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Protein

Retinoic acid receptor RXR-beta

Gene

Rxrb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi130 – 195Nuclear receptorPROSITE-ProRule annotationAdd BLAST66
Zinc fingeri130 – 150NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri166 – 190NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid receptor RXR-beta
Alternative name(s):
Nuclear receptor coregulator 1
Nuclear receptor subfamily 2 group B member 2
Retinoid X receptor beta
Gene namesi
Name:Rxrb
Synonyms:Nr2b2, Rcor-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3611 Rxrb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2805

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000053574‹1 – 458Retinoic acid receptor RXR-betaAdd BLAST›458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineBy similarity1
Modified residuei63PhosphoserineBy similarity1
Modified residuei255PhosphoserineBy similarity1
Modified residuei256PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP49743
PeptideAtlasiP49743
PRIDEiP49743

PTM databases

PhosphoSitePlusiP49743

Interactioni

Subunit structurei

Homodimer (in vitro) (By similarity). Heterodimer with other retinoic acid receptor family members. Binds DNA preferentially as a RAR/RXR heterodimer (PubMed:1662118). Interacts with NR1H3 (By similarity). Interacts with AKAP13 (By similarity).By similarity1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD
  • retinoic acid receptor binding Source: RGD
  • thyroid hormone receptor binding Source: RGD
  • vitamin D receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040499

Chemistry databases

BindingDBiP49743

Structurei

3D structure databases

ProteinModelPortaliP49743
SMRiP49743
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini221 – 454NR LBDPROSITE-ProRule annotationAdd BLAST234

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni‹1 – 129ModulatingBy similarityAdd BLAST›129
Regioni196 – 220HingeAdd BLAST25

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.Curated

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 150NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri166 – 190NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
HOVERGENiHBG005606
InParanoidiP49743
PhylomeDBiP49743

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR000003 Retinoid-X_rcpt/HNF4
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00545 RETINOIDXR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Fragment.

P49743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GEAGRDGMGD TGRDSRSPDS SSPNPLSQGI PPSSPPGPPH TPSAPPPPMP
60 70 80 90 100
PPPLGSPFPV ISSSMGSPGL PPPAPPGFSG PVSSPQINST VSLPGGGSGP
110 120 130 140 150
PEDVKPPVLG VRGLHCPPPP GGPGAGKRLC AICGDRSSGK HYGVYSCEGC
160 170 180 190 200
KGFFKRTIRK DLTYSCRDNK DCTVDKRQRN RCQYCRYQKC LATGMKREAV
210 220 230 240 250
QEERQRGKDK DGDGDGAGGA PEEMPVDRIL EAELAVEQKS DQGVEGPGAT
260 270 280 290 300
GGGGSSPNDP VTNICQAADK QLFTLVEWAK RIPHFSSLPL DDQVILLRAG
310 320 330 340 350
WNELLIASFS HRSIDVRDGI LLATGLHVHR NSAHSAGVGA IFDRVLTELV
360 370 380 390 400
SKMRDMRMDK TELGCLRAII LFNPDAKGLS NPGEVEILRE KVYASLETYC
410 420 430 440 450
KQKYPEQQGR FAKLLLRLPA LRSIGLKCLE HLFFFKLIGD TPIDTFLMEM

LEAPHQLA
Length:458
Mass (Da):49,078
Last modified:October 1, 1996 - v1
Checksum:i22D11956B11DB4BE
GO

Sequence cautioni

The sequence AAA42025 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81766 mRNA Translation: AAA42025.1 Different initiation.
PIRiA41651
UniGeneiRn.49295

Genome annotation databases

UCSCiRGD:3611 rat

Similar proteinsi

Entry informationi

Entry nameiRXRB_RAT
AccessioniPrimary (citable) accession number: P49743
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health