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Protein

YLP motif-containing protein 1

Gene

YLPM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
YLP motif-containing protein 1
Alternative name(s):
Nuclear protein ZAP3
ZAP113
Gene namesi
Name:YLPM1
Synonyms:C14orf170, ZAP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000119596.17
HGNCiHGNC:17798 YLPM1
neXtProtiNX_P49750

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi56252
OpenTargetsiENSG00000119596
PharmGKBiPA134962086

Polymorphism and mutation databases

BioMutaiYLPM1
DMDMi57015374

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000662981 – 2146YLP motif-containing protein 1Add BLAST2146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei735N6-methyllysineCombined sources1
Modified residuei756PhosphoserineCombined sources1
Modified residuei814Omega-N-methylarginineCombined sources1
Modified residuei829PhosphoserineCombined sources1
Modified residuei831Omega-N-methylarginineCombined sources1
Cross-linki891Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki983Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki983Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki1053Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki1053Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei1100PhosphoserineCombined sources1
Modified residuei1119PhosphoserineCombined sources1
Modified residuei1402PhosphoserineCombined sources1
Cross-linki1652Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1710Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP49750
MaxQBiP49750
PaxDbiP49750
PeptideAtlasiP49750
PRIDEiP49750

PTM databases

iPTMnetiP49750
PhosphoSitePlusiP49750

Expressioni

Tissue specificityi

Expressed in neuronal, neuroblastoma and embryonic kidney cell lines (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000119596
CleanExiHS_YLPM1
ExpressionAtlasiP49750 baseline and differential
GenevisibleiP49750 HS

Organism-specific databases

HPAiHPA048070
HPA061123

Interactioni

Subunit structurei

Interacts with PPP1CA and NCOA5. Forms a complex with ILF2, ILF3, KHDRBS1, RBMX, NCOA5 and PPP1CA (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121117, 51 interactors
DIPiDIP-53676N
IntActiP49750, 31 interactors
MINTiP49750
STRINGi9606.ENSP00000324463

Structurei

3D structure databases

ProteinModelPortaliP49750
SMRiP49750
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2096 – 2103Involved in interaction with PPP1CABy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 205Pro-richAdd BLAST191
Compositional biasi382 – 430Gln-richAdd BLAST49
Compositional biasi1002 – 1404Arg-richAdd BLAST403
Compositional biasi1683 – 1772Arg-richAdd BLAST90

Phylogenomic databases

eggNOGiKOG2400 Eukaryota
ENOG410YIR5 LUCA
GeneTreeiENSGT00440000039837
HOGENOMiHOG000168351
HOVERGENiHBG079363
InParanoidiP49750
KOiK17602
OMAiNLDSDQG
OrthoDBiEOG091G01X4
PhylomeDBiP49750
TreeFamiTF329361

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
SUPFAMiSSF52540 SSF52540, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 4 (identifier: P49750-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYPNWGRYGG SSHYPPPPVP PPPPVALPEA SPGPGYSSST TPAAPSSSGF
60 70 80 90 100
MSFREQHLAQ LQQLQQMHQK QMQCVLQPHH LPPPPLPPPP VMPGGGYGDW
110 120 130 140 150
QPPPPPMPPP PGPALSYQKQ QQYKHQMLHH QRDGPPGLVP MELESPPESP
160 170 180 190 200
PVPPGSYMPP SQSYMPPPQP PPSYYPPTSS QPYLPPAQPS PSQSPPSQSY
210 220 230 240 250
LAPTPSYSSS SSSSQSYLSH SQSYLPSSQA SPSRPSQGHS KSQLLAPPPP
260 270 280 290 300
SAPPGNKTTV QQEPLESGAK NKSTEQQQAA PEPDPSTMTP QEQQQYWYRQ
310 320 330 340 350
HLLSLQQRTK VHLPGHKKGP VVAKDTPEPV KEEVTVPATS QVPESPSSEE
360 370 380 390 400
PPLPPPNEEV PPPLPPEEPQ SEDPEEDARL KQLQAAAAHW QQHQQHRVGF
410 420 430 440 450
QYQGIMQKHT QLQQILQQYQ QIIQPPPHIQ TMSVDMQLRH YEMQQQQFQH
460 470 480 490 500
LYQEWEREFQ LWEEQLHSYP HKDQLQEYEK QWKTWQGHMK ATQSYLQEKV
510 520 530 540 550
NSFQNMKNQY MGNMSMPPPF VPYSQMPPPL PTMPPPVLPP SLPPPVMPPA
560 570 580 590 600
LPATVPPPGM PPPVMPPSLP TSVPPPGMPP SLSSAGPPPV LPPPSLSSAG
610 620 630 640 650
PPPVLPPPSL SSTAPPPVMP LPPLSSATPP PGIPPPGVPQ GIPPQLTAAP
660 670 680 690 700
VPPASSSQSS QVPEKPRPAL LPTPVSFGSA PPTTYHPPLQ SAGPSEQVNS
710 720 730 740 750
KAPLSKSALP YSSFSSDQGL GESSAAPSQP ITAVKDMPVR SGGLLPDPPR
760 770 780 790 800
SSYLESPRGP RFDGPRRFED LGSRCEGPRP KGPRFEGNRP DGPRPRYEGH
810 820 830 840 850
PAEGTKSKWG MIPRGPASQF YITPSTSLSP RQSGPQWKGP KPAFGQQHQQ
860 870 880 890 900
QPKSQAEPLS GNKEPLADTS SNQQKNFKMQ SAAFSIAADV KDVKAAQSNE
910 920 930 940 950
NLSDSQQEPP KSEVSEGPVE PSNWDQNVQS METQIDKAQA VTQPVPLANK
960 970 980 990 1000
PVPAQSTFPS KTGGMEGGTA VATSSLTADN DFKPVGIGLP HSENNQDKGL
1010 1020 1030 1040 1050
PRPDNRDNRL EGNRGNSSSY RGPGQSRMED TRDKGLVNRG RGQAISRGPG
1060 1070 1080 1090 1100
LVKQEDFRDK MMGRREDSRE KMNRGEGSRD RGLVRPGSSR EKVPGGLQGS
1110 1120 1130 1140 1150
QDRGAAGSRE RGPPRRAGSQ ERGPLRRAGS RERIPPRRAG SRERGPPRGP
1160 1170 1180 1190 1200
GSRERGLGRS DFGRDRGPFR PEPGDGGEKM YPYHRDEPPR APWNHGEERG
1210 1220 1230 1240 1250
HEEFPLDGRN APMERERLDD WDRERYWREC ERDYQDDTLE LYNREDRFSA
1260 1270 1280 1290 1300
PPSRSHDGDR RGPWWDDWER DQDMDEDYNR EMERDMDRDV DRISRPMDMY
1310 1320 1330 1340 1350
DRSLDNEWDR DYGRPLDEQE SQFRERDIPS LPPLPPLPPL PPLDRYRDDR
1360 1370 1380 1390 1400
WREERNREHG YDRDFRDRGE LRIREYPERG DTWREKRDYV PDRMDWERER
1410 1420 1430 1440 1450
LSDRWYPSDV DRHSPMAEHM PSSHHSSEMM GSDASLDSDQ GLGGVMVLSQ
1460 1470 1480 1490 1500
RQHEIILKAA QELKMLREQK EQLQKMKDFG SEPQMADHLP PQESRLQNTS
1510 1520 1530 1540 1550
SRPGMYPPPG SYRPPPPMGK PPGSIVRPSA PPARSSVPVT RPPVPIPPPP
1560 1570 1580 1590 1600
PPPPLPPPPP VIKPQTSAVE QERWDEDSFY GLWDTNDEQG LNSEFKSETA
1610 1620 1630 1640 1650
AIPSAPVLPP PPVHSSIPPP GPVPMGMPPM SKPPPVQQTV DYGHGRDIST
1660 1670 1680 1690 1700
NKVEQIPYGE RITLRPDPLP ERSTFETEHA GQRDRYDRER DREPYFDRQS
1710 1720 1730 1740 1750
NVIADHRDFK RDRETHRDRD RDRGVIDYDR DRFDRERRPR DDRAQSYRDK
1760 1770 1780 1790 1800
KDHSSSRRGG FDRPSYDRKS DRPVYEGPSM FGGERRTYPE ERMPLPAPSL
1810 1820 1830 1840 1850
SHQPPPAPRV EKKPESKNVD DILKPPGRES RPERIVVIMR GLPGSGKTHV
1860 1870 1880 1890 1900
AKLIRDKEVE FGGPAPRVLS LDDYFITEVE KEEKDPDSGK KVKKKVMEYE
1910 1920 1930 1940 1950
YEAEMEETYR TSMFKTFKKT LDDGFFPFII LDAINDRVRH FDQFWSAAKT
1960 1970 1980 1990 2000
KGFEVYLAEM SADNQTCGKR NIHGRKLKEI NKMADHWETA PRHMMRLDIR
2010 2020 2030 2040 2050
SLLQDAAIEE VEMEDFDANI EEQKEEKKDA EEEESELGYI PKSKWEMDTS
2060 2070 2080 2090 2100
EAKLDKLDGL RTGTKRKRDW EAIASRMEDY LQLPDDYDTR ASEPGKKRVR
2110 2120 2130 2140
WADLEEKKDA DRKRAIGFVV GQTDWEKITD ESGHLAEKAL NRTKYI
Length:2,146
Mass (Da):241,645
Last modified:March 28, 2018 - v4
Checksum:i2C8F694D43061047
GO
Isoform 3 (identifier: P49750-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-627: TMSVDMQLRH...VMPLPPLSSA → AT
     2038-2057: GYIPKSKWEMDTSEAKLDKL → VGDRPTTLNSVSLLKFLKKV
     2058-2146: Missing.

Show »
Length:1,862
Mass (Da):209,483
Checksum:i98C60B71D7C50896
GO
Isoform 1 (identifier: P49750-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-627: TMSVDMQLRH...VMPLPPLSSA → AT

Show »
Length:1,951
Mass (Da):219,985
Checksum:i11A41E942E59FFE0
GO

Sequence cautioni

The sequence AAC42008 differs from that shown. Reason: Frameshift at position 1723.Curated
The sequence AAF61275 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti421Q → R in AK095760 (PubMed:14702039).Curated1
Sequence conflicti524S → P in AK095760 (PubMed:14702039).Curated1
Sequence conflicti816P → S in AAC42006 (PubMed:7596406).Curated1
Sequence conflicti1599T → I in AAC42008 (PubMed:7596406).Curated1
Isoform 3 (identifier: P49750-3)
Sequence conflicti1861K → E in AAC42008 (PubMed:7596406).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_059470431 – 627TMSVD…PLSSA → AT in isoform 1 and isoform 3. Add BLAST197
Alternative sequenceiVSP_0594712038 – 2057GYIPK…KLDKL → VGDRPTTLNSVSLLKFLKKV in isoform 3. Add BLAST20
Alternative sequenceiVSP_0594722058 – 2146Missing in isoform 3. Add BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007956 Genomic DNA Translation: AAF61275.1 Sequence problems.
AK095760 mRNA No translation available.
L40403 mRNA Translation: AAC42008.1 Frameshift.
L40400 mRNA Translation: AAC42006.1
BC007792 mRNA Translation: AAH07792.1
CCDSiCCDS45135.1 [P49750-4]
RefSeqiNP_062535.2, NM_019589.2 [P49750-4]
UniGeneiHs.531111

Genome annotation databases

EnsembliENST00000325680; ENSP00000324463; ENSG00000119596 [P49750-4]
GeneIDi56252
KEGGihsa:56252
UCSCiuc001xqj.5 human [P49750-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiYLPM1_HUMAN
AccessioniPrimary (citable) accession number: P49750
Secondary accession number(s): P49752, Q96I64, Q9P1V7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 28, 2018
Last modified: May 23, 2018
This is version 144 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM

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