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Protein

Thrombopoietin

Gene

Thpo

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

GO - Molecular functioni

  • receptor binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombopoietin
Gene namesi
Name:Thpo
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi621438. Thpo.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: RGD
  • extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 326305ThrombopoietinPRO_0000008413Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 172Sequence analysis
Disulfide bondi50 ↔ 106Sequence analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence analysis
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence analysis
Glycosylationi235 – 2351N-linked (GlcNAc...)Sequence analysis
Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence analysis
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49745.
PRIDEiP49745.

PTM databases

PhosphoSiteiP49745.

Expressioni

Gene expression databases

GenevisibleiP49745. RN.

Interactioni

GO - Molecular functioni

  • receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067269.

Structurei

3D structure databases

ProteinModelPortaliP49745.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.

Sequence similaritiesi

Belongs to the EPO/TPO family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVHV. Eukaryota.
ENOG41116B9. LUCA.
GeneTreeiENSGT00390000006294.
HOGENOMiHOG000082495.
HOVERGENiHBG002468.
InParanoidiP49745.
KOiK06854.
OMAiCPEVNPL.
OrthoDBiEOG7PVWPW.
PhylomeDBiP49745.
TreeFamiTF338084.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR019767. EPO/TPO_CS.
IPR001323. EPO_TPO.
IPR003978. Thrombopoeitin.
[Graphical view]
PANTHERiPTHR10560. PTHR10560. 1 hit.
PfamiPF00758. EPO_TPO. 1 hit.
[Graphical view]
PRINTSiPR01485. THROMBOPTN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00817. EPO_TPO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELTDLLLVA ILLLTARLTL SSPVPPACDP RLLNKLLRDS YLLHSRLSQC
60 70 80 90 100
PDVNPLSIPV LLPAVDFSLG EWKTQTEQSK AQDILGAVSL LLEGVMAARG
110 120 130 140 150
QLEPSCLSSL LGQLSGQVRL LLGALQGLLG TQLPPQGRTT AHKDPSALFL
160 170 180 190 200
SLQQLLRGKV RFLLLVEGPA LCVRRTLPTT AVPSRTSQLL TLNKFPNRTS
210 220 230 240 250
GLLETNFSVV ARTAGPGLLN RLQGFRAKII PGQLNQTSGS LDQIPGYLNG
260 270 280 290 300
THEPVNGTHG LFAGTSLQTL EAPDVVPGAF NKGSLPLNLQ SGLPPIPSLA
310 320
ADGYTLFPPS PTFPTPGSPP QLPPVS
Length:326
Mass (Da):34,556
Last modified:October 1, 1996 - v1
Checksum:iF99D7F77F896FA2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32207 mRNA. Translation: BAA06906.1.
PIRiJC4125.
RefSeqiNP_112395.1. NM_031133.2.
XP_008767037.1. XM_008768815.1.
XP_008767038.1. XM_008768816.1.
XP_008767049.1. XM_008768827.1.
XP_008767050.1. XM_008768828.1.
UniGeneiRn.10576.

Genome annotation databases

EnsembliENSRNOT00000072402; ENSRNOP00000067269; ENSRNOG00000046850.
ENSRNOT00000073743; ENSRNOP00000065517; ENSRNOG00000050172.
GeneIDi103690065.
81811.
KEGGirno:103690065.
rno:81811.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32207 mRNA. Translation: BAA06906.1.
PIRiJC4125.
RefSeqiNP_112395.1. NM_031133.2.
XP_008767037.1. XM_008768815.1.
XP_008767038.1. XM_008768816.1.
XP_008767049.1. XM_008768827.1.
XP_008767050.1. XM_008768828.1.
UniGeneiRn.10576.

3D structure databases

ProteinModelPortaliP49745.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067269.

PTM databases

PhosphoSiteiP49745.

Proteomic databases

PaxDbiP49745.
PRIDEiP49745.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000072402; ENSRNOP00000067269; ENSRNOG00000046850.
ENSRNOT00000073743; ENSRNOP00000065517; ENSRNOG00000050172.
GeneIDi103690065.
81811.
KEGGirno:103690065.
rno:81811.

Organism-specific databases

CTDi7066.
RGDi621438. Thpo.

Phylogenomic databases

eggNOGiENOG410IVHV. Eukaryota.
ENOG41116B9. LUCA.
GeneTreeiENSGT00390000006294.
HOGENOMiHOG000082495.
HOVERGENiHBG002468.
InParanoidiP49745.
KOiK06854.
OMAiCPEVNPL.
OrthoDBiEOG7PVWPW.
PhylomeDBiP49745.
TreeFamiTF338084.

Miscellaneous databases

NextBioi615697.
PROiP49745.

Gene expression databases

GenevisibleiP49745. RN.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR019767. EPO/TPO_CS.
IPR001323. EPO_TPO.
IPR003978. Thrombopoeitin.
[Graphical view]
PANTHERiPTHR10560. PTHR10560. 1 hit.
PfamiPF00758. EPO_TPO. 1 hit.
[Graphical view]
PRINTSiPR01485. THROMBOPTN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00817. EPO_TPO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The sequence of a rat cDNA encoding thrombopoietin."
    Ogami K., Shimada Y., Sohma Y., Akahori H., Kato T., Kawamura K., Miyazaki H.
    Gene 158:309-310(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiTPO_RAT
AccessioniPrimary (citable) accession number: P49745
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 11, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.