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P49730

- RIR2_TOBAC

UniProt

P49730 - RIR2_TOBAC

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Protein

Ribonucleoside-diphosphate reductase small chain

Gene
N/A
Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi75 – 751Iron 1 By similarity
Metal bindingi106 – 1061Iron 1 By similarity
Metal bindingi106 – 1061Iron 2 By similarity
Metal bindingi109 – 1091Iron 1 By similarity
Active sitei113 – 1131 By similarity
Metal bindingi168 – 1681Iron 2 By similarity
Metal bindingi202 – 2021Iron 2 By similarity
Metal bindingi205 – 2051Iron 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleoside-diphosphate reductase R2 subunit
Ribonucleotide reductase small subunit
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Ribonucleoside-diphosphate reductase small chainPRO_0000190467Add
BLAST

Expressioni

Inductioni

Maximum level of expression in mid-S phase.

Interactioni

Subunit structurei

Heterodimer of a large and a small chain.

Structurei

3D structure databases

ProteinModelPortaliP49730.
SMRiP49730. Positions 2-287.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49730-1 [UniParc]FASTAAdd to Basket

« Hide

MPLIPEEPLL ASSPDRFCMF PIQYPQIWEM YKKALASFWT AEEVDLSSDT    50
RHWETLTPGE RHFITHVLAF FAASDGIVLE NLAGRFMKEV QVAEARAFYG 100
FQIAIENIHS EMYSLLLESY IKDSDEKSRL FRAVETNPCV EKKAKWALRW 150
IDGSETFAER LVAFACVEGI FFSGSFCAIF WLKKRGLMPG LTFSNELISR 200
DEGLHCDFAC LLYSLLRTKL TEERVKGIVA DAVEIEREFV CDALPCALVG 250
MNGDLMSKYI EFVADRLLDA LGYDKLYNAQ NPFDWMELIS LQGKTNFFEK 300
RVGEYQKASV MSSLNGNGAT HEFKLDEDF 329
Length:329
Mass (Da):37,608
Last modified:October 1, 1996 - v1
Checksum:i65E7A4183AF045FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92443 mRNA. Translation: CAA63194.1.
PIRiT03688.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92443 mRNA. Translation: CAA63194.1 .
PIRi T03688.

3D structure databases

ProteinModelPortali P49730.
SMRi P49730. Positions 2-287.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of tobacco ribonucleotide reductase RNR1 and RNR2 cDNAs and cell cycle-regulated expression in synchronized plant cells."
    Chaboute M.-E., Combettes B., Clement B., Gigot C., Philipps G.
    Plant Mol. Biol. 38:797-806(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Bright Yellow 2.

Entry informationi

Entry nameiRIR2_TOBAC
AccessioniPrimary (citable) accession number: P49730
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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