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P49746

- TSP3_HUMAN

UniProt

P49746 - TSP3_HUMAN

Protein

Thrombospondin-3

Gene

THBS3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.

    GO - Molecular functioni

    1. calcium ion binding Source: UniProtKB
    2. heparin binding Source: MGI

    GO - Biological processi

    1. bone trabecula formation Source: Ensembl
    2. cell-matrix adhesion Source: UniProtKB
    3. growth plate cartilage development Source: Ensembl
    4. ossification involved in bone maturation Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_16888. Signaling by PDGF.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thrombospondin-3
    Gene namesi
    Name:THBS3
    Synonyms:TSP3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:11787. THBS3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. perinuclear region of cytoplasm Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36499.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 956934Thrombospondin-3PRO_0000035849Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi266 – 266InterchainCurated
    Disulfide bondi269 – 269InterchainCurated
    Disulfide bondi278 ↔ 289PROSITE-ProRule annotation
    Disulfide bondi283 ↔ 300PROSITE-ProRule annotation
    Disulfide bondi303 ↔ 314PROSITE-ProRule annotation
    Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi320 ↔ 332PROSITE-ProRule annotation
    Disulfide bondi326 ↔ 341PROSITE-ProRule annotation
    Disulfide bondi344 ↔ 368PROSITE-ProRule annotation
    Disulfide bondi374 ↔ 388PROSITE-ProRule annotation
    Disulfide bondi382 ↔ 397PROSITE-ProRule annotation
    Disulfide bondi400 ↔ 412PROSITE-ProRule annotation
    Glycosylationi407 – 4071N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi418 ↔ 432PROSITE-ProRule annotation
    Disulfide bondi426 ↔ 442PROSITE-ProRule annotation
    Disulfide bondi444 ↔ 455PROSITE-ProRule annotation
    Disulfide bondi471 ↔ 478PROSITE-ProRule annotation
    Disulfide bondi483 ↔ 503PROSITE-ProRule annotation
    Disulfide bondi519 ↔ 539PROSITE-ProRule annotation
    Disulfide bondi542 ↔ 562PROSITE-ProRule annotation
    Disulfide bondi578 ↔ 598PROSITE-ProRule annotation
    Disulfide bondi601 ↔ 621PROSITE-ProRule annotation
    Disulfide bondi639 ↔ 659PROSITE-ProRule annotation
    Glycosylationi644 – 6441N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi679 ↔ 699PROSITE-ProRule annotation
    Disulfide bondi715 ↔ 936PROSITE-ProRule annotation
    Glycosylationi937 – 9371N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP49746.
    PaxDbiP49746.
    PRIDEiP49746.

    PTM databases

    PhosphoSiteiP49746.

    Expressioni

    Gene expression databases

    ArrayExpressiP49746.
    BgeeiP49746.
    CleanExiHS_THBS3.
    GenevestigatoriP49746.

    Organism-specific databases

    HPAiHPA006293.

    Interactioni

    Subunit structurei

    Oligomer; disulfide-linked.

    Protein-protein interaction databases

    BioGridi112917. 1 interaction.
    STRINGi9606.ENSP00000357362.

    Structurei

    3D structure databases

    ProteinModelPortaliP49746.
    SMRiP49746. Positions 52-148, 278-945.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 193171Laminin G-likeAdd
    BLAST
    Domaini316 – 35439EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini370 – 41041EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini414 – 45643EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Repeati457 – 49135TSP type-3 1Add
    BLAST
    Repeati492 – 52736TSP type-3 2Add
    BLAST
    Repeati528 – 55023TSP type-3 3Add
    BLAST
    Repeati551 – 58636TSP type-3 4Add
    BLAST
    Repeati587 – 60923TSP type-3 5Add
    BLAST
    Repeati610 – 64738TSP type-3 6Add
    BLAST
    Repeati648 – 68740TSP type-3 7Add
    BLAST
    Repeati688 – 72336TSP type-3 8Add
    BLAST
    Domaini727 – 941215TSP C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the thrombospondin family.Curated
    Contains 3 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.Curated
    Contains 1 TSP C-terminal (TSPC) domain.PROSITE-ProRule annotation
    Contains 8 TSP type-3 repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000007542.
    HOVERGENiHBG000636.
    InParanoidiP49746.
    KOiK04659.
    OMAiWRDKTSY.
    OrthoDBiEOG76QFGD.
    PhylomeDBiP49746.
    TreeFamiTF324917.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    4.10.1080.10. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR018097. EGF_Ca-bd_CS.
    IPR001791. Laminin_G.
    IPR024665. Thbs/COMP_coiled-coil.
    IPR028507. Thrombospondin-3.
    IPR003367. Thrombospondin_3-like_rpt.
    IPR017897. Thrombospondin_3_rpt.
    IPR008859. Thrombospondin_C.
    IPR028974. TSP_type-3_rpt.
    [Graphical view]
    PANTHERiPTHR10199:SF5. PTHR10199:SF5. 1 hit.
    PfamiPF11598. COMP. 1 hit.
    PF07645. EGF_CA. 2 hits.
    PF02412. TSP_3. 6 hits.
    PF05735. TSP_C. 1 hit.
    [Graphical view]
    SMARTiSM00181. EGF. 2 hits.
    SM00179. EGF_CA. 2 hits.
    SM00210. TSPN. 1 hit.
    [Graphical view]
    SUPFAMiSSF103647. SSF103647. 3 hits.
    SSF49899. SSF49899. 2 hits.
    PROSITEiPS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 3 hits.
    PS01187. EGF_CA. 2 hits.
    PS51234. TSP3. 8 hits.
    PS51236. TSP_CTER. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P49746-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    METQELRGAL ALLLLCFFTS ASQDLQVIDL LTVGESRQMV AVAEKIRTAL    50
    LTAGDIYLLS TFRLPPKQGG VLFGLYSRQD NTRWLEASVV GKINKVLVRY 100
    QREDGKVHAV NLQQAGLADG RTHTVLLRLR GPSRPSPALH LYVDCKLGDQ 150
    HAGLPALAPI PPAEVDGLEI RTGQKAYLRM QGFVESMKII LGGSMARVGA 200
    LSECPFQGDE SIHSAVTNAL HSILGEQTKA LVTQLTLFNQ ILVELRDDIR 250
    DQVKEMSLIR NTIMECQVCG FHEQRSHCSP NPCFRGVDCM EVYEYPGYRC 300
    GPCPPGLQGN GTHCSDINEC AHADPCFPGS SCINTMPGFH CEACPRGYKG 350
    TQVSGVGIDY ARASKQVCND IDECNDGNNG GCDPNSICTN TVGSFKCGPC 400
    RLGFLGNQSQ GCLPARTCHS PAHSPCHIHA HCLFERNGAV SCQCNVGWAG 450
    NGNVCGTDTD IDGYPDQALP CMDNNKHCKQ DNCLLTPNSG QEDADNDGVG 500
    DQCDDDADGD GIKNVEDNCR LFPNKDQQNS DTDSFGDACD NCPNVPNNDQ 550
    KDTDGNGEGD ACDNDVDGDG IPNGLDNCPK VPNPLQTDRD EDGVGDACDS 600
    CPEMSNPTQT DADSDLVGDV CDTNEDSDGD GHQDTKDNCP QLPNSSQLDS 650
    DNDGLGDECD GDDDNDGIPD YVPPGPDNCR LVPNPNQKDS DGNGVGDVCE 700
    DDFDNDAVVD PLDVCPESAE VTLTDFRAYQ TVVLDPEGDA QIDPNWVVLN 750
    QGMEIVQTMN SDPGLAVGYT AFNGVDFEGT FHVNTVTDDD YAGFLFSYQD 800
    SGRFYVVMWK QTEQTYWQAT PFRAVAQPGL QLKAVTSVSG PGEHLRNALW 850
    HTGHTPDQVR LLWTDPRNVG WRDKTSYRWQ LLHRPQVGYI RVKLYEGPQL 900
    VADSGVIIDT SMRGGRLGVF CFSQENIIWS NLQYRCNDTV PEDFEPFRRQ 950
    LLQGRV 956
    Length:956
    Mass (Da):104,201
    Last modified:October 1, 1996 - v1
    Checksum:iAE9B136DF0FFE5B8
    GO
    Isoform 2 (identifier: P49746-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         96-215: Missing.

    Show »
    Length:836
    Mass (Da):91,297
    Checksum:i8D7AA90E4B21CA96
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti279 – 2791S → G.
    Corresponds to variant rs35154152 [ dbSNP | Ensembl ].
    VAR_052658
    Natural varianti955 – 9551R → G in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035808

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei96 – 215120Missing in isoform 2. 1 PublicationVSP_045328Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L38969 mRNA. Translation: AAC41762.1.
    AL713999 Genomic DNA. Translation: CAI95084.1.
    AF023268 Genomic DNA. Translation: AAC51818.1.
    AK298592 mRNA. Translation: BAG60782.1.
    CH471121 Genomic DNA. Translation: EAW53110.1.
    BC018786 mRNA. Translation: AAH18786.1.
    CCDSiCCDS1099.1. [P49746-1]
    CCDS58034.1. [P49746-2]
    PIRiA57121.
    RefSeqiNP_001239536.1. NM_001252607.1.
    NP_001239537.1. NM_001252608.1. [P49746-2]
    NP_009043.1. NM_007112.4. [P49746-1]
    UniGeneiHs.169875.
    Hs.658188.

    Genome annotation databases

    EnsembliENST00000368378; ENSP00000357362; ENSG00000169231. [P49746-1]
    ENST00000457183; ENSP00000392207; ENSG00000169231. [P49746-2]
    GeneIDi7059.
    KEGGihsa:7059.
    UCSCiuc001fix.3. human. [P49746-1]
    uc010pfu.2. human.

    Polymorphism databases

    DMDMi1717814.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L38969 mRNA. Translation: AAC41762.1 .
    AL713999 Genomic DNA. Translation: CAI95084.1 .
    AF023268 Genomic DNA. Translation: AAC51818.1 .
    AK298592 mRNA. Translation: BAG60782.1 .
    CH471121 Genomic DNA. Translation: EAW53110.1 .
    BC018786 mRNA. Translation: AAH18786.1 .
    CCDSi CCDS1099.1. [P49746-1 ]
    CCDS58034.1. [P49746-2 ]
    PIRi A57121.
    RefSeqi NP_001239536.1. NM_001252607.1.
    NP_001239537.1. NM_001252608.1. [P49746-2 ]
    NP_009043.1. NM_007112.4. [P49746-1 ]
    UniGenei Hs.169875.
    Hs.658188.

    3D structure databases

    ProteinModelPortali P49746.
    SMRi P49746. Positions 52-148, 278-945.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112917. 1 interaction.
    STRINGi 9606.ENSP00000357362.

    PTM databases

    PhosphoSitei P49746.

    Polymorphism databases

    DMDMi 1717814.

    Proteomic databases

    MaxQBi P49746.
    PaxDbi P49746.
    PRIDEi P49746.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368378 ; ENSP00000357362 ; ENSG00000169231 . [P49746-1 ]
    ENST00000457183 ; ENSP00000392207 ; ENSG00000169231 . [P49746-2 ]
    GeneIDi 7059.
    KEGGi hsa:7059.
    UCSCi uc001fix.3. human. [P49746-1 ]
    uc010pfu.2. human.

    Organism-specific databases

    CTDi 7059.
    GeneCardsi GC01M155165.
    H-InvDB HIX0029532.
    HGNCi HGNC:11787. THBS3.
    HPAi HPA006293.
    MIMi 188062. gene.
    neXtProti NX_P49746.
    PharmGKBi PA36499.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000007542.
    HOVERGENi HBG000636.
    InParanoidi P49746.
    KOi K04659.
    OMAi WRDKTSY.
    OrthoDBi EOG76QFGD.
    PhylomeDBi P49746.
    TreeFami TF324917.

    Enzyme and pathway databases

    Reactomei REACT_16888. Signaling by PDGF.

    Miscellaneous databases

    ChiTaRSi THBS3. human.
    GeneWikii THBS3.
    GenomeRNAii 7059.
    NextBioi 27605.
    PROi P49746.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49746.
    Bgeei P49746.
    CleanExi HS_THBS3.
    Genevestigatori P49746.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    4.10.1080.10. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR018097. EGF_Ca-bd_CS.
    IPR001791. Laminin_G.
    IPR024665. Thbs/COMP_coiled-coil.
    IPR028507. Thrombospondin-3.
    IPR003367. Thrombospondin_3-like_rpt.
    IPR017897. Thrombospondin_3_rpt.
    IPR008859. Thrombospondin_C.
    IPR028974. TSP_type-3_rpt.
    [Graphical view ]
    PANTHERi PTHR10199:SF5. PTHR10199:SF5. 1 hit.
    Pfami PF11598. COMP. 1 hit.
    PF07645. EGF_CA. 2 hits.
    PF02412. TSP_3. 6 hits.
    PF05735. TSP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00181. EGF. 2 hits.
    SM00179. EGF_CA. 2 hits.
    SM00210. TSPN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103647. SSF103647. 3 hits.
    SSF49899. SSF49899. 2 hits.
    PROSITEi PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 3 hits.
    PS01187. EGF_CA. 2 hits.
    PS51234. TSP3. 8 hits.
    PS51236. TSP_CTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and organization of the human thrombospondin 3 gene (THBS3)."
      Adolph K.W., Long G.L., Winfield S., Ginns E.I., Bornstein P.
      Genomics 27:329-336(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Lung.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease."
      Winfield S.L., Tayebi N., Martin B.M., Ginns E.I., Sidransky E.
      Genome Res. 7:1020-1026(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-736.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 365-956.
      Tissue: Retina.
    7. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-955.

    Entry informationi

    Entry nameiTSP3_HUMAN
    AccessioniPrimary (citable) accession number: P49746
    Secondary accession number(s): B1AVR8, B4DQ20, Q8WV34
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 140 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

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