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Protein

Vacuolar protein sorting-associated protein 41 homolog

Gene

VPS41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complexe is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed:9159129, PubMed:23167963, PubMed:25445562, PubMed:25908847). Required for fusion of autophagosomes with lysosomes (PubMed:25783203). May link the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (PubMed:25445562, PubMed:25908847). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adaptor complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway (PubMed:24210660).By similarity4 Publications6 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri791 – 83949RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • GTPase binding Source: GO_Central
  • identical protein binding Source: IntAct
  • zinc ion binding Source: InterPro

GO - Biological processi

  • autophagy Source: UniProtKB-KW
  • endosomal vesicle fusion Source: UniProtKB
  • endosome to lysosome transport Source: UniProtKB
  • Golgi vesicle transport Source: UniProtKB
  • late endosome to lysosome transport Source: UniProtKB
  • protein targeting to vacuole Source: GO_Central
  • regulation of SNARE complex assembly Source: GO_Central
  • vacuole fusion, non-autophagic Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 41 homolog
Alternative name(s):
S53
Gene namesi
Name:VPS41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:12713. VPS41.

Subcellular locationi

GO - Cellular componenti

  • clathrin-coated vesicle Source: UniProtKB
  • CORVET complex Source: GO_Central
  • cytosol Source: UniProtKB
  • early endosome Source: UniProtKB-SubCell
  • endosome membrane Source: UniProtKB
  • Golgi apparatus Source: UniProtKB-SubCell
  • Golgi-associated vesicle Source: UniProtKB
  • HOPS complex Source: UniProtKB
  • late endosome Source: GO_Central
  • late endosome membrane Source: UniProtKB
  • lysosomal membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • microtubule cytoskeleton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37328.

Polymorphism and mutation databases

BioMutaiVPS41.
DMDMi218512109.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 854854Vacuolar protein sorting-associated protein 41 homologPRO_0000212823Add
BLAST

Proteomic databases

MaxQBiP49754.
PaxDbiP49754.
PRIDEiP49754.

PTM databases

iPTMnetiP49754.
PhosphoSiteiP49754.

Expressioni

Gene expression databases

BgeeiP49754.
CleanExiHS_VPS41.
ExpressionAtlasiP49754. baseline and differential.
GenevisibleiP49754. HS.

Organism-specific databases

HPAiHPA020080.
HPA020299.

Interactioni

Subunit structurei

Component of the putative homotypic fusion and vacuole protein sorting (HOPS) complex; the core of which composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, is associated with VPS39 and VPS41 (PubMed:23351085, PubMed:25445562, PubMed:25908847). Interacts with RILP, MON1B (PubMed:20434987, PubMed:25445562). Interacts with ARL8B (GTP-bound form); involved in recruitment to lysosomes and probably hierarchial assembly of the HOPS complex at lysosomal membranes (PubMed:25908847). In vitro can self-assemble into a lattice (PubMed:24210660). Associates with adaptor protein complex 3 (AP-3) and clathrin:AP-3 complexes (PubMed:21411634).4 Publications3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-2130459,EBI-2130459
RILPQ96NA24EBI-2130459,EBI-2856119
VIPAS39Q9H9C14EBI-2130459,EBI-749080
VPS18Q9P2533EBI-2130459,EBI-1053363

Protein-protein interaction databases

BioGridi117982. 22 interactions.
IntActiP49754. 14 interactions.
MINTiMINT-1187089.
STRINGi9606.ENSP00000309457.

Structurei

3D structure databases

ProteinModelPortaliP49754.
SMRiP49754. Positions 47-97, 521-552, 663-698.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati568 – 712145CHCRAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 540540Interaction with ARL8B1 PublicationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi18 – 2710Poly-Glu

Sequence similaritiesi

Belongs to the VPS41 family.Curated
Contains 1 CHCR (clathrin heavy-chain) repeat.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri791 – 83949RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2066. Eukaryota.
ENOG410XQBC. LUCA.
GeneTreeiENSGT00390000000481.
HOGENOMiHOG000247002.
HOVERGENiHBG056494.
InParanoidiP49754.
OMAiICSAKHR.
OrthoDBiEOG7DVD9K.
PhylomeDBiP49754.
TreeFamiTF300451.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
2.130.10.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR000547. Clathrin_H-chain/VPS_repeat.
IPR011990. TPR-like_helical_dom.
IPR016902. VPS41.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00637. Clathrin. 1 hit.
[Graphical view]
PIRSFiPIRSF028921. VPS41. 1 hit.
SMARTiSM00299. CLH. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50236. CHCR. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P49754-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAEEQETG SLEESTDESE EEESEEEPKL KYERLSNGVT EILQKDAASC
60 70 80 90 100
MTVHDKFLAL GTHYGKVYLL DVQGNITQKF DVSPVKINQI SLDESGEHMG
110 120 130 140 150
VCSEDGKVQV FGLYSGEEFH ETFDCPIKII AVHPHFVRSS CKQFVTGGKK
160 170 180 190 200
LLLFERSWMN RWKSAVLHEG EGNIRSVKWR GHLIAWANNM GVKIFDIISK
210 220 230 240 250
QRITNVPRDD ISLRPDMYPC SLCWKDNVTL IIGWGTSVKV CSVKERHASE
260 270 280 290 300
MRDLPSRYVE IVSQFETEFY ISGLAPLCDQ LVVLSYVKEI SEKTEREYCA
310 320 330 340 350
RPRLDIIQPL SETCEEISSD ALTVRGFQEN ECRDYHLEYS EGESLFYIVS
360 370 380 390 400
PRDVVVAKER DQDDHIDWLL EKKKYEEALM AAEISQKNIK RHKILDIGLA
410 420 430 440 450
YINHLVERGD YDIAARKCQK ILGKNAALWE YEVYKFKEIG QLKAISPYLP
460 470 480 490 500
RGDPVLKPLI YEMILHEFLE SDYEGFATLI REWPGDLYNN SVIVQAVRDH
510 520 530 540 550
LKKDSQNKTL LKTLAELYTY DKNYGNALEI YLTLRHKDVF QLIHKHNLFS
560 570 580 590 600
SIKDKIVLLM DFDSEKAVDM LLDNEDKISI KKVVEELEDR PELQHVYLHK
610 620 630 640 650
LFKRDHHKGQ RYHEKQISLY AEYDRPNLLP FLRDSTHCPL EKALEICQQR
660 670 680 690 700
NFVEETVYLL SRMGNSRSAL KMIMEELHDV DKAIEFAKEQ DDGELWEDLI
710 720 730 740 750
LYSIDKPPFI TGLLNNIGTH VDPILLIHRI KEGMEIPNLR DSLVKILQDY
760 770 780 790 800
NLQILLREGC KKILVADSLS LLKKMHRTQM KGVLVDEENI CESCLSPILP
810 820 830 840 850
SDAAKPFSVV VFHCRHMFHK ECLPMPSMNS AAQFCNICSA KNRGPGSAIL

EMKK
Length:854
Mass (Da):98,566
Last modified:December 16, 2008 - v3
Checksum:i037577D5FA3A18A0
GO
Isoform 2 (identifier: P49754-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     802-802: D → E
     803-854: Missing.

Show »
Length:802
Mass (Da):92,846
Checksum:iA55F7C217AC0D88E
GO
Isoform 3 (identifier: P49754-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-107: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:829
Mass (Da):95,924
Checksum:i6F1E1E9EAA2859B4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51E → V in AAB47563 (PubMed:9159129).Curated
Sequence conflicti615 – 6184KQIS → WHEG in AAC42004 (PubMed:7596406).Curated
Sequence conflicti736 – 7449IPNLRDSLV → DPQFERFLG in AAC42004 (PubMed:7596406).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti146 – 1461T → P Disrupts interaction with ARL8B; impairs lysosomal localization and degradation of endocytosed cargo. 1 Publication
Corresponds to variant rs35693565 [ dbSNP | Ensembl ].
VAR_047914
Natural varianti647 – 6471C → R.
Corresponds to variant rs11762417 [ dbSNP | Ensembl ].
VAR_047915
Natural varianti843 – 8431R → H.
Corresponds to variant rs1059508 [ dbSNP | Ensembl ].
VAR_047916

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei83 – 10725Missing in isoform 3. CuratedVSP_054169Add
BLAST
Alternative sequencei802 – 8021D → E in isoform 2. 1 PublicationVSP_006751
Alternative sequencei803 – 85452Missing in isoform 2. 1 PublicationVSP_006752Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87281 mRNA. Translation: AAB47758.1.
U87309 mRNA. Translation: AAB47563.1.
AC004850 Genomic DNA. No translation available.
AC005247 Genomic DNA. No translation available.
AC011292 Genomic DNA. No translation available.
BC044851 mRNA. Translation: AAH44851.1.
L40398 mRNA. Translation: AAC42004.1.
CCDSiCCDS5457.1. [P49754-1]
CCDS5458.2. [P49754-3]
RefSeqiNP_055211.2. NM_014396.3. [P49754-1]
NP_542198.2. NM_080631.3. [P49754-3]
UniGeneiHs.592184.

Genome annotation databases

EnsembliENST00000310301; ENSP00000309457; ENSG00000006715. [P49754-1]
ENST00000395969; ENSP00000379297; ENSG00000006715. [P49754-3]
GeneIDi27072.
KEGGihsa:27072.
UCSCiuc003tgy.3. human. [P49754-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87281 mRNA. Translation: AAB47758.1.
U87309 mRNA. Translation: AAB47563.1.
AC004850 Genomic DNA. No translation available.
AC005247 Genomic DNA. No translation available.
AC011292 Genomic DNA. No translation available.
BC044851 mRNA. Translation: AAH44851.1.
L40398 mRNA. Translation: AAC42004.1.
CCDSiCCDS5457.1. [P49754-1]
CCDS5458.2. [P49754-3]
RefSeqiNP_055211.2. NM_014396.3. [P49754-1]
NP_542198.2. NM_080631.3. [P49754-3]
UniGeneiHs.592184.

3D structure databases

ProteinModelPortaliP49754.
SMRiP49754. Positions 47-97, 521-552, 663-698.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117982. 22 interactions.
IntActiP49754. 14 interactions.
MINTiMINT-1187089.
STRINGi9606.ENSP00000309457.

PTM databases

iPTMnetiP49754.
PhosphoSiteiP49754.

Polymorphism and mutation databases

BioMutaiVPS41.
DMDMi218512109.

Proteomic databases

MaxQBiP49754.
PaxDbiP49754.
PRIDEiP49754.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310301; ENSP00000309457; ENSG00000006715. [P49754-1]
ENST00000395969; ENSP00000379297; ENSG00000006715. [P49754-3]
GeneIDi27072.
KEGGihsa:27072.
UCSCiuc003tgy.3. human. [P49754-1]

Organism-specific databases

CTDi27072.
GeneCardsiVPS41.
H-InvDBHIX0006614.
HGNCiHGNC:12713. VPS41.
HPAiHPA020080.
HPA020299.
MIMi605485. gene.
neXtProtiNX_P49754.
PharmGKBiPA37328.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2066. Eukaryota.
ENOG410XQBC. LUCA.
GeneTreeiENSGT00390000000481.
HOGENOMiHOG000247002.
HOVERGENiHBG056494.
InParanoidiP49754.
OMAiICSAKHR.
OrthoDBiEOG7DVD9K.
PhylomeDBiP49754.
TreeFamiTF300451.

Miscellaneous databases

ChiTaRSiVPS41. human.
GenomeRNAii27072.
NextBioi49663.
PROiP49754.
SOURCEiSearch...

Gene expression databases

BgeeiP49754.
CleanExiHS_VPS41.
ExpressionAtlasiP49754. baseline and differential.
GenevisibleiP49754. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
2.130.10.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR000547. Clathrin_H-chain/VPS_repeat.
IPR011990. TPR-like_helical_dom.
IPR016902. VPS41.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00637. Clathrin. 1 hit.
[Graphical view]
PIRSFiPIRSF028921. VPS41. 1 hit.
SMARTiSM00299. CLH. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50236. CHCR. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast."
    Radisky D.C., Snyder W.B., Emr S.D., Kaplan J.
    Proc. Natl. Acad. Sci. U.S.A. 94:5662-5666(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION.
    Tissue: Heart.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 615-744.
    Tissue: Brain.
  5. "Identification of the switch in early-to-late endosome transition."
    Poteryaev D., Datta S., Ackema K., Zerial M., Spang A.
    Cell 141:497-508(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MON1B.
  6. "VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease."
    Ruan Q., Harrington A.J., Caldwell K.A., Caldwell G.A., Standaert D.G.
    Neurobiol. Dis. 37:330-338(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: MISCELLANEOUS.
  7. "Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells."
    Zlatic S.A., Tornieri K., L'Hernault S.W., Faundez V.
    Mol. Biol. Cell 22:1699-1715(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, SUBCELLULAR LOCATION.
  8. "Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease."
    Harrington A.J., Yacoubian T.A., Slone S.R., Caldwell K.A., Caldwell G.A.
    J. Neurosci. 32:2142-2153(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: MISCELLANEOUS.
  9. "Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway."
    Asensio C.S., Sirkis D.W., Maas J.W. Jr., Egami K., To T.L., Brodsky F.M., Shu X., Cheng Y., Edwards R.H.
    Dev. Cell 27:425-437(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
  10. "Tethering complexes in the endocytic pathway: CORVET and HOPS."
    Solinger J.A., Spang A.
    FEBS J. 280:2743-2757(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON THE HOPS AND CORVET COMPLEXES.
  11. "hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins."
    Pols M.S., van Meel E., Oorschot V., ten Brink C., Fukuda M., Swetha M.G., Mayor S., Klumperman J.
    Nat. Commun. 4:1361-1361(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  12. "The HOPS proteins hVps41 and hVps39 are required for homotypic and heterotypic late endosome fusion."
    Pols M.S., ten Brink C., Gosavi P., Oorschot V., Klumperman J.
    Traffic 14:219-232(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  13. "RILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking."
    Lin X., Yang T., Wang S., Wang Z., Yun Y., Sun L., Zhou Y., Xu X., Akazawa C., Hong W., Wang T.
    Sci. Rep. 4:7282-7282(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RILP, SUBUNIT.
  14. "The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes."
    Khatter D., Raina V.B., Dwivedi D., Sindhwani A., Bahl S., Sharma M.
    J. Cell Sci. 128:1746-1761(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, INTERACTION WITH ARL8B, VARIANT PRO-146, CHARACTERIZATION OF VARIANT PRO-146.
  15. "Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes."
    Wartosch L., Guenesdogan U., Graham S.C., Luzio J.P.
    Traffic 16:727-742(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, FUNCTION OF THE HOPS COMPLEX.

Entry informationi

Entry nameiVPS41_HUMAN
AccessioniPrimary (citable) accession number: P49754
Secondary accession number(s): E9PF36
, Q86TP8, Q99851, Q99852
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 16, 2008
Last modified: January 20, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Protective against both alpha-synuclein and neurotoxic-mediated injury in invertebrate and cellular models of Parkinson's disease (PD); the function requires the AP-3 adaptor complex and the HOPS complex.2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.