG327614.
    HOVERGENiHBG007404.
    InParanoidiP49758.
    KOiK16449.
    OMAiEDAQDHI.
    OrthoDBiEOG7BZVS5.
    PhylomeDBiP49758.
    TreeFamiTF351956.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.196.10. 1 hit.
    4.10.260.10. 1 hit.
    InterProiIPR000591. DEP_dom.
    IPR015898. G-protein_gamma-like_dom.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00610. DEP. 1 hit.
    PF00631. G-gamma. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00049. DEP. 1 hit.
    SM00224. GGL. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF48670. SSF48670. 1 hit.
    PROSITEiPS50186. DEP. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequences (15)i

    Sequence statusi: Complete.

    This entry describes 15 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P49758-4) [UniParc]FASTAAdd to Basket

    Also known as: RGS6Lalpha2

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQGSGDQRA VGVADPEESS PNMIVYCKIE DIITKMQDDK TGGVPIRTVK    50
    SFLSKIPSVV TGTDIVQWLM KNLSIEDPVE AIHLGSLIAA QGYIFPISDH 100
    VLTMKDDGTF YRFQAPYFWP SNCWEPENTD YAIYLCKRTM QNKARLELAD 150
    YEAENLARLQ RAFARKWEFI FMQAEAQVKI DRKKDKTERK ILDSQERAFW 200
    DVHRPVPGCV NTTEMDIRKC RRLKNPQKVK KSVYGVTEES QAQSPVHVLS 250
    QPIRKTTKED IRKQITFLNA QIDRHCLKMS KVAESLIAYT EQYVEYDPLI 300
    TPAEPSNPWI SDDVALWDIE MSKEPSQQRV KRWGFSFDEI LKDQVGRDQF 350
    LRFLESEFSS ENLRFWLAVQ DLKKQPLQDV AKRVEEIWQE FLAPGAPSAI 400
    NLDSHSYEIT SQNVKDGGRY TFEDAQEHIY KLMKSDSYAR FLRSNAYQDL 450
    LLAKKKGKSL AGKRLTGLMQ SS 472
    Length:472
    Mass (Da):54,423
    Last modified:November 25, 2008 - v5
    Checksum:i1424518EA697CD76
    GO
    Isoform 2 (identifier: P49758-2) [UniParc]FASTAAdd to Basket

    Also known as: RGS6Lgamma1

    The sequence of this isoform differs from the canonical sequence as follows:
         457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVLYSNTPLAKRP

    Show »
    Length:485
    Mass (Da):56,138
    Checksum:i06D282213979376C
    GO
    Isoform 3 (identifier: P49758-3) [UniParc]FASTAAdd to Basket

    Also known as: RGS6Lalpha1

    The sequence of this isoform differs from the canonical sequence as follows:
         456-456: K → KPESEQGRRTSLEKFTRSV

    Show »
    Length:490
    Mass (Da):56,512
    Checksum:iC8BD1254D593D1F5
    GO
    Isoform 5 (identifier: P49758-5) [UniParc]FASTAAdd to Basket

    Also known as: RGS6Lbeta

    The sequence of this isoform differs from the canonical sequence as follows:
         457-472: GKSLAGKRLTGLMQSS → KVSKVVELP

    Show »
    Length:465
    Mass (Da):53,787
    Checksum:i2027294E5EF69596
    GO
    Isoform 6 (identifier: P49758-6) [UniParc]FASTAAdd to Basket

    Also known as: RGS6Lbeta-GGL

    The sequence of this isoform differs from the canonical sequence as follows:
         285-321: Missing.
         457-472: GKSLAGKRLTGLMQSS → KVSKVVELP

    Show »
    Length:428
    Mass (Da):49,520
    Checksum:iA2C52E54E4569178
    GO
    Isoform 7 (identifier: P49758-7) [UniParc]FASTAAdd to Basket

    Also known as: RGS6Lalpha2-GGL

    The sequence of this isoform differs from the canonical sequence as follows:
         285-321: Missing.

    Show »
    Length:435
    Mass (Da):50,155
    Checksum:i95405495A89187D4
    GO
    Isoform 8 (identifier: P49758-8) [UniParc]FASTAAdd to Basket

    Also known as: RGS6Lgamma2

    The sequence of this isoform differs from the canonical sequence as follows:
         457-472: GKSLAGKRLTGLMQSS → LYSNTPLAKRP

    Show »
    Length:467
    Mass (Da):54,049
    Checksum:iF2CE01A6D57BFD91
    GO
    Isoform 9 (identifier: P49758-9) [UniParc]FASTAAdd to Basket

    Also known as: RGS6Lalpha1-GGL

    The sequence of this isoform differs from the canonical sequence as follows:
         285-321: Missing.
         456-456: K → KPESEQGRRTSLEKFTRSV

    Show »
    Length:453
    Mass (Da):52,245
    Checksum:i78F9B10D25DF6B44
    GO
    Isoform 10 (identifier: P49758-10) [UniParc]FASTAAdd to Basket

    Also known as: RGS6Lgamma1-GGL

    The sequence of this isoform differs from the canonical sequence as follows:
         285-321: Missing.
         457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVLYSNTPLAKRP

    Show »
    Length:448
    Mass (Da):51,870
    Checksum:i5A6833E6530ADBAB
    GO
    Isoform 11 (identifier: P49758-11) [UniParc]FASTAAdd to Basket

    Also known as: RGS6Lgamma2-GGL

    The sequence of this isoform differs from the canonical sequence as follows:
         285-321: Missing.
         457-472: GKSLAGKRLTGLMQSS → LYSNTPLAKRP

    Show »
    Length:430
    Mass (Da):49,781
    Checksum:iF484A344D2614731
    GO
    Isoform 12 (identifier: P49758-12) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-139: Missing.
         457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVLYSNTPLAKRP

    Show »
    Length:346
    Mass (Da):40,588
    Checksum:iA0462F5A1DBDC9EA
    GO
    Isoform 13 (identifier: P49758-13) [UniParc]FASTAAdd to Basket

    Also known as: RGS6Lepsilon

    The sequence of this isoform differs from the canonical sequence as follows:
         457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVG

    Show »
    Length:475
    Mass (Da):54,953
    Checksum:iDBD7BC0ADF638F51
    GO
    Isoform 14 (identifier: P49758-14) [UniParc]FASTAAdd to Basket

    Also known as: RGS6Ldelta

    The sequence of this isoform differs from the canonical sequence as follows:
         457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVLLF

    Show »
    Length:477
    Mass (Da):55,270
    Checksum:iB8212487BC0ADF63
    GO
    Isoform 15 (identifier: P49758-15) [UniParc]FASTAAdd to Basket

    Also known as: RGS6Lgamma

    The sequence of this isoform differs from the canonical sequence as follows:
         457-472: GKSLAGKRLTGLMQSS → PESEQGRRTSLEKFTRSVCLQLLF

    Show »
    Length:480
    Mass (Da):55,614
    Checksum:i6781EF37312D17BC
    GO
    Isoform 16 (identifier: P49758-16) [UniParc]FASTAAdd to Basket

    Also known as: RGS6Leta

    The sequence of this isoform differs from the canonical sequence as follows:
         457-472: GKSLAGKRLTGLMQSS → VWLL

    Show »
    Length:460
    Mass (Da):53,319
    Checksum:i829707C9624AD2A3
    GO

    Sequence cautioni

    The sequence AAC42001.1 differs from that shown. Reason: Frameshift at several positions.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti165 – 1651R → K in AAC26049. (PubMed:12761221)Curated
    Sequence conflicti165 – 1651R → K in AAM03004. (PubMed:12761221)Curated
    Sequence conflicti165 – 1651R → K in AAM03005. (PubMed:12761221)Curated
    Sequence conflicti165 – 1651R → K in AAM03006. (PubMed:12761221)Curated
    Sequence conflicti165 – 1651R → K in AAM03007. (PubMed:12761221)Curated
    Sequence conflicti165 – 1651R → K in AAM03008. (PubMed:12761221)Curated
    Sequence conflicti165 – 1651R → K in AAM03009. (PubMed:12761221)Curated
    Sequence conflicti165 – 1651R → K in AAM03010. (PubMed:12761221)Curated
    Sequence conflicti165 – 1651R → K in AAM03011. (PubMed:12761221)Curated
    Sequence conflicti165 – 1651R → K in AAM03012. (PubMed:12761221)Curated
    Sequence conflicti165 – 1651R → K in AAM03013. (PubMed:12761221)Curated
    Sequence conflicti210 – 2101V → L in AAC26049. (PubMed:12761221)Curated
    Sequence conflicti210 – 2101V → L in AAM03004. (PubMed:12761221)Curated
    Sequence conflicti210 – 2101V → L in AAM03005. (PubMed:12761221)Curated
    Sequence conflicti210 – 2101V → L in AAM03006. (PubMed:12761221)Curated
    Sequence conflicti210 – 2101V → L in AAM03007. (PubMed:12761221)Curated
    Sequence conflicti210 – 2101V → L in AAM03008. (PubMed:12761221)Curated
    Sequence conflicti210 – 2101V → L in AAM03009. (PubMed:12761221)Curated
    Sequence conflicti210 – 2101V → L in AAM03010. (PubMed:12761221)Curated
    Sequence conflicti210 – 2101V → L in AAM03011. (PubMed:12761221)Curated
    Sequence conflicti210 – 2101V → L in AAM03012. (PubMed:12761221)Curated
    Sequence conflicti210 – 2101V → L in AAM03013. (PubMed:12761221)Curated
    Sequence conflicti312 – 3132DD → EE in AAC26049. (PubMed:12761221)Curated
    Sequence conflicti312 – 3132DD → EE in AAM03004. (PubMed:12761221)Curated
    Sequence conflicti312 – 3132DD → EE in AAM03005. (PubMed:12761221)Curated
    Sequence conflicti312 – 3132DD → EE in AAM03006. (PubMed:12761221)Curated
    Sequence conflicti312 – 3132DD → EE in AAM03009. (PubMed:12761221)Curated
    Sequence conflicti312 – 3132DD → EE in AAM03010. (PubMed:12761221)Curated
    Sequence conflicti324 – 3241E → D in AAC26049. (PubMed:12761221)Curated
    Sequence conflicti324 – 3241E → D in AAM03004. (PubMed:12761221)Curated
    Sequence conflicti324 – 3241E → D in AAM03005. (PubMed:12761221)Curated
    Sequence conflicti324 – 3241E → D in AAM03006. (PubMed:12761221)Curated
    Sequence conflicti324 – 3241E → D in AAM03007. (PubMed:12761221)Curated
    Sequence conflicti324 – 3241E → D in AAM03008. (PubMed:12761221)Curated
    Sequence conflicti324 – 3241E → D in AAM03009. (PubMed:12761221)Curated
    Sequence conflicti324 – 3241E → D in AAM03010. (PubMed:12761221)Curated
    Sequence conflicti324 – 3241E → D in AAM03011. (PubMed:12761221)Curated
    Sequence conflicti324 – 3241E → D in AAM03012. (PubMed:12761221)Curated
    Sequence conflicti324 – 3241E → D in AAM03013. (PubMed:12761221)Curated
    Sequence conflicti465 – 4651L → C in AAC42001. (PubMed:7596406)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 139139Missing in isoform 12. 1 PublicationVSP_035845Add
    BLAST
    Alternative sequencei285 – 32137Missing in isoform 6, isoform 7, isoform 9, isoform 10 and isoform 11. 1 PublicationVSP_035846Add
    BLAST
    Alternative sequencei456 – 4561K → KPESEQGRRTSLEKFTRSV in isoform 3 and isoform 9. 2 PublicationsVSP_035847
    Alternative sequencei457 – 47216GKSLA…LMQSS → PESEQGRRTSLEKFTRSVG in isoform 13. 1 PublicationVSP_047806Add
    BLAST
    Alternative sequencei457 – 47216GKSLA…LMQSS → PESEQGRRTSLEKFTRSVLL F in isoform 14. 1 PublicationVSP_047807Add
    BLAST
    Alternative sequencei457 – 47216GKSLA…LMQSS → PESEQGRRTSLEKFTRSVCL QLLF in isoform 15. 1 PublicationVSP_047808Add
    BLAST
    Alternative sequencei457 – 47216GKSLA…LMQSS → VWLL in isoform 16. 1 PublicationVSP_047809Add
    BLAST
    Alternative sequencei457 – 47216GKSLA…LMQSS → PESEQGRRTSLEKFTRSVLY SNTPLAKRP in isoform 2, isoform 10 and isoform 12. 1 PublicationVSP_035848Add
    BLAST
    Alternative sequencei457 – 47216GKSLA…LMQSS → KVSKVVELP in isoform 5 and isoform 6. 1 PublicationVSP_035849Add
    BLAST
    Alternative sequencei457 – 47216GKSLA…LMQSS → LYSNTPLAKRP in isoform 8 and isoform 11. 1 PublicationVSP_035850Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF073920 mRNA. Translation: AAC26049.2.
    AF073921 mRNA. Translation: AAC26050.1.
    AY309097 mRNA. Translation: AAP74386.1.
    AY309098 mRNA. Translation: AAP74387.1.
    AY309099 mRNA. Translation: AAP74388.1.
    AY309100 mRNA. Translation: AAP74389.1.
    AF465727
    , AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725, AF465726 Genomic DNA. Translation: AAM03004.1.
    AF465727
    , AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725, AF465726 Genomic DNA. Translation: AAM03005.1.
    AF465726
    , AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725 Genomic DNA. Translation: AAM03006.1.
    AF465727
    , AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725, AF465726 Genomic DNA. Translation: AAM03007.1.
    AF465727
    , AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725, AF465726 Genomic DNA. Translation: AAM03008.1.
    AF465727
    , AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725 Genomic DNA. Translation: AAM03009.1.
    AF465727
    , AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465722, AF465723, AF465724, AF465725 Genomic DNA. Translation: AAM03010.1.
    AF465727
    , AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725 Genomic DNA. Translation: AAM03011.1.
    AF465727
    , AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725 Genomic DNA. Translation: AAM03012.1.
    AF465726
    , AF465711, AF465712, AF465713, AF465714, AF465715, AF465716, AF465717, AF465718, AF465719, AF465720, AF465721, AF465723, AF465724, AF465725 Genomic DNA. Translation: AAM03013.1.
    AF107619 mRNA. Translation: AAD34717.1.
    AF107620 mRNA. Translation: AAD34718.1.
    AF156932 mRNA. Translation: AAD40183.1.
    AC004828 Genomic DNA. No translation available.
    AC005157 Genomic DNA. Translation: AAC83180.1.
    AC005226 Genomic DNA. No translation available.
    AC005227 Genomic DNA. No translation available.
    AC005477 Genomic DNA. Translation: AAD05031.1.
    AC005533 Genomic DNA. No translation available.
    AC005857 Genomic DNA. No translation available.
    AC005993 Genomic DNA. No translation available.
    L40394 mRNA. Translation: AAC42001.1. Frameshift.
    CCDSiCCDS55924.1. [P49758-3]
    CCDS55925.1. [P49758-9]
    CCDS9808.1. [P49758-4]
    RefSeqiNP_001191345.1. NM_001204416.1. [P49758-3]
    NP_001191346.1. NM_001204417.1. [P49758-2]
    NP_001191347.1. NM_001204418.1. [P49758-8]
    NP_001191348.1. NM_001204419.1. [P49758-9]
    NP_001191349.1. NM_001204420.1. [P49758-7]
    NP_001191350.1. NM_001204421.1. [P49758-10]
    NP_001191351.1. NM_001204422.1. [P49758-11]
    NP_001191352.1. NM_001204423.1.
    NP_001191353.1. NM_001204424.1. [P49758-3]
    NP_004287.3. NM_004296.5. [P49758-4]
    XP_005268291.1. XM_005268234.1. [P49758-2]
    XP_005268292.1. XM_005268235.2. [P49758-13]
    XP_005268293.1. XM_005268236.1. [P49758-4]
    XP_006720391.1. XM_006720328.1. [P49758-5]
    XP_006720392.1. XM_006720329.1. [P49758-5]
    XP_006720393.1. XM_006720330.1. [P49758-5]
    XP_006720394.1. XM_006720331.1. [P49758-9]
    XP_006720395.1. XM_006720332.1. [P49758-10]
    XP_006720396.1. XM_006720333.1. [P49758-7]
    UniGeneiHs.509872.

    Genome annotation databases

    EnsembliENST00000343854; ENSP00000341199; ENSG00000182732. [P49758-9]
    ENST00000355512; ENSP00000347699; ENSG00000182732. [P49758-16]
    ENST00000402788; ENSP00000383953; ENSG00000182732. [P49758-4]
    ENST00000404301; ENSP00000385243; ENSG00000182732. [P49758-15]
    ENST00000406236; ENSP00000384218; ENSG00000182732. [P49758-13]
    ENST00000407322; ENSP00000384612; ENSG00000182732. [P49758-14]
    ENST00000553525; ENSP00000451030; ENSG00000182732. [P49758-3]
    ENST00000553530; ENSP00000452331; ENSG00000182732. [P49758-4]
    ENST00000554474; ENSP00000450858; ENSG00000182732. [P49758-5]
    ENST00000554782; ENSP00000451912; ENSG00000182732. [P49758-12]
    ENST00000555571; ENSP00000450936; ENSG00000182732. [P49758-4]
    ENST00000556437; ENSP00000451855; ENSG00000182732. [P49758-3]
    GeneIDi9628.
    KEGGihsa:9628.
    UCSCiuc001xmx.4. human. [P49758-4]
    uc001xmy.4. human. [P49758-3]
    uc021rvw.1. human. [P49758-2]
    uc021rvx.1. human. [P49758-8]
    uc021rvy.1. human. [P49758-10]
    uc021rvz.1. human. [P49758-11]
    uc021rwa.1. human. [P49758-9]
    uc021rwb.1. human. [P49758-7]
    uc021rwc.1. human. [P49758-12]

    Polymorphism databases

    DMDMi215274268.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF073920 mRNA. Translation: AAC26049.2 .
    AF073921 mRNA. Translation: AAC26050.1 .
    AY309097 mRNA. Translation: AAP74386.1 .
    AY309098 mRNA. Translation: AAP74387.1 .
    AY309099 mRNA. Translation: AAP74388.1 .
    AY309100 mRNA. Translation: AAP74389.1 .
    AF465727
    , AF465711 , AF465712 , AF465713 , AF465714 , AF465715 , AF465716 , AF465717 , AF465718 , AF465719 , AF465720 , AF465721 , AF465722 , AF465723 , AF465724 , AF465725 , AF465726 Genomic DNA. Translation: AAM03004.1 .
    AF465727
    , AF465711 , AF465712 , AF465713 , AF465714 , AF465715 , AF465716 , AF465717 , AF465718 , AF465719 , AF465720 , AF465721 , AF465722 , AF465723 , AF465724 , AF465725 , AF465726 Genomic DNA. Translation: AAM03005.1 .
    AF465726
    , AF465711 , AF465712 , AF465713 , AF465714 , AF465715 , AF465716 , AF465717 , AF465718 , AF465719 , AF465720 , AF465721 , AF465722 , AF465723 , AF465724 , AF465725 Genomic DNA. Translation: AAM03006.1 .
    AF465727
    , AF465711 , AF465712 , AF465713 , AF465714 , AF465715 , AF465716 , AF465717 , AF465718 , AF465719 , AF465720 , AF465721 , AF465723 , AF465724 , AF465725 , AF465726 Genomic DNA. Translation: AAM03007.1 .
    AF465727
    , AF465711 , AF465712 , AF465713 , AF465714 , AF465715 , AF465716 , AF465717 , AF465718 , AF465719 , AF465720 , AF465721 , AF465723 , AF465724 , AF465725 , AF465726 Genomic DNA. Translation: AAM03008.1 .
    AF465727
    , AF465711 , AF465712 , AF465713 , AF465714 , AF465715 , AF465716 , AF465717 , AF465718 , AF465719 , AF465720 , AF465721 , AF465722 , AF465723 , AF465724 , AF465725 Genomic DNA. Translation: AAM03009.1 .
    AF465727
    , AF465711 , AF465712 , AF465713 , AF465714 , AF465715 , AF465716 , AF465717 , AF465718 , AF465719 , AF465720 , AF465721 , AF465722 , AF465723 , AF465724 , AF465725 Genomic DNA. Translation: AAM03010.1 .
    AF465727
    , AF465711 , AF465712 , AF465713 , AF465714 , AF465715 , AF465716 , AF465717 , AF465718 , AF465719 , AF465720 , AF465721 , AF465723 , AF465724 , AF465725 Genomic DNA. Translation: AAM03011.1 .
    AF465727
    , AF465711 , AF465712 , AF465713 , AF465714 , AF465715 , AF465716 , AF465717 , AF465718 , AF465719 , AF465720 , AF465721 , AF465723 , AF465724 , AF465725 Genomic DNA. Translation: AAM03012.1 .
    AF465726
    , AF465711 , AF465712 , AF465713 , AF465714 , AF465715 , AF465716 , AF465717 , AF465718 , AF465719 , AF465720 , AF465721 , AF465723 , AF465724 , AF465725 Genomic DNA. Translation: AAM03013.1 .
    AF107619 mRNA. Translation: AAD34717.1 .
    AF107620 mRNA. Translation: AAD34718.1 .
    AF156932 mRNA. Translation: AAD40183.1 .
    AC004828 Genomic DNA. No translation available.
    AC005157 Genomic DNA. Translation: AAC83180.1 .
    AC005226 Genomic DNA. No translation available.
    AC005227 Genomic DNA. No translation available.
    AC005477 Genomic DNA. Translation: AAD05031.1 .
    AC005533 Genomic DNA. No translation available.
    AC005857 Genomic DNA. No translation available.
    AC005993 Genomic DNA. No translation available.
    L40394 mRNA. Translation: AAC42001.1 . Frameshift.
    CCDSi CCDS55924.1. [P49758-3 ]
    CCDS55925.1. [P49758-9 ]
    CCDS9808.1. [P49758-4 ]
    RefSeqi NP_001191345.1. NM_001204416.1. [P49758-3 ]
    NP_001191346.1. NM_001204417.1. [P49758-2 ]
    NP_001191347.1. NM_001204418.1. [P49758-8 ]
    NP_001191348.1. NM_001204419.1. [P49758-9 ]
    NP_001191349.1. NM_001204420.1. [P49758-7 ]
    NP_001191350.1. NM_001204421.1. [P49758-10 ]
    NP_001191351.1. NM_001204422.1. [P49758-11 ]
    NP_001191352.1. NM_001204423.1.
    NP_001191353.1. NM_001204424.1. [P49758-3 ]
    NP_004287.3. NM_004296.5. [P49758-4 ]
    XP_005268291.1. XM_005268234.1. [P49758-2 ]
    XP_005268292.1. XM_005268235.2. [P49758-13 ]
    XP_005268293.1. XM_005268236.1. [P49758-4 ]
    XP_006720391.1. XM_006720328.1. [P49758-5 ]
    XP_006720392.1. XM_006720329.1. [P49758-5 ]
    XP_006720393.1. XM_006720330.1. [P49758-5 ]
    XP_006720394.1. XM_006720331.1. [P49758-9 ]
    XP_006720395.1. XM_006720332.1. [P49758-10 ]
    XP_006720396.1. XM_006720333.1. [P49758-7 ]
    UniGenei Hs.509872.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ES0 X-ray 2.10 A 325-470 [» ]
    ProteinModelPortali P49758.
    SMRi P49758. Positions 17-452.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114987. 9 interactions.
    IntActi P49758. 4 interactions.
    MINTi MINT-242744.

    PTM databases

    PhosphoSitei P49758.

    Polymorphism databases

    DMDMi 215274268.

    Proteomic databases

    PaxDbi P49758.
    PRIDEi P49758.

    Protocols and materials databases

    DNASUi 9628.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343854 ; ENSP00000341199 ; ENSG00000182732 . [P49758-9 ]
    ENST00000355512 ; ENSP00000347699 ; ENSG00000182732 . [P49758-16 ]
    ENST00000402788 ; ENSP00000383953 ; ENSG00000182732 . [P49758-4 ]
    ENST00000404301 ; ENSP00000385243 ; ENSG00000182732 . [P49758-15 ]
    ENST00000406236 ; ENSP00000384218 ; ENSG00000182732 . [P49758-13 ]
    ENST00000407322 ; ENSP00000384612 ; ENSG00000182732 . [P49758-14 ]
    ENST00000553525 ; ENSP00000451030 ; ENSG00000182732 . [P49758-3 ]
    ENST00000553530 ; ENSP00000452331 ; ENSG00000182732 . [P49758-4 ]
    ENST00000554474 ; ENSP00000450858 ; ENSG00000182732 . [P49758-5 ]
    ENST00000554782 ; ENSP00000451912 ; ENSG00000182732 . [P49758-12 ]
    ENST00000555571 ; ENSP00000450936 ; ENSG00000182732 . [P49758-4 ]
    ENST00000556437 ; ENSP00000451855 ; ENSG00000182732 . [P49758-3 ]
    GeneIDi 9628.
    KEGGi hsa:9628.
    UCSCi uc001xmx.4. human. [P49758-4 ]
    uc001xmy.4. human. [P49758-3 ]
    uc021rvw.1. human. [P49758-2 ]
    uc021rvx.1. human. [P49758-8 ]
    uc021rvy.1. human. [P49758-10 ]
    uc021rvz.1. human. [P49758-11 ]
    uc021rwa.1. human. [P49758-9 ]
    uc021rwb.1. human. [P49758-7 ]
    uc021rwc.1. human. [P49758-12 ]

    Organism-specific databases

    CTDi 9628.
    GeneCardsi GC14P072399.
    HGNCi HGNC:10002. RGS6.
    HPAi HPA003067.
    MIMi 603894. gene.
    neXtProti NX_P49758.
    PharmGKBi PA34377.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327614.
    HOVERGENi HBG007404.
    InParanoidi P49758.
    KOi K16449.
    OMAi EDAQDHI.
    OrthoDBi EOG7BZVS5.
    PhylomeDBi P49758.
    TreeFami TF351956.

    Enzyme and pathway databases

    Reactomei REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    EvolutionaryTracei P49758.
    GeneWikii RGS6.
    GenomeRNAii 9628.
    NextBioi 36131.
    PROi P49758.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49758.
    Bgeei P49758.
    Genevestigatori P49758.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.196.10. 1 hit.
    4.10.260.10. 1 hit.
    InterProi IPR000591. DEP_dom.
    IPR015898. G-protein_gamma-like_dom.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00610. DEP. 1 hit.
    PF00631. G-gamma. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00049. DEP. 1 hit.
    SM00224. GGL. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF48670. SSF48670. 1 hit.
    PROSITEi PS50186. DEP. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants."
      Chatterjee T.K., Liu Z., Fisher R.A.
      J. Biol. Chem. 278:30261-30271(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15 AND 16).
    2. "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11."
      Snow B.E., Betts L., Mangion J., Sondek J., Siderovski D.P.
      Proc. Natl. Acad. Sci. U.S.A. 96:6489-6494(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), MUTAGENESIS OF ASP-297 AND TRP-309.
      Tissue: Brain.
    3. "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways."
      Posner B.A., Gilman A.G., Harris B.A.
      J. Biol. Chem. 274:31087-31093(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
    4. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 362-472 (ISOFORM 1).
      Tissue: Brain.
    6. Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 325-470, DOMAIN RGS.

    Entry informationi

    Entry nameiRGS6_HUMAN
    AccessioniPrimary (citable) accession number: P49758
    Secondary accession number(s): C9JE95
    , F8W7W5, O75576, O75577, Q7Z4K3, Q7Z4K4, Q7Z4K5, Q7Z4K6, Q8TE13, Q8TE14, Q8TE15, Q8TE16, Q8TE17, Q8TE18, Q8TE19, Q8TE20, Q8TE21, Q8TE22, Q9UDS8, Q9UDT0, Q9Y245, Q9Y647
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 142 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3