P49756 (RBM25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA-binding protein 25

Alternative name(s):
Arg/Glu/Asp-rich protein of 120 kDa
Short name=RED120
Protein S164
RNA-binding motif protein 25
RNA-binding region-containing protein 7

Gene names

Name:	RBM25
Synonyms:	RNPC7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	843 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Ref.14
Subunit structure	Interacts with LUC7L3 and SRRM1. Specifically associates with functional splicing complexes, including Sm proteins and U1, U2, U4, U5 and U6 snRNAs. Associates with exon junction complex (EJC) proteins, including APEX1, BAT1, NCBP1, RBM8A and RNPS1. Interaction with NCBP1 is RNA-dependent. Ref.7 Ref.14
Subcellular location	Nucleus speckle. Cytoplasm. Note: Colocalizes predominantly, with SFRS2 and LUC7L3 splicing factors, in nuclear speckles. Cytoplasmic localization is faint. Ref.7 Ref.14
Post-translational modification	Sumoylated. Ref.9
Sequence similarities	Contains 1 PWI domain. Contains 1 RRM (RNA recognition motif) domain.
Sequence caution	The sequence AAH62440.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH62440.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAH83496.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAG52915.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
PTM	Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW apoptotic process Inferred from direct assay Ref.14. Source: UniProtKB mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW regulation of alternative mRNA splicing, via spliceosome Inferred from direct assay Ref.14. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nuclear speck Inferred from direct assay Ref.14. Source: UniProtKB
Molecular_function	mRNA binding Inferred from direct assay Ref.14. Source: UniProtKB nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P49756-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P49756-2)

The sequence of this isoform differs from the canonical sequence as follows:
     290-294: KLEEE → RSYGD
     295-843: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: P49756-3)

The sequence of this isoform differs from the canonical sequence as follows:
     290-300: KLEEEKGKKEK → VVFLSFHLIPI
     301-843: Missing.

Isoform 4 (identifier: P49756-4)

The sequence of this isoform differs from the canonical sequence as follows:
     109-164: KCGLVLSWKR...KKLLVKVDAK → PSDSVSTRSQ...QRRKLLMGLG
     165-843: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 843

843

RNA-binding protein 25

PRO_0000081784

Regions

Domain

87 – 164

78

RRM

Domain

750 – 843

94

PWI

Region

285 – 644

360

Necessary for nuclear speckle localization

Compositional bias

292 – 608

317

Glu-rich

Compositional bias

309 – 549

241

Arg-rich

Amino acid modifications

Modified residue

583

1

Phosphoserine Ref.17 Ref.19

Modified residue

677

1

Phosphoserine Ref.6 Ref.11 Ref.16 Ref.17 Ref.19

Modified residue

683

1

Phosphoserine Ref.11 Ref.17 Ref.19

Modified residue

703

1

Phosphoserine Ref.15 Ref.17 Ref.19

Cross-link

477

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.12

Natural variations

Alternative sequence

109 – 164

56

KCGLV…KVDAK → PSDSVSTRSQNLPSVHSDYY MTCKLERKSYSLKLMQRQRH SWMNGKQRRKLLMGLG in isoform 4.

VSP_039881

Alternative sequence

165 – 843

679

Missing in isoform 4.

VSP_039882

Alternative sequence

290 – 300

11

KLEEEKGKKEK → VVFLSFHLIPI in isoform 3.

VSP_036791

Alternative sequence

290 – 294

5

KLEEE → RSYGD in isoform 2.

VSP_036792

Alternative sequence

295 – 843

549

Missing in isoform 2.

VSP_036793

Alternative sequence

301 – 843

543

Missing in isoform 3.

VSP_036794

Experimental info

Sequence conflict

428

1

D → K in BAB15362. Ref.1

Sequence conflict

571 – 574

4

RRRQ → EAQE in AAC41999. Ref.8

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

843

Helix Strand Turn

Details...

Helix

739 – 744

6

Helix

749 – 754

6

Turn

759 – 761

3

Helix

764 – 769

6

Helix

771 – 782

12

Helix

789 – 799

11

Helix

804 – 815

12

Helix

818 – 839

22

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 14, 2009. Version 3. Checksum: 80534590147A342A	FASTA	843	100,185
	10 20 30 40 50 60 MSFPPHLNRP PMGIPALPPG IPPPQFPGFP PPVPPGTPMI PVPMSIMAPA PTVLVPTVSM 70 80 90 100 110 120 VGKHLGARKD HPGLKAKEND ENCGPTTTVF VGNISEKASD MLIRQLLAKC GLVLSWKRVQ 130 140 150 160 170 180 GASGKLQAFG FCEYKEPEST LRALRLLHDL QIGEKKLLVK VDAKTKAQLD EWKAKKKASN 190 200 210 220 230 240 GNARPETVTN DDEEALDEET KRRDQMIKGA IEVLIREYSS ELNAPSQESD SHPRKKKKEK 250 260 270 280 290 300 KEDIFRRFPV APLIPYPLIT KEDINAIEME EDKRDLISRE ISKFRDTHKK LEEEKGKKEK 310 320 330 340 350 360 ERQEIEKERR ERERERERER ERRERERERE REREREKEKE RERERERDRD RDRTKERDRD 370 380 390 400 410 420 RDRERDRDRD RERSSDRNKD RSRSREKSRD RERERERERE RERERERERE RERERERERE 430 440 450 460 470 480 REREREKDKK RDREEDEEDA YERRKLERKL REKEAAYQER LKNWEIRERK KTREYEKEAE 490 500 510 520 530 540 REEERRREMA KEAKRLKEFL EDYDDDRDDP KYYRGSALQK RLRDREKEME ADERDRKREK 550 560 570 580 590 600 EELEEIRQRL LAEGHPDPDA ELQRMEQEAE RRRQPQIKQE PESEEEEEEK QEKEEKREEP 610 620 630 640 650 660 MEEEEEPEQK PCLKPTLRPI SSAPSVSSAS GNATPNTPGD ESPCGIIIPH ENSPDQQQPE 670 680 690 700 710 720 EHRPKIGLSL KLGASNSPGQ PNSVKRKKLP VDSVFNKFED EDSDDVPRKR KLVPLDYGED 730 740 750 760 770 780 DKNATKGTVN TEEKRKHIKS LIEKIPTAKP ELFAYPLDWS IVDSILMERR IRPWINKKII 790 800 810 820 830 840 EYIGEEEATL VDFVCSKVMA HSSPQSILDD VAMVLDEEAE VFIVKMWRLL IYETEAKKIG LVK
	Isoform 2 [UniParc]. Checksum: 184FE9019A3E3D95	FASTA	294	32,822
	10 20 30 40 50 60 MSFPPHLNRP PMGIPALPPG IPPPQFPGFP PPVPPGTPMI PVPMSIMAPA PTVLVPTVSM 70 80 90 100 110 120 VGKHLGARKD HPGLKAKEND ENCGPTTTVF VGNISEKASD MLIRQLLAKC GLVLSWKRVQ 130 140 150 160 170 180 GASGKLQAFG FCEYKEPEST LRALRLLHDL QIGEKKLLVK VDAKTKAQLD EWKAKKKASN 190 200 210 220 230 240 GNARPETVTN DDEEALDEET KRRDQMIKGA IEVLIREYSS ELNAPSQESD SHPRKKKKEK 250 260 270 280 290 KEDIFRRFPV APLIPYPLIT KEDINAIEME EDKRDLISRE ISKFRDTHKR SYGD
	Isoform 3 [UniParc]. Checksum: 81D1498626DDD750	FASTA	300	33,510
	10 20 30 40 50 60 MSFPPHLNRP PMGIPALPPG IPPPQFPGFP PPVPPGTPMI PVPMSIMAPA PTVLVPTVSM 70 80 90 100 110 120 VGKHLGARKD HPGLKAKEND ENCGPTTTVF VGNISEKASD MLIRQLLAKC GLVLSWKRVQ 130 140 150 160 170 180 GASGKLQAFG FCEYKEPEST LRALRLLHDL QIGEKKLLVK VDAKTKAQLD EWKAKKKASN 190 200 210 220 230 240 GNARPETVTN DDEEALDEET KRRDQMIKGA IEVLIREYSS ELNAPSQESD SHPRKKKKEK 250 260 270 280 290 300 KEDIFRRFPV APLIPYPLIT KEDINAIEME EDKRDLISRE ISKFRDTHKV VFLSFHLIPI
	Isoform 4 [UniParc]. Checksum: 5D5562C8AAD78BAE	FASTA	164	17,953
	10 20 30 40 50 60 MSFPPHLNRP PMGIPALPPG IPPPQFPGFP PPVPPGTPMI PVPMSIMAPA PTVLVPTVSM 70 80 90 100 110 120 VGKHLGARKD HPGLKAKEND ENCGPTTTVF VGNISEKASD MLIRQLLAPS DSVSTRSQNL 130 140 150 160 PSVHSDYYMT CKLERKSYSL KLMQRQRHSW MNGKQRRKLL MGLG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-430 (ISOFORM 1). Tissue: Amygdala and Kidney epithelium.
[2]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Cerebellum, Fetal brain, Prostate and Uterus.
[5]	"Complete sequence of the gene for presenilin 1." Rowen L., Madan A., Qin S., Abbasi N., Dors M., Ratcliffe A., Madan A., Dickhoff R., Shaffer T., James R., Lasky S., Hood L. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 109-843.
[6]	Bienvenut W.V., Lilla S., von Kriegsheim A., Lempens A., Kolch W. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 146-155; 209-216 AND 672-685, PHOSPHORYLATION AT SER-677, MASS SPECTROMETRY. Tissue: Ovarian carcinoma.
[7]	"Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3'-end formation." Fortes P., Longman D., McCracken S., Ip J.Y., Poot R., Mattaj I.W., Caceres J.F., Blencowe B.J. FEBS Lett. 581:3087-3097(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 146-155 AND 247-261, SUBCELLULAR LOCATION, INTERACTION WITH APEX1; BAT1; NCBP1; RBM8; RNPS1 AND SRRM1.
[8]	"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease." Sherrington R., Rogaev E.I., Liang Y., Rogaeva E.A., Levesque G., Ikeda M., Chi H., Lin C., Li G., Holman K., Tsuda T., Mar L., Foncin J.-F., Bruni A.C., Montesi M.P., Sorbi S., Rainero I., Pinessi L. , Nee L., Chumakov I., Pollen D., Brookes A., Sanseau P., Polinsky R.J., Wasco W., da Silva H.A.R., Haines J.L., Pericak-Vance M.A., Tanzi R.E., Roses A.D., Fraser P.E., Rommens J.M., St George-Hyslop P.H. Nature 375:754-760(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 571-843. Tissue: Brain.
[9]	"Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates." Gocke C.B., Yu H., Kang J. J. Biol. Chem. 280:5004-5012(2005) [PubMed] [Europe PMC] [Abstract] Cited for: SUMOYLATION.
[10]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[11]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-677 AND SER-683, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry." Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D. Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-477, MASS SPECTROMETRY. Tissue: Mammary cancer.
[13]	"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: T-cell.
[14]	"Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection." Zhou A., Ou A.C., Cho A., Benz E.J. Jr., Huang S.C. Mol. Cell. Biol. 28:5924-5936(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH LUC7L3, SUBCELLULAR LOCATION.
[15]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-703, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-677, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[17]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-583; SER-677; SER-683 AND SER-703, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[18]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[19]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-583; SER-677; SER-683 AND SER-703, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK026107 mRNA. Translation: BAB15362.1.
AK094697 mRNA. Translation: BAG52915.1. Sequence problems.
AL442663 Genomic DNA. No translation available.
AC004858 Genomic DNA. Translation: AAF19255.1.
CH471061 Genomic DNA. Translation: EAW81087.1.
BC062440 mRNA. Translation: AAH62440.1. Sequence problems.
BC083496 mRNA. Translation: AAH83496.1. Different initiation.
BC111066 mRNA. Translation: AAI11067.1.
BC113389 mRNA. Translation: AAI13390.1.
BC113391 mRNA. Translation: AAI13392.1.
BC136775 mRNA. Translation: AAI36776.1.
BC136776 mRNA. Translation: AAI36777.1.
BC144407 mRNA. Translation: AAI44408.1.
AF109907 Genomic DNA. Translation: AAC97961.1.
L40392 mRNA. Translation: AAC41999.1.

IPI

IPI00004273.
IPI00924634.
IPI00925670.
IPI00926163.

RefSeq

NP_067062.1. NM_021239.2.

UniGene

Hs.531106.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3V53	X-ray	2.90	A/B/C/D/E	734-843	[»]

ProteinModelPortal

P49756.

ModBase

Search...

Protein-protein interaction databases

IntAct

P49756. 4 interactions.

MINT

MINT-4545359.

PTM databases

PhosphoSite

P49756.

Polymorphism databases

DMDM

226693631.

Proteomic databases

PaxDb

P49756.

PRIDE

P49756.

Protocols and materials databases

DNASU

58517.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000261973; ENSP00000261973; ENSG00000119707.
ENST00000525321; ENSP00000436868; ENSG00000119707.
ENST00000526754; ENSP00000436225; ENSG00000119707.
ENST00000527432; ENSP00000431150; ENSG00000119707.
ENST00000528081; ENSP00000434444; ENSG00000119707.
ENST00000540173; ENSP00000437934; ENSG00000119707.

GeneID

58517.

KEGG

hsa:58517.

UCSC

uc001xnn.4. human.
uc001xno.3. human.

Organism-specific databases

CTD

58517.

GeneCards

GC14P073525.

HGNC

HGNC:23244. RBM25.

HPA

HPA003025.

MIM

612427. gene.

neXtProt

NX_P49756.

PharmGKB

PA134912024.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG250187.

HOVERGEN

HBG068941.

InParanoid

P49756.

KO

K12822.

OMA

EDINAME.

OrthoDB

EOG498V0R.

PhylomeDB

P49756.

Gene expression databases

ArrayExpress

P49756.

Bgee

P49756.

CleanEx

HS_RBM25.

Genevestigator

P49756.

GermOnline

ENSG00000119707. Homo sapiens.

Family and domain databases

Gene3D

1.20.1390.10. 1 hit.
3.30.70.330. 1 hit.

InterPro

IPR012677. Nucleotide-bd_a/b_plait.
IPR002483. PWI_dom.
IPR000504. RRM_dom.
[Graphical view]

Pfam

PF01480. PWI. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]

SMART

SM00311. PWI. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view]

SUPFAM

SSF101233. PWI. 1 hit.

PROSITE

PS51025. PWI. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

RBM25. human.

GenomeRNAi

58517.

NextBio

65066.

SOURCE

Search...

Entry information

Entry name

RBM25_HUMAN

Accession

Primary (citable) accession number: P49756
Secondary accession number(s): A0PJL9 , B2RNA8, B3KT03, Q2TA72, Q5XJ17, Q6P665, Q9H6A1, Q9UEQ5, Q9UIE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	April 14, 2009
Last modified:	May 1, 2013
This is version 100 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.