P49750 (YLPM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
YLP motif-containing protein 1

Alternative name(s):
Nuclear protein ZAP3
ZAP113

Gene names

Name:	YLPM1
Synonyms:	C14orf170, ZAP3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1951 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation By similarity.
Subunit structure	Interacts with PPP1CA and NCOA5. Forms a complex with ILF2, ILF3, KHDRBS1, RBMX, NCOA5 and PPP1CA By similarity.
Subcellular location	Nucleus. Nucleus speckle By similarity. Note: Migrates to nucleolar caps upon blockage of transcription. Ref.7
Tissue specificity	Expressed in neuronal, neuroblastoma and embryonic kidney cell lines (at protein level). Ref.7
Sequence caution	The sequence AAC42008.1 differs from that shown. Reason: Frameshift at position 1723. The sequence AAF61275.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Molecular function	Repressor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nuclear speck Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P49750-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 3 (identifier: P49750-3) The sequence of this isoform differs from the canonical sequence as follows:      1843-1862: GYIPKSKWEMDTSEAKLDKL → VGDRPTTLNSVSLLKFLKKV      1863-1951: Missing.
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Sequence conflict	1861	1	K → E in AAC42008. Ref.3
Isoform 4 (identifier: P49750-4) The sequence of this isoform differs from the canonical sequence as follows:      431-432: AT → TMSVDMQLRH...VMPLPPLSSA
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Sequence conflict	524	1	S → P in AK095760. Ref.2

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1951	1951	YLP motif-containing protein 1		PRO_0000066298
Regions
	Region	1901 – 1908	8	Involved in interaction with PPP1CA By similarity
	Compositional bias	15 – 205	191	Pro-rich
	Compositional bias	382 – 430	49	Gln-rich
	Compositional bias	807 – 1209	403	Arg-rich
	Compositional bias	1488 – 1577	90	Arg-rich
Amino acid modifications
	Modified residue	634	1	Phosphoserine Ref.5 Ref.8 Ref.9 Ref.10 Ref.11
	Modified residue	924	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	431 – 432	2	AT → TMSVDMQLRHYEMQQQQFQH LYQEWEREFQLWEEQLHSYP HKDQLQEYEKQWKTWQGHMK ATQSYLQEKVNSFQNMKNQY MGNMSMPPPFVPYSQMPPPL PTMPPPVLPPSLPPPVMPPA LPATVPPPGMPPPVMPPSLP TSVPPPGMPPSLSSAGPPPV LPPPSLSSAGPPPVLPPPSL SSTAPPPVMPLPPLSSA in isoform 4.		VSP_040649
	Alternative sequence	1843 – 1862	20	GYIPK…KLDKL → VGDRPTTLNSVSLLKFLKKV in isoform 3.		VSP_012538
	Alternative sequence	1863 – 1951	89	Missing in isoform 3.		VSP_012539
Experimental info
	Sequence conflict	421	1	Q → R in AK095760. Ref.2
	Sequence conflict	621	1	P → S in AAC42006. Ref.3
	Sequence conflict	1404	1	T → I in AAC42008. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 4, 2005. Version 3. Checksum: 11A41E942E59FFE0	FASTA	1,951	219,985
	10 20 30 40 50 60 MYPNWGRYGG SSHYPPPPVP PPPPVALPEA SPGPGYSSST TPAAPSSSGF MSFREQHLAQ 70 80 90 100 110 120 LQQLQQMHQK QMQCVLQPHH LPPPPLPPPP VMPGGGYGDW QPPPPPMPPP PGPALSYQKQ 130 140 150 160 170 180 QQYKHQMLHH QRDGPPGLVP MELESPPESP PVPPGSYMPP SQSYMPPPQP PPSYYPPTSS 190 200 210 220 230 240 QPYLPPAQPS PSQSPPSQSY LAPTPSYSSS SSSSQSYLSH SQSYLPSSQA SPSRPSQGHS 250 260 270 280 290 300 KSQLLAPPPP SAPPGNKTTV QQEPLESGAK NKSTEQQQAA PEPDPSTMTP QEQQQYWYRQ 310 320 330 340 350 360 HLLSLQQRTK VHLPGHKKGP VVAKDTPEPV KEEVTVPATS QVPESPSSEE PPLPPPNEEV 370 380 390 400 410 420 PPPLPPEEPQ SEDPEEDARL KQLQAAAAHW QQHQQHRVGF QYQGIMQKHT QLQQILQQYQ 430 440 450 460 470 480 QIIQPPPHIQ ATTPPPGIPP PGVPQGIPPQ LTAAPVPPAS SSQSSQVPEK PRPALLPTPV 490 500 510 520 530 540 SFGSAPPTTY HPPLQSAGPS EQVNSKAPLS KSALPYSSFS SDQGLGESSA APSQPITAVK 550 560 570 580 590 600 DMPVRSGGLL PDPPRSSYLE SPRGPRFDGP RRFEDLGSRC EGPRPKGPRF EGNRPDGPRP 610 620 630 640 650 660 RYEGHPAEGT KSKWGMIPRG PASQFYITPS TSLSPRQSGP QWKGPKPAFG QQHQQQPKSQ 670 680 690 700 710 720 AEPLSGNKEP LADTSSNQQK NFKMQSAAFS IAADVKDVKA AQSNENLSDS QQEPPKSEVS 730 740 750 760 770 780 EGPVEPSNWD QNVQSMETQI DKAQAVTQPV PLANKPVPAQ STFPSKTGGM EGGTAVATSS 790 800 810 820 830 840 LTADNDFKPV GIGLPHSENN QDKGLPRPDN RDNRLEGNRG NSSSYRGPGQ SRMEDTRDKG 850 860 870 880 890 900 LVNRGRGQAI SRGPGLVKQE DFRDKMMGRR EDSREKMNRG EGSRDRGLVR PGSSREKVPG 910 920 930 940 950 960 GLQGSQDRGA AGSRERGPPR RAGSQERGPL RRAGSRERIP PRRAGSRERG PPRGPGSRER 970 980 990 1000 1010 1020 GLGRSDFGRD RGPFRPEPGD GGEKMYPYHR DEPPRAPWNH GEERGHEEFP LDGRNAPMER 1030 1040 1050 1060 1070 1080 ERLDDWDRER YWRECERDYQ DDTLELYNRE DRFSAPPSRS HDGDRRGPWW DDWERDQDMD 1090 1100 1110 1120 1130 1140 EDYNREMERD MDRDVDRISR PMDMYDRSLD NEWDRDYGRP LDEQESQFRE RDIPSLPPLP 1150 1160 1170 1180 1190 1200 PLPPLPPLDR YRDDRWREER NREHGYDRDF RDRGELRIRE YPERGDTWRE KRDYVPDRMD 1210 1220 1230 1240 1250 1260 WERERLSDRW YPSDVDRHSP MAEHMPSSHH SSEMMGSDAS LDSDQGLGGV MVLSQRQHEI 1270 1280 1290 1300 1310 1320 ILKAAQELKM LREQKEQLQK MKDFGSEPQM ADHLPPQESR LQNTSSRPGM YPPPGSYRPP 1330 1340 1350 1360 1370 1380 PPMGKPPGSI VRPSAPPARS SVPVTRPPVP IPPPPPPPPL PPPPPVIKPQ TSAVEQERWD 1390 1400 1410 1420 1430 1440 EDSFYGLWDT NDEQGLNSEF KSETAAIPSA PVLPPPPVHS SIPPPGPVPM GMPPMSKPPP 1450 1460 1470 1480 1490 1500 VQQTVDYGHG RDISTNKVEQ IPYGERITLR PDPLPERSTF ETEHAGQRDR YDRERDREPY 1510 1520 1530 1540 1550 1560 FDRQSNVIAD HRDFKRDRET HRDRDRDRGV IDYDRDRFDR ERRPRDDRAQ SYRDKKDHSS 1570 1580 1590 1600 1610 1620 SRRGGFDRPS YDRKSDRPVY EGPSMFGGER RTYPEERMPL PAPSLSHQPP PAPRVEKKPE 1630 1640 1650 1660 1670 1680 SKNVDDILKP PGRESRPERI VVIMRGLPGS GKTHVAKLIR DKEVEFGGPA PRVLSLDDYF 1690 1700 1710 1720 1730 1740 ITEVEKEEKD PDSGKKVKKK VMEYEYEAEM EETYRTSMFK TFKKTLDDGF FPFIILDAIN 1750 1760 1770 1780 1790 1800 DRVRHFDQFW SAAKTKGFEV YLAEMSADNQ TCGKRNIHGR KLKEINKMAD HWETAPRHMM 1810 1820 1830 1840 1850 1860 RLDIRSLLQD AAIEEVEMED FDANIEEQKE EKKDAEEEES ELGYIPKSKW EMDTSEAKLD 1870 1880 1890 1900 1910 1920 KLDGLRTGTK RKRDWEAIAS RMEDYLQLPD DYDTRASEPG KKRVRWADLE EKKDADRKRA 1930 1940 1950 IGFVVGQTDW EKITDESGHL AEKALNRTKY I
	Isoform 3 [UniParc]. Checksum: 98C60B71D7C50896	FASTA	1,862	209,483
	10 20 30 40 50 60 MYPNWGRYGG SSHYPPPPVP PPPPVALPEA SPGPGYSSST TPAAPSSSGF MSFREQHLAQ 70 80 90 100 110 120 LQQLQQMHQK QMQCVLQPHH LPPPPLPPPP VMPGGGYGDW QPPPPPMPPP PGPALSYQKQ 130 140 150 160 170 180 QQYKHQMLHH QRDGPPGLVP MELESPPESP PVPPGSYMPP SQSYMPPPQP PPSYYPPTSS 190 200 210 220 230 240 QPYLPPAQPS PSQSPPSQSY LAPTPSYSSS SSSSQSYLSH SQSYLPSSQA SPSRPSQGHS 250 260 270 280 290 300 KSQLLAPPPP SAPPGNKTTV QQEPLESGAK NKSTEQQQAA PEPDPSTMTP QEQQQYWYRQ 310 320 330 340 350 360 HLLSLQQRTK VHLPGHKKGP VVAKDTPEPV KEEVTVPATS QVPESPSSEE PPLPPPNEEV 370 380 390 400 410 420 PPPLPPEEPQ SEDPEEDARL KQLQAAAAHW QQHQQHRVGF QYQGIMQKHT QLQQILQQYQ 430 440 450 460 470 480 QIIQPPPHIQ ATTPPPGIPP PGVPQGIPPQ LTAAPVPPAS SSQSSQVPEK PRPALLPTPV 490 500 510 520 530 540 SFGSAPPTTY HPPLQSAGPS EQVNSKAPLS KSALPYSSFS SDQGLGESSA APSQPITAVK 550 560 570 580 590 600 DMPVRSGGLL PDPPRSSYLE SPRGPRFDGP RRFEDLGSRC EGPRPKGPRF EGNRPDGPRP 610 620 630 640 650 660 RYEGHPAEGT KSKWGMIPRG PASQFYITPS TSLSPRQSGP QWKGPKPAFG QQHQQQPKSQ 670 680 690 700 710 720 AEPLSGNKEP LADTSSNQQK NFKMQSAAFS IAADVKDVKA AQSNENLSDS QQEPPKSEVS 730 740 750 760 770 780 EGPVEPSNWD QNVQSMETQI DKAQAVTQPV PLANKPVPAQ STFPSKTGGM EGGTAVATSS 790 800 810 820 830 840 LTADNDFKPV GIGLPHSENN QDKGLPRPDN RDNRLEGNRG NSSSYRGPGQ SRMEDTRDKG 850 860 870 880 890 900 LVNRGRGQAI SRGPGLVKQE DFRDKMMGRR EDSREKMNRG EGSRDRGLVR PGSSREKVPG 910 920 930 940 950 960 GLQGSQDRGA AGSRERGPPR RAGSQERGPL RRAGSRERIP PRRAGSRERG PPRGPGSRER 970 980 990 1000 1010 1020 GLGRSDFGRD RGPFRPEPGD GGEKMYPYHR DEPPRAPWNH GEERGHEEFP LDGRNAPMER 1030 1040 1050 1060 1070 1080 ERLDDWDRER YWRECERDYQ DDTLELYNRE DRFSAPPSRS HDGDRRGPWW DDWERDQDMD 1090 1100 1110 1120 1130 1140 EDYNREMERD MDRDVDRISR PMDMYDRSLD NEWDRDYGRP LDEQESQFRE RDIPSLPPLP 1150 1160 1170 1180 1190 1200 PLPPLPPLDR YRDDRWREER NREHGYDRDF RDRGELRIRE YPERGDTWRE KRDYVPDRMD 1210 1220 1230 1240 1250 1260 WERERLSDRW YPSDVDRHSP MAEHMPSSHH SSEMMGSDAS LDSDQGLGGV MVLSQRQHEI 1270 1280 1290 1300 1310 1320 ILKAAQELKM LREQKEQLQK MKDFGSEPQM ADHLPPQESR LQNTSSRPGM YPPPGSYRPP 1330 1340 1350 1360 1370 1380 PPMGKPPGSI VRPSAPPARS SVPVTRPPVP IPPPPPPPPL PPPPPVIKPQ TSAVEQERWD 1390 1400 1410 1420 1430 1440 EDSFYGLWDT NDEQGLNSEF KSETAAIPSA PVLPPPPVHS SIPPPGPVPM GMPPMSKPPP 1450 1460 1470 1480 1490 1500 VQQTVDYGHG RDISTNKVEQ IPYGERITLR PDPLPERSTF ETEHAGQRDR YDRERDREPY 1510 1520 1530 1540 1550 1560 FDRQSNVIAD HRDFKRDRET HRDRDRDRGV IDYDRDRFDR ERRPRDDRAQ SYRDKKDHSS 1570 1580 1590 1600 1610 1620 SRRGGFDRPS YDRKSDRPVY EGPSMFGGER RTYPEERMPL PAPSLSHQPP PAPRVEKKPE 1630 1640 1650 1660 1670 1680 SKNVDDILKP PGRESRPERI VVIMRGLPGS GKTHVAKLIR DKEVEFGGPA PRVLSLDDYF 1690 1700 1710 1720 1730 1740 ITEVEKEEKD PDSGKKVKKK VMEYEYEAEM EETYRTSMFK TFKKTLDDGF FPFIILDAIN 1750 1760 1770 1780 1790 1800 DRVRHFDQFW SAAKTKGFEV YLAEMSADNQ TCGKRNIHGR KLKEINKMAD HWETAPRHMM 1810 1820 1830 1840 1850 1860 RLDIRSLLQD AAIEEVEMED FDANIEEQKE EKKDAEEEES ELVGDRPTTL NSVSLLKFLK KV
	Isoform 4 [UniParc]. Checksum: 2C8F694D43061047	FASTA	2,146	241,645
	10 20 30 40 50 60 MYPNWGRYGG SSHYPPPPVP PPPPVALPEA SPGPGYSSST TPAAPSSSGF MSFREQHLAQ 70 80 90 100 110 120 LQQLQQMHQK QMQCVLQPHH LPPPPLPPPP VMPGGGYGDW QPPPPPMPPP PGPALSYQKQ 130 140 150 160 170 180 QQYKHQMLHH QRDGPPGLVP MELESPPESP PVPPGSYMPP SQSYMPPPQP PPSYYPPTSS 190 200 210 220 230 240 QPYLPPAQPS PSQSPPSQSY LAPTPSYSSS SSSSQSYLSH SQSYLPSSQA SPSRPSQGHS 250 260 270 280 290 300 KSQLLAPPPP SAPPGNKTTV QQEPLESGAK NKSTEQQQAA PEPDPSTMTP QEQQQYWYRQ 310 320 330 340 350 360 HLLSLQQRTK VHLPGHKKGP VVAKDTPEPV KEEVTVPATS QVPESPSSEE PPLPPPNEEV 370 380 390 400 410 420 PPPLPPEEPQ SEDPEEDARL KQLQAAAAHW QQHQQHRVGF QYQGIMQKHT QLQQILQQYQ 430 440 450 460 470 480 QIIQPPPHIQ TMSVDMQLRH YEMQQQQFQH LYQEWEREFQ LWEEQLHSYP HKDQLQEYEK 490 500 510 520 530 540 QWKTWQGHMK ATQSYLQEKV NSFQNMKNQY MGNMSMPPPF VPYSQMPPPL PTMPPPVLPP 550 560 570 580 590 600 SLPPPVMPPA LPATVPPPGM PPPVMPPSLP TSVPPPGMPP SLSSAGPPPV LPPPSLSSAG 610 620 630 640 650 660 PPPVLPPPSL SSTAPPPVMP LPPLSSATPP PGIPPPGVPQ GIPPQLTAAP VPPASSSQSS 670 680 690 700 710 720 QVPEKPRPAL LPTPVSFGSA PPTTYHPPLQ SAGPSEQVNS KAPLSKSALP YSSFSSDQGL 730 740 750 760 770 780 GESSAAPSQP ITAVKDMPVR SGGLLPDPPR SSYLESPRGP RFDGPRRFED LGSRCEGPRP 790 800 810 820 830 840 KGPRFEGNRP DGPRPRYEGH PAEGTKSKWG MIPRGPASQF YITPSTSLSP RQSGPQWKGP 850 860 870 880 890 900 KPAFGQQHQQ QPKSQAEPLS GNKEPLADTS SNQQKNFKMQ SAAFSIAADV KDVKAAQSNE 910 920 930 940 950 960 NLSDSQQEPP KSEVSEGPVE PSNWDQNVQS METQIDKAQA VTQPVPLANK PVPAQSTFPS 970 980 990 1000 1010 1020 KTGGMEGGTA VATSSLTADN DFKPVGIGLP HSENNQDKGL PRPDNRDNRL EGNRGNSSSY 1030 1040 1050 1060 1070 1080 RGPGQSRMED TRDKGLVNRG RGQAISRGPG LVKQEDFRDK MMGRREDSRE KMNRGEGSRD 1090 1100 1110 1120 1130 1140 RGLVRPGSSR EKVPGGLQGS QDRGAAGSRE RGPPRRAGSQ ERGPLRRAGS RERIPPRRAG 1150 1160 1170 1180 1190 1200 SRERGPPRGP GSRERGLGRS DFGRDRGPFR PEPGDGGEKM YPYHRDEPPR APWNHGEERG 1210 1220 1230 1240 1250 1260 HEEFPLDGRN APMERERLDD WDRERYWREC ERDYQDDTLE LYNREDRFSA PPSRSHDGDR 1270 1280 1290 1300 1310 1320 RGPWWDDWER DQDMDEDYNR EMERDMDRDV DRISRPMDMY DRSLDNEWDR DYGRPLDEQE 1330 1340 1350 1360 1370 1380 SQFRERDIPS LPPLPPLPPL PPLDRYRDDR WREERNREHG YDRDFRDRGE LRIREYPERG 1390 1400 1410 1420 1430 1440 DTWREKRDYV PDRMDWERER LSDRWYPSDV DRHSPMAEHM PSSHHSSEMM GSDASLDSDQ 1450 1460 1470 1480 1490 1500 GLGGVMVLSQ RQHEIILKAA QELKMLREQK EQLQKMKDFG SEPQMADHLP PQESRLQNTS 1510 1520 1530 1540 1550 1560 SRPGMYPPPG SYRPPPPMGK PPGSIVRPSA PPARSSVPVT RPPVPIPPPP PPPPLPPPPP 1570 1580 1590 1600 1610 1620 VIKPQTSAVE QERWDEDSFY GLWDTNDEQG LNSEFKSETA AIPSAPVLPP PPVHSSIPPP 1630 1640 1650 1660 1670 1680 GPVPMGMPPM SKPPPVQQTV DYGHGRDIST NKVEQIPYGE RITLRPDPLP ERSTFETEHA 1690 1700 1710 1720 1730 1740 GQRDRYDRER DREPYFDRQS NVIADHRDFK RDRETHRDRD RDRGVIDYDR DRFDRERRPR 1750 1760 1770 1780 1790 1800 DDRAQSYRDK KDHSSSRRGG FDRPSYDRKS DRPVYEGPSM FGGERRTYPE ERMPLPAPSL 1810 1820 1830 1840 1850 1860 SHQPPPAPRV EKKPESKNVD DILKPPGRES RPERIVVIMR GLPGSGKTHV AKLIRDKEVE 1870 1880 1890 1900 1910 1920 FGGPAPRVLS LDDYFITEVE KEEKDPDSGK KVKKKVMEYE YEAEMEETYR TSMFKTFKKT 1930 1940 1950 1960 1970 1980 LDDGFFPFII LDAINDRVRH FDQFWSAAKT KGFEVYLAEM SADNQTCGKR NIHGRKLKEI 1990 2000 2010 2020 2030 2040 NKMADHWETA PRHMMRLDIR SLLQDAAIEE VEMEDFDANI EEQKEEKKDA EEEESELGYI 2050 2060 2070 2080 2090 2100 PKSKWEMDTS EAKLDKLDGL RTGTKRKRDW EAIASRMEDY LQLPDDYDTR ASEPGKKRVR 2110 2120 2130 2140 WADLEEKKDA DRKRAIGFVV GQTDWEKITD ESGHLAEKAL NRTKYI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-433 (ISOFORM 4).
[3]	"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease." Sherrington R., Rogaev E.I., Liang Y., Rogaeva E.A., Levesque G., Ikeda M., Chi H., Lin C., Li G., Holman K., Tsuda T., Mar L., Foncin J.-F., Bruni A.C., Montesi M.P., Sorbi S., Rainero I., Pinessi L. , Nee L., Chumakov I., Pollen D., Brookes A., Sanseau P., Polinsky R.J., Wasco W., da Silva H.A.R., Haines J.L., Pericak-Vance M.A., Tanzi R.E., Roses A.D., Fraser P.E., Rommens J.M., St George-Hyslop P.H. Nature 375:754-760(1995) [PubMed: 7596406] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 539-847 AND 1397-1951 (ISOFORM 3). Tissue: Brain.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1566-1951 (ISOFORM 1). Tissue: Skin.
[5]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-634, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-924, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G." Ulke-Lemee A., Trinkle-Mulcahy L., Chaulk S., Bernstein N.K., Morrice N., Glover M., Lamond A.I., Moorhead G.B.G. Biochim. Biophys. Acta 1774:1339-1350(2007) [PubMed: 17890166] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[8]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-634, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-634, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-634, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-634, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC007956 Genomic DNA. Translation: AAF61275.1. Sequence problems. AK095760 mRNA. No translation available. L40403 mRNA. Translation: AAC42008.1. Frameshift. L40400 mRNA. Translation: AAC42006.1. BC007792 mRNA. Translation: AAH07792.1.
IPI	IPI00165434. IPI00514265. IPI00940874.
RefSeq	NP_062535.2. NM_019589.2.
UniGene	Hs.531111.
3D structure databases
ProteinModelPortal	P49750.
SMR	P49750. Positions 1637-1776.
ModBase	Search...
Protein-protein interaction databases
IntAct	P49750. 11 interactions.
STRING	P49750.
PTM databases
PhosphoSite	P49750.
Polymorphism databases
DMDM	57015374.
Proteomic databases
PRIDE	P49750.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000423680; ENSP00000409619; ENSG00000119596.
GeneID	56252.
KEGG	hsa:56252.
UCSC	uc001xqj.2. human.
Organism-specific databases
CTD	56252.
GeneCards	GC14P075230.
HGNC	HGNC:17798. YLPM1.
neXtProt	NX_P49750.
PharmGKB	PA134962086.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10331.
GeneTree	ENSGT00440000039837.
HOVERGEN	HBG079363.
InParanoid	P49750.
OMA	QSYLAPT.
Gene expression databases
ArrayExpress	P49750.
Bgee	P49750.
CleanEx	HS_YLPM1.
Genevestigator	P49750.
GermOnline	ENSG00000119596. Homo sapiens.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

YLPM1_HUMAN

Accession

Primary (citable) accession number: P49750
Secondary accession number(s): P49752, Q96I64, Q9P1V7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 4, 2005
Last modified:	January 25, 2012
This is version 85 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.